TWI293958B - Functional derivatives of the long pentraxin ptx3 for the preparation of an autologous vaccine for the treatment of tumours - Google Patents
Functional derivatives of the long pentraxin ptx3 for the preparation of an autologous vaccine for the treatment of tumours Download PDFInfo
- Publication number
- TWI293958B TWI293958B TW092103564A TW92103564A TWI293958B TW I293958 B TWI293958 B TW I293958B TW 092103564 A TW092103564 A TW 092103564A TW 92103564 A TW92103564 A TW 92103564A TW I293958 B TWI293958 B TW I293958B
- Authority
- TW
- Taiwan
- Prior art keywords
- ptx3
- tumor
- cells
- seq
- derivative
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title claims description 32
- 238000002360 preparation method Methods 0.000 title claims description 11
- 229940037642 autologous vaccine Drugs 0.000 title claims description 8
- 101001082142 Homo sapiens Pentraxin-related protein PTX3 Proteins 0.000 claims description 73
- 102100027351 Pentraxin-related protein PTX3 Human genes 0.000 claims description 73
- 210000004881 tumor cell Anatomy 0.000 claims description 50
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 18
- 229960005486 vaccine Drugs 0.000 claims description 17
- 239000002671 adjuvant Substances 0.000 claims description 9
- 101100192405 Mus musculus Ptx3 gene Proteins 0.000 claims description 7
- 239000003814 drug Substances 0.000 claims description 5
- 239000007787 solid Substances 0.000 claims description 5
- 201000005787 hematologic cancer Diseases 0.000 claims description 2
- 208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 claims description 2
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- 210000004027 cell Anatomy 0.000 description 40
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 20
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- 108060008682 Tumor Necrosis Factor Proteins 0.000 description 2
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 description 2
- 238000001042 affinity chromatography Methods 0.000 description 2
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- UVGHPGOONBRLCX-NJSLBKSFSA-N (2,5-dioxopyrrolidin-1-yl) 6-[5-[(3as,4s,6ar)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]hexanoate Chemical compound C([C@H]1[C@H]2NC(=O)N[C@H]2CS1)CCCC(=O)NCCCCCC(=O)ON1C(=O)CCC1=O UVGHPGOONBRLCX-NJSLBKSFSA-N 0.000 description 1
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- 108700026244 Open Reading Frames Proteins 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 101150095640 PTX3 gene Proteins 0.000 description 1
- 102000003992 Peroxidases Human genes 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 description 1
- 244000269722 Thea sinensis Species 0.000 description 1
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- 229940037003 alum Drugs 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 239000000538 analytical sample Substances 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
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- 239000000739 antihistaminic agent Substances 0.000 description 1
- 108091006004 biotinylated proteins Proteins 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 210000000349 chromosome Anatomy 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- UQHKFADEQIVWID-UHFFFAOYSA-N cytokinin Natural products C1=NC=2C(NCC=C(CO)C)=NC=NC=2N1C1CC(O)C(CO)O1 UQHKFADEQIVWID-UHFFFAOYSA-N 0.000 description 1
- 239000004062 cytokinin Substances 0.000 description 1
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- 231100000673 dose–response relationship Toxicity 0.000 description 1
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- 108040007629 peroxidase activity proteins Proteins 0.000 description 1
- 210000001539 phagocyte Anatomy 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
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- 230000020382 suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I Effects 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/4756—Neuregulins, i.e. p185erbB2 ligands, glial growth factor, heregulin, ARIA, neu differentiation factor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/102—Pasteurellales, e.g. Actinobacillus, Pasteurella; Haemophilus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5152—Tumor cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2002RM000109A ITRM20020109A1 (it) | 2002-02-28 | 2002-02-28 | Derivati funzionali della pentraxina lunga ptx3 per preparare un vaccino autologo per la cura dei tumori. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW200303755A TW200303755A (en) | 2003-09-16 |
| TWI293958B true TWI293958B (en) | 2008-03-01 |
Family
ID=11456119
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW092103564A TWI293958B (en) | 2002-02-28 | 2003-02-20 | Functional derivatives of the long pentraxin ptx3 for the preparation of an autologous vaccine for the treatment of tumours |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20090110666A1 (enExample) |
| EP (1) | EP1478661A2 (enExample) |
| JP (1) | JP2005538690A (enExample) |
| KR (1) | KR20040099291A (enExample) |
| AR (1) | AR038854A1 (enExample) |
| AU (1) | AU2003214645A1 (enExample) |
| CA (1) | CA2475526A1 (enExample) |
| IT (1) | ITRM20020109A1 (enExample) |
| MX (1) | MXPA04008217A (enExample) |
| PL (1) | PL372719A1 (enExample) |
| TW (1) | TWI293958B (enExample) |
| WO (1) | WO2003072603A2 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITMI20040858A1 (it) | 2004-04-29 | 2004-07-29 | Farma Dev S R L | Anticorpi monoclonali ibridomi metodo migliorato per determinare la proteina ptx3 e kit per detta determinazione |
| ITRM20040489A1 (it) * | 2004-10-08 | 2005-01-08 | Sigma Tau Ind Farmaceuti | Pentraxina lunga ptx3 deglicosilata o desialidata. |
| SI1973944T1 (sl) * | 2006-01-24 | 2016-07-29 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | FGF2 vezavni peptidi in njihova uporaba |
| US9226960B2 (en) | 2010-04-16 | 2016-01-05 | Andrew B. Bush | FGF modulation of in vivo antibody production and humoral immunity |
| US8435525B1 (en) * | 2010-04-16 | 2013-05-07 | Andrew B. Bush | FGF modulation of in vivo antibody production and humoral immunity |
| TWI531375B (zh) | 2015-05-29 | 2016-05-01 | 國立成功大學 | 抑制癌細胞活性之短肽治療劑及含此之醫藥組成物 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5849478A (en) * | 1986-08-14 | 1998-12-15 | Cashman; Daniel P. | Blocked-polymerase polynucleotide immunoassay method and kit |
| US5290551A (en) * | 1990-05-08 | 1994-03-01 | Thomas Jefferson University | Treatment of melanoma with a vaccine comprising irradiated autologous melanoma tumor cells conjugated to a hapten |
| IT1298487B1 (it) * | 1997-12-19 | 2000-01-10 | Sigma Tau Ind Farmaceuti | Composizioni farmaceutiche comprendenti pentraxina lunga ptx3 per la terapia di patologie di tipo infettivo, infiammatorio o tumorale, |
| IT1317927B1 (it) * | 2000-11-03 | 2003-07-15 | Sigma Tau Ind Farmaceuti | Uso della pentraxina lunga ptx3 per la preparazione di un medicamentoper il trattamento di patologie autoimmuni. |
| IT1317930B1 (it) * | 2000-11-08 | 2003-07-15 | Sigma Tau Ind Farmaceuti | Uso della pentraxina lunga ptx3 per la preparazione di un medicamentoper il trattamento di patalogie associate ad una alterata attivazione |
| US20020122820A1 (en) * | 2001-01-16 | 2002-09-05 | Hildebrand William H. | Soluble MHC artificial antigen presenting cells |
| AU2002324328B2 (en) * | 2001-08-03 | 2007-09-06 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Use of long pentraxin PTX3 for treating female infertility |
| US7041648B2 (en) * | 2001-08-03 | 2006-05-09 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Compositions and methods for treating female fertility |
| ITRM20020191A1 (it) * | 2002-04-08 | 2003-10-08 | Sigma Tau Ind Farmaceuti | Uso della pentraxina lunga ptx3 per la preparazione di un medicamentoper il trattamento di patologie tumorali associate ad una alterata att |
| US20040137544A1 (en) * | 2002-10-31 | 2004-07-15 | Roberto Latini | PTX3 as an early prognostic indicator of cardiovascular and cerebrovascular pathologies |
| ITRM20030596A1 (it) * | 2003-12-23 | 2005-06-24 | Sigma Tau Ind Farmaceuti | Uso di inibitori della pentraxina lunga ptx3, per la preparazione di un medicamento per la prevenzione e cura di patologie che rispondono all'inibizione dell'attivita' biologica di detta ptx3. |
| US20070023879A1 (en) * | 2005-07-29 | 2007-02-01 | Vinayak Pandey | Single unit heat sink, voltage regulator, and package solution for an integrated circuit |
-
2002
- 2002-02-28 IT IT2002RM000109A patent/ITRM20020109A1/it unknown
-
2003
- 2003-02-20 TW TW092103564A patent/TWI293958B/zh active
- 2003-02-25 US US10/506,046 patent/US20090110666A1/en not_active Abandoned
- 2003-02-25 AU AU2003214645A patent/AU2003214645A1/en not_active Abandoned
- 2003-02-25 CA CA002475526A patent/CA2475526A1/en not_active Abandoned
- 2003-02-25 PL PL03372719A patent/PL372719A1/xx unknown
- 2003-02-25 MX MXPA04008217A patent/MXPA04008217A/es unknown
- 2003-02-25 JP JP2003571309A patent/JP2005538690A/ja active Pending
- 2003-02-25 EP EP03710225A patent/EP1478661A2/en not_active Withdrawn
- 2003-02-25 WO PCT/IT2003/000104 patent/WO2003072603A2/en not_active Ceased
- 2003-02-25 KR KR10-2004-7013464A patent/KR20040099291A/ko not_active Ceased
- 2003-02-27 AR ARP030100642A patent/AR038854A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| TW200303755A (en) | 2003-09-16 |
| EP1478661A2 (en) | 2004-11-24 |
| WO2003072603A2 (en) | 2003-09-04 |
| PL372719A1 (en) | 2005-07-25 |
| CA2475526A1 (en) | 2003-09-04 |
| WO2003072603A3 (en) | 2004-03-18 |
| US20090110666A1 (en) | 2009-04-30 |
| AR038854A1 (es) | 2005-01-26 |
| MXPA04008217A (es) | 2004-11-26 |
| WO2003072603A9 (en) | 2004-10-07 |
| AU2003214645A1 (en) | 2003-09-09 |
| AU2003214645A8 (en) | 2003-09-09 |
| KR20040099291A (ko) | 2004-11-26 |
| ITRM20020109A0 (it) | 2002-02-28 |
| ITRM20020109A1 (it) | 2003-08-28 |
| JP2005538690A (ja) | 2005-12-22 |
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