ES2708571T3 - Derivados de aminoácidos sustituidos con N-urea como moduladores del receptor de péptido formilado - Google Patents
Derivados de aminoácidos sustituidos con N-urea como moduladores del receptor de péptido formilado Download PDFInfo
- Publication number
- ES2708571T3 ES2708571T3 ES14744725T ES14744725T ES2708571T3 ES 2708571 T3 ES2708571 T3 ES 2708571T3 ES 14744725 T ES14744725 T ES 14744725T ES 14744725 T ES14744725 T ES 14744725T ES 2708571 T3 ES2708571 T3 ES 2708571T3
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- alkyl
- amino
- carbamoyl
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
- C07K5/06043—Leu-amino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/30—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by halogen atoms, or by nitro or nitroso groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Ophthalmology & Optometry (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361846787P | 2013-07-16 | 2013-07-16 | |
| PCT/US2014/046203 WO2015009545A1 (en) | 2013-07-16 | 2014-07-10 | Derivatives of n-urea substituted amino acids as formyl peptide receptor modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2708571T3 true ES2708571T3 (es) | 2019-04-10 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES14744725T Active ES2708571T3 (es) | 2013-07-16 | 2014-07-10 | Derivados de aminoácidos sustituidos con N-urea como moduladores del receptor de péptido formilado |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US9428549B2 (enExample) |
| EP (1) | EP3022174B1 (enExample) |
| JP (1) | JP6653253B2 (enExample) |
| KR (1) | KR102313757B1 (enExample) |
| CN (1) | CN105377814B (enExample) |
| AU (1) | AU2014290618B2 (enExample) |
| CA (1) | CA2917811C (enExample) |
| DK (1) | DK3022174T3 (enExample) |
| ES (1) | ES2708571T3 (enExample) |
| RU (1) | RU2696581C2 (enExample) |
| WO (1) | WO2015009545A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3078656B1 (en) | 2011-10-26 | 2020-07-01 | Allergan, Inc. | Amide derivatives of n-urea substituted amino acids as formyl peptide receptor like-1 (fprl-1) receptor modulators |
| CA3114347A1 (en) | 2013-03-06 | 2014-09-12 | Allergan, Inc. | Use of agonists of formyl peptide receptor 2 for treating dermatological diseases |
| BR112016011417A8 (pt) | 2013-11-21 | 2020-05-05 | Allergan Inc | derivados de fenilcarbamatos como moduladores do receptor de formil peptídeo, composição farmacêutica, e seus usos |
| JP6453231B2 (ja) | 2013-11-28 | 2019-01-16 | 杏林製薬株式会社 | ウレア誘導体、またはその薬理学的に許容される塩 |
| US9663457B2 (en) | 2014-04-09 | 2017-05-30 | Allergan, Inc. | Carbamoyl hydrazine derivatives as formyl peptide modulators |
| WO2015179707A1 (en) | 2014-05-21 | 2015-11-26 | Allergan, Inc. | Imidazole derivatives as formyl peptide receptor modulators |
| MX2017015040A (es) | 2015-05-27 | 2018-08-14 | Kyorin Seiyaku Kk | Derivado de urea o sal farmacologicamente aceptable del mismo. |
| ES2791340T3 (es) | 2015-05-27 | 2020-11-03 | Kyorin Seiyaku Kk | Derivado de urea o sal farmacológicamente aceptable del mismo |
| EP3331897B1 (en) * | 2015-08-05 | 2021-03-24 | Allergan, Inc. | Phenyl urea analogs as formyl peptide receptor 1 (fpr1) selective agonists |
| DK3762380T3 (da) | 2018-03-05 | 2022-01-17 | Bristol Myers Squibb Co | Phenylpyrrolidinon-formylpeptid-2-receptoragonister |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2533210A1 (fr) | 1982-09-17 | 1984-03-23 | Lyon I Universite Claude | Edulcorants de synthese |
| US5284828A (en) | 1990-05-14 | 1994-02-08 | Fujisawa Pharmaceutical Co. Ltd. | Peptide compound and its preparation |
| JP3387948B2 (ja) | 1992-12-04 | 2003-03-17 | 富山化学工業株式会社 | 新規なフェニルアラニン誘導体またはその塩 |
| US20030009022A1 (en) * | 1993-03-31 | 2003-01-09 | Cadus Pharmaceutical Corporation | Methods and compositions for identifying receptor effectors |
| AU691565B2 (en) * | 1994-02-09 | 1998-05-21 | Shionogi & Co., Ltd. | Carbamoylmethylurea derivative |
| JP2968842B2 (ja) * | 1994-02-09 | 1999-11-02 | 塩野義製薬株式会社 | カルバモイルメチルウレア誘導体 |
| US6423689B1 (en) * | 1997-12-22 | 2002-07-23 | Warner-Lambert Company | Peptidyl calcium channel blockers |
| AU4572999A (en) * | 1998-06-18 | 2000-01-05 | Sepracor, Inc. | Tetrapeptides, analogs and peptidomimetics which bind selectively mammalian opioid receptors |
| AU2003214249A1 (en) * | 2002-04-03 | 2003-10-13 | Bayer Aktiengesellschaft | Diagnostics and therapeutics for diseases associated with n-formyl peptide receptor like 1 (fprl1) |
| BRPI0416272A (pt) * | 2003-11-07 | 2007-01-09 | Acadia Pharm Inc | usos do receptor fprl1, e de compostos, uso profilático de compostos, métodos de triagem para um composto capaz de afetar uma ou mais atividades de um receptor fprl1, de tratamento ou prevenção de inflamação, de identificação de um composto de indução de vasodilatação, para antagonismo de uma resposta vasoconstrutiva a um sulfidopeptìdeo leucotrieno em um indivìduo, e para estimulação de proliferação celular em um indivìduo, e, composto |
| HRP20130972T1 (hr) * | 2009-05-18 | 2013-11-22 | Actelion Pharmaceuticals Ltd. | Premošteni derivati spiro [2,4] heptana kao alx-receptori i/ili fprl2-agonisti |
| AU2011336973A1 (en) * | 2010-12-03 | 2013-07-11 | Allergan, Inc. | Pharmaceutical compositions comprising 3,4- dihydroisoquinolin-2(1 H)-yl-3-phenylurea derivatives having formyl peptide receptor like-1 (FPRL-1) agonist or antagonist activity |
| EP3078656B1 (en) * | 2011-10-26 | 2020-07-01 | Allergan, Inc. | Amide derivatives of n-urea substituted amino acids as formyl peptide receptor like-1 (fprl-1) receptor modulators |
| US8541577B2 (en) * | 2011-11-10 | 2013-09-24 | Allergan, Inc. | Aryl urea derivatives as N-formyl peptide receptors like-1 (FPRL-1) receptor modulators |
| US8735622B2 (en) * | 2011-11-30 | 2014-05-27 | The Regents Of The University Of Colorado, A Body Corporate | Histone demethylase inhibitors and methods for using the same |
| CA3114347A1 (en) * | 2013-03-06 | 2014-09-12 | Allergan, Inc. | Use of agonists of formyl peptide receptor 2 for treating dermatological diseases |
| ES3036990T3 (en) * | 2013-03-06 | 2025-09-26 | Allergan Inc | Use of agonists of formyl peptide receptor 2 for treating ocular inflammatory diseases |
-
2014
- 2014-07-10 AU AU2014290618A patent/AU2014290618B2/en not_active Ceased
- 2014-07-10 EP EP14744725.4A patent/EP3022174B1/en active Active
- 2014-07-10 WO PCT/US2014/046203 patent/WO2015009545A1/en not_active Ceased
- 2014-07-10 DK DK14744725.4T patent/DK3022174T3/da active
- 2014-07-10 ES ES14744725T patent/ES2708571T3/es active Active
- 2014-07-10 RU RU2016104844A patent/RU2696581C2/ru active
- 2014-07-10 JP JP2016526992A patent/JP6653253B2/ja not_active Expired - Fee Related
- 2014-07-10 US US14/328,540 patent/US9428549B2/en active Active
- 2014-07-10 CA CA2917811A patent/CA2917811C/en active Active
- 2014-07-10 CN CN201480040132.5A patent/CN105377814B/zh not_active Expired - Fee Related
- 2014-07-10 KR KR1020167003770A patent/KR102313757B1/ko not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2917811C (en) | 2021-08-31 |
| AU2014290618B2 (en) | 2018-04-05 |
| JP2016529235A (ja) | 2016-09-23 |
| WO2015009545A1 (en) | 2015-01-22 |
| DK3022174T3 (da) | 2019-01-02 |
| RU2696581C2 (ru) | 2019-08-05 |
| EP3022174A1 (en) | 2016-05-25 |
| EP3022174B1 (en) | 2018-09-05 |
| US20150025021A1 (en) | 2015-01-22 |
| CA2917811A1 (en) | 2015-01-22 |
| JP6653253B2 (ja) | 2020-02-26 |
| CN105377814B (zh) | 2018-04-03 |
| AU2014290618A1 (en) | 2016-02-18 |
| KR20160031007A (ko) | 2016-03-21 |
| KR102313757B1 (ko) | 2021-10-18 |
| US9428549B2 (en) | 2016-08-30 |
| RU2016104844A (ru) | 2017-08-21 |
| CN105377814A (zh) | 2016-03-02 |
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