JP2005538690A5 - - Google Patents
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- Publication number
- JP2005538690A5 JP2005538690A5 JP2003571309A JP2003571309A JP2005538690A5 JP 2005538690 A5 JP2005538690 A5 JP 2005538690A5 JP 2003571309 A JP2003571309 A JP 2003571309A JP 2003571309 A JP2003571309 A JP 2003571309A JP 2005538690 A5 JP2005538690 A5 JP 2005538690A5
- Authority
- JP
- Japan
- Prior art keywords
- ptx3
- seq
- derivative
- tumor
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000004881 tumor cell Anatomy 0.000 claims 11
- 125000003275 alpha amino acid group Chemical group 0.000 claims 8
- 206010028980 Neoplasm Diseases 0.000 claims 6
- 101100192405 Mus musculus Ptx3 gene Proteins 0.000 claims 5
- 229960005486 vaccine Drugs 0.000 claims 5
- 101001082142 Homo sapiens Pentraxin-related protein PTX3 Proteins 0.000 claims 4
- BFHAYPLBUQVNNJ-UHFFFAOYSA-N Pectenotoxin 3 Natural products OC1C(C)CCOC1(O)C1OC2C=CC(C)=CC(C)CC(C)(O3)CCC3C(O3)(O4)CCC3(C=O)CC4C(O3)C(=O)CC3(C)C(O)C(O3)CCC3(O3)CCCC3C(C)C(=O)OC2C1 BFHAYPLBUQVNNJ-UHFFFAOYSA-N 0.000 claims 4
- 102100027351 Pentraxin-related protein PTX3 Human genes 0.000 claims 4
- 208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 claims 4
- 239000007787 solid Substances 0.000 claims 4
- 101100352284 Homo sapiens PITX3 gene Proteins 0.000 claims 3
- 101100031710 Homo sapiens PTX3 gene Proteins 0.000 claims 3
- 108700025763 PTX3 Proteins 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims 2
- 239000002299 complementary DNA Substances 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 238000001990 intravenous administration Methods 0.000 claims 2
- 239000012528 membrane Substances 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 230000002062 proliferating effect Effects 0.000 claims 2
- 238000007920 subcutaneous administration Methods 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 108090001008 Avidin Proteins 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 229960002685 biotin Drugs 0.000 claims 1
- 235000020958 biotin Nutrition 0.000 claims 1
- 239000011616 biotin Substances 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 239000002738 chelating agent Substances 0.000 claims 1
- 150000002632 lipids Chemical class 0.000 claims 1
- 239000002502 liposome Substances 0.000 claims 1
- 210000001165 lymph node Anatomy 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2002RM000109A ITRM20020109A1 (it) | 2002-02-28 | 2002-02-28 | Derivati funzionali della pentraxina lunga ptx3 per preparare un vaccino autologo per la cura dei tumori. |
| PCT/IT2003/000104 WO2003072603A2 (en) | 2002-02-28 | 2003-02-25 | Long pentraxin ptx3 functional derivatives for preparing an autologous vaccine for the treatment of tumours |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005538690A JP2005538690A (ja) | 2005-12-22 |
| JP2005538690A5 true JP2005538690A5 (enExample) | 2006-04-06 |
Family
ID=11456119
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003571309A Pending JP2005538690A (ja) | 2002-02-28 | 2003-02-25 | 腫瘍の治療用の自己ワクチンの調製のための長いペントラキシンｐｔｘ３機能性誘導体 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20090110666A1 (enExample) |
| EP (1) | EP1478661A2 (enExample) |
| JP (1) | JP2005538690A (enExample) |
| KR (1) | KR20040099291A (enExample) |
| AR (1) | AR038854A1 (enExample) |
| AU (1) | AU2003214645A1 (enExample) |
| CA (1) | CA2475526A1 (enExample) |
| IT (1) | ITRM20020109A1 (enExample) |
| MX (1) | MXPA04008217A (enExample) |
| PL (1) | PL372719A1 (enExample) |
| TW (1) | TWI293958B (enExample) |
| WO (1) | WO2003072603A2 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITMI20040858A1 (it) | 2004-04-29 | 2004-07-29 | Farma Dev S R L | Anticorpi monoclonali ibridomi metodo migliorato per determinare la proteina ptx3 e kit per detta determinazione |
| ITRM20040489A1 (it) | 2004-10-08 | 2005-01-08 | Sigma Tau Ind Farmaceuti | Pentraxina lunga ptx3 deglicosilata o desialidata. |
| PL1973944T3 (pl) * | 2006-01-24 | 2016-09-30 | Peptydy wiążące fgf2 i ich zastosowanie | |
| US9226960B2 (en) | 2010-04-16 | 2016-01-05 | Andrew B. Bush | FGF modulation of in vivo antibody production and humoral immunity |
| US8435525B1 (en) * | 2010-04-16 | 2013-05-07 | Andrew B. Bush | FGF modulation of in vivo antibody production and humoral immunity |
| TWI531375B (zh) | 2015-05-29 | 2016-05-01 | 國立成功大學 | 抑制癌細胞活性之短肽治療劑及含此之醫藥組成物 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5849478A (en) * | 1986-08-14 | 1998-12-15 | Cashman; Daniel P. | Blocked-polymerase polynucleotide immunoassay method and kit |
| US5290551A (en) * | 1990-05-08 | 1994-03-01 | Thomas Jefferson University | Treatment of melanoma with a vaccine comprising irradiated autologous melanoma tumor cells conjugated to a hapten |
| IT1298487B1 (it) * | 1997-12-19 | 2000-01-10 | Sigma Tau Ind Farmaceuti | Composizioni farmaceutiche comprendenti pentraxina lunga ptx3 per la terapia di patologie di tipo infettivo, infiammatorio o tumorale, |
| IT1317927B1 (it) * | 2000-11-03 | 2003-07-15 | Sigma Tau Ind Farmaceuti | Uso della pentraxina lunga ptx3 per la preparazione di un medicamentoper il trattamento di patologie autoimmuni. |
| IT1317930B1 (it) * | 2000-11-08 | 2003-07-15 | Sigma Tau Ind Farmaceuti | Uso della pentraxina lunga ptx3 per la preparazione di un medicamentoper il trattamento di patalogie associate ad una alterata attivazione |
| US20020122820A1 (en) * | 2001-01-16 | 2002-09-05 | Hildebrand William H. | Soluble MHC artificial antigen presenting cells |
| US7041648B2 (en) * | 2001-08-03 | 2006-05-09 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Compositions and methods for treating female fertility |
| PT1411971E (pt) * | 2001-08-03 | 2006-07-31 | Sigma Tau Ind Farmaceuti | Utilizacao de pentraxina longa ptx3 para o tratamento de infertilidade feminina |
| ITRM20020191A1 (it) * | 2002-04-08 | 2003-10-08 | Sigma Tau Ind Farmaceuti | Uso della pentraxina lunga ptx3 per la preparazione di un medicamentoper il trattamento di patologie tumorali associate ad una alterata att |
| US20040137544A1 (en) * | 2002-10-31 | 2004-07-15 | Roberto Latini | PTX3 as an early prognostic indicator of cardiovascular and cerebrovascular pathologies |
| ITRM20030596A1 (it) * | 2003-12-23 | 2005-06-24 | Sigma Tau Ind Farmaceuti | Uso di inibitori della pentraxina lunga ptx3, per la preparazione di un medicamento per la prevenzione e cura di patologie che rispondono all'inibizione dell'attivita' biologica di detta ptx3. |
| US20070023879A1 (en) * | 2005-07-29 | 2007-02-01 | Vinayak Pandey | Single unit heat sink, voltage regulator, and package solution for an integrated circuit |
-
2002
- 2002-02-28 IT IT2002RM000109A patent/ITRM20020109A1/it unknown
-
2003
- 2003-02-20 TW TW092103564A patent/TWI293958B/zh active
- 2003-02-25 WO PCT/IT2003/000104 patent/WO2003072603A2/en not_active Ceased
- 2003-02-25 JP JP2003571309A patent/JP2005538690A/ja active Pending
- 2003-02-25 MX MXPA04008217A patent/MXPA04008217A/es unknown
- 2003-02-25 US US10/506,046 patent/US20090110666A1/en not_active Abandoned
- 2003-02-25 AU AU2003214645A patent/AU2003214645A1/en not_active Abandoned
- 2003-02-25 EP EP03710225A patent/EP1478661A2/en not_active Withdrawn
- 2003-02-25 PL PL03372719A patent/PL372719A1/xx unknown
- 2003-02-25 CA CA002475526A patent/CA2475526A1/en not_active Abandoned
- 2003-02-25 KR KR10-2004-7013464A patent/KR20040099291A/ko not_active Ceased
- 2003-02-27 AR ARP030100642A patent/AR038854A1/es unknown
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