ES2710857T3 - Uso de polianiones para inhibir la actividad citotóxica de las histonas en el tratamiento de la sepsis - Google Patents

Info

Publication number

ES2710857T3

ES2710857T3 ES11845528T ES11845528T ES2710857T3 ES 2710857 T3 ES2710857 T3 ES 2710857T3 ES 11845528 T ES11845528 T ES 11845528T ES 11845528 T ES11845528 T ES 11845528T ES 2710857 T3 ES2710857 T3 ES 2710857T3

Authority

ES

Spain

Prior art keywords

polyanion

monosaccharide

histone

group

sulfate

Prior art date

2010-12-01

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

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• 108010033040 Histones Proteins 0.000 title claims abstract description 238
• 229920000447 polyanionic polymer Polymers 0.000 title claims abstract description 128
• 102000006947 Histones Human genes 0.000 title claims abstract description 99
• 206010040047 Sepsis Diseases 0.000 title claims abstract description 73
• 230000001472 cytotoxic effect Effects 0.000 title claims abstract description 13
• 238000011282 treatment Methods 0.000 title description 33
• -1 cyclic monosaccharide Chemical class 0.000 claims abstract description 112
• 238000000034 method Methods 0.000 claims abstract description 76
• 229920001542 oligosaccharide Polymers 0.000 claims abstract description 44
• 150000002482 oligosaccharides Chemical class 0.000 claims abstract description 42
• 150000002772 monosaccharides Chemical class 0.000 claims abstract description 41
• 230000015271 coagulation Effects 0.000 claims abstract description 17
• 238000005345 coagulation Methods 0.000 claims abstract description 17
• 230000002401 inhibitory effect Effects 0.000 claims abstract description 16
• 150000005846 sugar alcohols Chemical class 0.000 claims abstract description 16
• 230000014508 negative regulation of coagulation Effects 0.000 claims abstract description 13
• 230000036961 partial effect Effects 0.000 claims abstract description 13
• 125000004122 cyclic group Chemical group 0.000 claims abstract description 12
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