ES2760002T3 - Métodos de tratamiento de la psoriasis de uñas y cuero cabelludo - Google Patents
Métodos de tratamiento de la psoriasis de uñas y cuero cabelludo Download PDFInfo
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- ES2760002T3 ES2760002T3 ES15714136T ES15714136T ES2760002T3 ES 2760002 T3 ES2760002 T3 ES 2760002T3 ES 15714136 T ES15714136 T ES 15714136T ES 15714136 T ES15714136 T ES 15714136T ES 2760002 T3 ES2760002 T3 ES 2760002T3
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Classifications
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Microbiology (AREA)
- Mycology (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461972638P | 2014-03-31 | 2014-03-31 | |
| US201462031850P | 2014-07-31 | 2014-07-31 | |
| US201462041879P | 2014-08-26 | 2014-08-26 | |
| PCT/US2015/021613 WO2015153144A1 (en) | 2014-03-31 | 2015-03-19 | Methods of treating nail and scalp psoriasis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2760002T3 true ES2760002T3 (es) | 2020-05-12 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES15714136T Active ES2760002T3 (es) | 2014-03-31 | 2015-03-19 | Métodos de tratamiento de la psoriasis de uñas y cuero cabelludo |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20170174772A1 (enExample) |
| EP (1) | EP3126392B1 (enExample) |
| JP (1) | JP6596014B2 (enExample) |
| KR (2) | KR102530900B1 (enExample) |
| CN (1) | CN106456751B (enExample) |
| AU (1) | AU2015241373B2 (enExample) |
| CA (1) | CA2944605C (enExample) |
| ES (1) | ES2760002T3 (enExample) |
| MY (1) | MY184189A (enExample) |
| SG (1) | SG11201607881SA (enExample) |
| WO (1) | WO2015153144A1 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7833527B2 (en) | 2006-10-02 | 2010-11-16 | Amgen Inc. | Methods of treating psoriasis using IL-17 Receptor A antibodies |
| IN2012DN06720A (enExample) | 2010-01-15 | 2015-10-23 | Kirin Amgen Inc | |
| CN105534996B (zh) * | 2016-02-24 | 2018-05-01 | 长沙佰顺生物科技有限公司 | 一种治疗银屑病的药物组合物 |
| GB201612043D0 (en) * | 2016-07-11 | 2016-08-24 | Crescendo Biologics Ltd | Composition for treatment of disorders |
| JP7033774B2 (ja) * | 2017-08-25 | 2022-03-11 | 国立大学法人 東京大学 | 抗サイトカイン抗体療法 |
| US12161748B2 (en) | 2018-01-31 | 2024-12-10 | Twi Biotechnology, Inc. | Topical formulations comprising tofacitinib |
| JP7324210B2 (ja) * | 2018-01-31 | 2023-08-09 | ティダブリューアイ・バイオテクノロジー・インコーポレイテッド | トファシチニブを含む局所製剤 |
| EP3756689A4 (en) | 2018-02-22 | 2022-07-27 | Tokai University Educational System | INHIBITOR OF IL-17A ACTIVITY AND ITS USE |
| MX2021009851A (es) | 2019-02-18 | 2021-09-10 | Lilly Co Eli | Formulacion de anticuerpos terapeuticos. |
| JP2022547678A (ja) * | 2019-09-11 | 2022-11-15 | ボシュ ヘルス アイルランド リミテッド | Ｉｌ－１７ｒａ抗体を用いた非アルコール性脂肪性肝疾患（ｎａｆｌｄ）の治療方法 |
| CN114423455A (zh) * | 2019-09-25 | 2022-04-29 | 国立大学法人东京大学 | 用于治疗系统性硬化症的药物组合物 |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| IL83878A (en) | 1987-09-13 | 1995-07-31 | Yeda Res & Dev | Soluble protein corresponding to tnf inhibitory protein its preparation and pharmaceutical compositions containing it |
| IL98078A0 (en) | 1991-05-07 | 1992-06-21 | Yeda Res & Dev | Pharmaceutical compositions comprising an anticytokyne |
| US5204244A (en) | 1987-10-27 | 1993-04-20 | Oncogen | Production of chimeric antibodies by homologous recombination |
| GB8807803D0 (en) | 1988-03-31 | 1988-05-05 | Glaxo Group Ltd | Biochemical product |
| EP0362371A4 (en) | 1988-04-15 | 1990-10-24 | Protein Design Labs, Inc. | Il-2 receptor-specific chimeric antibodies |
| IL94039A (en) | 1989-08-06 | 2006-09-05 | Yeda Res & Dev | Antibodies to tbp - 1 and their use |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5116964A (en) | 1989-02-23 | 1992-05-26 | Genentech, Inc. | Hybrid immunoglobulins |
| DK0393438T3 (da) | 1989-04-21 | 2005-05-30 | Amgen Inc | TNF-receptor, TNF-bindende proteiner og DNAér, der koder herfor |
| DE3922089A1 (de) | 1989-05-09 | 1990-12-13 | Basf Ag | Neue proteine und ihre herstellung |
| CA2017025C (en) | 1989-05-18 | 2008-07-22 | David Wallach | Tumor necrosis factor binding protein ii, its purification and antibodies thereto |
| IL95031A (en) | 1989-07-18 | 2007-03-08 | Amgen Inc | Method for the production of a human recombinant tumor necrosis factor inhibitor |
| US5395760A (en) | 1989-09-05 | 1995-03-07 | Immunex Corporation | DNA encoding tumor necrosis factor-α and -β receptors |
| AU630497B2 (en) | 1989-09-05 | 1992-10-29 | Immunex Corporation | Tumor necrosis factor-alpha and -beta receptors |
| DE10399023I2 (de) | 1989-09-12 | 2006-11-23 | Ahp Mfg B V | TFN-bindende Proteine |
| JPH03127800A (ja) | 1989-10-13 | 1991-05-30 | Teijin Ltd | 腫瘍壊死因子活性抑制物質 |
| DK0433900T3 (da) | 1989-12-13 | 1996-01-29 | Yeda Res & Dev | Ekspression af rekombinant tumornekrosefaktor bindingsprotein I (TBP-I) |
| US5136021A (en) | 1990-02-27 | 1992-08-04 | Health Research, Inc. | TNF-inhibitory protein and a method of production |
| US6552170B1 (en) | 1990-04-06 | 2003-04-22 | Amgen Inc. | PEGylation reagents and compounds formed therewith |
| US6458360B1 (en) | 1990-04-25 | 2002-10-01 | The Johns Hopkins University | Soluble complement regulatory molecules |
| GB2246569A (en) | 1990-06-15 | 1992-02-05 | Charing Cross Sunley Research | Tumour necrosis factor - alpha binding protein |
| DK0464533T3 (da) | 1990-06-28 | 1999-04-26 | Gen Hospital Corp | Fusionsproteiner med immunglobulindele, deres fremstilling og anvendelse |
| WO1992001002A1 (en) | 1990-07-11 | 1992-01-23 | Teijin Limited | Tumor necrosis factor activity inhibitor and production thereof |
| SG63617A1 (en) | 1991-01-18 | 1999-03-30 | Amgen Boulder Inc | Methods for treating tumar necrosis factor mediated diseases |
| ES2199935T3 (es) | 1991-03-15 | 2004-03-01 | Amgen Inc. | Pegilacion de polipeptidos. |
| IL99120A0 (en) | 1991-08-07 | 1992-07-15 | Yeda Res & Dev | Multimers of the soluble forms of tnf receptors,their preparation and pharmaceutical compositions containing them |
| JP3122139B2 (ja) | 1991-10-15 | 2001-01-09 | マラーキー，ミッシェル，エフ． | 後期段階炎症反応の治療用組成物 |
| CA2133326C (en) | 1992-03-30 | 2005-03-01 | Craig A. Smith | Fusion proteins comprising tumor necrosis factor receptor |
| EP0639079B1 (en) | 1992-04-30 | 2000-01-12 | Amgen Inc. | Methods for treating interleukin-1 and tumor necrosis factor mediated diseases |
| JPH05312248A (ja) | 1992-05-08 | 1993-11-22 | Nissan Motor Co Ltd | シフトレバー装置 |
| JPH07504203A (ja) | 1992-09-15 | 1995-05-11 | イミュネックス・コーポレーション | 腫瘍壊死因子アンタゴニストを用いるｔｎｆ−依存性炎症の治療方法 |
| EP0672142B1 (en) | 1992-12-04 | 2001-02-28 | Medical Research Council | Multivalent and multispecific binding proteins, their manufacture and use |
| DK0817847T4 (da) | 1995-03-23 | 2009-10-05 | Immunex Corp | IL-17-receptor |
| US7030565B2 (en) | 2004-07-27 | 2006-04-18 | Jerrell Penn Hollaway | Lamp control circuit with selectable color signals |
| EP1909831A4 (en) | 2005-06-14 | 2013-02-20 | Amgen Inc | SELF-BUFFING PROTEIN FORMULATIONS |
| US7833527B2 (en) | 2006-10-02 | 2010-11-16 | Amgen Inc. | Methods of treating psoriasis using IL-17 Receptor A antibodies |
| UA99716C2 (ru) * | 2006-10-02 | 2012-09-25 | Кирин-Амген Инк. | Антитело, которое специфично связывает человеческий il-17 рецептор а (il-17ra) |
| IN2012DN06720A (enExample) * | 2010-01-15 | 2015-10-23 | Kirin Amgen Inc | |
| EP2625199B1 (en) * | 2010-10-08 | 2017-11-22 | Novartis AG | Methods of treating psoriasis using il-17 antagonists |
| US9413463B2 (en) | 2013-08-30 | 2016-08-09 | Google Inc. | Apparatus and method for efficient two-way optical communication where transmitter may interfere with receiver |
| US9209965B2 (en) | 2014-01-14 | 2015-12-08 | Microsemi Semiconductor Ulc | Network interface with clock recovery module on line card |
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| WO2015153144A1 (en) | 2015-10-08 |
| KR20160130248A (ko) | 2016-11-10 |
| CN106456751B (zh) | 2021-02-02 |
| AU2015241373B2 (en) | 2020-11-05 |
| JP6596014B2 (ja) | 2019-10-23 |
| EP3126392A1 (en) | 2017-02-08 |
| CA2944605A1 (en) | 2015-10-08 |
| CN106456751A (zh) | 2017-02-22 |
| KR102530900B1 (ko) | 2023-05-12 |
| AU2015241373A1 (en) | 2016-10-06 |
| EP3126392B1 (en) | 2019-09-11 |
| KR20220093008A (ko) | 2022-07-04 |
| US20170174772A1 (en) | 2017-06-22 |
| MY184189A (en) | 2021-03-24 |
| JP2017511316A (ja) | 2017-04-20 |
| CA2944605C (en) | 2023-10-17 |
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