ES2728353T3 - Compuesto de (6S,9aS)-N-bencil-6-[(4-hidroxifenil)metil]-4,7-dioxo-8-({6-[3-(piperazin-1-il)azetidin-1-il]piridin-2-il}metil)-2-(prop-2-en-1-il)-octahidro-1H-pirazino[2,1-c][1,2,4]triazin-1-carboxamida - Google Patents

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Publication number

ES2728353T3

ES2728353T3 ES14873998T ES14873998T ES2728353T3 ES 2728353 T3 ES2728353 T3 ES 2728353T3 ES 14873998 T ES14873998 T ES 14873998T ES 14873998 T ES14873998 T ES 14873998T ES 2728353 T3 ES2728353 T3 ES 2728353T3

Authority

ES

Spain

Prior art keywords

methyl

azetidin

prop

octahydro

triazin

Prior art date

2013-12-25

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

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• 150000001875 compounds Chemical class 0.000 title claims abstract description 462
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• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract description 32
• 125000005843 halogen group Chemical group 0.000 claims abstract description 9
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• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 57
• 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims description 25
• 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims description 22
• 125000004566 azetidin-1-yl group Chemical group N1(CCC1)* 0.000 claims description 18
• MHZGAVWIXHVIET-UHFFFAOYSA-N N1(NC=NC=C1)C(=O)N Chemical compound N1(NC=NC=C1)C(=O)N MHZGAVWIXHVIET-UHFFFAOYSA-N 0.000 claims description 16
• 125000004203 4-hydroxyphenyl group Chemical group [H]OC1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 10
• 229910052731 fluorine Chemical group 0.000 claims description 10
• 125000001153 fluoro group Chemical group F* 0.000 claims description 9
• 229910019142 PO4 Inorganic materials 0.000 claims description 8
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 8
• 239000010452 phosphate Substances 0.000 claims description 8
• 125000000217 alkyl group Chemical group 0.000 claims description 7
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 7
• 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 6
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• 238000004519 manufacturing process Methods 0.000 description 352
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• 125000003088 (fluoren-9-ylmethoxy)carbonyl group Chemical group 0.000 description 12
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