CA2932912C - Systems and methods for subretinal delivery of therapeutic agents - Google Patents

Systems and methods for subretinal delivery of therapeutic agents Download PDF

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Publication number
CA2932912C
CA2932912C CA2932912A CA2932912A CA2932912C CA 2932912 C CA2932912 C CA 2932912C CA 2932912 A CA2932912 A CA 2932912A CA 2932912 A CA2932912 A CA 2932912A CA 2932912 C CA2932912 C CA 2932912C
Authority
CA
Canada
Prior art keywords
inner tube
treatment device
retinal
therapeutic agents
retina
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2932912A
Other languages
English (en)
French (fr)
Other versions
CA2932912A1 (en
Inventor
Pooria S. Kashani
Michael Papac
Original Assignee
Novartis AG
Alcon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis AG, Alcon Inc filed Critical Novartis AG
Publication of CA2932912A1 publication Critical patent/CA2932912A1/en
Application granted granted Critical
Publication of CA2932912C publication Critical patent/CA2932912C/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A61F9/0017—Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
    • A61M5/178—Syringes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/00491—Surgical glue applicators

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Ophthalmology & Optometry (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medicinal Preparation (AREA)
CA2932912A 2013-12-18 2014-11-06 Systems and methods for subretinal delivery of therapeutic agents Expired - Fee Related CA2932912C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14/132,859 2013-12-18
US14/132,859 US10010447B2 (en) 2013-12-18 2013-12-18 Systems and methods for subretinal delivery of therapeutic agents
PCT/US2014/064407 WO2015094507A1 (en) 2013-12-18 2014-11-06 Systems and methods for subretinal delivery of therapeutic agents

Publications (2)

Publication Number Publication Date
CA2932912A1 CA2932912A1 (en) 2015-06-25
CA2932912C true CA2932912C (en) 2019-04-09

Family

ID=53367065

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2932912A Expired - Fee Related CA2932912C (en) 2013-12-18 2014-11-06 Systems and methods for subretinal delivery of therapeutic agents

Country Status (8)

Country Link
US (1) US10010447B2 (enExample)
EP (1) EP3068353B1 (enExample)
JP (1) JP6438030B2 (enExample)
CN (1) CN105979914B (enExample)
AU (1) AU2014367150C1 (enExample)
CA (1) CA2932912C (enExample)
ES (1) ES2733398T3 (enExample)
WO (1) WO2015094507A1 (enExample)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9730834B2 (en) * 2013-12-20 2017-08-15 Novartis Ag Variable stiffness cannula and methods for a surgical system
US9925088B2 (en) * 2014-06-06 2018-03-27 Janssen Biotech, Inc. Sub-retinal tangential needle catheter guide and introducer
US20160331584A1 (en) * 2015-05-14 2016-11-17 Novartis Ag Surgical tool tracking to control surgical system
US10507134B2 (en) 2015-05-27 2019-12-17 Novartis Ag Systems and methods for pulsed posterior vitreous detachment creation
CA3006032A1 (en) * 2015-12-14 2017-06-22 Alcon Inc. Patch for sealing retinal breaks and associated devices, systems, and methods
EP3362014B1 (en) 2015-12-14 2020-02-26 Alcon Inc. Uni-port hybrid gauge surgical apparatuses
TW201722377A (zh) 2015-12-16 2017-07-01 諾華公司 用於插管遞送式治療材料施加裝置之裝置及方法
US10478553B2 (en) * 2016-03-09 2019-11-19 Orbit Biomedical Limited Apparatus for subretinal administration of therapeutic agent via a curved needle
US10646374B2 (en) * 2016-06-17 2020-05-12 Orbit Biomedical Limited Apparatus and method to form entry bleb for subretinal delivery of therapeutic agent
US11033427B2 (en) 2017-04-13 2021-06-15 Alcon Inc. Vitreoretinal instruments for fluid aspiration
CN111278352B (zh) * 2017-10-27 2023-03-28 爱尔康公司 用于玻璃体视网膜手术的脚踏板控制的oct显示
US11433174B2 (en) * 2018-12-12 2022-09-06 Alcon Inc. Retractable backflush instrument
US12318343B2 (en) 2019-05-29 2025-06-03 Alcon Inc. Retina massage and smoothing device
PE20240329A1 (es) 2019-06-05 2024-02-27 Regeneron Pharma Dispositivos y metodos para administracion de dosis de precision
DE102020115346A1 (de) * 2020-06-09 2021-12-09 Carl Zeiss Meditec Ag Kontrollierte Injektion zwischen zwei Gewebeschichten des menschlichen Auges
TWI757205B (zh) * 2020-06-30 2022-03-01 財團法人工業技術研究院 微針電轉染裝置
US20220117781A1 (en) * 2020-10-15 2022-04-21 Alcon Inc. Wireless injector
WO2022130122A1 (en) * 2020-12-17 2022-06-23 Alcon Inc. A retractable backflush instrument
EP4281025B1 (en) 2021-01-25 2026-02-18 Alcon Inc. Apparatus for subretinal injection
JP6964912B1 (ja) * 2021-05-28 2021-11-10 株式会社中京メディカル 眼球装着管
US20240350312A1 (en) * 2021-08-10 2024-10-24 Nallakrishnan Family Trust Surgical Instrument And Method For Goniotomy Procedure
US12649031B2 (en) 2021-09-08 2026-06-09 Regeneron Pharmaceuticals, Inc. Methods for delivering agents with pre-filled syringes to minimize intraocular inflammation
KR20250052375A (ko) * 2022-07-11 2025-04-18 제넨테크, 인크. 유리체 통과 망막하 주입기
CN120265236A (zh) * 2022-10-07 2025-07-04 博士伦爱尔兰有限公司 用于晶状体乳化术的输注套管
USD1120314S1 (en) 2022-11-30 2026-03-24 Regeneron Pharmaceuticals, Inc. Dose delivery device
CN116983137A (zh) * 2023-07-28 2023-11-03 上海市同济医院 一种视网膜精准注射装置
CN119770839B (zh) * 2025-03-11 2025-07-04 瑞安市人民医院(瑞安市人民医院医疗服务集团瑞安市红十字医院) 一种食道精准上药器

Family Cites Families (118)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4830877B1 (enExample) * 1966-11-25 1973-09-25
US5164188A (en) 1989-11-22 1992-11-17 Visionex, Inc. Biodegradable ocular implants
US5084009A (en) * 1990-04-18 1992-01-28 Mackool Richard J Fluid infusion sleeve for use during eye surgery
US5273530A (en) 1990-11-14 1993-12-28 The University Of Rochester Intraretinal delivery and withdrawal instruments
US5767079A (en) 1992-07-08 1998-06-16 Celtrix Pharmaceuticals, Inc. Method of treating ophthalmic disorders using TGF -β
CA2150554A1 (en) 1992-12-02 1994-06-09 Sheng-Wan Tsao Cyclodextrin and polymer based drug delivery system
US5985307A (en) 1993-04-14 1999-11-16 Emory University Device and method for non-occlusive localized drug delivery
US5399352A (en) 1993-04-14 1995-03-21 Emory University Device for local drug delivery and methods for using the same
WO1995003009A1 (en) 1993-07-22 1995-02-02 Oculex Pharmaceuticals, Inc. Method of treatment of macular degeneration
US5443505A (en) 1993-11-15 1995-08-22 Oculex Pharmaceuticals, Inc. Biocompatible ocular implants
AU1441395A (en) 1993-12-21 1995-07-10 St. Louis University Ocular diagnostics and therapies
SE9402816D0 (sv) 1994-08-24 1994-08-24 Pharmacia Ab Method and meams for drug administration
WO1996009838A1 (en) 1994-09-28 1996-04-04 Celtrix Pharmaceuticals, Inc. METHOD OF TREATING MACULAR DEGENERATION USING TGF-$g(b)
US5899882A (en) 1994-10-27 1999-05-04 Novoste Corporation Catheter apparatus for radiation treatment of a desired area in the vascular system of a patient
CN1177919A (zh) * 1995-03-10 1998-04-01 托马斯·J·钱伯斯 柔性眼内晶状体插入系统
US5755700A (en) * 1995-07-27 1998-05-26 Michiel S. Kritzinger Corneal irrigation cannula and method of using
US6015403A (en) 1996-02-26 2000-01-18 Alcon Laboratories, Inc. Ophthalmic surgery probe with soft tip
US5948427A (en) 1996-04-25 1999-09-07 Point Medical Corporation Microparticulate surgical adhesive
US5941250A (en) * 1996-11-21 1999-08-24 University Of Louisville Research Foundation Inc. Retinal tissue implantation method
EA199901013A1 (ru) 1997-05-16 2000-06-26 Амген Инк. Гели пролонгированного действия
IL135800A0 (en) 1997-10-27 2001-05-20 Univ California Methods and pharmaceutical compositions for the closure of retinal breaks
US6764461B2 (en) * 1997-12-01 2004-07-20 Scimed Life Systems, Inc. Catheter system for the delivery of a low volume bolus
US7344499B1 (en) 1998-06-10 2008-03-18 Georgia Tech Research Corporation Microneedle device for extraction and sensing of bodily fluids
US6503231B1 (en) 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
US6936053B1 (en) 1998-07-02 2005-08-30 Jeffrey N. Weiss Ocular implant needle
US6378526B1 (en) 1998-08-03 2002-04-30 Insite Vision, Incorporated Methods of ophthalmic administration
US6309374B1 (en) 1998-08-03 2001-10-30 Insite Vision Incorporated Injection apparatus and method of using same
US6219575B1 (en) 1998-10-23 2001-04-17 Babak Nemati Method and apparatus to enhance optical transparency of biological tissues
JP2002534139A (ja) 1999-01-05 2002-10-15 マサチューセッツ・アイ・アンド・イア・インファーマリー 網膜と脈絡膜への経強膜徐放性薬剤標的送達
BR0017385A (pt) 1999-02-17 2003-12-09 Bausch & Lomb Dispositivo para reduzir uma lente oftálmica dentro da cápsula de lente de um olho de mamìfero, dispositivo médico e sistema de turbina pneumática de velocidade variável
CA2373178C (en) 1999-05-07 2013-07-02 Johns Hopkins University School Of Medicine The use of a protein tyrosine kinase pathway inhibitor in the treatment of ocular disorders
US6159218A (en) * 1999-05-19 2000-12-12 Aramant; Robert B. Retinal tissue implantation tool
US6743211B1 (en) 1999-11-23 2004-06-01 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
US6489350B1 (en) 1999-09-15 2002-12-03 Elan Pharmaceuticals, Inc. Methods for treating neuropathic pain using heteroarylmethanesulfonamides
AU775149B2 (en) 1999-10-21 2004-07-22 Alcon Inc. Sub-tenon drug delivery
CA2370369A1 (en) * 1999-11-24 2001-05-31 Grieshaber & Co. Ag Schaffhausen Device for improving the aqueous humour outflow in the eye of a living being
KR100855740B1 (ko) 1999-12-10 2008-09-03 아이싸이언스 인터벤셔날 코포레이션 안 질환의 치료방법
US20030211166A1 (en) 2001-07-31 2003-11-13 Yamamoto Ronald K Microparticulate biomaterial composition for medical use
US6491670B1 (en) 2000-04-04 2002-12-10 Duke University Miniaturized surgical instruments especially useful for the opthalmologic surgical procedures and methods of making the same
US6696415B2 (en) 2000-04-17 2004-02-24 Children's Hospital Research Foundation Treatment of ocular neovascularization and related diseases
JP4995396B2 (ja) 2000-06-14 2012-08-08 アメリカ合衆国 植物性エストロゲンのイソフラボン組成物、それらの製剤及び放射線傷害に対する防護および処置用のその使用
US7331944B2 (en) * 2000-10-23 2008-02-19 Medical Instill Technologies, Inc. Ophthalmic dispenser and associated method
US20030171722A1 (en) 2001-01-04 2003-09-11 Michel Paques Microsurgical injection and/or distending instruments and surgical method and apparatus utilizing same
AU2002240004A1 (en) 2001-01-25 2002-08-06 Philip J. Ferrone Infusion cannula
US6827738B2 (en) * 2001-01-30 2004-12-07 Timothy R. Willis Refractive intraocular implant lens and method
US6945984B2 (en) 2001-08-23 2005-09-20 Alcon Grieshaber Ag Micro surgical instrument
US8491549B2 (en) 2001-11-21 2013-07-23 Iscience Interventional Corporation Ophthalmic microsurgical system
WO2003070219A1 (en) 2002-02-22 2003-08-28 Santen Pharmaceutical Co., Ltd. Drug delivery system for the subconjunctival administration of fine grains
US20050165413A1 (en) 2002-03-22 2005-07-28 Conston Stanley R. Ophthalmic microfiducial device and method for use
CA2492140A1 (en) 2002-07-12 2004-01-22 Iscience Surgical Corporation Ultrasound interfacing device for tissue imaging
EP1539066B1 (en) 2002-09-17 2012-11-07 Iscience Surgical Corporation Apparatus surgical bypass of aqueous humor
US6899717B2 (en) 2002-09-18 2005-05-31 Allergan, Inc. Methods and apparatus for delivery of ocular implants
SI1539157T1 (sl) 2002-09-18 2013-11-29 Trustees Of The University Of Pennsylvania Rapamicin za uporabo pri inhibiciji ali preprečevanju horoidalne neovaskularizacije
US7141048B1 (en) 2002-10-17 2006-11-28 Alcon, Inc. Vitreoretinal instrument
AU2003301347A1 (en) 2002-10-17 2004-05-04 Control Delivery Systems, Inc. Methods for monitoring treatment of disease
US7285107B1 (en) 2002-10-17 2007-10-23 Alcon, Inc. Vitreoretinal instrument
WO2004073551A2 (en) 2003-02-18 2004-09-02 Massachusetts Eye And Ear Infirmary Transscleral drug delivery device and related methods
AU2004231968B2 (en) 2003-04-16 2011-02-24 Iscience Surgical Corporation Opthalmic microsurgical instruments
US20050009910A1 (en) 2003-07-10 2005-01-13 Allergan, Inc. Delivery of an active drug to the posterior part of the eye via subconjunctival or periocular delivery of a prodrug
JP4180993B2 (ja) 2003-08-06 2008-11-12 日本化薬株式会社 ガス発生器
CN101912325A (zh) 2004-01-12 2010-12-15 i科学外科公司 一种输送粘性材料的注射器
AU2011218623B2 (en) 2004-01-23 2014-01-23 Nova Eye, Inc. Composite Ophthalmic Microcannula
EP2248494B1 (en) 2004-01-23 2013-06-05 iScience Interventional Corporation Composite ophthalmic microcannula
AU2011221361A1 (en) 2004-01-23 2011-09-29 Iscience Surgical Corporation Composite Ophthalmic Microcannula
US20100173866A1 (en) 2004-04-29 2010-07-08 Iscience Interventional Corporation Apparatus and method for ocular treatment
EP1740239A4 (en) 2004-04-29 2008-12-03 Iscience Interventional Corp DEVICE AND METHOD FOR THE SURGICAL REINFORCEMENT OF THE DRAINAGE OF AQUEOUS HUMOR
KR20110139772A (ko) 2004-04-29 2011-12-29 아이싸이언스 인터벤셔날 코포레이션 안과 치료를 위한 장치와 방법
US20080058704A1 (en) 2004-04-29 2008-03-06 Michael Hee Apparatus and Method for Ocular Treatment
US20050244462A1 (en) 2004-04-30 2005-11-03 Allergan, Inc. Devices and methods for treating a mammalian eye
US9138228B2 (en) 2004-08-11 2015-09-22 Emory University Vascular conduit device and system for implanting
WO2006042252A2 (en) 2004-10-08 2006-04-20 Potentia Pharmeceuticals, Inc. Viral complement control proteins for eye disorders
ATE448826T1 (de) * 2004-12-07 2009-12-15 Cook Inc Einführvorrichtung
AU2012200785A1 (en) 2004-12-16 2012-03-01 Iscience Interventional Corporation Ophthalmic implant for treatment of glaucoma
KR20070092279A (ko) 2004-12-16 2007-09-12 아이싸이언스 인터벤셔날 코포레이션 녹내장 치료를 위한 안과 이식물
JP5388582B2 (ja) 2006-01-17 2014-01-15 トランセンド・メディカル・インコーポレイテッド 薬剤投与処置装置
US20070202186A1 (en) 2006-02-22 2007-08-30 Iscience Interventional Corporation Apparatus and formulations for suprachoroidal drug delivery
US8197435B2 (en) 2006-05-02 2012-06-12 Emory University Methods and devices for drug delivery to ocular tissue using microneedle
WO2007131050A2 (en) 2006-05-02 2007-11-15 Georgia Tech Research Corporation Method for drug delivery to ocular tissue using microneedle
US9039761B2 (en) 2006-08-04 2015-05-26 Allergan, Inc. Ocular implant delivery assemblies with distal caps
US9681947B2 (en) * 2006-10-23 2017-06-20 Novartis Ag Intraocular lens delivery system with temperature control
CA2674891C (en) * 2007-01-09 2016-03-15 Fovea Pharmaceuticals Apparatus for intra-ocular injection
EP2764846A1 (en) 2007-02-08 2014-08-13 Kaneka Corporation Injector for eye
US20080195135A1 (en) 2007-02-12 2008-08-14 Alcon, Inc. Surgical Probe
US7846123B2 (en) 2007-04-24 2010-12-07 Emory University Conduit device and system for implanting a conduit device in a tissue wall
US8147512B1 (en) 2007-06-06 2012-04-03 Scanlan International, Inc. Dual closing guide for a surgical instrument
US20090036827A1 (en) 2007-07-31 2009-02-05 Karl Cazzini Juxtascleral Drug Delivery and Ocular Implant System
US20100305514A1 (en) 2008-01-10 2010-12-02 Bausch & Lomb Incorporated Intravitreal injection system having coaxial cannulae and use thereof
US20100081707A1 (en) * 2008-02-21 2010-04-01 Ali Robin R Devices and methods for delivering polynucleotides into retinal cells of the macula and fovea
EP2262555A2 (en) 2008-03-27 2010-12-22 iScience Interventional Corporation Microliter injector
US8425473B2 (en) 2009-01-23 2013-04-23 Iscience Interventional Corporation Subretinal access device
US20100191177A1 (en) 2009-01-23 2010-07-29 Iscience Interventional Corporation Device for aspirating fluids
US8057483B2 (en) 2009-02-14 2011-11-15 Ocular Transplantation Llc Subretinal implantation instrument
WO2010132751A1 (en) 2009-05-15 2010-11-18 Iscience Interventional Corporation Methods and apparatus for sub-retinal catheterization
US8419673B2 (en) * 2009-09-21 2013-04-16 Alcon Research, Ltd. Glaucoma drainage device with pump
WO2011057283A1 (en) 2009-11-09 2011-05-12 Iscience Interventional Corporation Expandable cannula for infusion of fluids
US8177747B2 (en) 2009-12-22 2012-05-15 Alcon Research, Ltd. Method and apparatus for drug delivery
WO2011106781A1 (en) 2010-02-26 2011-09-01 Iscience Interventional Corporation Apparatus for enhancement of aqueous humor drainage from the eye
US9408746B2 (en) 2010-03-31 2016-08-09 Ocuject, Llc Device and method for intraocular drug delivery
AU2011235002B2 (en) 2010-03-31 2016-08-11 Ocuject, Llc Device and method for intraocular drug delivery
US8702644B2 (en) * 2010-05-13 2014-04-22 Ethicon Endo-Surgery, Inc. Instrument for debriding tissue and applying therapeutic cells
BR112012030160B1 (pt) 2010-05-27 2020-11-03 Iscience Interventional Corporation ferramenta e dispositivo para inserção circunferencial total para um implante no canal de schlemm do olho
CA2804200C (en) * 2010-06-30 2017-06-13 Laurimed, Llc Devices and methods for cutting and evacuating tissue
EP3453717A1 (en) 2010-07-21 2019-03-13 Eastern Virginia Medical School Peptide compounds to regulate the complement system
US8821135B2 (en) 2010-08-25 2014-09-02 Emory University Devices and systems for medical fluid treatment
WO2012051575A2 (en) * 2010-10-15 2012-04-19 Iscience Interventional Corporation Device for ocular access
US8535268B2 (en) 2010-12-22 2013-09-17 Alcon Research, Ltd. Device for at least one of injection or aspiration
US9320875B2 (en) 2011-02-01 2016-04-26 Emory University Systems for implanting and using a conduit within a tissue wall
US20120322144A1 (en) 2011-06-14 2012-12-20 Emory University Microfluidic devices and systems
US20130149214A1 (en) 2011-12-12 2013-06-13 Emory University Microvascular fluidic devices, systems and methods related thereto
US9101444B2 (en) * 2012-01-12 2015-08-11 Innfocus, Inc. Method, surgical kit and device for treating glaucoma
DE202013000688U1 (de) 2012-07-03 2013-03-05 Novartis Ag Glas-Spritze
US9757536B2 (en) 2012-07-17 2017-09-12 Novartis Ag Soft tip cannula
CA2882184C (en) 2012-08-27 2021-09-07 Clearside Biomedical, Inc. Apparatus and methods for drug delivery using microneedles
AU2013342275B2 (en) 2012-11-08 2017-11-09 Clearside Biomedical, Inc. Methods and devices for the treatment of ocular diseases in human subjects
SG10201702674PA (en) 2013-05-03 2017-06-29 Clearside Biomedical Inc Apparatus and methods for ocular injection
WO2014197317A1 (en) 2013-06-03 2014-12-11 Clearside Biomedical, Inc. Apparatus and methods for drug delivery using multiple reservoirs
US20150148838A1 (en) 2013-11-26 2015-05-28 Novartis Ag Systems and Methods for a Surgical Tissue Manipulator
US9730834B2 (en) 2013-12-20 2017-08-15 Novartis Ag Variable stiffness cannula and methods for a surgical system

Also Published As

Publication number Publication date
EP3068353B1 (en) 2019-05-08
CN105979914B (zh) 2018-03-27
JP6438030B2 (ja) 2018-12-12
EP3068353A4 (en) 2017-08-02
AU2014367150A1 (en) 2016-07-28
ES2733398T3 (es) 2019-11-28
US20150164687A1 (en) 2015-06-18
JP2017500123A (ja) 2017-01-05
CA2932912A1 (en) 2015-06-25
AU2014367150B2 (en) 2017-08-24
AU2014367150C1 (en) 2018-04-12
US10010447B2 (en) 2018-07-03
CN105979914A (zh) 2016-09-28
EP3068353A1 (en) 2016-09-21
WO2015094507A1 (en) 2015-06-25

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