KR20160130248A - 손발톱 및 두피 건선의 치료 방법 - Google Patents
손발톱 및 두피 건선의 치료 방법 Download PDFInfo
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- KR20160130248A KR20160130248A KR1020167026333A KR20167026333A KR20160130248A KR 20160130248 A KR20160130248 A KR 20160130248A KR 1020167026333 A KR1020167026333 A KR 1020167026333A KR 20167026333 A KR20167026333 A KR 20167026333A KR 20160130248 A KR20160130248 A KR 20160130248A
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- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- Y10S514/863—
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- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Microbiology (AREA)
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| US7767206B2 (en) | 2006-10-02 | 2010-08-03 | Amgen Inc. | Neutralizing determinants of IL-17 Receptor A and antibodies that bind thereto |
| WO2011088120A1 (en) | 2010-01-15 | 2011-07-21 | Amgen Inc. | Antibody formulation and therapeutic regimens |
| CN105534996B (zh) * | 2016-02-24 | 2018-05-01 | 长沙佰顺生物科技有限公司 | 一种治疗银屑病的药物组合物 |
| GB201612043D0 (en) * | 2016-07-11 | 2016-08-24 | Crescendo Biologics Ltd | Composition for treatment of disorders |
| JP7033774B2 (ja) * | 2017-08-25 | 2022-03-11 | 国立大学法人 東京大学 | 抗サイトカイン抗体療法 |
| EP3746086A4 (en) * | 2018-01-31 | 2021-10-20 | TWI Biotechnology, Inc. | TOPICAL FORMULATIONS INCLUDING TOFACITINIB |
| US12161748B2 (en) | 2018-01-31 | 2024-12-10 | Twi Biotechnology, Inc. | Topical formulations comprising tofacitinib |
| KR20200123435A (ko) | 2018-02-22 | 2020-10-29 | 토카이 유니버시티 에듀케이셔널시스템 | Il-17a 활성 저해제 및 그 용도 |
| CN120241997A (zh) | 2019-02-18 | 2025-07-04 | 伊莱利利公司 | 治疗性抗体制剂 |
| WO2021048359A1 (en) * | 2019-09-11 | 2021-03-18 | Bausch Health Ireland Limited | Methods of treating nonalcoholic fatty liver disease (nafld) using il-17ra antibody |
| WO2021060425A1 (ja) * | 2019-09-25 | 2021-04-01 | 国立大学法人東京大学 | 全身性強皮症治療用医薬組成物 |
Family Cites Families (42)
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|---|---|---|---|---|
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| IL83878A (en) | 1987-09-13 | 1995-07-31 | Yeda Res & Dev | Soluble protein corresponding to tnf inhibitory protein its preparation and pharmaceutical compositions containing it |
| IL98078A0 (en) | 1991-05-07 | 1992-06-21 | Yeda Res & Dev | Pharmaceutical compositions comprising an anticytokyne |
| US5204244A (en) | 1987-10-27 | 1993-04-20 | Oncogen | Production of chimeric antibodies by homologous recombination |
| GB8807803D0 (en) | 1988-03-31 | 1988-05-05 | Glaxo Group Ltd | Biochemical product |
| FI895955A7 (fi) | 1988-04-15 | 1989-12-13 | Protein Design Labs Inc | Il-2-reseptorispesifisiä "kimeerisiä" vasta-aineita |
| IL94039A (en) | 1989-08-06 | 2006-09-05 | Yeda Res & Dev | Antibodies to tbp - 1 and their use |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5116964A (en) | 1989-02-23 | 1992-05-26 | Genentech, Inc. | Hybrid immunoglobulins |
| DE59010941D1 (de) | 1989-04-21 | 2005-03-24 | Amgen Inc | TNF-Rezeptor, TNF bindende Proteine und dafür kodierende DNAs |
| DE3922089A1 (de) | 1989-05-09 | 1990-12-13 | Basf Ag | Neue proteine und ihre herstellung |
| DE69017753T3 (de) | 1989-05-18 | 2013-06-20 | Yeda Research And Development Co., Ltd. | Tumor-Nekrosefaktor-Bindungsprotein II, seine Reinigung und spezifische Antikörper |
| IL95031A (en) | 1989-07-18 | 2007-03-08 | Amgen Inc | Method for the production of a human recombinant tumor necrosis factor inhibitor |
| US5395760A (en) | 1989-09-05 | 1995-03-07 | Immunex Corporation | DNA encoding tumor necrosis factor-α and -β receptors |
| WO1991003553A1 (en) | 1989-09-05 | 1991-03-21 | Immunex Corporation | TUMOR NECROSIS FACTOR-α AND -β RECEPTORS |
| DE10399023I2 (de) | 1989-09-12 | 2006-11-23 | Ahp Mfg B V | TFN-bindende Proteine |
| JPH03127800A (ja) | 1989-10-13 | 1991-05-30 | Teijin Ltd | 腫瘍壊死因子活性抑制物質 |
| DE69022559T2 (de) | 1989-12-13 | 1996-05-02 | Yeda Res & Dev | Expression des rekombinanten Tumor-Nekrosisfaktor-Bindungsproteins I (TBP-I). |
| US5136021A (en) | 1990-02-27 | 1992-08-04 | Health Research, Inc. | TNF-inhibitory protein and a method of production |
| US6552170B1 (en) | 1990-04-06 | 2003-04-22 | Amgen Inc. | PEGylation reagents and compounds formed therewith |
| US6458360B1 (en) | 1990-04-25 | 2002-10-01 | The Johns Hopkins University | Soluble complement regulatory molecules |
| GB2246569A (en) | 1990-06-15 | 1992-02-05 | Charing Cross Sunley Research | Tumour necrosis factor - alpha binding protein |
| DE59109269D1 (de) | 1990-06-28 | 2005-12-15 | Hoechst Ag | Fusionsproteine mit Immunglobulinanteilen, ihre Herstellung und Verwendung |
| WO1992001002A1 (en) | 1990-07-11 | 1992-01-23 | Teijin Limited | Tumor necrosis factor activity inhibitor and production thereof |
| AU1235692A (en) | 1991-01-18 | 1992-08-27 | Synergen, Inc. | Methods for treating tumor necrosis factor mediated diseases |
| ATE240740T1 (de) | 1991-03-15 | 2003-06-15 | Amgen Inc | Pegylation von polypeptiden |
| IL99120A0 (en) | 1991-08-07 | 1992-07-15 | Yeda Res & Dev | Multimers of the soluble forms of tnf receptors,their preparation and pharmaceutical compositions containing them |
| EP0611302B1 (en) | 1991-10-15 | 2000-03-29 | MULLARKEY, Michael F. | Receptors for treating late phase inflammatory responses |
| EP0670730B1 (en) | 1992-03-30 | 2003-06-04 | Immunex Corporation | Fusion protein comprising two tumor necrosis factor receptors |
| JPH07509223A (ja) | 1992-04-30 | 1995-10-12 | アムジェン インコーポレイテッド | インターロイキン−1媒介疾患および腫瘍壊死因子媒介疾患の治療方法 |
| JPH05312248A (ja) | 1992-05-08 | 1993-11-22 | Nissan Motor Co Ltd | シフトレバー装置 |
| NZ256293A (en) | 1992-09-15 | 1997-06-24 | Immunex Corp | Method of treating tumour necrosis factor - mediated inflammation by use of tnf antagonist |
| DK0672142T3 (da) | 1992-12-04 | 2001-06-18 | Medical Res Council | Multivalente og multispecifikke bindingsproteiner samt fremstilling og anvendelse af disse |
| NZ306653A (en) | 1995-03-23 | 1999-03-29 | Immunex Corp | Isolated dna il-17 receptors |
| US7030565B2 (en) | 2004-07-27 | 2006-04-18 | Jerrell Penn Hollaway | Lamp control circuit with selectable color signals |
| WO2006138181A2 (en) | 2005-06-14 | 2006-12-28 | Amgen Inc. | Self-buffering protein formulations |
| UA99716C2 (ru) * | 2006-10-02 | 2012-09-25 | Кирин-Амген Инк. | Антитело, которое специфично связывает человеческий il-17 рецептор а (il-17ra) |
| US7767206B2 (en) | 2006-10-02 | 2010-08-03 | Amgen Inc. | Neutralizing determinants of IL-17 Receptor A and antibodies that bind thereto |
| WO2011088120A1 (en) | 2010-01-15 | 2011-07-21 | Amgen Inc. | Antibody formulation and therapeutic regimens |
| CN103154031A (zh) * | 2010-10-08 | 2013-06-12 | 诺华有限公司 | 利用il-17拮抗剂治疗牛皮癣的方法 |
| US9413463B2 (en) | 2013-08-30 | 2016-08-09 | Google Inc. | Apparatus and method for efficient two-way optical communication where transmitter may interfere with receiver |
| US9209965B2 (en) | 2014-01-14 | 2015-12-08 | Microsemi Semiconductor Ulc | Network interface with clock recovery module on line card |
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| CA2944605C (en) | 2023-10-17 |
| MY184189A (en) | 2021-03-24 |
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| WO2015153144A1 (en) | 2015-10-08 |
| AU2015241373B2 (en) | 2020-11-05 |
| CA2944605A1 (en) | 2015-10-08 |
| EP3126392B1 (en) | 2019-09-11 |
| JP6596014B2 (ja) | 2019-10-23 |
| CN106456751B (zh) | 2021-02-02 |
| EP3126392A1 (en) | 2017-02-08 |
| SG11201607881SA (en) | 2016-10-28 |
| US20170174772A1 (en) | 2017-06-22 |
| JP2017511316A (ja) | 2017-04-20 |
| KR102530900B1 (ko) | 2023-05-12 |
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