BR112016012002A2 - Vitanolídeos úteis para o tratamento de doenças neurodegenerativas - Google Patents
Vitanolídeos úteis para o tratamento de doenças neurodegenerativasInfo
- Publication number
- BR112016012002A2 BR112016012002A2 BR112016012002A BR112016012002A BR112016012002A2 BR 112016012002 A2 BR112016012002 A2 BR 112016012002A2 BR 112016012002 A BR112016012002 A BR 112016012002A BR 112016012002 A BR112016012002 A BR 112016012002A BR 112016012002 A2 BR112016012002 A2 BR 112016012002A2
- Authority
- BR
- Brazil
- Prior art keywords
- treatment
- neurodegenerative diseases
- vitanolids
- useful
- vianolide
- Prior art date
Links
- 208000015122 neurodegenerative disease Diseases 0.000 title abstract 3
- 229930014626 natural product Natural products 0.000 abstract 1
- 230000004770 neurodegeneration Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361908455P | 2013-11-25 | 2013-11-25 | |
| PCT/US2014/067436 WO2015077780A1 (en) | 2013-11-25 | 2014-11-25 | Withanolides useful for the treatment of neurodegenerative diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112016012002A2 true BR112016012002A2 (pt) | 2017-09-19 |
Family
ID=52023694
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112016012002A BR112016012002A2 (pt) | 2013-11-25 | 2014-11-25 | Vitanolídeos úteis para o tratamento de doenças neurodegenerativas |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US10351590B2 (enExample) |
| EP (1) | EP3074414B1 (enExample) |
| JP (1) | JP6517833B2 (enExample) |
| KR (1) | KR20160137945A (enExample) |
| CN (1) | CN105940010B (enExample) |
| AU (1) | AU2014352629B2 (enExample) |
| BR (1) | BR112016012002A2 (enExample) |
| CA (1) | CA2931064C (enExample) |
| ES (1) | ES2728870T3 (enExample) |
| MX (1) | MX364528B (enExample) |
| PL (1) | PL3074414T3 (enExample) |
| TR (1) | TR201905218T4 (enExample) |
| WO (1) | WO2015077780A1 (enExample) |
| ZA (1) | ZA201603117B (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019116069A1 (en) * | 2017-12-11 | 2019-06-20 | Ethnodyne | Compounds for treating neurodegenerative disorders |
| US20210087222A1 (en) * | 2017-12-11 | 2021-03-25 | Ethnodyne | Compounds for treating neurodegenerative disorders |
| EP3724207A1 (en) * | 2017-12-11 | 2020-10-21 | Ethnodyne | Compounds for treating neurodegenerative disorders |
| CN111377994A (zh) * | 2018-12-28 | 2020-07-07 | 南开大学 | 七种来源于灯笼果的醉茄内酯类化合物及其制备方法和用途 |
| CA3231484A1 (en) | 2021-10-01 | 2023-04-06 | Qinwen Mao | Pathologic tdp-43 as a biomarker for the diagnosis of tdp-43 proteinopathy |
| CN116063373B (zh) * | 2023-02-14 | 2025-04-15 | 广西医科大学 | 天然产物27-Deoxywithaferin A的制备方法 |
| EP4788688A1 (en) * | 2023-10-03 | 2026-08-12 | Enveda Therapeutics, Inc. | Withaferin a analog and method for treatment using the same |
| CN117924401B (zh) * | 2024-01-22 | 2026-05-12 | 黑龙江中医药大学 | 一种具有神经炎症抑制活性的化合物及其提取方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010030395A2 (en) * | 2008-09-15 | 2010-03-18 | Whitehead Institute For Biomedical Research | Withaferin a analogs and uses thereof |
| WO2010053655A2 (en) | 2008-11-07 | 2010-05-14 | University Of Kansas | Therapeutic methods with withaferin a and analogs |
| US8598339B2 (en) | 2011-02-01 | 2013-12-03 | University Of Kansas | Withanolide isolated from Physalis longifolia and analogs and methods of use thereof |
| ES2679289T3 (es) * | 2011-06-22 | 2018-08-23 | UNIVERSITé LAVAL | Procedimientos para el pronóstico y/o diagnóstico de una enfermedad neurodegenerativa, procedimientos para identificar compuestos candidatos y compuestos para tratar una enfermedad neurodegenerativa |
-
2014
- 2014-11-25 TR TR2019/05218T patent/TR201905218T4/tr unknown
- 2014-11-25 CA CA2931064A patent/CA2931064C/en active Active
- 2014-11-25 JP JP2016554830A patent/JP6517833B2/ja not_active Expired - Fee Related
- 2014-11-25 BR BR112016012002A patent/BR112016012002A2/pt not_active IP Right Cessation
- 2014-11-25 EP EP14812105.6A patent/EP3074414B1/en not_active Not-in-force
- 2014-11-25 MX MX2016006544A patent/MX364528B/es active IP Right Grant
- 2014-11-25 CN CN201480064227.0A patent/CN105940010B/zh not_active Expired - Fee Related
- 2014-11-25 KR KR1020167015115A patent/KR20160137945A/ko not_active Ceased
- 2014-11-25 ES ES14812105T patent/ES2728870T3/es active Active
- 2014-11-25 WO PCT/US2014/067436 patent/WO2015077780A1/en not_active Ceased
- 2014-11-25 AU AU2014352629A patent/AU2014352629B2/en not_active Ceased
- 2014-11-25 PL PL14812105T patent/PL3074414T3/pl unknown
- 2014-11-25 US US15/038,927 patent/US10351590B2/en active Active
-
2016
- 2016-05-10 ZA ZA2016/03117A patent/ZA201603117B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20160137945A (ko) | 2016-12-02 |
| EP3074414A1 (en) | 2016-10-05 |
| WO2015077780A1 (en) | 2015-05-28 |
| MX364528B (es) | 2019-04-30 |
| AU2014352629B2 (en) | 2019-03-28 |
| JP6517833B2 (ja) | 2019-05-22 |
| JP2016537432A (ja) | 2016-12-01 |
| MX2016006544A (es) | 2016-12-12 |
| CN105940010B (zh) | 2018-03-30 |
| PL3074414T3 (pl) | 2019-12-31 |
| US10351590B2 (en) | 2019-07-16 |
| CN105940010A (zh) | 2016-09-14 |
| CA2931064A1 (en) | 2015-05-28 |
| CA2931064C (en) | 2022-10-18 |
| EP3074414B1 (en) | 2019-01-09 |
| US20170022247A1 (en) | 2017-01-26 |
| ES2728870T3 (es) | 2019-10-29 |
| ZA201603117B (en) | 2020-05-27 |
| AU2014352629A1 (en) | 2016-05-26 |
| TR201905218T4 (tr) | 2019-05-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 8A ANUIDADE. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2698 DE 20-09-2022 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |