ES2745525T3 - Compuestos de aminopiridina sustituida con heteroarilo - Google Patents
Compuestos de aminopiridina sustituida con heteroarilo Download PDFInfo
- Publication number
- ES2745525T3 ES2745525T3 ES16734538T ES16734538T ES2745525T3 ES 2745525 T3 ES2745525 T3 ES 2745525T3 ES 16734538 T ES16734538 T ES 16734538T ES 16734538 T ES16734538 T ES 16734538T ES 2745525 T3 ES2745525 T3 ES 2745525T3
- Authority
- ES
- Spain
- Prior art keywords
- pyridin
- pyrazolo
- carbonitrile
- triazol
- isopropylamino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 0 CN(C1N=C2*)C=NC1C=C2[Rh] Chemical compound CN(C1N=C2*)C=NC1C=C2[Rh] 0.000 description 8
- SGTGXXLTWWAIDL-UHFFFAOYSA-N CC(C)Nc(cc(-[n]1ncc2c1ncc(C#N)c2)nc1)c1-c1c[n](CC(F)(F)F)nc1 Chemical compound CC(C)Nc(cc(-[n]1ncc2c1ncc(C#N)c2)nc1)c1-c1c[n](CC(F)(F)F)nc1 SGTGXXLTWWAIDL-UHFFFAOYSA-N 0.000 description 1
- WRWNPDTZJNLWHL-UHFFFAOYSA-N CC(C)Nc(cc(-[n]1ncc2c1ncc(C#N)c2)nc1)c1-c1cc(C2CNC2)n[o]1 Chemical compound CC(C)Nc(cc(-[n]1ncc2c1ncc(C#N)c2)nc1)c1-c1cc(C2CNC2)n[o]1 WRWNPDTZJNLWHL-UHFFFAOYSA-N 0.000 description 1
- SWRKUPLIPIEAOS-UHFFFAOYSA-N CC(C)Nc(cc(-[n]1ncc2cc(C#N)cnc12)nc1)c1-[n]1nnc(C2CCN(CC(F)F)CC2)c1 Chemical compound CC(C)Nc(cc(-[n]1ncc2cc(C#N)cnc12)nc1)c1-[n]1nnc(C2CCN(CC(F)F)CC2)c1 SWRKUPLIPIEAOS-UHFFFAOYSA-N 0.000 description 1
- CPLQNQBMMGLAAJ-UHFFFAOYSA-N CC(C)Nc(cc(-[n]1ncc2cc(C#N)cnc12)nc1)c1-[n]1nnc(C2CCNCC2)c1 Chemical compound CC(C)Nc(cc(-[n]1ncc2cc(C#N)cnc12)nc1)c1-[n]1nnc(C2CCNCC2)c1 CPLQNQBMMGLAAJ-UHFFFAOYSA-N 0.000 description 1
- GVPHIPBSKCVWBA-DLBZAZTESA-N CC(C)Nc(cc(nc1)Cl)c1-c1c[n]([C@@H](CCN(C2)C(OC(C)(C)C)=O)[C@@H]2O)nn1 Chemical compound CC(C)Nc(cc(nc1)Cl)c1-c1c[n]([C@@H](CCN(C2)C(OC(C)(C)C)=O)[C@@H]2O)nn1 GVPHIPBSKCVWBA-DLBZAZTESA-N 0.000 description 1
- CNAUUJIWAQALDJ-UHFFFAOYSA-N CC(C)Nc1cc(-[n]2ncc3c2ncc(C#N)c3)ncc1-c1c[n](C(C2)CN2C(C)C)nn1 Chemical compound CC(C)Nc1cc(-[n]2ncc3c2ncc(C#N)c3)ncc1-c1c[n](C(C2)CN2C(C)C)nn1 CNAUUJIWAQALDJ-UHFFFAOYSA-N 0.000 description 1
- HIUCJCFXTWGEIE-UHFFFAOYSA-N CC(C)Nc1cc(-[n]2ncc3c2ncc(C#N)c3)ncc1-c1c[n](C(C2)CN2C(CC2CC2)=O)nn1 Chemical compound CC(C)Nc1cc(-[n]2ncc3c2ncc(C#N)c3)ncc1-c1c[n](C(C2)CN2C(CC2CC2)=O)nn1 HIUCJCFXTWGEIE-UHFFFAOYSA-N 0.000 description 1
- JMLWLLVDDWTHOR-UHFFFAOYSA-N CC(C)Nc1cc(-[n]2ncc3c2ncc(C#N)c3)ncc1-c1cc(C(C2)CN2C(C)=O)n[o]1 Chemical compound CC(C)Nc1cc(-[n]2ncc3c2ncc(C#N)c3)ncc1-c1cc(C(C2)CN2C(C)=O)n[o]1 JMLWLLVDDWTHOR-UHFFFAOYSA-N 0.000 description 1
- BFKKIDHWWRDAPL-UHFFFAOYSA-N CC(C)Nc1cc(-[n]2ncc3cc(C#N)cnc23)ncc1-c1c[n](C(C2)CN2c2nnc(C)[o]2)nn1 Chemical compound CC(C)Nc1cc(-[n]2ncc3cc(C#N)cnc23)ncc1-c1c[n](C(C2)CN2c2nnc(C)[o]2)nn1 BFKKIDHWWRDAPL-UHFFFAOYSA-N 0.000 description 1
- ZRJCNMYMCUBLAI-UHFFFAOYSA-N CC(C)Nc1cc(Cl)ncc1-c1c[nH]nc1 Chemical compound CC(C)Nc1cc(Cl)ncc1-c1c[nH]nc1 ZRJCNMYMCUBLAI-UHFFFAOYSA-N 0.000 description 1
- QGSSQOPZQYGFHL-UHFFFAOYSA-N CC(C)Nc1cc(Cl)ncc1-c1c[n](CC(C)F)nn1 Chemical compound CC(C)Nc1cc(Cl)ncc1-c1c[n](CC(C)F)nn1 QGSSQOPZQYGFHL-UHFFFAOYSA-N 0.000 description 1
- UMBXYHRYEHEXSL-SFHVURJKSA-N CC(C)Nc1cc(Cl)ncc1-c1c[n](C[C@H](Cc2ccccc2)NC(OC(C)(C)C)=O)nn1 Chemical compound CC(C)Nc1cc(Cl)ncc1-c1c[n](C[C@H](Cc2ccccc2)NC(OC(C)(C)C)=O)nn1 UMBXYHRYEHEXSL-SFHVURJKSA-N 0.000 description 1
- JNDCZWRSJRYUDD-UHFFFAOYSA-N CC(C)Nc1cc(Cl)ncc1-c1nnc(C(N(CC2)CCN2C(OC(C)(C)C)=O)=O)[o]1 Chemical compound CC(C)Nc1cc(Cl)ncc1-c1nnc(C(N(CC2)CCN2C(OC(C)(C)C)=O)=O)[o]1 JNDCZWRSJRYUDD-UHFFFAOYSA-N 0.000 description 1
- IMFLIGANAFVVEX-UHFFFAOYSA-O CC(C)Nc1cc(Cl)ncc1C(N=N)=C[NH2+]CC(C)F Chemical compound CC(C)Nc1cc(Cl)ncc1C(N=N)=C[NH2+]CC(C)F IMFLIGANAFVVEX-UHFFFAOYSA-O 0.000 description 1
- GTVJTOUCOLLRGC-UHFFFAOYSA-N CC(C)[n]1ncc(O)c1 Chemical compound CC(C)[n]1ncc(O)c1 GTVJTOUCOLLRGC-UHFFFAOYSA-N 0.000 description 1
- JANHZYJACYIJQP-UHFFFAOYSA-N CCCN1C=NC2C=NC([Rh])=NC12 Chemical compound CCCN1C=NC2C=NC([Rh])=NC12 JANHZYJACYIJQP-UHFFFAOYSA-N 0.000 description 1
- NOEFIUWJGDCTGB-UHFFFAOYSA-N CCOC(c(c(NC(C)C)c1)cnc1-[n](cc1)c2c1cncn2)=O Chemical compound CCOC(c(c(NC(C)C)c1)cnc1-[n](cc1)c2c1cncn2)=O NOEFIUWJGDCTGB-UHFFFAOYSA-N 0.000 description 1
- BLHTXORQJNCSII-UHFFFAOYSA-N Cc1c[n](C)cn1 Chemical compound Cc1c[n](C)cn1 BLHTXORQJNCSII-UHFFFAOYSA-N 0.000 description 1
- SZQCPPRPWDXLMM-UHFFFAOYSA-N Cc1c[n](C)nc1 Chemical compound Cc1c[n](C)nc1 SZQCPPRPWDXLMM-UHFFFAOYSA-N 0.000 description 1
- FICAQKBMCKEFDI-UHFFFAOYSA-N Cc1n[o]c(C)c1 Chemical compound Cc1n[o]c(C)c1 FICAQKBMCKEFDI-UHFFFAOYSA-N 0.000 description 1
- ZOEPGDLOKCFSAJ-WOJBJXKFSA-N N#Cc1cc(cn[n]2-c(nc3)cc(NC4CC4)c3-c3c[n]([C@H](CNCC4)[C@@H]4O)nn3)c2nc1 Chemical compound N#Cc1cc(cn[n]2-c(nc3)cc(NC4CC4)c3-c3c[n]([C@H](CNCC4)[C@@H]4O)nn3)c2nc1 ZOEPGDLOKCFSAJ-WOJBJXKFSA-N 0.000 description 1
- DEJUUKULVAIMNF-UHFFFAOYSA-N Nc1cc(Cl)ncc1I Chemical compound Nc1cc(Cl)ncc1I DEJUUKULVAIMNF-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Urology & Nephrology (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN1877DE2015 | 2015-06-24 | ||
| PCT/US2016/038858 WO2016210034A1 (en) | 2015-06-24 | 2016-06-23 | Heteroaryl substituted aminopyridine compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2745525T3 true ES2745525T3 (es) | 2020-03-02 |
Family
ID=56322320
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES16734538T Active ES2745525T3 (es) | 2015-06-24 | 2016-06-23 | Compuestos de aminopiridina sustituida con heteroarilo |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US10294229B2 (enExample) |
| EP (1) | EP3313840B1 (enExample) |
| JP (1) | JP6843775B2 (enExample) |
| CN (1) | CN107849039B (enExample) |
| AR (1) | AR105113A1 (enExample) |
| ES (1) | ES2745525T3 (enExample) |
| TW (1) | TW201718571A (enExample) |
| UY (1) | UY36748A (enExample) |
| WO (1) | WO2016210034A1 (enExample) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016210037A1 (en) | 2015-06-24 | 2016-12-29 | Bristol-Myers Squibb Company | Heteroaryl substituted aminopyridine compounds |
| CN109952303B (zh) * | 2016-10-14 | 2022-10-21 | 林伯士拉克许米公司 | Tyk2抑制剂及其用途 |
| JOP20180011A1 (ar) | 2017-02-16 | 2019-01-30 | Gilead Sciences Inc | مشتقات بيرولو [1، 2-b]بيريدازين |
| JP7154229B2 (ja) | 2017-05-11 | 2022-10-17 | ブリストル－マイヤーズ スクイブ カンパニー | Ｉｒａｋ－４阻害剤として有用なチエノピリジンおよびベンゾチオフェン |
| CA3076613A1 (en) | 2017-09-22 | 2019-03-28 | Kymera Therapeutics, Inc. | Protein degraders and uses thereof |
| WO2019060693A1 (en) | 2017-09-22 | 2019-03-28 | Kymera Therapeutics, Inc. | CRBN LIGANDS AND USES THEREOF |
| TWI812649B (zh) * | 2017-10-10 | 2023-08-21 | 美商絡速藥業公司 | 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之調配物 |
| WO2019111218A1 (en) | 2017-12-08 | 2019-06-13 | Cadila Healthcare Limited | Novel heterocyclic compounds as irak4 inhibitors |
| IL315310A (en) | 2017-12-26 | 2024-10-01 | Kymera Therapeutics Inc | Irak degraders and uses thereof |
| EP3737675A4 (en) | 2018-01-12 | 2022-01-05 | Kymera Therapeutics, Inc. | Crbn ligands and uses thereof |
| US11485743B2 (en) | 2018-01-12 | 2022-11-01 | Kymera Therapeutics, Inc. | Protein degraders and uses thereof |
| WO2020010227A1 (en) | 2018-07-06 | 2020-01-09 | Kymera Therapeutics, Inc. | Protein degraders and uses thereof |
| US11292792B2 (en) | 2018-07-06 | 2022-04-05 | Kymera Therapeutics, Inc. | Tricyclic CRBN ligands and uses thereof |
| TWI842978B (zh) | 2018-07-13 | 2024-05-21 | 美商基利科學股份有限公司 | 衍生物 |
| KR102659550B1 (ko) * | 2018-08-13 | 2024-04-23 | 길리애드 사이언시즈, 인코포레이티드 | Irak4 억제제로서의 피롤로[1,2-b]피리다진 유도체 |
| TWI727392B (zh) | 2018-08-13 | 2021-05-11 | 美商基利科學股份有限公司 | 噻二唑irak4抑制劑 |
| JP7169429B2 (ja) | 2018-08-13 | 2022-11-10 | ギリアード サイエンシーズ， インコーポレイテッド | ＩＲＡＫ４阻害剤としてのピロロ［１，２－ｂ］ピリダジン誘導体 |
| JP7623943B2 (ja) | 2018-11-30 | 2025-01-29 | カイメラ セラピューティクス， インコーポレイテッド | Ｉｒａｋ分解剤およびそれらの使用 |
| CN109836376B (zh) * | 2019-04-10 | 2022-03-22 | 江苏汉阔生物有限公司 | 一种以2，3-吡啶二羧酸为原料制备2-氯代烟酸的方法 |
| JP7570399B2 (ja) | 2019-07-18 | 2024-10-21 | ブリストル－マイヤーズ スクイブ カンパニー | Ｉｒａｋ４阻害剤として有用な三環式ヘテロアリール化合物 |
| EP3999512B1 (en) | 2019-07-18 | 2023-08-23 | Bristol-Myers Squibb Company | Pyrazolo[3,4-d]pyrrolo[1,2-b]pyridazinyl compounds useful as irak4 inhibitors |
| KR20220041124A (ko) * | 2019-07-23 | 2022-03-31 | 브리스톨-마이어스 스큅 컴퍼니 | Irak4 억제제로서 유용한 티에노피리디닐 및 티아졸로피리디닐 화합물 |
| ES2983263T3 (es) | 2019-08-06 | 2024-10-22 | Bristol Myers Squibb Co | Compuestos heterocíclicos bicíclicos útiles como inhibidores de IRAK4 |
| US11578071B2 (en) | 2019-10-04 | 2023-02-14 | University Of Kentucky Research Foundation | Preparation of pyrazolo[3,4-B]pyridines as antimalarials |
| KR20220145325A (ko) | 2019-12-17 | 2022-10-28 | 카이메라 쎄라퓨틱스 인코포레이티드 | Irak 분해제 및 이의 용도 |
| US11591332B2 (en) | 2019-12-17 | 2023-02-28 | Kymera Therapeutics, Inc. | IRAK degraders and uses thereof |
| EP4077286A1 (en) | 2019-12-18 | 2022-10-26 | Elanco Tiergesundheit AG | Isoxazoline derivatives as pesticides |
| US12391702B2 (en) | 2020-02-03 | 2025-08-19 | Bristol-Myers Squibb Company | Benzo[5,6][1,4]dioxino[2,3-b]pyridine compounds useful as IRAK4 inhibitors |
| US20230142629A1 (en) * | 2020-02-19 | 2023-05-11 | Nurix Therapeutics, Inc. | Bifunctional degraders of interleukin-1 receptor-associated kinases and therapeutic use thereof |
| TW202210483A (zh) | 2020-06-03 | 2022-03-16 | 美商凱麥拉醫療公司 | Irak降解劑之結晶型 |
| AR124547A1 (es) * | 2020-12-30 | 2023-04-05 | Kymera Therapeutics Inc | Degradadores de irak y sus usos |
| MX2023009527A (es) | 2021-02-15 | 2023-08-24 | Kymera Therapeutics Inc | Degradadores de la cinasa 4 asociada al receptor de interleucina 1 (irak4) y usos de los mismos. |
| AR125798A1 (es) | 2021-05-07 | 2023-08-16 | Kymera Therapeutics Inc | Degradadores cdk2 y usos de los mismos |
| DK4367118T3 (da) | 2021-08-18 | 2025-03-24 | Nurix Therapeutics Inc | Bifunktionelle nedbrydere af interleukin-1-receptor-associerede kinaser og terapeutisk brug heraf |
| EP4422635A4 (en) | 2021-10-29 | 2025-11-26 | Kymera Therapeutics Inc | IRAQ4 DEGRADATION AGENTS AND THEIR SYNTHESIS |
| CA3243560A1 (en) | 2022-01-31 | 2023-08-03 | Kymera Therapeutics, Inc. | Iraqi Degradation Agents and Their Uses |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2450769A1 (en) | 2001-06-15 | 2002-12-27 | Vertex Pharmaceuticals Incorporated | 5-(2-aminopyrimidin-4-yl) benzisoxazoles as protein kinase inhibitors |
| AUPR688101A0 (en) | 2001-08-08 | 2001-08-30 | Luminis Pty Limited | Protein domains and their ligands |
| GB0211019D0 (en) | 2002-05-14 | 2002-06-26 | Syngenta Ltd | Novel compounds |
| CN1665789A (zh) | 2002-06-28 | 2005-09-07 | 山之内制药株式会社 | 二氨基嘧啶酰胺衍生物 |
| JP2006516561A (ja) | 2003-01-17 | 2006-07-06 | ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー | 細胞増殖の阻害剤としての２−アミノピリジン置換ヘテロ環類 |
| EP1651636A1 (en) | 2003-07-10 | 2006-05-03 | Neurogen Corporation | Substituted heterocyclic diarylamine analogues |
| GB0402653D0 (en) | 2004-02-06 | 2004-03-10 | Cyclacel Ltd | Compounds |
| US7521457B2 (en) | 2004-08-20 | 2009-04-21 | Boehringer Ingelheim International Gmbh | Pyrimidines as PLK inhibitors |
| FR2896503B1 (fr) | 2006-01-23 | 2012-07-13 | Aventis Pharma Sa | Nouveaux derives soufres d'uree cyclique, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de kinases |
| CA2685588A1 (en) | 2007-06-08 | 2008-12-11 | Bayer Cropscience Sa | Fungicide heterocyclyl-pyrimidinyl-amino derivatives |
| WO2009046416A1 (en) | 2007-10-05 | 2009-04-09 | Targegen Inc. | Anilinopyrimidines as jak kinase inhibitors |
| WO2010058846A1 (ja) | 2008-11-21 | 2010-05-27 | アステラス製薬株式会社 | ４，６-ジアミノニコチンアミド化合物 |
| KR101361027B1 (ko) | 2008-11-28 | 2014-02-11 | 코와 가부시키가이샤 | 피리딘-3-카르복시아미드 유도체 |
| ES2444777T3 (es) | 2009-06-12 | 2014-02-26 | Bristol-Myers Squibb Company | Compuestos de nicotinamida útiles como moduladores de quinasas |
| AU2010313397B2 (en) | 2009-10-30 | 2015-07-02 | Janssen Pharmaceutica Nv | Phenoxy-substituted pyrimidines as opioid receptor modulators |
| KR20120130104A (ko) | 2010-02-01 | 2012-11-28 | 닛뽕 케미파 가부시키가이샤 | Ｇｐｒ119 작동약 |
| BR112013027787A2 (pt) | 2011-04-29 | 2017-06-27 | Icahn School Med Mount Sinai | compostos, composição farmacêutica, método para tratar um distúrbio proliferativo celular, método para tratar um distúrbio neurológico, métodos para inibir uma ou mais quinases, método para inibir a proliferação celular de células cancerosas, método para induzir a morte celular de células cancerosas, método para induzir a apoptose de células cancerosas, método para induzir a apoptose em uma célula e métodos para produzir compostos |
| WO2013106612A1 (en) | 2012-01-13 | 2013-07-18 | Bristol-Myers Squibb Company | Heterocyclic-substituted pyridyl compounds useful as kinase inhibitors |
| WO2013106614A1 (en) | 2012-01-13 | 2013-07-18 | Bristol-Myers Squibb Company | Triazolyl-substituted pyridyl compounds useful as kinase inhibitors |
| CN104254533B (zh) | 2012-01-13 | 2017-09-08 | 百时美施贵宝公司 | 用作激酶抑制剂的噻唑或噻二唑取代的吡啶基化合物 |
| US9598440B2 (en) * | 2012-10-08 | 2017-03-21 | Merck Sharp & Dohme Corp. | Inhibitors of IRAK4 activity |
| TWI620737B (zh) | 2012-11-08 | 2018-04-11 | 必治妥美雅史谷比公司 | 作爲ＩＬ－１２、ＩＬ－２３及／或ＩＦＮα反應調節劑之經烷基－醯胺取代之吡啶化合物 |
| PE20150953A1 (es) | 2012-11-08 | 2015-06-20 | Bristol Myers Squibb Co | Compuestos de piridilo sustituidos con heteroarilo utiles como moduladores de cinasa |
| WO2014074657A1 (en) | 2012-11-08 | 2014-05-15 | Bristol-Myers Squibb Company | Bicyclic heterocycle substituted pyridyl compounds useful as kinase modulators |
| TWI582077B (zh) | 2013-11-07 | 2017-05-11 | 必治妥美雅史谷比公司 | 作爲ＩＬ－１２、ＩＬ－２３及／或ＩＦＮα反應調節劑之經烷基－醯胺取代之吡啶化合物 |
| TW201609693A (zh) | 2014-01-03 | 2016-03-16 | 必治妥美雅史谷比公司 | 雜芳基取代之菸鹼醯胺化合物 |
| WO2016210037A1 (en) | 2015-06-24 | 2016-12-29 | Bristol-Myers Squibb Company | Heteroaryl substituted aminopyridine compounds |
-
2016
- 2016-06-23 TW TW105119777A patent/TW201718571A/zh unknown
- 2016-06-23 WO PCT/US2016/038858 patent/WO2016210034A1/en not_active Ceased
- 2016-06-23 CN CN201680040987.7A patent/CN107849039B/zh active Active
- 2016-06-23 US US15/738,362 patent/US10294229B2/en active Active
- 2016-06-23 AR ARP160101892A patent/AR105113A1/es unknown
- 2016-06-23 UY UY0001036748A patent/UY36748A/es not_active Application Discontinuation
- 2016-06-23 EP EP16734538.8A patent/EP3313840B1/en active Active
- 2016-06-23 ES ES16734538T patent/ES2745525T3/es active Active
- 2016-06-23 JP JP2017566643A patent/JP6843775B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| TW201718571A (zh) | 2017-06-01 |
| CN107849039B (zh) | 2020-07-03 |
| AR105113A1 (es) | 2017-09-06 |
| UY36748A (es) | 2016-12-30 |
| CN107849039A (zh) | 2018-03-27 |
| EP3313840A1 (en) | 2018-05-02 |
| US10294229B2 (en) | 2019-05-21 |
| JP2018522859A (ja) | 2018-08-16 |
| JP6843775B2 (ja) | 2021-03-17 |
| WO2016210034A1 (en) | 2016-12-29 |
| EP3313840B1 (en) | 2019-07-24 |
| US20180186799A1 (en) | 2018-07-05 |
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