ES2728870T3 - Witanólidos útiles para el tratamiento de enfermedades neurodegenerativas - Google Patents
Witanólidos útiles para el tratamiento de enfermedades neurodegenerativas Download PDFInfo
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- ES2728870T3 ES2728870T3 ES14812105T ES14812105T ES2728870T3 ES 2728870 T3 ES2728870 T3 ES 2728870T3 ES 14812105 T ES14812105 T ES 14812105T ES 14812105 T ES14812105 T ES 14812105T ES 2728870 T3 ES2728870 T3 ES 2728870T3
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- 239000003765 sweetening agent Substances 0.000 description 1
- 229920003002 synthetic resin Polymers 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 229960001367 tartaric acid Drugs 0.000 description 1
- ILMRJRBKQSSXGY-UHFFFAOYSA-N tert-butyl(dimethyl)silicon Chemical group C[Si](C)C(C)(C)C ILMRJRBKQSSXGY-UHFFFAOYSA-N 0.000 description 1
- BCNZYOJHNLTNEZ-UHFFFAOYSA-N tert-butyldimethylsilyl chloride Chemical compound CC(C)(C)[Si](C)(C)Cl BCNZYOJHNLTNEZ-UHFFFAOYSA-N 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 125000005985 thienyl[1,3]dithianyl group Chemical group 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 230000005945 translocation Effects 0.000 description 1
- 125000004665 trialkylsilyl group Chemical group 0.000 description 1
- 125000003866 trichloromethyl group Chemical group ClC(Cl)(Cl)* 0.000 description 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
- 125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- YFTHZRPMJXBUME-UHFFFAOYSA-N tripropylamine Chemical compound CCCN(CCC)CCC YFTHZRPMJXBUME-UHFFFAOYSA-N 0.000 description 1
- 125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1
- 238000010798 ubiquitination Methods 0.000 description 1
- 230000034512 ubiquitination Effects 0.000 description 1
- 229960002703 undecylenic acid Drugs 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- WVMINIQLCDVTLH-IVFYTCICSA-N viscosalactone B Chemical compound C([C@@H]1[C@H]([C@@H]2[C@]3(CC[C@@H]4[C@@]5(C)C(=O)C[C@H](O)[C@H](O)[C@@]65O[C@@H]6C[C@H]4[C@@H]3CC2)C)C)C(C)=C(CO)C(=O)O1 WVMINIQLCDVTLH-IVFYTCICSA-N 0.000 description 1
- WVMINIQLCDVTLH-UHFFFAOYSA-N viscosaltacone B Natural products C1CC2C3CC4OC44C(O)C(O)CC(=O)C4(C)C3CCC2(C)C1C(C)C1CC(C)=C(CO)C(=O)O1 WVMINIQLCDVTLH-UHFFFAOYSA-N 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 239000011701 zinc Chemical class 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361908455P | 2013-11-25 | 2013-11-25 | |
| PCT/US2014/067436 WO2015077780A1 (en) | 2013-11-25 | 2014-11-25 | Withanolides useful for the treatment of neurodegenerative diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2728870T3 true ES2728870T3 (es) | 2019-10-29 |
Family
ID=52023694
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES14812105T Active ES2728870T3 (es) | 2013-11-25 | 2014-11-25 | Witanólidos útiles para el tratamiento de enfermedades neurodegenerativas |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US10351590B2 (enExample) |
| EP (1) | EP3074414B1 (enExample) |
| JP (1) | JP6517833B2 (enExample) |
| KR (1) | KR20160137945A (enExample) |
| CN (1) | CN105940010B (enExample) |
| AU (1) | AU2014352629B2 (enExample) |
| BR (1) | BR112016012002A2 (enExample) |
| CA (1) | CA2931064C (enExample) |
| ES (1) | ES2728870T3 (enExample) |
| MX (1) | MX364528B (enExample) |
| PL (1) | PL3074414T3 (enExample) |
| TR (1) | TR201905218T4 (enExample) |
| WO (1) | WO2015077780A1 (enExample) |
| ZA (1) | ZA201603117B (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11634452B2 (en) | 2017-12-11 | 2023-04-25 | Ethnodyne | Compounds for treating neurodegenerative disorders |
| EP3723859B1 (en) * | 2017-12-11 | 2023-08-30 | Ethnodyne | Compounds for treating neurodegenerative disorders |
| US20210079035A1 (en) * | 2017-12-11 | 2021-03-18 | Ethnodyne | Compounds for treating neurodegenerative disorders |
| CN111377994A (zh) * | 2018-12-28 | 2020-07-07 | 南开大学 | 七种来源于灯笼果的醉茄内酯类化合物及其制备方法和用途 |
| CA3231484A1 (en) | 2021-10-01 | 2023-04-06 | Qinwen Mao | Pathologic tdp-43 as a biomarker for the diagnosis of tdp-43 proteinopathy |
| CN116063373B (zh) * | 2023-02-14 | 2025-04-15 | 广西医科大学 | 天然产物27-Deoxywithaferin A的制备方法 |
| TW202521103A (zh) * | 2023-10-03 | 2025-06-01 | 美商恩維達醫療公司 | 醉茄素a（withaferin a）類似物及使用彼之治療方法 |
| CN117924401B (zh) * | 2024-01-22 | 2026-05-12 | 黑龙江中医药大学 | 一种具有神经炎症抑制活性的化合物及其提取方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110230551A1 (en) | 2008-09-15 | 2011-09-22 | Leslie Gunatilaka | Withaferin a analogs and uses thereof |
| WO2010053655A2 (en) | 2008-11-07 | 2010-05-14 | University Of Kansas | Therapeutic methods with withaferin a and analogs |
| US8598339B2 (en) | 2011-02-01 | 2013-12-03 | University Of Kansas | Withanolide isolated from Physalis longifolia and analogs and methods of use thereof |
| WO2012174666A1 (en) * | 2011-06-22 | 2012-12-27 | UNIVERSITé LAVAL | Methods for the prognostic and/or diagnostic of neurodegenerative disease, methods to identify candidate compounds and compounds for treating neurodegenerative disease |
-
2014
- 2014-11-25 KR KR1020167015115A patent/KR20160137945A/ko not_active Ceased
- 2014-11-25 JP JP2016554830A patent/JP6517833B2/ja not_active Expired - Fee Related
- 2014-11-25 EP EP14812105.6A patent/EP3074414B1/en active Active
- 2014-11-25 ES ES14812105T patent/ES2728870T3/es active Active
- 2014-11-25 MX MX2016006544A patent/MX364528B/es active IP Right Grant
- 2014-11-25 CA CA2931064A patent/CA2931064C/en active Active
- 2014-11-25 WO PCT/US2014/067436 patent/WO2015077780A1/en not_active Ceased
- 2014-11-25 BR BR112016012002A patent/BR112016012002A2/pt not_active IP Right Cessation
- 2014-11-25 TR TR2019/05218T patent/TR201905218T4/tr unknown
- 2014-11-25 US US15/038,927 patent/US10351590B2/en active Active
- 2014-11-25 CN CN201480064227.0A patent/CN105940010B/zh not_active Expired - Fee Related
- 2014-11-25 PL PL14812105T patent/PL3074414T3/pl unknown
- 2014-11-25 AU AU2014352629A patent/AU2014352629B2/en not_active Ceased
-
2016
- 2016-05-10 ZA ZA2016/03117A patent/ZA201603117B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP3074414B1 (en) | 2019-01-09 |
| CN105940010A (zh) | 2016-09-14 |
| CN105940010B (zh) | 2018-03-30 |
| US20170022247A1 (en) | 2017-01-26 |
| AU2014352629A1 (en) | 2016-05-26 |
| MX364528B (es) | 2019-04-30 |
| TR201905218T4 (tr) | 2019-05-21 |
| AU2014352629B2 (en) | 2019-03-28 |
| EP3074414A1 (en) | 2016-10-05 |
| CA2931064A1 (en) | 2015-05-28 |
| CA2931064C (en) | 2022-10-18 |
| PL3074414T3 (pl) | 2019-12-31 |
| KR20160137945A (ko) | 2016-12-02 |
| JP6517833B2 (ja) | 2019-05-22 |
| MX2016006544A (es) | 2016-12-12 |
| ZA201603117B (en) | 2020-05-27 |
| BR112016012002A2 (pt) | 2017-09-19 |
| US10351590B2 (en) | 2019-07-16 |
| WO2015077780A1 (en) | 2015-05-28 |
| JP2016537432A (ja) | 2016-12-01 |
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