ES2709509T3 - Procedimientos para el tratamiento de cáncer amplificado por HER2 - Google Patents
Procedimientos para el tratamiento de cáncer amplificado por HER2 Download PDFInfo
- Publication number
- ES2709509T3 ES2709509T3 ES14835935T ES14835935T ES2709509T3 ES 2709509 T3 ES2709509 T3 ES 2709509T3 ES 14835935 T ES14835935 T ES 14835935T ES 14835935 T ES14835935 T ES 14835935T ES 2709509 T3 ES2709509 T3 ES 2709509T3
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- Prior art keywords
- her2
- ibrutinib
- therapeutic agent
- cancer
- amplified
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| MX380504B (es) | 2010-06-03 | 2025-03-12 | Pharmacyclics Llc | El uso de inhibidores de la tirosina quinasa de bruton (btk). |
| KR20140048968A (ko) | 2011-07-13 | 2014-04-24 | 파마시클릭스, 인코포레이티드 | 브루톤형 티로신 키나제의 억제제 |
| MA37711A1 (fr) | 2012-06-04 | 2017-05-31 | Pharmacyclics Inc | Formes cristallines d'un inhibiteur de tyrosine kinase de bruton |
| HK1206073A1 (en) | 2012-07-24 | 2015-12-31 | 药品循环有限责任公司 | Mutations associated with resistance to inhibitors of bruton's tyrosine kinase (btk) |
| CA2920534A1 (en) * | 2013-08-12 | 2015-02-19 | Pharmacyclics Llc | Methods for the treatment of her2 amplified cancer |
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| WO2015127234A1 (en) * | 2014-02-20 | 2015-08-27 | Board Of Regents, The University Of Texas System | Use of ibrutinib to treat egfr mutant cancer |
| US9885086B2 (en) | 2014-03-20 | 2018-02-06 | Pharmacyclics Llc | Phospholipase C gamma 2 and resistance associated mutations |
| AR102871A1 (es) | 2014-12-03 | 2017-03-29 | Pharmacyclics Llc | Métodos de tratamiento de fibrosis |
| IL315294A (en) | 2015-03-03 | 2024-10-01 | Pharmacyclics Llc | Pharmaceutical formulations of proton tyrosine kinase inhibitor |
| US10045990B2 (en) | 2015-03-04 | 2018-08-14 | Arizona Board Of Regents On Behalf Of Arizona State University | ERBB4 inhibitors and methods of use thereof |
| WO2016161347A1 (en) * | 2015-04-03 | 2016-10-06 | Pharmacyclics Llc | Combinations for generating tumor-specific immunological memory |
| EP3892302B8 (en) | 2015-04-06 | 2023-10-18 | Janssen Pharmaceutica NV | Compositions containing ibrutinib |
| JP6871919B2 (ja) | 2015-06-16 | 2021-05-19 | ナノファギックス エルエルシー | 薬物送達及びイメージング化学コンジュゲート、製剤及びその使用方法 |
| JP2018522028A (ja) * | 2015-07-31 | 2018-08-09 | ファーマサイクリックス エルエルシー | ブルトン型チロシンキナーゼ阻害剤の組み合わせ及びそれらの使用 |
| KR102075886B1 (ko) * | 2015-09-01 | 2020-02-11 | 다이호야쿠힌고교 가부시키가이샤 | 신규한 피라졸로[3,4-d]피리미딘 화합물 또는 그 염 |
| US10668068B2 (en) * | 2015-10-07 | 2020-06-02 | The Research Foundation For The State University Of New York | Treating cancer with drug combinations |
| CN107349426B (zh) * | 2017-07-12 | 2018-03-23 | 马骥 | 阿司匹林与曲妥珠单抗联合或协同在肿瘤治疗中的应用 |
| CZ2017787A3 (cs) | 2017-12-08 | 2019-06-19 | Zentiva, K.S. | Farmaceutické kompozice obsahující ibrutinib |
| TWI798334B (zh) | 2018-01-31 | 2023-04-11 | 大陸商迪哲（江蘇）醫藥股份有限公司 | Ｅｒｂｂ／ｂｔｋ抑制劑 |
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-
2014
- 2014-08-12 CA CA2920534A patent/CA2920534A1/en not_active Abandoned
- 2014-08-12 EP EP14835935.9A patent/EP3033079B1/en not_active Revoked
- 2014-08-12 JP JP2016534804A patent/JP6429292B2/ja not_active Expired - Fee Related
- 2014-08-12 US US14/458,157 patent/US9415050B2/en active Active
- 2014-08-12 WO PCT/US2014/050783 patent/WO2015023703A1/en not_active Ceased
- 2014-08-12 ES ES14835935T patent/ES2709509T3/es active Active
-
2016
- 2016-06-30 US US15/198,694 patent/US9724349B2/en active Active
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2017
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2018
- 2018-07-06 US US16/029,131 patent/US20190167687A1/en not_active Abandoned
- 2018-10-25 JP JP2018201232A patent/JP2019031546A/ja not_active Ceased
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2020
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- 2020-09-17 JP JP2020156557A patent/JP2021008475A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CA2920534A1 (en) | 2015-02-19 |
| JP6429292B2 (ja) | 2018-11-28 |
| JP2016528251A (ja) | 2016-09-15 |
| WO2015023703A1 (en) | 2015-02-19 |
| US9415050B2 (en) | 2016-08-16 |
| EP3033079B1 (en) | 2018-10-31 |
| US9724349B2 (en) | 2017-08-08 |
| US20180071294A1 (en) | 2018-03-15 |
| US20150044217A1 (en) | 2015-02-12 |
| EP3033079A4 (en) | 2017-04-05 |
| JP2019031546A (ja) | 2019-02-28 |
| US20170151243A1 (en) | 2017-06-01 |
| US10016434B2 (en) | 2018-07-10 |
| EP3033079A1 (en) | 2016-06-22 |
| JP2021008475A (ja) | 2021-01-28 |
| US20190167687A1 (en) | 2019-06-06 |
| US20210145835A1 (en) | 2021-05-20 |
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