AU2014367150C1 - Systems and methods for subretinal delivery of therapeutic agents - Google Patents

Systems and methods for subretinal delivery of therapeutic agents Download PDF

Info

Publication number
AU2014367150C1
AU2014367150C1 AU2014367150A AU2014367150A AU2014367150C1 AU 2014367150 C1 AU2014367150 C1 AU 2014367150C1 AU 2014367150 A AU2014367150 A AU 2014367150A AU 2014367150 A AU2014367150 A AU 2014367150A AU 2014367150 C1 AU2014367150 C1 AU 2014367150C1
Authority
AU
Australia
Prior art keywords
treatment device
inner tube
retinal
retina
retinal treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2014367150A
Other languages
English (en)
Other versions
AU2014367150A1 (en
AU2014367150B2 (en
Inventor
Pooria S. Kashani
Michael Papac
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alcon Inc
Original Assignee
Alcon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcon Inc filed Critical Alcon Inc
Publication of AU2014367150A1 publication Critical patent/AU2014367150A1/en
Application granted granted Critical
Publication of AU2014367150B2 publication Critical patent/AU2014367150B2/en
Publication of AU2014367150C1 publication Critical patent/AU2014367150C1/en
Assigned to ALCON INC. reassignment ALCON INC. Request for Assignment Assignors: NOVARTIS AG
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A61F9/0017—Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/00491—Surgical glue applicators

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Ophthalmology & Optometry (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medicinal Preparation (AREA)
AU2014367150A 2013-12-18 2014-11-06 Systems and methods for subretinal delivery of therapeutic agents Ceased AU2014367150C1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14/132,859 2013-12-18
US14/132,859 US10010447B2 (en) 2013-12-18 2013-12-18 Systems and methods for subretinal delivery of therapeutic agents
PCT/US2014/064407 WO2015094507A1 (en) 2013-12-18 2014-11-06 Systems and methods for subretinal delivery of therapeutic agents

Publications (3)

Publication Number Publication Date
AU2014367150A1 AU2014367150A1 (en) 2016-07-28
AU2014367150B2 AU2014367150B2 (en) 2017-08-24
AU2014367150C1 true AU2014367150C1 (en) 2018-04-12

Family

ID=53367065

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2014367150A Ceased AU2014367150C1 (en) 2013-12-18 2014-11-06 Systems and methods for subretinal delivery of therapeutic agents

Country Status (8)

Country Link
US (1) US10010447B2 (enExample)
EP (1) EP3068353B1 (enExample)
JP (1) JP6438030B2 (enExample)
CN (1) CN105979914B (enExample)
AU (1) AU2014367150C1 (enExample)
CA (1) CA2932912C (enExample)
ES (1) ES2733398T3 (enExample)
WO (1) WO2015094507A1 (enExample)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9730834B2 (en) * 2013-12-20 2017-08-15 Novartis Ag Variable stiffness cannula and methods for a surgical system
US9925088B2 (en) * 2014-06-06 2018-03-27 Janssen Biotech, Inc. Sub-retinal tangential needle catheter guide and introducer
US20160331584A1 (en) * 2015-05-14 2016-11-17 Novartis Ag Surgical tool tracking to control surgical system
US10507134B2 (en) 2015-05-27 2019-12-17 Novartis Ag Systems and methods for pulsed posterior vitreous detachment creation
CA3006032A1 (en) * 2015-12-14 2017-06-22 Novartis Ag Patch for sealing retinal breaks and associated devices, systems, and methods
ES2778687T3 (es) 2015-12-14 2020-08-11 Alcon Inc Aparatos quirúrgicos de calibre híbrido de un solo orificio
TW201722377A (zh) 2015-12-16 2017-07-01 諾華公司 用於插管遞送式治療材料施加裝置之裝置及方法
US10478553B2 (en) * 2016-03-09 2019-11-19 Orbit Biomedical Limited Apparatus for subretinal administration of therapeutic agent via a curved needle
US10646374B2 (en) * 2016-06-17 2020-05-12 Orbit Biomedical Limited Apparatus and method to form entry bleb for subretinal delivery of therapeutic agent
US11033427B2 (en) 2017-04-13 2021-06-15 Alcon Inc. Vitreoretinal instruments for fluid aspiration
US11382501B2 (en) * 2017-10-27 2022-07-12 Alcon Inc. Foot pedal controlled OCT-display for vitreoretinal surgery
US11433174B2 (en) * 2018-12-12 2022-09-06 Alcon Inc. Retractable backflush instrument
US12318343B2 (en) 2019-05-29 2025-06-03 Alcon Inc. Retina massage and smoothing device
DE102020115346A1 (de) * 2020-06-09 2021-12-09 Carl Zeiss Meditec Ag Kontrollierte Injektion zwischen zwei Gewebeschichten des menschlichen Auges
US12496442B2 (en) * 2020-06-30 2025-12-16 Industrial Technology Research Institute Microneedle electroporation device
CA3193981A1 (en) * 2020-10-15 2022-04-21 Paul R. Hallen Wireless injector
CA3201659A1 (en) * 2020-12-17 2022-06-23 Reto GRUEEBLER A retractable backflush instrument
WO2022157607A1 (en) 2021-01-25 2022-07-28 Alcon Inc. Method and apparatus for subretinal injection
JP6964912B1 (ja) * 2021-05-28 2021-11-10 株式会社中京メディカル 眼球装着管
US20240350312A1 (en) * 2021-08-10 2024-10-24 Nallakrishnan Family Trust Surgical Instrument And Method For Goniotomy Procedure
JP2025523037A (ja) * 2022-07-11 2025-07-17 ジェネンテック， インコーポレイテッド 経硝子体網膜下注射器
CN119770839B (zh) * 2025-03-11 2025-07-04 瑞安市人民医院(瑞安市人民医院医疗服务集团瑞安市红十字医院) 一种食道精准上药器

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120271272A1 (en) * 2010-10-15 2012-10-25 Iscience Interventional Corporation Device for ocular access

Family Cites Families (117)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4830877B1 (enExample) * 1966-11-25 1973-09-25
US5164188A (en) 1989-11-22 1992-11-17 Visionex, Inc. Biodegradable ocular implants
US5084009A (en) * 1990-04-18 1992-01-28 Mackool Richard J Fluid infusion sleeve for use during eye surgery
US5273530A (en) 1990-11-14 1993-12-28 The University Of Rochester Intraretinal delivery and withdrawal instruments
US5767079A (en) 1992-07-08 1998-06-16 Celtrix Pharmaceuticals, Inc. Method of treating ophthalmic disorders using TGF -β
WO1994012217A1 (en) 1992-12-02 1994-06-09 Insite Vision Incorporated Cyclodextrin and polymer based drug delivery system
US5985307A (en) 1993-04-14 1999-11-16 Emory University Device and method for non-occlusive localized drug delivery
US5399352A (en) 1993-04-14 1995-03-21 Emory University Device for local drug delivery and methods for using the same
WO1995003009A1 (en) 1993-07-22 1995-02-02 Oculex Pharmaceuticals, Inc. Method of treatment of macular degeneration
US5443505A (en) 1993-11-15 1995-08-22 Oculex Pharmaceuticals, Inc. Biocompatible ocular implants
WO1995017673A1 (en) 1993-12-21 1995-06-29 Ocutech, Inc. Ocular diagnostics and therapies
SE9402816D0 (sv) 1994-08-24 1994-08-24 Pharmacia Ab Method and meams for drug administration
AU3584895A (en) 1994-09-28 1996-04-19 Celtrix Pharmaceuticals, Inc. Method of treating macular degeneration using tgf-beta
US5899882A (en) 1994-10-27 1999-05-04 Novoste Corporation Catheter apparatus for radiation treatment of a desired area in the vascular system of a patient
CN1177919A (zh) * 1995-03-10 1998-04-01 托马斯·J·钱伯斯 柔性眼内晶状体插入系统
US5755700A (en) * 1995-07-27 1998-05-26 Michiel S. Kritzinger Corneal irrigation cannula and method of using
US6015403A (en) 1996-02-26 2000-01-18 Alcon Laboratories, Inc. Ophthalmic surgery probe with soft tip
US5948427A (en) 1996-04-25 1999-09-07 Point Medical Corporation Microparticulate surgical adhesive
US5941250A (en) * 1996-11-21 1999-08-24 University Of Louisville Research Foundation Inc. Retinal tissue implantation method
DE69838750T2 (de) 1997-05-16 2008-10-30 Amgen Inc., Thousand Oaks Zeitverzögerte gelzusammensetzungen mit verlängerter wirkstoffverabreichung
WO1999021512A1 (en) 1997-10-27 1999-05-06 The Regents Of The University Of California Methods and pharmaceutical compositions for the closure of retinal breaks
US6764461B2 (en) * 1997-12-01 2004-07-20 Scimed Life Systems, Inc. Catheter system for the delivery of a low volume bolus
US7344499B1 (en) 1998-06-10 2008-03-18 Georgia Tech Research Corporation Microneedle device for extraction and sensing of bodily fluids
US6503231B1 (en) 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
US6936053B1 (en) 1998-07-02 2005-08-30 Jeffrey N. Weiss Ocular implant needle
US6378526B1 (en) 1998-08-03 2002-04-30 Insite Vision, Incorporated Methods of ophthalmic administration
US6309374B1 (en) 1998-08-03 2001-10-30 Insite Vision Incorporated Injection apparatus and method of using same
US6219575B1 (en) 1998-10-23 2001-04-17 Babak Nemati Method and apparatus to enhance optical transparency of biological tissues
JP2002534139A (ja) 1999-01-05 2002-10-15 マサチューセッツ・アイ・アンド・イア・インファーマリー 網膜と脈絡膜への経強膜徐放性薬剤標的送達
CA2371812A1 (en) 1999-02-17 2000-08-24 Baush & Lomb Incorporated Methods, apparatus and system for removal of lenses from mammalian eyes
MXPA01011344A (es) 1999-05-07 2004-06-03 Univ Johns Hopkins Med El uso de un inhibidor de la ruta de proteina tirosina quinasa en el tratamiento de trastornos oculares.
US6159218A (en) * 1999-05-19 2000-12-12 Aramant; Robert B. Retinal tissue implantation tool
US6743211B1 (en) 1999-11-23 2004-06-01 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
US6489350B1 (en) 1999-09-15 2002-12-03 Elan Pharmaceuticals, Inc. Methods for treating neuropathic pain using heteroarylmethanesulfonamides
CA2383572C (en) 1999-10-21 2007-12-11 Alcon Universal Ltd. Sub-tenon drug delivery
JP2003514616A (ja) * 1999-11-24 2003-04-22 グリースハーバー ウント コンパニー アーゲー シャフハウゼン 生体の眼の房水の流出を改善するための装置
JP2003530144A (ja) 1999-12-10 2003-10-14 アイサイエンス コーポレイション 眼の病気の治療
US20030211166A1 (en) 2001-07-31 2003-11-13 Yamamoto Ronald K Microparticulate biomaterial composition for medical use
US6491670B1 (en) 2000-04-04 2002-12-10 Duke University Miniaturized surgical instruments especially useful for the opthalmologic surgical procedures and methods of making the same
AU2001259085A1 (en) 2000-04-17 2001-10-30 Childrens Hospital Research Foundation Treatment of ocular neovascularization and related diseases
ATE363902T1 (de) 2000-06-14 2007-06-15 Us Health Isoflavonen gegen strahlungsinduzierte mortalität
US7331944B2 (en) * 2000-10-23 2008-02-19 Medical Instill Technologies, Inc. Ophthalmic dispenser and associated method
US20030171722A1 (en) 2001-01-04 2003-09-11 Michel Paques Microsurgical injection and/or distending instruments and surgical method and apparatus utilizing same
WO2002058607A2 (en) 2001-01-25 2002-08-01 Ferrone Philip J Infusion cannula
US6827738B2 (en) * 2001-01-30 2004-12-07 Timothy R. Willis Refractive intraocular implant lens and method
US6945984B2 (en) 2001-08-23 2005-09-20 Alcon Grieshaber Ag Micro surgical instrument
AU2002365403B2 (en) 2001-11-21 2009-07-09 Iscience Interventional Corporation Ophthalmic microsurgical system
PT1484054E (pt) 2002-02-22 2012-11-28 Santen Pharmaceutical Co Ltd Sistema de administração de fármaco para administração subconjuntival de partículas finas
JP4369246B2 (ja) 2002-03-22 2009-11-18 アイサイエンス コーポレイション 眼用超小型基準デバイス及び使用方法
CA2492140A1 (en) 2002-07-12 2004-01-22 Iscience Surgical Corporation Ultrasound interfacing device for tissue imaging
WO2004026347A2 (en) 2002-09-17 2004-04-01 Iscience Surgical Corporation Apparatus and method for surgical bypass of aqueous humor
US6899717B2 (en) 2002-09-18 2005-05-31 Allergan, Inc. Methods and apparatus for delivery of ocular implants
ES2428354T3 (es) 2002-09-18 2013-11-07 Trustees Of The University Of Pennsylvania Rapamicina para usar en la inhibición o prevención de la neovascularización coroidea
AU2003301347A1 (en) 2002-10-17 2004-05-04 Control Delivery Systems, Inc. Methods for monitoring treatment of disease
US7285107B1 (en) 2002-10-17 2007-10-23 Alcon, Inc. Vitreoretinal instrument
US7141048B1 (en) 2002-10-17 2006-11-28 Alcon, Inc. Vitreoretinal instrument
WO2004073551A2 (en) 2003-02-18 2004-09-02 Massachusetts Eye And Ear Infirmary Transscleral drug delivery device and related methods
US20070073275A1 (en) 2003-04-16 2007-03-29 Conston Stanley R Ophthalmic microsurgical instruments
US20050009910A1 (en) 2003-07-10 2005-01-13 Allergan, Inc. Delivery of an active drug to the posterior part of the eye via subconjunctival or periocular delivery of a prodrug
JP4180993B2 (ja) 2003-08-06 2008-11-12 日本化薬株式会社 ガス発生器
US7967772B2 (en) 2004-01-12 2011-06-28 Iscience Interventional Corporation Injector for viscous materials
AU2011218623B2 (en) 2004-01-23 2014-01-23 Nova Eye, Inc. Composite Ophthalmic Microcannula
AU2011221361A1 (en) 2004-01-23 2011-09-29 Iscience Surgical Corporation Composite Ophthalmic Microcannula
PT2248494E (pt) 2004-01-23 2013-08-23 Iscience Interventional Corp Microcânula oftálmica compósita
US20100173866A1 (en) 2004-04-29 2010-07-08 Iscience Interventional Corporation Apparatus and method for ocular treatment
WO2005107845A1 (en) 2004-04-29 2005-11-17 Iscience Interventional Corporation Apparatus and method for ocular treatment
KR20070033974A (ko) 2004-04-29 2007-03-27 아이싸이언스 인터벤셔날 코포레이션 방수 배출의 외과적 강화를 위한 장치와 방법
US20080058704A1 (en) 2004-04-29 2008-03-06 Michael Hee Apparatus and Method for Ocular Treatment
US20050244462A1 (en) 2004-04-30 2005-11-03 Allergan, Inc. Devices and methods for treating a mammalian eye
US9138228B2 (en) 2004-08-11 2015-09-22 Emory University Vascular conduit device and system for implanting
WO2006042252A2 (en) 2004-10-08 2006-04-20 Potentia Pharmeceuticals, Inc. Viral complement control proteins for eye disorders
EP1819390B1 (en) * 2004-12-07 2009-11-18 Cook Incorporated Introducer apparatus
AU2012200785A1 (en) 2004-12-16 2012-03-01 Iscience Interventional Corporation Ophthalmic implant for treatment of glaucoma
CN101128171A (zh) 2004-12-16 2008-02-20 I科学干预公司 治疗青光眼的眼用植入物
US9084662B2 (en) 2006-01-17 2015-07-21 Transcend Medical, Inc. Drug delivery treatment device
US20070202186A1 (en) 2006-02-22 2007-08-30 Iscience Interventional Corporation Apparatus and formulations for suprachoroidal drug delivery
WO2007131050A2 (en) 2006-05-02 2007-11-15 Georgia Tech Research Corporation Method for drug delivery to ocular tissue using microneedle
US8197435B2 (en) 2006-05-02 2012-06-12 Emory University Methods and devices for drug delivery to ocular tissue using microneedle
US9039761B2 (en) 2006-08-04 2015-05-26 Allergan, Inc. Ocular implant delivery assemblies with distal caps
US9681947B2 (en) * 2006-10-23 2017-06-20 Novartis Ag Intraocular lens delivery system with temperature control
DK2124856T3 (en) * 2007-01-09 2019-02-11 Fovea Pharmaceuticals DEVICE FOR INTRAOCULAR INJECTION
US20100057093A1 (en) 2007-02-08 2010-03-04 Takeshi Ide Injector for eye
US20080195135A1 (en) 2007-02-12 2008-08-14 Alcon, Inc. Surgical Probe
US7846123B2 (en) 2007-04-24 2010-12-07 Emory University Conduit device and system for implanting a conduit device in a tissue wall
US8147512B1 (en) 2007-06-06 2012-04-03 Scanlan International, Inc. Dual closing guide for a surgical instrument
US20090036827A1 (en) 2007-07-31 2009-02-05 Karl Cazzini Juxtascleral Drug Delivery and Ocular Implant System
WO2009089409A2 (en) 2008-01-10 2009-07-16 Bausch & Lomb Incorporated Intravitreal injection system having coaxial cannulae and use thereof
WO2009105690A2 (en) * 2008-02-21 2009-08-27 Targeted Genetics Corporation Devices and methods for delivering polynucleotides into retinal cells of the macula and fovea
US20090247955A1 (en) 2008-03-27 2009-10-01 Iscience Interventional Corporation Microliter injector
US8425473B2 (en) 2009-01-23 2013-04-23 Iscience Interventional Corporation Subretinal access device
US20100191177A1 (en) 2009-01-23 2010-07-29 Iscience Interventional Corporation Device for aspirating fluids
US8057483B2 (en) 2009-02-14 2011-11-15 Ocular Transplantation Llc Subretinal implantation instrument
JP2012526637A (ja) 2009-05-15 2012-11-01 アイサイエンス・インターベンショナル・コーポレーション 網膜下カテーテル挿入のための方法及び装置
US8419673B2 (en) * 2009-09-21 2013-04-16 Alcon Research, Ltd. Glaucoma drainage device with pump
WO2011057283A1 (en) 2009-11-09 2011-05-12 Iscience Interventional Corporation Expandable cannula for infusion of fluids
US8177747B2 (en) 2009-12-22 2012-05-15 Alcon Research, Ltd. Method and apparatus for drug delivery
WO2011106781A1 (en) 2010-02-26 2011-09-01 Iscience Interventional Corporation Apparatus for enhancement of aqueous humor drainage from the eye
US9408746B2 (en) 2010-03-31 2016-08-09 Ocuject, Llc Device and method for intraocular drug delivery
AU2011235002B2 (en) 2010-03-31 2016-08-11 Ocuject, Llc Device and method for intraocular drug delivery
US8702644B2 (en) * 2010-05-13 2014-04-22 Ethicon Endo-Surgery, Inc. Instrument for debriding tissue and applying therapeutic cells
BR112012030160B1 (pt) 2010-05-27 2020-11-03 Iscience Interventional Corporation ferramenta e dispositivo para inserção circunferencial total para um implante no canal de schlemm do olho
ES2545816T3 (es) * 2010-06-30 2015-09-16 Laurimed, Llc Dispositivos de corte y evacuación de tejido
CA2804998C (en) 2010-07-21 2018-11-13 Eastern Virginia Medical School Peptide compounds to regulate the complement system
US8821135B2 (en) 2010-08-25 2014-09-02 Emory University Devices and systems for medical fluid treatment
US8535268B2 (en) 2010-12-22 2013-09-17 Alcon Research, Ltd. Device for at least one of injection or aspiration
EP2670346A2 (en) 2011-02-01 2013-12-11 Georgia Tech Research Corporation Systems for implanting and using a conduit within a tissue wall
US20120322144A1 (en) 2011-06-14 2012-12-20 Emory University Microfluidic devices and systems
US20130149214A1 (en) 2011-12-12 2013-06-13 Emory University Microvascular fluidic devices, systems and methods related thereto
US9101444B2 (en) * 2012-01-12 2015-08-11 Innfocus, Inc. Method, surgical kit and device for treating glaucoma
JOP20200175A1 (ar) 2012-07-03 2017-06-16 Novartis Ag حقنة
US9757536B2 (en) 2012-07-17 2017-09-12 Novartis Ag Soft tip cannula
CA2882184C (en) 2012-08-27 2021-09-07 Clearside Biomedical, Inc. Apparatus and methods for drug delivery using microneedles
ES3023054T3 (en) 2012-11-08 2025-05-29 Clearside Biomedical Inc Methods for the treatment of ocular disease in human subjects
KR102282973B1 (ko) 2013-05-03 2021-07-27 클리어사이드 바이오메디컬, 인코포레이드 안구용 주사를 위한 장치 및 방법
US10188550B2 (en) 2013-06-03 2019-01-29 Clearside Biomedical, Inc. Apparatus and methods for drug delivery using multiple reservoirs
US20150148838A1 (en) 2013-11-26 2015-05-28 Novartis Ag Systems and Methods for a Surgical Tissue Manipulator
US9730834B2 (en) 2013-12-20 2017-08-15 Novartis Ag Variable stiffness cannula and methods for a surgical system

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120271272A1 (en) * 2010-10-15 2012-10-25 Iscience Interventional Corporation Device for ocular access

Also Published As

Publication number Publication date
EP3068353B1 (en) 2019-05-08
AU2014367150A1 (en) 2016-07-28
WO2015094507A1 (en) 2015-06-25
JP6438030B2 (ja) 2018-12-12
AU2014367150B2 (en) 2017-08-24
CA2932912A1 (en) 2015-06-25
EP3068353A1 (en) 2016-09-21
JP2017500123A (ja) 2017-01-05
CN105979914B (zh) 2018-03-27
CN105979914A (zh) 2016-09-28
US20150164687A1 (en) 2015-06-18
ES2733398T3 (es) 2019-11-28
US10010447B2 (en) 2018-07-03
CA2932912C (en) 2019-04-09
EP3068353A4 (en) 2017-08-02

Similar Documents

Publication Publication Date Title
AU2014367150C1 (en) Systems and methods for subretinal delivery of therapeutic agents
EP3193987B1 (en) Therapeutic agent delivery device
GB2548988B (en) Ophthalmic delivery device
US10912883B2 (en) Gas-powered fluid injection system
EP3797742B1 (en) Apparatus for suprachoroidal administration of therapeutic agent
JP4505219B2 (ja) 網膜下への薬剤送達のための方法およびデバイス
JP2023169335A (ja) 湾曲した針を介する治療剤の網膜下投与のための装置
US20230046514A1 (en) System and method for resistance-dependent, self-regulated medical penetration
EP3448465B1 (en) Self-powered syringe
US10507134B2 (en) Systems and methods for pulsed posterior vitreous detachment creation
CN115337139B (zh) 眼部穿刺装置和眼部植入器具总成
CN115337140B (zh) 眼部植入器具总成
CN106038053A (zh) 眼球后注药装置
CN105902341B (zh) Tenon囊下注药装置
CN218943684U (zh) 一种眼部经Tenon氏囊下球后注射针
HK40047835B (en) Apparatus for suprachoroidal administration of therapeutic agent

Legal Events

Date Code Title Description
DA2 Applications for amendment section 104

Free format text: THE NATURE OF THE AMENDMENT IS AS SHOWN IN THE STATEMENT(S) FILED 27 NOV 2017

DA3 Amendments made section 104

Free format text: THE NATURE OF THE AMENDMENT IS AS SHOWN IN THE STATEMENT(S) FILED 27 NOV 2017

FGA Letters patent sealed or granted (standard patent)
PC Assignment registered

Owner name: ALCON INC.

Free format text: FORMER OWNER(S): NOVARTIS AG

MK14 Patent ceased section 143(a) (annual fees not paid) or expired