ES2733398T3 - Sistemas y métodos para administración sub-retiniana de agentes terapéuticos - Google Patents
Sistemas y métodos para administración sub-retiniana de agentes terapéuticos Download PDFInfo
- Publication number
- ES2733398T3 ES2733398T3 ES14872431T ES14872431T ES2733398T3 ES 2733398 T3 ES2733398 T3 ES 2733398T3 ES 14872431 T ES14872431 T ES 14872431T ES 14872431 T ES14872431 T ES 14872431T ES 2733398 T3 ES2733398 T3 ES 2733398T3
- Authority
- ES
- Spain
- Prior art keywords
- retinal
- inner tube
- retina
- treatment device
- therapeutic agents
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000003814 drug Substances 0.000 title claims abstract description 72
- 229940124597 therapeutic agent Drugs 0.000 title claims abstract description 72
- 238000000034 method Methods 0.000 title description 28
- 230000002207 retinal effect Effects 0.000 claims abstract description 83
- 210000001525 retina Anatomy 0.000 claims abstract description 66
- 238000011282 treatment Methods 0.000 claims abstract description 58
- 239000012530 fluid Substances 0.000 claims abstract description 39
- 238000007789 sealing Methods 0.000 claims abstract description 33
- 238000010992 reflux Methods 0.000 claims abstract description 14
- 238000001356 surgical procedure Methods 0.000 claims abstract description 5
- 230000000284 resting effect Effects 0.000 claims abstract 2
- 238000002347 injection Methods 0.000 claims description 26
- 239000007924 injection Substances 0.000 claims description 26
- 239000012528 membrane Substances 0.000 claims description 13
- 230000007246 mechanism Effects 0.000 claims description 7
- 230000004913 activation Effects 0.000 claims description 5
- 238000004891 communication Methods 0.000 claims description 5
- 210000000981 epithelium Anatomy 0.000 claims description 3
- 238000012014 optical coherence tomography Methods 0.000 claims description 3
- 239000000243 solution Substances 0.000 claims 1
- 239000000499 gel Substances 0.000 description 22
- 210000003583 retinal pigment epithelium Anatomy 0.000 description 15
- 239000012190 activator Substances 0.000 description 9
- 230000035515 penetration Effects 0.000 description 6
- 210000001519 tissue Anatomy 0.000 description 6
- 239000000463 material Substances 0.000 description 5
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 4
- 210000003161 choroid Anatomy 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- 210000003786 sclera Anatomy 0.000 description 4
- 210000000130 stem cell Anatomy 0.000 description 4
- 239000003855 balanced salt solution Substances 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 238000002224 dissection Methods 0.000 description 3
- 238000007726 management method Methods 0.000 description 3
- 239000000565 sealant Substances 0.000 description 3
- 230000009471 action Effects 0.000 description 2
- 210000004556 brain Anatomy 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 230000008878 coupling Effects 0.000 description 2
- 238000010168 coupling process Methods 0.000 description 2
- 238000005859 coupling reaction Methods 0.000 description 2
- 210000004279 orbit Anatomy 0.000 description 2
- 108091008695 photoreceptors Proteins 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 210000004127 vitreous body Anatomy 0.000 description 2
- 206010010356 Congenital anomaly Diseases 0.000 description 1
- 208000003098 Ganglion Cysts Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 208000005400 Synovial Cyst Diseases 0.000 description 1
- 229920006362 Teflon® Polymers 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 210000004087 cornea Anatomy 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 210000003754 fetus Anatomy 0.000 description 1
- 238000010304 firing Methods 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 210000003128 head Anatomy 0.000 description 1
- 239000000017 hydrogel Substances 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 210000004126 nerve fiber Anatomy 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 210000001328 optic nerve Anatomy 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000002861 polymer material Substances 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 239000000790 retinal pigment Substances 0.000 description 1
- 229910001285 shape-memory alloy Inorganic materials 0.000 description 1
- 239000007779 soft material Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
- A61F9/0017—Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/00491—Surgical glue applicators
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Ophthalmology & Optometry (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14/132,859 US10010447B2 (en) | 2013-12-18 | 2013-12-18 | Systems and methods for subretinal delivery of therapeutic agents |
| PCT/US2014/064407 WO2015094507A1 (en) | 2013-12-18 | 2014-11-06 | Systems and methods for subretinal delivery of therapeutic agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2733398T3 true ES2733398T3 (es) | 2019-11-28 |
Family
ID=53367065
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES14872431T Active ES2733398T3 (es) | 2013-12-18 | 2014-11-06 | Sistemas y métodos para administración sub-retiniana de agentes terapéuticos |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US10010447B2 (enExample) |
| EP (1) | EP3068353B1 (enExample) |
| JP (1) | JP6438030B2 (enExample) |
| CN (1) | CN105979914B (enExample) |
| AU (1) | AU2014367150C1 (enExample) |
| CA (1) | CA2932912C (enExample) |
| ES (1) | ES2733398T3 (enExample) |
| WO (1) | WO2015094507A1 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9730834B2 (en) * | 2013-12-20 | 2017-08-15 | Novartis Ag | Variable stiffness cannula and methods for a surgical system |
| US9925088B2 (en) * | 2014-06-06 | 2018-03-27 | Janssen Biotech, Inc. | Sub-retinal tangential needle catheter guide and introducer |
| US20160331584A1 (en) * | 2015-05-14 | 2016-11-17 | Novartis Ag | Surgical tool tracking to control surgical system |
| US10507134B2 (en) | 2015-05-27 | 2019-12-17 | Novartis Ag | Systems and methods for pulsed posterior vitreous detachment creation |
| ES2778687T3 (es) | 2015-12-14 | 2020-08-11 | Alcon Inc | Aparatos quirúrgicos de calibre híbrido de un solo orificio |
| CA3006032A1 (en) * | 2015-12-14 | 2017-06-22 | Novartis Ag | Patch for sealing retinal breaks and associated devices, systems, and methods |
| TW201722377A (zh) | 2015-12-16 | 2017-07-01 | 諾華公司 | 用於插管遞送式治療材料施加裝置之裝置及方法 |
| US10478553B2 (en) * | 2016-03-09 | 2019-11-19 | Orbit Biomedical Limited | Apparatus for subretinal administration of therapeutic agent via a curved needle |
| US10646374B2 (en) * | 2016-06-17 | 2020-05-12 | Orbit Biomedical Limited | Apparatus and method to form entry bleb for subretinal delivery of therapeutic agent |
| US11033427B2 (en) | 2017-04-13 | 2021-06-15 | Alcon Inc. | Vitreoretinal instruments for fluid aspiration |
| AU2018357332B2 (en) * | 2017-10-27 | 2024-10-03 | Alcon Inc. | Foot pedal controlled OCT-display for vitreoretinal surgery |
| US11433174B2 (en) * | 2018-12-12 | 2022-09-06 | Alcon Inc. | Retractable backflush instrument |
| US12318343B2 (en) | 2019-05-29 | 2025-06-03 | Alcon Inc. | Retina massage and smoothing device |
| DE102020115346A1 (de) * | 2020-06-09 | 2021-12-09 | Carl Zeiss Meditec Ag | Kontrollierte Injektion zwischen zwei Gewebeschichten des menschlichen Auges |
| CN116322585A (zh) * | 2020-10-15 | 2023-06-23 | 爱尔康公司 | 无线注射器 |
| CA3201659A1 (en) * | 2020-12-17 | 2022-06-23 | Reto GRUEEBLER | A retractable backflush instrument |
| US12214160B2 (en) | 2021-01-25 | 2025-02-04 | Alcon Inc. | Method and apparatus for subretinal injection |
| JP6964912B1 (ja) * | 2021-05-28 | 2021-11-10 | 株式会社中京メディカル | 眼球装着管 |
| US20240350312A1 (en) * | 2021-08-10 | 2024-10-24 | Nallakrishnan Family Trust | Surgical Instrument And Method For Goniotomy Procedure |
| AU2023308426A1 (en) * | 2022-07-11 | 2025-01-23 | Genentech, Inc. | Transvitreal subretinal injector |
| CN119770839B (zh) * | 2025-03-11 | 2025-07-04 | 瑞安市人民医院(瑞安市人民医院医疗服务集团瑞安市红十字医院) | 一种食道精准上药器 |
Family Cites Families (118)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4830877B1 (enExample) * | 1966-11-25 | 1973-09-25 | ||
| US5164188A (en) | 1989-11-22 | 1992-11-17 | Visionex, Inc. | Biodegradable ocular implants |
| US5084009A (en) * | 1990-04-18 | 1992-01-28 | Mackool Richard J | Fluid infusion sleeve for use during eye surgery |
| US5273530A (en) | 1990-11-14 | 1993-12-28 | The University Of Rochester | Intraretinal delivery and withdrawal instruments |
| US5767079A (en) | 1992-07-08 | 1998-06-16 | Celtrix Pharmaceuticals, Inc. | Method of treating ophthalmic disorders using TGF -β |
| CA2150554A1 (en) | 1992-12-02 | 1994-06-09 | Sheng-Wan Tsao | Cyclodextrin and polymer based drug delivery system |
| US5985307A (en) | 1993-04-14 | 1999-11-16 | Emory University | Device and method for non-occlusive localized drug delivery |
| US5399352A (en) | 1993-04-14 | 1995-03-21 | Emory University | Device for local drug delivery and methods for using the same |
| WO1995003009A1 (en) | 1993-07-22 | 1995-02-02 | Oculex Pharmaceuticals, Inc. | Method of treatment of macular degeneration |
| US5443505A (en) | 1993-11-15 | 1995-08-22 | Oculex Pharmaceuticals, Inc. | Biocompatible ocular implants |
| AU1441395A (en) | 1993-12-21 | 1995-07-10 | St. Louis University | Ocular diagnostics and therapies |
| SE9402816D0 (sv) | 1994-08-24 | 1994-08-24 | Pharmacia Ab | Method and meams for drug administration |
| AU3584895A (en) | 1994-09-28 | 1996-04-19 | Celtrix Pharmaceuticals, Inc. | Method of treating macular degeneration using tgf-beta |
| US5899882A (en) | 1994-10-27 | 1999-05-04 | Novoste Corporation | Catheter apparatus for radiation treatment of a desired area in the vascular system of a patient |
| CN1177919A (zh) * | 1995-03-10 | 1998-04-01 | 托马斯·J·钱伯斯 | 柔性眼内晶状体插入系统 |
| US5755700A (en) * | 1995-07-27 | 1998-05-26 | Michiel S. Kritzinger | Corneal irrigation cannula and method of using |
| US6015403A (en) | 1996-02-26 | 2000-01-18 | Alcon Laboratories, Inc. | Ophthalmic surgery probe with soft tip |
| US5948427A (en) | 1996-04-25 | 1999-09-07 | Point Medical Corporation | Microparticulate surgical adhesive |
| US5941250A (en) * | 1996-11-21 | 1999-08-24 | University Of Louisville Research Foundation Inc. | Retinal tissue implantation method |
| WO1998051348A2 (en) | 1997-05-16 | 1998-11-19 | Amgen Inc. | Sustained-release delayed gels |
| WO1999021512A1 (en) | 1997-10-27 | 1999-05-06 | The Regents Of The University Of California | Methods and pharmaceutical compositions for the closure of retinal breaks |
| US6764461B2 (en) * | 1997-12-01 | 2004-07-20 | Scimed Life Systems, Inc. | Catheter system for the delivery of a low volume bolus |
| US6503231B1 (en) | 1998-06-10 | 2003-01-07 | Georgia Tech Research Corporation | Microneedle device for transport of molecules across tissue |
| US7344499B1 (en) | 1998-06-10 | 2008-03-18 | Georgia Tech Research Corporation | Microneedle device for extraction and sensing of bodily fluids |
| US6936053B1 (en) | 1998-07-02 | 2005-08-30 | Jeffrey N. Weiss | Ocular implant needle |
| US6309374B1 (en) | 1998-08-03 | 2001-10-30 | Insite Vision Incorporated | Injection apparatus and method of using same |
| US6378526B1 (en) | 1998-08-03 | 2002-04-30 | Insite Vision, Incorporated | Methods of ophthalmic administration |
| US6219575B1 (en) | 1998-10-23 | 2001-04-17 | Babak Nemati | Method and apparatus to enhance optical transparency of biological tissues |
| JP2002534139A (ja) | 1999-01-05 | 2002-10-15 | マサチューセッツ・アイ・アンド・イア・インファーマリー | 網膜と脈絡膜への経強膜徐放性薬剤標的送達 |
| CA2371812A1 (en) | 1999-02-17 | 2000-08-24 | Baush & Lomb Incorporated | Methods, apparatus and system for removal of lenses from mammalian eyes |
| AU774495B2 (en) | 1999-05-07 | 2004-07-01 | Johns Hopkins University School Of Medicine, The | The use of a protein tyrosine kinase pathway inhibitor in the treatment of ocular disorders |
| US6159218A (en) * | 1999-05-19 | 2000-12-12 | Aramant; Robert B. | Retinal tissue implantation tool |
| US6743211B1 (en) | 1999-11-23 | 2004-06-01 | Georgia Tech Research Corporation | Devices and methods for enhanced microneedle penetration of biological barriers |
| WO2001019321A2 (en) | 1999-09-15 | 2001-03-22 | Elan Pharmaceuticals, Inc. | Methods for treating neuropathic pain using hetreoarylmethanesulfonamides |
| US6413245B1 (en) | 1999-10-21 | 2002-07-02 | Alcon Universal Ltd. | Sub-tenon drug delivery |
| WO2001037767A1 (de) * | 1999-11-24 | 2001-05-31 | Grieshaber & Co. Ag | Einrichtung zum verbessern des kammerwasserabflusses im auge eines lebewesens |
| JP2003530144A (ja) | 1999-12-10 | 2003-10-14 | アイサイエンス コーポレイション | 眼の病気の治療 |
| US20030211166A1 (en) | 2001-07-31 | 2003-11-13 | Yamamoto Ronald K | Microparticulate biomaterial composition for medical use |
| US6491670B1 (en) | 2000-04-04 | 2002-12-10 | Duke University | Miniaturized surgical instruments especially useful for the opthalmologic surgical procedures and methods of making the same |
| US6696415B2 (en) | 2000-04-17 | 2004-02-24 | Children's Hospital Research Foundation | Treatment of ocular neovascularization and related diseases |
| ES2288169T3 (es) | 2000-06-14 | 2008-01-01 | The United States Of America, Represented By The Secretary, Dept. Of Health And Human Services | Isoflavonas contra la mortalidad inducida por radiacion. |
| US7331944B2 (en) * | 2000-10-23 | 2008-02-19 | Medical Instill Technologies, Inc. | Ophthalmic dispenser and associated method |
| US20030171722A1 (en) | 2001-01-04 | 2003-09-11 | Michel Paques | Microsurgical injection and/or distending instruments and surgical method and apparatus utilizing same |
| AU2002240004A1 (en) | 2001-01-25 | 2002-08-06 | Philip J. Ferrone | Infusion cannula |
| US6827738B2 (en) * | 2001-01-30 | 2004-12-07 | Timothy R. Willis | Refractive intraocular implant lens and method |
| US6945984B2 (en) | 2001-08-23 | 2005-09-20 | Alcon Grieshaber Ag | Micro surgical instrument |
| EP1455698A1 (en) | 2001-11-21 | 2004-09-15 | Iscience Corporation | Ophthalmic microsurgical system |
| DK1484054T3 (da) | 2002-02-22 | 2012-11-26 | Santen Pharmaceutical Co Ltd | Lægemiddelafgivelsessystem til subkonjunktival indgivelse af fine korn |
| JP4369246B2 (ja) | 2002-03-22 | 2009-11-18 | アイサイエンス コーポレイション | 眼用超小型基準デバイス及び使用方法 |
| EP1524938A2 (en) | 2002-07-12 | 2005-04-27 | Iscience Surgical Corporation | Ultrasound interfacing device for tissue imaging |
| AU2003273339B2 (en) | 2002-09-17 | 2008-08-14 | Iscience Interventional Corporation | Apparatus and method for surgical bypass of aqueous humor |
| US6899717B2 (en) | 2002-09-18 | 2005-05-31 | Allergan, Inc. | Methods and apparatus for delivery of ocular implants |
| JP2006511475A (ja) | 2002-09-18 | 2006-04-06 | トラスティーズ オブ ザ ユニバーシティ オブ ペンシルベニア | 脈絡膜新生血管症の抑制方法 |
| US7141048B1 (en) | 2002-10-17 | 2006-11-28 | Alcon, Inc. | Vitreoretinal instrument |
| US7285107B1 (en) | 2002-10-17 | 2007-10-23 | Alcon, Inc. | Vitreoretinal instrument |
| WO2004036182A2 (en) | 2002-10-17 | 2004-04-29 | Control Delivery Systems, Inc. | Methods for monitoring treatment of disease |
| WO2004073551A2 (en) | 2003-02-18 | 2004-09-02 | Massachusetts Eye And Ear Infirmary | Transscleral drug delivery device and related methods |
| US20070073275A1 (en) | 2003-04-16 | 2007-03-29 | Conston Stanley R | Ophthalmic microsurgical instruments |
| US20050009910A1 (en) | 2003-07-10 | 2005-01-13 | Allergan, Inc. | Delivery of an active drug to the posterior part of the eye via subconjunctival or periocular delivery of a prodrug |
| JP4180993B2 (ja) | 2003-08-06 | 2008-11-12 | 日本化薬株式会社 | ガス発生器 |
| US7967772B2 (en) | 2004-01-12 | 2011-06-28 | Iscience Interventional Corporation | Injector for viscous materials |
| DE10168535T1 (de) | 2004-01-23 | 2011-03-17 | Iscience Interventional Corp., Menlo Park | Zusammengesetzte Ophthalmische Mikrokanuele |
| AU2011218623B2 (en) | 2004-01-23 | 2014-01-23 | Nova Eye, Inc. | Composite Ophthalmic Microcannula |
| AU2011221361A1 (en) | 2004-01-23 | 2011-09-29 | Iscience Surgical Corporation | Composite Ophthalmic Microcannula |
| US20100173866A1 (en) | 2004-04-29 | 2010-07-08 | Iscience Interventional Corporation | Apparatus and method for ocular treatment |
| US20080058704A1 (en) | 2004-04-29 | 2008-03-06 | Michael Hee | Apparatus and Method for Ocular Treatment |
| EP2468327A1 (en) | 2004-04-29 | 2012-06-27 | iScience Interventional Corporation | Apparatus and method for surgical enhancement of aqueous humor drainage |
| CN101052434A (zh) | 2004-04-29 | 2007-10-10 | I科学干预公司 | 用于治疗眼睛的装置和方法 |
| US20050244462A1 (en) | 2004-04-30 | 2005-11-03 | Allergan, Inc. | Devices and methods for treating a mammalian eye |
| US9138228B2 (en) | 2004-08-11 | 2015-09-22 | Emory University | Vascular conduit device and system for implanting |
| US7947267B2 (en) | 2004-10-08 | 2011-05-24 | Potentia Pharmaceuticals, Inc. | Viral complement control proteins for eye disorders |
| DE602005017816D1 (de) * | 2004-12-07 | 2009-12-31 | Cook Inc | Einführvorrichtung |
| AU2012200785A1 (en) | 2004-12-16 | 2012-03-01 | Iscience Interventional Corporation | Ophthalmic implant for treatment of glaucoma |
| DE05854403T1 (de) | 2004-12-16 | 2010-08-26 | Iscience Interventional Corp., Menlo Park | Ophthalmisches implantat zur glaukombehandlung |
| EP3338743A1 (en) | 2006-01-17 | 2018-06-27 | Novartis Ag | Drug delivery treatment device |
| US20070202186A1 (en) | 2006-02-22 | 2007-08-30 | Iscience Interventional Corporation | Apparatus and formulations for suprachoroidal drug delivery |
| US7918814B2 (en) | 2006-05-02 | 2011-04-05 | Georgia Tech Research Corporation | Method for drug delivery to ocular tissue using microneedle |
| US8197435B2 (en) | 2006-05-02 | 2012-06-12 | Emory University | Methods and devices for drug delivery to ocular tissue using microneedle |
| US20080097335A1 (en) | 2006-08-04 | 2008-04-24 | Allergan, Inc. | Ocular implant delivery assemblies |
| US9681947B2 (en) * | 2006-10-23 | 2017-06-20 | Novartis Ag | Intraocular lens delivery system with temperature control |
| DK2124857T3 (en) * | 2007-01-09 | 2017-07-03 | Fovea Pharmaceuticals | DEVICE FOR INTRAOCULAR INJECTION |
| US20100057093A1 (en) | 2007-02-08 | 2010-03-04 | Takeshi Ide | Injector for eye |
| US20080195135A1 (en) | 2007-02-12 | 2008-08-14 | Alcon, Inc. | Surgical Probe |
| US7846123B2 (en) | 2007-04-24 | 2010-12-07 | Emory University | Conduit device and system for implanting a conduit device in a tissue wall |
| US8147512B1 (en) | 2007-06-06 | 2012-04-03 | Scanlan International, Inc. | Dual closing guide for a surgical instrument |
| US20090036827A1 (en) | 2007-07-31 | 2009-02-05 | Karl Cazzini | Juxtascleral Drug Delivery and Ocular Implant System |
| WO2009089409A2 (en) | 2008-01-10 | 2009-07-16 | Bausch & Lomb Incorporated | Intravitreal injection system having coaxial cannulae and use thereof |
| US20100081707A1 (en) * | 2008-02-21 | 2010-04-01 | Ali Robin R | Devices and methods for delivering polynucleotides into retinal cells of the macula and fovea |
| US20090247955A1 (en) | 2008-03-27 | 2009-10-01 | Iscience Interventional Corporation | Microliter injector |
| US8425473B2 (en) | 2009-01-23 | 2013-04-23 | Iscience Interventional Corporation | Subretinal access device |
| US20100191177A1 (en) | 2009-01-23 | 2010-07-29 | Iscience Interventional Corporation | Device for aspirating fluids |
| US8057483B2 (en) | 2009-02-14 | 2011-11-15 | Ocular Transplantation Llc | Subretinal implantation instrument |
| KR20120018353A (ko) | 2009-05-15 | 2012-03-02 | 아이싸이언스 인터벤셔날 코포레이션 | 망막하 카테터 삽입을 위한 장치 및 방법 |
| US8419673B2 (en) * | 2009-09-21 | 2013-04-16 | Alcon Research, Ltd. | Glaucoma drainage device with pump |
| WO2011057283A1 (en) | 2009-11-09 | 2011-05-12 | Iscience Interventional Corporation | Expandable cannula for infusion of fluids |
| US8177747B2 (en) | 2009-12-22 | 2012-05-15 | Alcon Research, Ltd. | Method and apparatus for drug delivery |
| WO2011106781A1 (en) | 2010-02-26 | 2011-09-01 | Iscience Interventional Corporation | Apparatus for enhancement of aqueous humor drainage from the eye |
| CN103037802B (zh) | 2010-03-31 | 2016-08-24 | 奥库杰克特有限责任公司 | 用于眼内药物递送的设备和方法 |
| US9408746B2 (en) | 2010-03-31 | 2016-08-09 | Ocuject, Llc | Device and method for intraocular drug delivery |
| US8702644B2 (en) * | 2010-05-13 | 2014-04-22 | Ethicon Endo-Surgery, Inc. | Instrument for debriding tissue and applying therapeutic cells |
| BR112012030160B1 (pt) | 2010-05-27 | 2020-11-03 | Iscience Interventional Corporation | ferramenta e dispositivo para inserção circunferencial total para um implante no canal de schlemm do olho |
| BR112012033572A2 (pt) * | 2010-06-30 | 2016-11-29 | Laurimed Llc | dispositivo de corte de tecido acionado a vácuo, método de corte e remoção do tecido de um indivíduo, método para realizar uma polipectomia, método para realizar uma discectomia e aparelho para raspagem de tecido em um indivíduo |
| US8906845B2 (en) | 2010-07-21 | 2014-12-09 | Eastern Virginia Medical School | Peptide compounds to regulate the complement system |
| US8821135B2 (en) | 2010-08-25 | 2014-09-02 | Emory University | Devices and systems for medical fluid treatment |
| BR112013009205A2 (pt) | 2010-10-15 | 2016-07-26 | Iscience Interventional Corp | dispositivo para colocação na esclera de um olho, método para acessar o espaço supracoroidal de um olho, para acessar o espaço subretinal de um olho e para colocar um orifício dentro de um trato escleral em um olho. |
| US8535268B2 (en) | 2010-12-22 | 2013-09-17 | Alcon Research, Ltd. | Device for at least one of injection or aspiration |
| CA2826413A1 (en) | 2011-02-01 | 2012-08-09 | Georgia Tech Research Corporation | Systems for implanting and using a conduit within a tissue wall |
| US20120322144A1 (en) | 2011-06-14 | 2012-12-20 | Emory University | Microfluidic devices and systems |
| US20130149214A1 (en) | 2011-12-12 | 2013-06-13 | Emory University | Microvascular fluidic devices, systems and methods related thereto |
| US9101444B2 (en) * | 2012-01-12 | 2015-08-11 | Innfocus, Inc. | Method, surgical kit and device for treating glaucoma |
| JOP20200175A1 (ar) | 2012-07-03 | 2017-06-16 | Novartis Ag | حقنة |
| US9757536B2 (en) | 2012-07-17 | 2017-09-12 | Novartis Ag | Soft tip cannula |
| CA2882184C (en) | 2012-08-27 | 2021-09-07 | Clearside Biomedical, Inc. | Apparatus and methods for drug delivery using microneedles |
| CA3240136A1 (en) | 2012-11-08 | 2014-05-15 | Clearside Biomedical, Inc. | Methods and devices for the treatment of ocular diseases in human subjects |
| SG10201702674PA (en) | 2013-05-03 | 2017-06-29 | Clearside Biomedical Inc | Apparatus and methods for ocular injection |
| EP3003454B1 (en) | 2013-06-03 | 2020-01-08 | Clearside Biomedical, Inc. | Apparatus for drug delivery using multiple reservoirs |
| US20150148838A1 (en) | 2013-11-26 | 2015-05-28 | Novartis Ag | Systems and Methods for a Surgical Tissue Manipulator |
| US9730834B2 (en) | 2013-12-20 | 2017-08-15 | Novartis Ag | Variable stiffness cannula and methods for a surgical system |
-
2013
- 2013-12-18 US US14/132,859 patent/US10010447B2/en active Active
-
2014
- 2014-11-06 JP JP2016541160A patent/JP6438030B2/ja active Active
- 2014-11-06 CN CN201480068903.1A patent/CN105979914B/zh not_active Expired - Fee Related
- 2014-11-06 CA CA2932912A patent/CA2932912C/en not_active Expired - Fee Related
- 2014-11-06 WO PCT/US2014/064407 patent/WO2015094507A1/en not_active Ceased
- 2014-11-06 ES ES14872431T patent/ES2733398T3/es active Active
- 2014-11-06 EP EP14872431.3A patent/EP3068353B1/en active Active
- 2014-11-06 AU AU2014367150A patent/AU2014367150C1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| AU2014367150A1 (en) | 2016-07-28 |
| JP6438030B2 (ja) | 2018-12-12 |
| AU2014367150C1 (en) | 2018-04-12 |
| EP3068353A1 (en) | 2016-09-21 |
| US20150164687A1 (en) | 2015-06-18 |
| CN105979914A (zh) | 2016-09-28 |
| AU2014367150B2 (en) | 2017-08-24 |
| US10010447B2 (en) | 2018-07-03 |
| CA2932912C (en) | 2019-04-09 |
| JP2017500123A (ja) | 2017-01-05 |
| CA2932912A1 (en) | 2015-06-25 |
| EP3068353B1 (en) | 2019-05-08 |
| EP3068353A4 (en) | 2017-08-02 |
| CN105979914B (zh) | 2018-03-27 |
| WO2015094507A1 (en) | 2015-06-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2733398T3 (es) | Sistemas y métodos para administración sub-retiniana de agentes terapéuticos | |
| ES2950350T3 (es) | Dispositivo de administración oftálmica | |
| ES2871138T3 (es) | Aparato para la administración supracoroidea de agente terapéutico | |
| ES2961233T3 (es) | Dispositivo de administración de agente terapéutico con cánula y aguja que pueden avanzar | |
| KR102205295B1 (ko) | 곡침을 통해 치료제를 망막하 투여하기 위한 장치 | |
| US8425473B2 (en) | Subretinal access device | |
| JP4505219B2 (ja) | 網膜下への薬剤送達のための方法およびデバイス | |
| ES2935384T3 (es) | Sistemas de implante ocular | |
| JP5996544B2 (ja) | 眼球アクセス用装置 | |
| JP3688287B1 (ja) | 眼科用インプラントを送達するための装置 | |
| ES2817775T3 (es) | Implante ocular con calidades de rigidez | |
| JP2020049361A (ja) | Ａｂ ｅｘｔｅｒｎｏ（眼外から眼内へ）の眼内シャント配置 | |
| KR20120018353A (ko) | 망막하 카테터 삽입을 위한 장치 및 방법 | |
| WO2019090195A1 (en) | Gas-powered fluid injection system | |
| ES2886966T3 (es) | Jeringa autoalimentada | |
| CN115337140B (zh) | 眼部植入器具总成 | |
| CN105902341A (zh) | Tenon囊下注药装置 | |
| WO2023001244A1 (zh) | 一种眼用注射组件、注射装置及使用方法 | |
| US8747429B2 (en) | Scleral buckling procedure and device | |
| CN206315188U (zh) | Tenon囊下注药装置 |