ES2750211T3 - Medios cromatográficos para el almacenamiento y suministro de productos biológicos terapéuticos y moléculas pequeñas - Google Patents
Medios cromatográficos para el almacenamiento y suministro de productos biológicos terapéuticos y moléculas pequeñas Download PDFInfo
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- ES2750211T3 ES2750211T3 ES13739077T ES13739077T ES2750211T3 ES 2750211 T3 ES2750211 T3 ES 2750211T3 ES 13739077 T ES13739077 T ES 13739077T ES 13739077 T ES13739077 T ES 13739077T ES 2750211 T3 ES2750211 T3 ES 2750211T3
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- FQPSGWSUVKBHSU-UHFFFAOYSA-N methacrylamide Chemical compound CC(=C)C(N)=O FQPSGWSUVKBHSU-UHFFFAOYSA-N 0.000 description 1
- DCUFMVPCXCSVNP-UHFFFAOYSA-N methacrylic anhydride Chemical compound CC(=C)C(=O)OC(=O)C(C)=C DCUFMVPCXCSVNP-UHFFFAOYSA-N 0.000 description 1
- YDKNBNOOCSNPNS-UHFFFAOYSA-N methyl 1,3-benzoxazole-2-carboxylate Chemical compound C1=CC=C2OC(C(=O)OC)=NC2=C1 YDKNBNOOCSNPNS-UHFFFAOYSA-N 0.000 description 1
- 238000001471 micro-filtration Methods 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- FJYACARVIOXIAK-UHFFFAOYSA-N n'-hydroxyprop-2-enimidamide Chemical compound C=CC(N)=NO FJYACARVIOXIAK-UHFFFAOYSA-N 0.000 description 1
- QHQMBOKYHCJVKF-UHFFFAOYSA-N n-[12-(prop-2-enoylamino)dodecyl]prop-2-enamide Chemical compound C=CC(=O)NCCCCCCCCCCCCNC(=O)C=C QHQMBOKYHCJVKF-UHFFFAOYSA-N 0.000 description 1
- HBMNNOUETVVBHK-UHFFFAOYSA-N n-[3-(dimethylamino)propyl]-2-methylprop-2-enamide;2-methylprop-2-enoic acid Chemical compound CC(=C)C(O)=O.CN(C)CCCNC(=O)C(C)=C HBMNNOUETVVBHK-UHFFFAOYSA-N 0.000 description 1
- UYOYYIPNSNHABT-UHFFFAOYSA-N n-dodecyl-n-ethyl-2-methylprop-2-enamide Chemical compound CCCCCCCCCCCCN(CC)C(=O)C(C)=C UYOYYIPNSNHABT-UHFFFAOYSA-N 0.000 description 1
- 229920005615 natural polymer Polymers 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- NZIDBRBFGPQCRY-UHFFFAOYSA-N octyl 2-methylprop-2-enoate Chemical compound CCCCCCCCOC(=O)C(C)=C NZIDBRBFGPQCRY-UHFFFAOYSA-N 0.000 description 1
- LJAGLQVRUZWQGK-UHFFFAOYSA-N oxecane-2,10-dione Chemical compound O=C1CCCCCCCC(=O)O1 LJAGLQVRUZWQGK-UHFFFAOYSA-N 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 108010092851 peginterferon alfa-2b Proteins 0.000 description 1
- 229960003931 peginterferon alfa-2b Drugs 0.000 description 1
- 238000005191 phase separation Methods 0.000 description 1
- QIWKUEJZZCOPFV-UHFFFAOYSA-N phenyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OC1=CC=CC=C1 QIWKUEJZZCOPFV-UHFFFAOYSA-N 0.000 description 1
- WRAQQYDMVSCOTE-UHFFFAOYSA-N phenyl prop-2-enoate Chemical compound C=CC(=O)OC1=CC=CC=C1 WRAQQYDMVSCOTE-UHFFFAOYSA-N 0.000 description 1
- 229940031999 pneumococcal conjugate vaccine Drugs 0.000 description 1
- 229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 description 1
- 229920002492 poly(sulfone) Polymers 0.000 description 1
- 239000004417 polycarbonate Substances 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 229920002523 polyethylene Glycol 1000 Polymers 0.000 description 1
- 239000002685 polymerization catalyst Substances 0.000 description 1
- 239000003505 polymerization initiator Substances 0.000 description 1
- 229920001451 polypropylene glycol Chemical group 0.000 description 1
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 1
- 229920000131 polyvinylidene Polymers 0.000 description 1
- 235000011056 potassium acetate Nutrition 0.000 description 1
- 229960004109 potassium acetate Drugs 0.000 description 1
- 239000001508 potassium citrate Substances 0.000 description 1
- 229960002635 potassium citrate Drugs 0.000 description 1
- QEEAPRPFLLJWCF-UHFFFAOYSA-K potassium citrate (anhydrous) Chemical compound [K+].[K+].[K+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O QEEAPRPFLLJWCF-UHFFFAOYSA-K 0.000 description 1
- 235000011082 potassium citrates Nutrition 0.000 description 1
- WFIZEGIEIOHZCP-UHFFFAOYSA-M potassium formate Chemical compound [K+].[O-]C=O WFIZEGIEIOHZCP-UHFFFAOYSA-M 0.000 description 1
- USHAGKDGDHPEEY-UHFFFAOYSA-L potassium persulfate Chemical compound [K+].[K+].[O-]S(=O)(=O)OOS([O-])(=O)=O USHAGKDGDHPEEY-UHFFFAOYSA-L 0.000 description 1
- 229910000160 potassium phosphate Inorganic materials 0.000 description 1
- 235000011009 potassium phosphates Nutrition 0.000 description 1
- ARJOQCYCJMAIFR-UHFFFAOYSA-N prop-2-enoyl prop-2-enoate Chemical compound C=CC(=O)OC(=O)C=C ARJOQCYCJMAIFR-UHFFFAOYSA-N 0.000 description 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 239000013074 reference sample Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 230000009834 selective interaction Effects 0.000 description 1
- HELHAJAZNSDZJO-OLXYHTOASA-L sodium L-tartrate Chemical compound [Na+].[Na+].[O-]C(=O)[C@H](O)[C@@H](O)C([O-])=O HELHAJAZNSDZJO-OLXYHTOASA-L 0.000 description 1
- HLBBKKJFGFRGMU-UHFFFAOYSA-M sodium formate Chemical compound [Na+].[O-]C=O HLBBKKJFGFRGMU-UHFFFAOYSA-M 0.000 description 1
- 235000019254 sodium formate Nutrition 0.000 description 1
- 235000011008 sodium phosphates Nutrition 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 239000001433 sodium tartrate Substances 0.000 description 1
- 229960002167 sodium tartrate Drugs 0.000 description 1
- 235000011004 sodium tartrates Nutrition 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 238000002336 sorption--desorption measurement Methods 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 239000010421 standard material Substances 0.000 description 1
- 125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 230000007847 structural defect Effects 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 150000003459 sulfonic acid esters Chemical class 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 229960001832 taliglucerase alfa Drugs 0.000 description 1
- 108010072309 taliglucerase alfa Proteins 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 229960001612 trastuzumab emtansine Drugs 0.000 description 1
- 241000712461 unidentified influenza virus Species 0.000 description 1
- 229960003824 ustekinumab Drugs 0.000 description 1
- 229960003862 vemurafenib Drugs 0.000 description 1
- GPXBXXGIAQBQNI-UHFFFAOYSA-N vemurafenib Chemical compound CCCS(=O)(=O)NC1=CC=C(F)C(C(=O)C=2C3=CC(=CN=C3NC=2)C=2C=CC(Cl)=CC=2)=C1F GPXBXXGIAQBQNI-UHFFFAOYSA-N 0.000 description 1
- 229960000834 vinyl ether Drugs 0.000 description 1
- 239000011800 void material Substances 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
- 150000003738 xylenes Chemical class 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7007—Drug-containing films, membranes or sheets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/544—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Inorganic Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261588312P | 2012-01-19 | 2012-01-19 | |
| PCT/US2013/022057 WO2013109825A1 (en) | 2012-01-19 | 2013-01-18 | Chromatographic media for storage and delivery of therapeutic biologics and small molecules |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2750211T3 true ES2750211T3 (es) | 2020-03-25 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES13739077T Active ES2750211T3 (es) | 2012-01-19 | 2013-01-18 | Medios cromatográficos para el almacenamiento y suministro de productos biológicos terapéuticos y moléculas pequeñas |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US20130189322A1 (enExample) |
| EP (1) | EP2804634B1 (enExample) |
| JP (2) | JP6552822B2 (enExample) |
| KR (1) | KR102113296B1 (enExample) |
| AU (1) | AU2013209620B2 (enExample) |
| CA (2) | CA3124806C (enExample) |
| DK (1) | DK2804634T3 (enExample) |
| ES (1) | ES2750211T3 (enExample) |
| IN (1) | IN2014DN06817A (enExample) |
| WO (1) | WO2013109825A1 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY178616A (en) | 2012-09-17 | 2020-10-19 | Grace W R & Co | Chromatography media and devices |
| EP3024843B1 (en) | 2013-07-25 | 2022-08-31 | Bio-Rad Laboratories, Inc. | Enhanced functionality and delivery of a protein from a porous substrate |
| FR3012978A1 (fr) * | 2013-11-12 | 2015-05-15 | Biocarecell | Filtre biocompatible et procede de fabrication d'un filtre biocompatible. |
| SG11201605712SA (en) | 2014-01-16 | 2016-08-30 | Grace W R & Co | Affinity chromatography media and chromatography devices |
| CN107847907A (zh) | 2014-05-02 | 2018-03-27 | 格雷斯公司 | 官能化载体材料以及制备和使用官能化载体材料的方法 |
| IS3008B (is) * | 2014-05-14 | 2018-12-15 | Calor ehf | Stöðgandi lausnir fyrir prótín og peptíð |
| BR112017026193B1 (pt) | 2015-06-05 | 2021-09-14 | W.R. Grace & Co-Conn | Adsorventes, método de produção dos adsorventes e uso dos adsorventes |
| AU2019254473A1 (en) * | 2018-04-16 | 2020-12-03 | Merck Patent Gmbh | Additives for protein formulations to improve thermal stability |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5059654A (en) * | 1983-02-14 | 1991-10-22 | Cuno Inc. | Affinity matrices of modified polysaccharide supports |
| DE229810T1 (de) * | 1985-07-09 | 1987-11-05 | Quadrant Bioresources Ltd., Soulbury, Leighton Buzzard, Bedfordshire | Beschuetzung von proteinen und aehnlichem. |
| WO1992008790A1 (en) * | 1990-11-14 | 1992-05-29 | Cargill, Incorporated | Conjugates of poly(vinylsaccharide) with proteins for the stabilization of proteins |
| US5159049A (en) * | 1991-04-22 | 1992-10-27 | Allen Robert C | Method for stabilizing polyacrylamide gels |
| US5583162A (en) * | 1994-06-06 | 1996-12-10 | Biopore Corporation | Polymeric microbeads and method of preparation |
| US6284282B1 (en) * | 1998-04-29 | 2001-09-04 | Genentech, Inc. | Method of spray freeze drying proteins for pharmaceutical administration |
| SE9904475D0 (sv) * | 1999-12-08 | 1999-12-08 | Artursson | Nucleic acid delivery system |
| US6896894B2 (en) * | 2001-10-30 | 2005-05-24 | Battelle Memorial Institute | Proteins stabilized with polysaccharide gums |
| CA2474698C (en) * | 2002-02-08 | 2009-07-21 | Alkermes Controlled Therapeutics, Inc. | Polymer-based compositions for sustained release |
| US20040137004A1 (en) * | 2002-03-19 | 2004-07-15 | Glenn Gregory M | Patch for transcutaneous immunization |
| US6666281B2 (en) | 2002-03-19 | 2003-12-23 | Deere & Company | Bearing guard for a ground-working implement |
| EP2143481A1 (en) | 2003-02-19 | 2010-01-13 | Natrix Separations Inc. | Composite materials comprising supported porous gels |
| US7785769B2 (en) * | 2003-07-25 | 2010-08-31 | The United States of America as reprsented by the Secretary of the Navy | Immobilization of oligonucleotides and proteins in sugar-containing hydrogels |
| US8182694B2 (en) | 2004-04-08 | 2012-05-22 | Natrix Separations Inc. | Membrane stacks |
| EP1758937B1 (en) * | 2004-05-24 | 2009-09-02 | Genvault Corporation | Stable protein storage and stable nucleic acid storage in recoverable form |
| AU2005251838B2 (en) * | 2004-06-07 | 2011-04-21 | Merck Millipore Ltd. | Stable composite material comprising supported porous gels |
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2013
- 2013-01-18 ES ES13739077T patent/ES2750211T3/es active Active
- 2013-01-18 KR KR1020147022518A patent/KR102113296B1/ko active Active
- 2013-01-18 CA CA3124806A patent/CA3124806C/en active Active
- 2013-01-18 EP EP13739077.9A patent/EP2804634B1/en active Active
- 2013-01-18 IN IN6817DEN2014 patent/IN2014DN06817A/en unknown
- 2013-01-18 CA CA2861932A patent/CA2861932C/en active Active
- 2013-01-18 AU AU2013209620A patent/AU2013209620B2/en active Active
- 2013-01-18 WO PCT/US2013/022057 patent/WO2013109825A1/en not_active Ceased
- 2013-01-18 DK DK13739077T patent/DK2804634T3/da active
- 2013-01-18 US US13/744,583 patent/US20130189322A1/en not_active Abandoned
- 2013-01-18 JP JP2014553432A patent/JP6552822B2/ja active Active
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2018
- 2018-09-20 JP JP2018175774A patent/JP2019011341A/ja active Pending
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2019
- 2019-09-04 US US16/560,370 patent/US20200069602A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| KR102113296B1 (ko) | 2020-06-02 |
| US20130189322A1 (en) | 2013-07-25 |
| AU2013209620B2 (en) | 2017-06-15 |
| KR20140117529A (ko) | 2014-10-07 |
| JP6552822B2 (ja) | 2019-07-31 |
| CA3124806C (en) | 2023-09-26 |
| CA2861932C (en) | 2021-09-14 |
| AU2013209620A1 (en) | 2014-08-28 |
| CA2861932A1 (en) | 2013-07-27 |
| JP2015504092A (ja) | 2015-02-05 |
| EP2804634B1 (en) | 2019-08-28 |
| IN2014DN06817A (enExample) | 2015-05-22 |
| EP2804634A4 (en) | 2015-07-22 |
| DK2804634T3 (da) | 2019-11-04 |
| US20200069602A1 (en) | 2020-03-05 |
| WO2013109825A1 (en) | 2013-07-25 |
| CA3124806A1 (en) | 2013-07-27 |
| EP2804634A1 (en) | 2014-11-26 |
| JP2019011341A (ja) | 2019-01-24 |
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