ES2728870T3 - Witanólidos útiles para el tratamiento de enfermedades neurodegenerativas - Google Patents
Witanólidos útiles para el tratamiento de enfermedades neurodegenerativas Download PDFInfo
- Publication number
- ES2728870T3 ES2728870T3 ES14812105T ES14812105T ES2728870T3 ES 2728870 T3 ES2728870 T3 ES 2728870T3 ES 14812105 T ES14812105 T ES 14812105T ES 14812105 T ES14812105 T ES 14812105T ES 2728870 T3 ES2728870 T3 ES 2728870T3
- Authority
- ES
- Spain
- Prior art keywords
- compound
- patient
- methyl
- hydrogen
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361908455P | 2013-11-25 | 2013-11-25 | |
| PCT/US2014/067436 WO2015077780A1 (en) | 2013-11-25 | 2014-11-25 | Withanolides useful for the treatment of neurodegenerative diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2728870T3 true ES2728870T3 (es) | 2019-10-29 |
Family
ID=52023694
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES14812105T Active ES2728870T3 (es) | 2013-11-25 | 2014-11-25 | Witanólidos útiles para el tratamiento de enfermedades neurodegenerativas |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US10351590B2 (enExample) |
| EP (1) | EP3074414B1 (enExample) |
| JP (1) | JP6517833B2 (enExample) |
| KR (1) | KR20160137945A (enExample) |
| CN (1) | CN105940010B (enExample) |
| AU (1) | AU2014352629B2 (enExample) |
| BR (1) | BR112016012002A2 (enExample) |
| CA (1) | CA2931064C (enExample) |
| ES (1) | ES2728870T3 (enExample) |
| MX (1) | MX364528B (enExample) |
| PL (1) | PL3074414T3 (enExample) |
| TR (1) | TR201905218T4 (enExample) |
| WO (1) | WO2015077780A1 (enExample) |
| ZA (1) | ZA201603117B (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019116069A1 (en) * | 2017-12-11 | 2019-06-20 | Ethnodyne | Compounds for treating neurodegenerative disorders |
| US20210087222A1 (en) * | 2017-12-11 | 2021-03-25 | Ethnodyne | Compounds for treating neurodegenerative disorders |
| EP3724207A1 (en) * | 2017-12-11 | 2020-10-21 | Ethnodyne | Compounds for treating neurodegenerative disorders |
| CN111377994A (zh) * | 2018-12-28 | 2020-07-07 | 南开大学 | 七种来源于灯笼果的醉茄内酯类化合物及其制备方法和用途 |
| CA3231484A1 (en) | 2021-10-01 | 2023-04-06 | Qinwen Mao | Pathologic tdp-43 as a biomarker for the diagnosis of tdp-43 proteinopathy |
| CN116063373B (zh) * | 2023-02-14 | 2025-04-15 | 广西医科大学 | 天然产物27-Deoxywithaferin A的制备方法 |
| EP4788688A1 (en) * | 2023-10-03 | 2026-08-12 | Enveda Therapeutics, Inc. | Withaferin a analog and method for treatment using the same |
| CN117924401B (zh) * | 2024-01-22 | 2026-05-12 | 黑龙江中医药大学 | 一种具有神经炎症抑制活性的化合物及其提取方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010030395A2 (en) * | 2008-09-15 | 2010-03-18 | Whitehead Institute For Biomedical Research | Withaferin a analogs and uses thereof |
| WO2010053655A2 (en) | 2008-11-07 | 2010-05-14 | University Of Kansas | Therapeutic methods with withaferin a and analogs |
| US8598339B2 (en) | 2011-02-01 | 2013-12-03 | University Of Kansas | Withanolide isolated from Physalis longifolia and analogs and methods of use thereof |
| ES2679289T3 (es) * | 2011-06-22 | 2018-08-23 | UNIVERSITé LAVAL | Procedimientos para el pronóstico y/o diagnóstico de una enfermedad neurodegenerativa, procedimientos para identificar compuestos candidatos y compuestos para tratar una enfermedad neurodegenerativa |
-
2014
- 2014-11-25 TR TR2019/05218T patent/TR201905218T4/tr unknown
- 2014-11-25 CA CA2931064A patent/CA2931064C/en active Active
- 2014-11-25 JP JP2016554830A patent/JP6517833B2/ja not_active Expired - Fee Related
- 2014-11-25 BR BR112016012002A patent/BR112016012002A2/pt not_active IP Right Cessation
- 2014-11-25 EP EP14812105.6A patent/EP3074414B1/en not_active Not-in-force
- 2014-11-25 MX MX2016006544A patent/MX364528B/es active IP Right Grant
- 2014-11-25 CN CN201480064227.0A patent/CN105940010B/zh not_active Expired - Fee Related
- 2014-11-25 KR KR1020167015115A patent/KR20160137945A/ko not_active Ceased
- 2014-11-25 ES ES14812105T patent/ES2728870T3/es active Active
- 2014-11-25 WO PCT/US2014/067436 patent/WO2015077780A1/en not_active Ceased
- 2014-11-25 AU AU2014352629A patent/AU2014352629B2/en not_active Ceased
- 2014-11-25 PL PL14812105T patent/PL3074414T3/pl unknown
- 2014-11-25 US US15/038,927 patent/US10351590B2/en active Active
-
2016
- 2016-05-10 ZA ZA2016/03117A patent/ZA201603117B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20160137945A (ko) | 2016-12-02 |
| EP3074414A1 (en) | 2016-10-05 |
| WO2015077780A1 (en) | 2015-05-28 |
| MX364528B (es) | 2019-04-30 |
| AU2014352629B2 (en) | 2019-03-28 |
| JP6517833B2 (ja) | 2019-05-22 |
| JP2016537432A (ja) | 2016-12-01 |
| MX2016006544A (es) | 2016-12-12 |
| CN105940010B (zh) | 2018-03-30 |
| PL3074414T3 (pl) | 2019-12-31 |
| US10351590B2 (en) | 2019-07-16 |
| CN105940010A (zh) | 2016-09-14 |
| CA2931064A1 (en) | 2015-05-28 |
| CA2931064C (en) | 2022-10-18 |
| EP3074414B1 (en) | 2019-01-09 |
| BR112016012002A2 (pt) | 2017-09-19 |
| US20170022247A1 (en) | 2017-01-26 |
| ZA201603117B (en) | 2020-05-27 |
| AU2014352629A1 (en) | 2016-05-26 |
| TR201905218T4 (tr) | 2019-05-21 |
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