JP6438030B2 - 治療薬の網膜下の送達のためのシステム - Google Patents

治療薬の網膜下の送達のためのシステム Download PDF

Info

Publication number
JP6438030B2
JP6438030B2 JP2016541160A JP2016541160A JP6438030B2 JP 6438030 B2 JP6438030 B2 JP 6438030B2 JP 2016541160 A JP2016541160 A JP 2016541160A JP 2016541160 A JP2016541160 A JP 2016541160A JP 6438030 B2 JP6438030 B2 JP 6438030B2
Authority
JP
Japan
Prior art keywords
retina
inner tube
retinal
chamber
therapeutic agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2016541160A
Other languages
English (en)
Japanese (ja)
Other versions
JP2017500123A (ja
JP2017500123A5 (enExample
Inventor
エス．カシャニ プーリア
エス．カシャニ プーリア
パパック マイケル
パパック マイケル
Original Assignee
ノバルティス アーゲー
ノバルティス アーゲー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ノバルティス アーゲー, ノバルティス アーゲー filed Critical ノバルティス アーゲー
Publication of JP2017500123A publication Critical patent/JP2017500123A/ja
Publication of JP2017500123A5 publication Critical patent/JP2017500123A5/ja
Application granted granted Critical
Publication of JP6438030B2 publication Critical patent/JP6438030B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A61F9/0017—Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/00491—Surgical glue applicators

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Ophthalmology & Optometry (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medicinal Preparation (AREA)
JP2016541160A 2013-12-18 2014-11-06 治療薬の網膜下の送達のためのシステム Active JP6438030B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14/132,859 2013-12-18
US14/132,859 US10010447B2 (en) 2013-12-18 2013-12-18 Systems and methods for subretinal delivery of therapeutic agents
PCT/US2014/064407 WO2015094507A1 (en) 2013-12-18 2014-11-06 Systems and methods for subretinal delivery of therapeutic agents

Publications (3)

Publication Number Publication Date
JP2017500123A JP2017500123A (ja) 2017-01-05
JP2017500123A5 JP2017500123A5 (enExample) 2017-11-16
JP6438030B2 true JP6438030B2 (ja) 2018-12-12

Family

ID=53367065

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2016541160A Active JP6438030B2 (ja) 2013-12-18 2014-11-06 治療薬の網膜下の送達のためのシステム

Country Status (8)

Country Link
US (1) US10010447B2 (enExample)
EP (1) EP3068353B1 (enExample)
JP (1) JP6438030B2 (enExample)
CN (1) CN105979914B (enExample)
AU (1) AU2014367150C1 (enExample)
CA (1) CA2932912C (enExample)
ES (1) ES2733398T3 (enExample)
WO (1) WO2015094507A1 (enExample)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9730834B2 (en) * 2013-12-20 2017-08-15 Novartis Ag Variable stiffness cannula and methods for a surgical system
US9925088B2 (en) * 2014-06-06 2018-03-27 Janssen Biotech, Inc. Sub-retinal tangential needle catheter guide and introducer
US20160331584A1 (en) * 2015-05-14 2016-11-17 Novartis Ag Surgical tool tracking to control surgical system
US10507134B2 (en) 2015-05-27 2019-12-17 Novartis Ag Systems and methods for pulsed posterior vitreous detachment creation
CA3006053C (en) 2015-12-14 2024-01-23 Novartis Ag Uni-port hybrid gauge surgical apparatuses and methods
CA3006032A1 (en) * 2015-12-14 2017-06-22 Alcon Inc. Patch for sealing retinal breaks and associated devices, systems, and methods
TW201722377A (zh) 2015-12-16 2017-07-01 諾華公司 用於插管遞送式治療材料施加裝置之裝置及方法
US10478553B2 (en) * 2016-03-09 2019-11-19 Orbit Biomedical Limited Apparatus for subretinal administration of therapeutic agent via a curved needle
US10646374B2 (en) * 2016-06-17 2020-05-12 Orbit Biomedical Limited Apparatus and method to form entry bleb for subretinal delivery of therapeutic agent
US11033427B2 (en) 2017-04-13 2021-06-15 Alcon Inc. Vitreoretinal instruments for fluid aspiration
JP7258873B2 (ja) * 2017-10-27 2023-04-17 アルコン インコーポレイティド 網膜硝子体手術のためのフットペダル制御によるｏｃｔ画像表示
US11433174B2 (en) * 2018-12-12 2022-09-06 Alcon Inc. Retractable backflush instrument
US12318343B2 (en) 2019-05-29 2025-06-03 Alcon Inc. Retina massage and smoothing device
MA54325A (fr) 2019-06-05 2022-05-11 Regeneron Pharma Dispositifs et procédés pour l'administration précise de doses
DE102020115346A1 (de) * 2020-06-09 2021-12-09 Carl Zeiss Meditec Ag Kontrollierte Injektion zwischen zwei Gewebeschichten des menschlichen Auges
US12496442B2 (en) * 2020-06-30 2025-12-16 Industrial Technology Research Institute Microneedle electroporation device
WO2022079546A1 (en) * 2020-10-15 2022-04-21 Alcon Inc. Wireless injector
EP4262644A1 (en) * 2020-12-17 2023-10-25 Alcon Inc. A retractable backflush instrument
US12214160B2 (en) 2021-01-25 2025-02-04 Alcon Inc. Method and apparatus for subretinal injection
JP6964912B1 (ja) * 2021-05-28 2021-11-10 株式会社中京メディカル 眼球装着管
US20240350312A1 (en) * 2021-08-10 2024-10-24 Nallakrishnan Family Trust Surgical Instrument And Method For Goniotomy Procedure
EP4554534A1 (en) * 2022-07-11 2025-05-21 Genentech, Inc. Transvitreal subretinal injector
KR20250084170A (ko) * 2022-10-07 2025-06-10 보슈 롬 아일랜드 리미티드 수정체 유화용 주입 슬리브
USD1120314S1 (en) 2022-11-30 2026-03-24 Regeneron Pharmaceuticals, Inc. Dose delivery device
CN116983137A (zh) * 2023-07-28 2023-11-03 上海市同济医院 一种视网膜精准注射装置
CN119770839B (zh) * 2025-03-11 2025-07-04 瑞安市人民医院(瑞安市人民医院医疗服务集团瑞安市红十字医院) 一种食道精准上药器

Family Cites Families (118)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4830877B1 (enExample) * 1966-11-25 1973-09-25
US5164188A (en) 1989-11-22 1992-11-17 Visionex, Inc. Biodegradable ocular implants
US5084009A (en) * 1990-04-18 1992-01-28 Mackool Richard J Fluid infusion sleeve for use during eye surgery
US5273530A (en) 1990-11-14 1993-12-28 The University Of Rochester Intraretinal delivery and withdrawal instruments
US5767079A (en) 1992-07-08 1998-06-16 Celtrix Pharmaceuticals, Inc. Method of treating ophthalmic disorders using TGF -β
JPH08503951A (ja) 1992-12-02 1996-04-30 インサイト・ビジョン・インコーポレイテッド シクロデキストリンとポリマーを用いた薬剤供給系
US5985307A (en) 1993-04-14 1999-11-16 Emory University Device and method for non-occlusive localized drug delivery
US5399352A (en) 1993-04-14 1995-03-21 Emory University Device for local drug delivery and methods for using the same
WO1995003009A1 (en) 1993-07-22 1995-02-02 Oculex Pharmaceuticals, Inc. Method of treatment of macular degeneration
US5443505A (en) 1993-11-15 1995-08-22 Oculex Pharmaceuticals, Inc. Biocompatible ocular implants
WO1995017673A1 (en) 1993-12-21 1995-06-29 Ocutech, Inc. Ocular diagnostics and therapies
SE9402816D0 (sv) 1994-08-24 1994-08-24 Pharmacia Ab Method and meams for drug administration
AU3584895A (en) 1994-09-28 1996-04-19 Celtrix Pharmaceuticals, Inc. Method of treating macular degeneration using tgf-beta
US5899882A (en) 1994-10-27 1999-05-04 Novoste Corporation Catheter apparatus for radiation treatment of a desired area in the vascular system of a patient
CN1177919A (zh) * 1995-03-10 1998-04-01 托马斯·J·钱伯斯 柔性眼内晶状体插入系统
US5755700A (en) * 1995-07-27 1998-05-26 Michiel S. Kritzinger Corneal irrigation cannula and method of using
US6015403A (en) 1996-02-26 2000-01-18 Alcon Laboratories, Inc. Ophthalmic surgery probe with soft tip
US5948427A (en) 1996-04-25 1999-09-07 Point Medical Corporation Microparticulate surgical adhesive
US5941250A (en) * 1996-11-21 1999-08-24 University Of Louisville Research Foundation Inc. Retinal tissue implantation method
KR20010012374A (ko) 1997-05-16 2001-02-15 스티븐 엠. 오드레 지속 효과를 갖는 서방성 겔
EP1027016A4 (en) 1997-10-27 2006-03-08 Univ California METHODS AND PHARMACEUTICAL COMPOSITIONS FOR REFERRING RETINAL RIPPLE
US6764461B2 (en) * 1997-12-01 2004-07-20 Scimed Life Systems, Inc. Catheter system for the delivery of a low volume bolus
US6503231B1 (en) 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
US7344499B1 (en) 1998-06-10 2008-03-18 Georgia Tech Research Corporation Microneedle device for extraction and sensing of bodily fluids
US6936053B1 (en) 1998-07-02 2005-08-30 Jeffrey N. Weiss Ocular implant needle
US6309374B1 (en) 1998-08-03 2001-10-30 Insite Vision Incorporated Injection apparatus and method of using same
US6378526B1 (en) 1998-08-03 2002-04-30 Insite Vision, Incorporated Methods of ophthalmic administration
US6219575B1 (en) 1998-10-23 2001-04-17 Babak Nemati Method and apparatus to enhance optical transparency of biological tissues
EP1154691A4 (en) 1999-01-05 2004-07-07 Massachusetts Eye & Ear Infirm TARGETED ADMINISTRATION OF REGULATED RELEASE MEDICINE TO RETINA AND CHOROID THROUGH SCLEROTIC
AU2998400A (en) 1999-02-17 2000-09-04 Bausch & Lomb Incorporated Methods, apparatus and system for removal of lenses from mammalian eyes
AU774495B2 (en) 1999-05-07 2004-07-01 Johns Hopkins University School Of Medicine, The The use of a protein tyrosine kinase pathway inhibitor in the treatment of ocular disorders
US6159218A (en) * 1999-05-19 2000-12-12 Aramant; Robert B. Retinal tissue implantation tool
US6743211B1 (en) 1999-11-23 2004-06-01 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
EP1215963A4 (en) 1999-09-15 2005-07-27 Elan Pharm Inc METHOD FOR THE TREATMENT OF NEUROPATHIC PAIN USING HETEROARYLMETHANSULFONAMIDES
ES2240180T3 (es) 1999-10-21 2005-10-16 Alcon Inc. Administracion sub-tenon de medicamentos.
AU776599B2 (en) * 1999-11-24 2004-09-16 Grieshaber & Co. Ag Device for improving the aqueous humour outflow in the eye of a living thing
CA2393673A1 (en) 1999-12-10 2001-06-14 Iscience Corporation Treatment of ocular disease
US20030211166A1 (en) 2001-07-31 2003-11-13 Yamamoto Ronald K Microparticulate biomaterial composition for medical use
US6491670B1 (en) 2000-04-04 2002-12-10 Duke University Miniaturized surgical instruments especially useful for the opthalmologic surgical procedures and methods of making the same
WO2001079506A2 (en) 2000-04-17 2001-10-25 Children's Hospital Research Foundation Treatment of ocular neovascularization and related diseases
ATE363902T1 (de) 2000-06-14 2007-06-15 Us Health Isoflavonen gegen strahlungsinduzierte mortalität
US7331944B2 (en) * 2000-10-23 2008-02-19 Medical Instill Technologies, Inc. Ophthalmic dispenser and associated method
US20030171722A1 (en) 2001-01-04 2003-09-11 Michel Paques Microsurgical injection and/or distending instruments and surgical method and apparatus utilizing same
AU2002240004A1 (en) 2001-01-25 2002-08-06 Philip J. Ferrone Infusion cannula
US6827738B2 (en) * 2001-01-30 2004-12-07 Timothy R. Willis Refractive intraocular implant lens and method
US6945984B2 (en) 2001-08-23 2005-09-20 Alcon Grieshaber Ag Micro surgical instrument
JP4303116B2 (ja) 2001-11-21 2009-07-29 アイサイエンス コーポレイション 眼科マイクロサージャリー装置
SI1484054T1 (sl) 2002-02-22 2012-12-31 Santen Pharmaceutical Co. Ltd. Sistem razdeljevanja zdravil za subkonjuktivalno dajane finih zrn
US20050165413A1 (en) 2002-03-22 2005-07-28 Conston Stanley R. Ophthalmic microfiducial device and method for use
AU2003249200B2 (en) 2002-07-12 2009-08-13 Iscience Interventional Corporation Ultrasound interfacing device for tissue imaging
EP1539066B1 (en) 2002-09-17 2012-11-07 Iscience Surgical Corporation Apparatus surgical bypass of aqueous humor
ES2428354T3 (es) 2002-09-18 2013-11-07 Trustees Of The University Of Pennsylvania Rapamicina para usar en la inhibición o prevención de la neovascularización coroidea
US6899717B2 (en) 2002-09-18 2005-05-31 Allergan, Inc. Methods and apparatus for delivery of ocular implants
AU2003301347A1 (en) 2002-10-17 2004-05-04 Control Delivery Systems, Inc. Methods for monitoring treatment of disease
US7141048B1 (en) 2002-10-17 2006-11-28 Alcon, Inc. Vitreoretinal instrument
US7285107B1 (en) 2002-10-17 2007-10-23 Alcon, Inc. Vitreoretinal instrument
US20060167435A1 (en) 2003-02-18 2006-07-27 Adamis Anthony P Transscleral drug delivery device and related methods
ATE439107T1 (de) 2003-04-16 2009-08-15 Iscience Interventional Corp Mikrochirurgische instrumente für die ophthalmologie
US20050009910A1 (en) 2003-07-10 2005-01-13 Allergan, Inc. Delivery of an active drug to the posterior part of the eye via subconjunctival or periocular delivery of a prodrug
JP4180993B2 (ja) 2003-08-06 2008-11-12 日本化薬株式会社 ガス発生器
CN1950124B (zh) 2004-01-12 2010-11-10 Ⅰ科学外科公司 一种输送粘性材料的注射器
AU2011221361A1 (en) 2004-01-23 2011-09-29 Iscience Surgical Corporation Composite Ophthalmic Microcannula
AU2011218623B2 (en) 2004-01-23 2014-01-23 Nova Eye, Inc. Composite Ophthalmic Microcannula
KR101195052B1 (ko) 2004-01-23 2012-10-29 아이싸이언스 인터벤셔날 코포레이션 복합체 안과 마이크로캐뉼라
US20080058704A1 (en) 2004-04-29 2008-03-06 Michael Hee Apparatus and Method for Ocular Treatment
AU2005240073A1 (en) 2004-04-29 2005-11-17 Iscience Surgical Corporation Apparatus and method for ocular treatment
US20100173866A1 (en) 2004-04-29 2010-07-08 Iscience Interventional Corporation Apparatus and method for ocular treatment
WO2005107664A2 (en) 2004-04-29 2005-11-17 Iscience Interventional Corporation Apparatus and method for surgical enhancement of aqueous humor drainage
US20050244462A1 (en) 2004-04-30 2005-11-03 Allergan, Inc. Devices and methods for treating a mammalian eye
US9138228B2 (en) 2004-08-11 2015-09-22 Emory University Vascular conduit device and system for implanting
US7947267B2 (en) 2004-10-08 2011-05-24 Potentia Pharmaceuticals, Inc. Viral complement control proteins for eye disorders
EP1819390B1 (en) * 2004-12-07 2009-11-18 Cook Incorporated Introducer apparatus
AU2012200785A1 (en) 2004-12-16 2012-03-01 Iscience Interventional Corporation Ophthalmic implant for treatment of glaucoma
BRPI0519087B8 (pt) 2004-12-16 2021-06-22 Iscience Interventional Corp instrumento para inserção de um implante no canal de schlemm do olho
EP1978892B1 (en) 2006-01-17 2017-11-15 Novartis Ag Drug delivery treatment device
US20070202186A1 (en) 2006-02-22 2007-08-30 Iscience Interventional Corporation Apparatus and formulations for suprachoroidal drug delivery
US8197435B2 (en) 2006-05-02 2012-06-12 Emory University Methods and devices for drug delivery to ocular tissue using microneedle
WO2007131050A2 (en) 2006-05-02 2007-11-15 Georgia Tech Research Corporation Method for drug delivery to ocular tissue using microneedle
US20080097335A1 (en) 2006-08-04 2008-04-24 Allergan, Inc. Ocular implant delivery assemblies
US9681947B2 (en) * 2006-10-23 2017-06-20 Novartis Ag Intraocular lens delivery system with temperature control
DK2124857T3 (en) * 2007-01-09 2017-07-03 Fovea Pharmaceuticals DEVICE FOR INTRAOCULAR INJECTION
EP2111821A4 (en) 2007-02-08 2013-10-23 Kaneka Corp INJECTOR FOR EYES
US20080195135A1 (en) 2007-02-12 2008-08-14 Alcon, Inc. Surgical Probe
US7846123B2 (en) 2007-04-24 2010-12-07 Emory University Conduit device and system for implanting a conduit device in a tissue wall
US8147512B1 (en) 2007-06-06 2012-04-03 Scanlan International, Inc. Dual closing guide for a surgical instrument
US20090036827A1 (en) 2007-07-31 2009-02-05 Karl Cazzini Juxtascleral Drug Delivery and Ocular Implant System
US20100305514A1 (en) 2008-01-10 2010-12-02 Bausch & Lomb Incorporated Intravitreal injection system having coaxial cannulae and use thereof
WO2009105690A2 (en) * 2008-02-21 2009-08-27 Targeted Genetics Corporation Devices and methods for delivering polynucleotides into retinal cells of the macula and fovea
EP2262555A2 (en) 2008-03-27 2010-12-22 iScience Interventional Corporation Microliter injector
US20100191177A1 (en) 2009-01-23 2010-07-29 Iscience Interventional Corporation Device for aspirating fluids
US8425473B2 (en) 2009-01-23 2013-04-23 Iscience Interventional Corporation Subretinal access device
US8057483B2 (en) 2009-02-14 2011-11-15 Ocular Transplantation Llc Subretinal implantation instrument
EP2429607A4 (en) 2009-05-15 2014-01-08 Iscience Interventional Corp METHOD AND DEVICE FOR SUBRETINAL CATHETERIZATION
US8419673B2 (en) * 2009-09-21 2013-04-16 Alcon Research, Ltd. Glaucoma drainage device with pump
WO2011057283A1 (en) 2009-11-09 2011-05-12 Iscience Interventional Corporation Expandable cannula for infusion of fluids
US8177747B2 (en) 2009-12-22 2012-05-15 Alcon Research, Ltd. Method and apparatus for drug delivery
WO2011106781A1 (en) 2010-02-26 2011-09-01 Iscience Interventional Corporation Apparatus for enhancement of aqueous humor drainage from the eye
EP2552349A4 (en) 2010-03-31 2017-12-06 Ocuject, LLC Device and method for intraocular drug delivery
US9408746B2 (en) 2010-03-31 2016-08-09 Ocuject, Llc Device and method for intraocular drug delivery
US8702644B2 (en) * 2010-05-13 2014-04-22 Ethicon Endo-Surgery, Inc. Instrument for debriding tissue and applying therapeutic cells
CN103002842A (zh) 2010-05-27 2013-03-27 I科学干预公司 用于把周向植入物放置在巩膜静脉窦中的装置
CA2804200C (en) * 2010-06-30 2017-06-13 Laurimed, Llc Devices and methods for cutting and evacuating tissue
PL2606058T3 (pl) 2010-07-21 2017-09-29 Eastern Virginia Medical School Związki peptydowe do regulowania układu dopełniacza
US8821135B2 (en) 2010-08-25 2014-09-02 Emory University Devices and systems for medical fluid treatment
EP2627292B1 (en) 2010-10-15 2018-10-10 Clearside Biomedical, Inc. Device for ocular access
US8535268B2 (en) 2010-12-22 2013-09-17 Alcon Research, Ltd. Device for at least one of injection or aspiration
AU2012212215B2 (en) 2011-02-01 2015-07-30 Emory University Systems for implanting and using a conduit within a tissue wall
US20120322144A1 (en) 2011-06-14 2012-12-20 Emory University Microfluidic devices and systems
US20130149214A1 (en) 2011-12-12 2013-06-13 Emory University Microvascular fluidic devices, systems and methods related thereto
US9101444B2 (en) * 2012-01-12 2015-08-11 Innfocus, Inc. Method, surgical kit and device for treating glaucoma
DE202013000688U1 (de) 2012-07-03 2013-03-05 Novartis Ag Glas-Spritze
US9757536B2 (en) 2012-07-17 2017-09-12 Novartis Ag Soft tip cannula
EP2887982B1 (en) 2012-08-27 2022-11-23 Clearside Biomedical, Inc. Apparatus for drug delivery using microneedles
KR102467714B1 (ko) 2012-11-08 2022-11-16 클리어사이드 바이오메디컬, 인코포레이드 인간 대상체에서 안구 질병을 치료하기 위한 방법 및 장치
AU2014259694B2 (en) 2013-05-03 2018-11-08 Clearside Biomedical, Inc. Apparatus and methods for ocular injection
US10188550B2 (en) 2013-06-03 2019-01-29 Clearside Biomedical, Inc. Apparatus and methods for drug delivery using multiple reservoirs
US20150148838A1 (en) 2013-11-26 2015-05-28 Novartis Ag Systems and Methods for a Surgical Tissue Manipulator
US9730834B2 (en) 2013-12-20 2017-08-15 Novartis Ag Variable stiffness cannula and methods for a surgical system

Also Published As

Publication number Publication date
ES2733398T3 (es) 2019-11-28
WO2015094507A1 (en) 2015-06-25
CA2932912A1 (en) 2015-06-25
US20150164687A1 (en) 2015-06-18
EP3068353A1 (en) 2016-09-21
US10010447B2 (en) 2018-07-03
CN105979914B (zh) 2018-03-27
AU2014367150A1 (en) 2016-07-28
JP2017500123A (ja) 2017-01-05
EP3068353A4 (en) 2017-08-02
EP3068353B1 (en) 2019-05-08
CA2932912C (en) 2019-04-09
AU2014367150C1 (en) 2018-04-12
AU2014367150B2 (en) 2017-08-24
CN105979914A (zh) 2016-09-28

Similar Documents

Publication Publication Date Title
JP2017500123A (ja) 治療薬の網膜下の送達のためのシステム及び方法
US20230248569A1 (en) Ocular implant systems
US10905586B2 (en) Methods and devices for drug delivery to ocular tissue using microneedle
JP2023169335A (ja) 湾曲した針を介する治療剤の網膜下投与のための装置
US8425473B2 (en) Subretinal access device
US7431710B2 (en) Ocular implants with anchors and methods thereof
EP1615604B1 (en) Opthalmic microsurgical instruments
JP2020049361A (ja) Ａｂ ｅｘｔｅｒｎｏ（眼外から眼内へ）の眼内シャント配置
US20050271704A1 (en) Injectable glaucoma implants with multiple openings
JP2007501066A (ja) 緑内障治療装置および方法
US11076984B2 (en) Method of performing subretinal drainage and agent delivery
US20210393436A1 (en) Methods and devices for drug delivery to ocular tissue using microneedle
CN105902341B (zh) Tenon囊下注药装置
KR102377814B1 (ko) 치료 기구
US11759355B1 (en) Method of delivering leading blebs and agent to subretinal space
EP4465942A2 (en) Devices and methods for injecting medication substances towards a target site in a body tissue

Legal Events

Date Code Title Description
A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20160805

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20170612

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20170627

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20170927

A524 Written submission of copy of amendment under article 19 pct

Free format text: JAPANESE INTERMEDIATE CODE: A524

Effective date: 20171005

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20171107

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20180119

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20180626

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20180920

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20180928

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20181016

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20181115

R150 Certificate of patent or registration of utility model

Ref document number: 6438030

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

S111 Request for change of ownership or part of ownership

Free format text: JAPANESE INTERMEDIATE CODE: R313113

R350 Written notification of registration of transfer

Free format text: JAPANESE INTERMEDIATE CODE: R350

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250