SI2961410T1 - Uporaba derivatov pirazolopirimidina za zdravljenje motenj povezanih s PI3K - Google Patents

Uporaba derivatov pirazolopirimidina za zdravljenje motenj povezanih s PI3K

Info

Publication number
SI2961410T1
SI2961410T1 SI201431449T SI201431449T SI2961410T1 SI 2961410 T1 SI2961410 T1 SI 2961410T1 SI 201431449 T SI201431449 T SI 201431449T SI 201431449 T SI201431449 T SI 201431449T SI 2961410 T1 SI2961410 T1 SI 2961410T1
Authority
SI
Slovenia
Prior art keywords
pi3k
treatment
related disorders
pyrazolopyrimidine derivatives
pyrazolopyrimidine
Prior art date
Application number
SI201431449T
Other languages
English (en)
Slovenian (sl)
Inventor
Yun-Long Li
Wenqing Yao
Andrew P. Combs
Eddy W. Yue
Song Mei
Wenyu Zhu
Joseph Glenn
Jr. Thomas P. Maduskuie
Richard B. Sparks
Brent Douty
Chunhong He
Original Assignee
Incyte Holdings Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Holdings Corporation filed Critical Incyte Holdings Corporation
Publication of SI2961410T1 publication Critical patent/SI2961410T1/sl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
SI201431449T 2013-03-01 2014-02-28 Uporaba derivatov pirazolopirimidina za zdravljenje motenj povezanih s PI3K SI2961410T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361771480P 2013-03-01 2013-03-01
PCT/US2014/019372 WO2014134426A1 (en) 2013-03-01 2014-02-28 USE OF PYRAZOLOPYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PI3Kδ RELATED DISORDERS
EP14710739.5A EP2961410B1 (en) 2013-03-01 2014-02-28 Use of pyrazolopyrimidine derivatives for the treatment of pi3k related disorders

Publications (1)

Publication Number Publication Date
SI2961410T1 true SI2961410T1 (sl) 2020-03-31

Family

ID=50288319

Family Applications (1)

Application Number Title Priority Date Filing Date
SI201431449T SI2961410T1 (sl) 2013-03-01 2014-02-28 Uporaba derivatov pirazolopirimidina za zdravljenje motenj povezanih s PI3K

Country Status (32)

Country Link
US (6) US9932341B2 (enExample)
EP (3) EP4233869A3 (enExample)
JP (5) JP6545106B2 (enExample)
KR (5) KR102454308B1 (enExample)
CN (2) CN105120871B (enExample)
AR (1) AR094964A1 (enExample)
AU (5) AU2014223257B2 (enExample)
BR (1) BR112015020941A2 (enExample)
CA (1) CA2901993C (enExample)
CL (1) CL2015002442A1 (enExample)
CR (1) CR20150472A (enExample)
CY (1) CY1122712T1 (enExample)
DK (1) DK2961410T3 (enExample)
EA (2) EA201591612A1 (enExample)
ES (2) ES2774436T3 (enExample)
HR (1) HRP20200263T1 (enExample)
HU (1) HUE047719T2 (enExample)
IL (6) IL311666A (enExample)
LT (1) LT2961410T (enExample)
MX (2) MX367713B (enExample)
MY (1) MY177875A (enExample)
PE (1) PE20151996A1 (enExample)
PH (3) PH12021552233A1 (enExample)
PL (1) PL2961410T3 (enExample)
PT (1) PT2961410T (enExample)
RS (1) RS59958B1 (enExample)
SG (3) SG11201506654UA (enExample)
SI (1) SI2961410T1 (enExample)
SM (1) SMT202000043T1 (enExample)
TW (5) TWI736135B (enExample)
UA (1) UA119641C2 (enExample)
WO (1) WO2014134426A1 (enExample)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR077280A1 (es) 2009-06-29 2011-08-17 Incyte Corp Pirimidinonas como inhibidores de pi3k, y composiciones farmaceuticas que los comprenden
IL299533B2 (en) 2011-09-02 2025-01-01 Incyte Holdings Corp Heterocycloamines as PI3K inhibitors
AR090548A1 (es) 2012-04-02 2014-11-19 Incyte Corp Azaheterociclobencilaminas biciclicas como inhibidores de pi3k
EP2943485B1 (en) 2013-01-14 2017-09-20 Incyte Holdings Corporation Bicyclic aromatic carboxamide compounds useful as pim kinase inhibitors
AU2014207691B2 (en) 2013-01-15 2018-08-30 Incyte Holdings Corporation Thiazolecarboxamides and pyridinecarboxamide compounds useful as Pim kinase inhibitors
TWI736135B (zh) * 2013-03-01 2021-08-11 美商英塞特控股公司 吡唑并嘧啶衍生物治療PI3Kδ相關病症之用途
EP3036238A1 (en) 2013-08-23 2016-06-29 Incyte Corporation Furo- and thieno-pyridine carboxamide compounds useful as pim kinase inhibitors
DK3129021T3 (da) 2014-04-08 2020-11-09 Incyte Corp Behandling af b-celle-maligniteter ved en kombination af jak- og pi3k-inhibitorer
US10077277B2 (en) 2014-06-11 2018-09-18 Incyte Corporation Bicyclic heteroarylaminoalkyl phenyl derivatives as PI3K inhibitors
US9580418B2 (en) 2014-07-14 2017-02-28 Incyte Corporation Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors
US9822124B2 (en) 2014-07-14 2017-11-21 Incyte Corporation Bicyclic heteroaromatic carboxamide compounds useful as Pim kinase inhibitors
US9586949B2 (en) 2015-02-09 2017-03-07 Incyte Corporation Aza-heteroaryl compounds as PI3K-gamma inhibitors
SG11201706917WA (en) * 2015-02-27 2017-09-28 Incyte Corp Salts of pi3k inhibitor and processes for their preparation
WO2016183063A1 (en) 2015-05-11 2016-11-17 Incyte Corporation Crystalline forms of a pi3k inhibitor
US9540347B2 (en) 2015-05-29 2017-01-10 Incyte Corporation Pyridineamine compounds useful as Pim kinase inhibitors
TWI734699B (zh) 2015-09-09 2021-08-01 美商英塞特公司 Pim激酶抑制劑之鹽
WO2017059251A1 (en) 2015-10-02 2017-04-06 Incyte Corporation Heterocyclic compounds useful as pim kinase inhibitors
WO2017079519A1 (en) 2015-11-06 2017-05-11 Incyte Corporation Heterocyclic compounds as pi3k-gamma inhibitors
US20170190689A1 (en) 2016-01-05 2017-07-06 Incyte Corporation Pyridine and pyridimine compounds as pi3k-gamma inhibitors
US9822122B2 (en) 2016-03-31 2017-11-21 Oncternal Therapeutics, Inc. Indoline analogs and uses thereof
US10138248B2 (en) 2016-06-24 2018-11-27 Incyte Corporation Substituted imidazo[2,1-f][1,2,4]triazines, substituted imidazo[1,2-a]pyridines, substituted imidazo[1,2-b]pyridazines and substituted imidazo[1,2-a]pyrazines as PI3K-γ inhibitors
JP7128264B2 (ja) * 2017-09-08 2022-08-30 ベイジーン リミテッド PI3Kδ阻害剤としてのイミダゾ[1,5-a]ピラジン誘導体
MA50398B1 (fr) 2017-10-18 2021-10-29 Incyte Corp Dérivés d'imidazole condensés, substitués par des groupes hydroxy tertiaires, utilisés comme inhibiteurs de pi3k-gamma
TW201924683A (zh) 2017-12-08 2019-07-01 美商英塞特公司 用於治療骨髓增生性贅瘤的低劑量組合療法
HUE060515T2 (hu) * 2018-01-10 2023-03-28 Idorsia Pharmaceuticals Ltd 2,4,6,7-Tetrahidro-pirazolo[4,3-d]pirimidin-5-on származékok és rokon vegyületek mint C5A receptor modulátorok vasculitis és gyulladásos betegségek kezelésére
MD3762368T2 (ro) 2018-03-08 2022-07-31 Incyte Corp Compuși diol aminopirazină ca inhibitori ai PI3K-Y
SG11202011680YA (en) * 2018-06-01 2020-12-30 Incyte Corp Dosing regimen for the treatment of pi3k related disorders
WO2020010003A1 (en) 2018-07-02 2020-01-09 Incyte Corporation AMINOPYRAZINE DERIVATIVES AS PI3K-γ INHIBITORS
TWI727392B (zh) * 2018-08-13 2021-05-11 美商基利科學股份有限公司 噻二唑irak4抑制劑
CN110833552A (zh) * 2018-08-15 2020-02-25 广西梧州制药(集团)股份有限公司 吡唑并嘧啶衍生物在治疗狼疮肾炎的用途
CR20250050A (es) * 2018-09-05 2025-03-19 Incyte Corp Formas cristalinas de un inhibidor de fosfoinositida 3–quinasa (pi3k) (divisional 2021-0165)
WO2022115120A1 (en) 2020-11-30 2022-06-02 Incyte Corporation Combination therapy with an anti-cd19 antibody and parsaclisib
JP2023551519A (ja) 2020-11-30 2023-12-08 インサイト・コーポレイション 抗cd19抗体とパルサクリシブの組み合わせ療法
CN112808550B (zh) * 2020-12-28 2021-10-01 青岛理工大学 用于海洋工程的劣化免疫仿生防护界面及制备方法
WO2023114369A2 (en) 2021-12-16 2023-06-22 Incyte Corporation Topical formulations of pi3k-delta inhibitors

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5521184A (en) 1992-04-03 1996-05-28 Ciba-Geigy Corporation Pyrimidine derivatives and processes for the preparation thereof
WO2000009495A1 (en) 1998-08-11 2000-02-24 Novartis Ag Isoquinoline derivatives with angiogenesis inhibiting activity
US6133031A (en) 1999-08-19 2000-10-17 Isis Pharmaceuticals Inc. Antisense inhibition of focal adhesion kinase expression
GB9905075D0 (en) 1999-03-06 1999-04-28 Zeneca Ltd Chemical compounds
GB0004890D0 (en) 2000-03-01 2000-04-19 Astrazeneca Uk Ltd Chemical compounds
PL202623B1 (pl) 2000-06-28 2009-07-31 Smithkline Beecham Plc Sposób wytwarzania drobno zmielonego preparatu substancji leczniczej, drobno zmielona substancja lecznicza wytworzona tym sposobem i zawierająca ją kompozycja farmaceutyczna
DE60230890D1 (de) 2001-09-19 2009-03-05 Aventis Pharma Sa Indolizine als kinaseproteinhemmer
MXPA04004137A (es) 2001-10-30 2005-01-25 Novartis Ag Derivados de estauroesporina como inhibidores de la actividad de cinasa de tirosina del receptor flt3.
TW200406374A (en) 2002-05-29 2004-05-01 Novartis Ag Diaryl urea derivatives useful for the treatment of protein kinase dependent diseases
GB0215676D0 (en) 2002-07-05 2002-08-14 Novartis Ag Organic compounds
AR042052A1 (es) 2002-11-15 2005-06-08 Vertex Pharma Diaminotriazoles utiles como inhibidores de proteinquinasas
UA80767C2 (en) 2002-12-20 2007-10-25 Pfizer Prod Inc Pyrimidine derivatives for the treatment of abnormal cell growth
GB0305929D0 (en) 2003-03-14 2003-04-23 Novartis Ag Organic compounds
PE20050952A1 (es) 2003-09-24 2005-12-19 Novartis Ag Derivados de isoquinolina como inhibidores de b-raf
WO2005123719A1 (en) 2004-06-10 2005-12-29 Irm Llc Compounds and compositions as protein kinase inhibitors
BRPI0517887A (pt) 2004-11-24 2008-10-21 Novartis Ag combinações de inibidores de jaks
CN102532133A (zh) 2006-01-17 2012-07-04 沃泰克斯药物股份有限公司 适用作詹纳斯激酶抑制剂的吖吲哚类
WO2009026701A1 (en) 2007-08-29 2009-03-05 Methylgene Inc. Sirtuin inhibitors
WO2009157880A1 (en) 2008-06-27 2009-12-30 S*Bio Pte Ltd Pyrazine substituted purines
AR073651A1 (es) * 2008-09-24 2010-11-24 Novartis Ag Formulaciones galenicas de compuestos organicos
EP2346508B1 (en) * 2008-09-26 2016-08-24 Intellikine, LLC Heterocyclic kinase inhibitors
EP2416771A4 (en) 2009-04-09 2012-10-31 Oncothyreon Inc METHODS AND COMPOSITIONS OF PI3 KINASE INHIBITORS USED IN THE TREATMENT OF FIBROSIS
AR077280A1 (es) 2009-06-29 2011-08-17 Incyte Corp Pirimidinonas como inhibidores de pi3k, y composiciones farmaceuticas que los comprenden
US8293753B2 (en) 2009-07-02 2012-10-23 Novartis Ag Substituted 2-carboxamide cycloamino ureas
SI2470546T1 (sl) 2009-08-28 2013-12-31 Takeda Pharmaceutical Company Limited Spojine heksahidrooksazinopteridina za uporabo kot MTOR inhibitorji
US8759359B2 (en) 2009-12-18 2014-06-24 Incyte Corporation Substituted heteroaryl fused derivatives as PI3K inhibitors
AR079529A1 (es) 2009-12-18 2012-02-01 Incyte Corp Derivados arilo y heteroarilo sustituidos y fundidos como inhibidores de la pi3k
US9193721B2 (en) 2010-04-14 2015-11-24 Incyte Holdings Corporation Fused derivatives as PI3Kδ inhibitors
US9062055B2 (en) 2010-06-21 2015-06-23 Incyte Corporation Fused pyrrole derivatives as PI3K inhibitors
ES2764848T3 (es) 2010-12-20 2020-06-04 Incyte Holdings Corp N-(1-(fenilo sustituido)etilo)-9H-purina-6-aminas como inhibidores de PI3K
WO2012106343A2 (en) 2011-02-01 2012-08-09 The Board Of Trustees Of The University Of Illinois Hdac inhibitors and therapeutic methods using the same
WO2012125629A1 (en) 2011-03-14 2012-09-20 Incyte Corporation Substituted diamino-pyrimidine and diamino-pyridine derivatives as pi3k inhibitors
WO2012135009A1 (en) 2011-03-25 2012-10-04 Incyte Corporation Pyrimidine-4,6-diamine derivatives as pi3k inhibitors
IL299533B2 (en) 2011-09-02 2025-01-01 Incyte Holdings Corp Heterocycloamines as PI3K inhibitors
AR090548A1 (es) 2012-04-02 2014-11-19 Incyte Corp Azaheterociclobencilaminas biciclicas como inhibidores de pi3k
TWI736135B (zh) 2013-03-01 2021-08-11 美商英塞特控股公司 吡唑并嘧啶衍生物治療PI3Kδ相關病症之用途
US10077277B2 (en) * 2014-06-11 2018-09-18 Incyte Corporation Bicyclic heteroarylaminoalkyl phenyl derivatives as PI3K inhibitors
SG11201706917WA (en) 2015-02-27 2017-09-28 Incyte Corp Salts of pi3k inhibitor and processes for their preparation
SG11202011680YA (en) * 2018-06-01 2020-12-30 Incyte Corp Dosing regimen for the treatment of pi3k related disorders
WO2020102150A1 (en) * 2018-11-13 2020-05-22 Incyte Corporation Heterocyclic derivatives as pi3k inhibitors

Also Published As

Publication number Publication date
TW201444846A (zh) 2014-12-01
JP2019142941A (ja) 2019-08-29
EP3632442B1 (en) 2023-04-05
AU2018264053A1 (en) 2018-12-06
EP3632442A1 (en) 2020-04-08
PE20151996A1 (es) 2016-01-13
TWI736135B (zh) 2021-08-11
HUE047719T2 (hu) 2020-05-28
US20220106318A1 (en) 2022-04-07
IL240784A0 (en) 2015-10-29
CR20150472A (es) 2016-01-04
MX2015011273A (es) 2015-12-03
SMT202000043T1 (it) 2020-03-13
RS59958B1 (sr) 2020-03-31
KR102717616B1 (ko) 2024-10-16
EP4233869A2 (en) 2023-08-30
JP7556010B2 (ja) 2024-09-25
TWI687220B (zh) 2020-03-11
AU2018264053B2 (en) 2020-08-20
KR20150135327A (ko) 2015-12-02
IL301180A (en) 2023-05-01
AU2022218495A1 (en) 2022-09-08
AU2024287194A1 (en) 2025-01-23
AR094964A1 (es) 2015-09-09
CN109010343A (zh) 2018-12-18
EP4233869A3 (en) 2023-11-01
MX367713B (es) 2019-09-03
KR102454308B1 (ko) 2022-10-14
KR20240152422A (ko) 2024-10-21
LT2961410T (lt) 2020-02-10
DK2961410T3 (da) 2020-02-17
JP2016510035A (ja) 2016-04-04
IL283943B2 (en) 2023-08-01
IL267853B (en) 2020-03-31
BR112015020941A2 (pt) 2017-07-18
EA202192151A1 (ru) 2021-12-31
AU2014223257B2 (en) 2018-11-29
TW202214254A (zh) 2022-04-16
KR102586858B1 (ko) 2023-10-11
CN105120871B (zh) 2018-08-10
IL240784B (en) 2020-06-30
CY1122712T1 (el) 2021-03-12
US20210332059A1 (en) 2021-10-28
TW202019428A (zh) 2020-06-01
IL274771A (en) 2020-07-30
SG10201707130UA (en) 2017-10-30
KR20210110409A (ko) 2021-09-07
AU2014223257A1 (en) 2015-09-24
AU2022218495B2 (en) 2024-10-03
JP7189185B2 (ja) 2022-12-13
TWI841376B (zh) 2024-05-01
EP2961410A1 (en) 2016-01-06
IL311666A (en) 2024-05-01
AU2020210278A1 (en) 2020-08-20
CL2015002442A1 (es) 2016-02-05
CA2901993A1 (en) 2014-09-04
US9932341B2 (en) 2018-04-03
SG11201506654UA (en) 2015-09-29
TW201929860A (zh) 2019-08-01
KR102298150B1 (ko) 2021-09-07
MY177875A (en) 2020-09-24
PT2961410T (pt) 2020-03-02
TW202333734A (zh) 2023-09-01
ES2774436T3 (es) 2020-07-21
EP2961410B1 (en) 2019-12-11
JP2025003975A (ja) 2025-01-14
US12152033B2 (en) 2024-11-26
PL2961410T3 (pl) 2020-05-18
MX2019010422A (es) 2019-10-15
PH12021552233A1 (en) 2022-07-18
US20190040067A1 (en) 2019-02-07
WO2014134426A1 (en) 2014-09-04
JP2021020914A (ja) 2021-02-18
IL283943B1 (en) 2023-04-01
CN105120871A (zh) 2015-12-02
KR20230145517A (ko) 2023-10-17
EA201591612A1 (ru) 2016-05-31
HRP20200263T1 (hr) 2020-05-29
PH12015501920B1 (en) 2016-01-18
US20140249132A1 (en) 2014-09-04
PH12019501321B1 (en) 2020-10-12
JP2023036609A (ja) 2023-03-14
TWI657090B (zh) 2019-04-21
AU2020210278B2 (en) 2022-05-26
US20250289823A1 (en) 2025-09-18
SG10201912275YA (en) 2020-04-29
IL267853A (en) 2019-09-26
HK1221398A1 (en) 2017-06-02
JP6776399B2 (ja) 2020-10-28
PH12019501321A1 (en) 2020-10-12
UA119641C2 (uk) 2019-07-25
JP6545106B2 (ja) 2019-07-17
IL283943A (en) 2021-07-29
KR20220143146A (ko) 2022-10-24
CA2901993C (en) 2023-03-07
ES2945212T3 (es) 2023-06-29
PH12015501920A1 (en) 2016-01-18
US20220119393A1 (en) 2022-04-21

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