DK3022174T3 - Derivater af n-urinstof-substituerede aminosyrer som formylpeptidreceptormodulatorer - Google Patents
Derivater af n-urinstof-substituerede aminosyrer som formylpeptidreceptormodulatorer Download PDFInfo
- Publication number
- DK3022174T3 DK3022174T3 DK14744725.4T DK14744725T DK3022174T3 DK 3022174 T3 DK3022174 T3 DK 3022174T3 DK 14744725 T DK14744725 T DK 14744725T DK 3022174 T3 DK3022174 T3 DK 3022174T3
- Authority
- DK
- Denmark
- Prior art keywords
- urine
- derivatives
- amino acids
- substituted amino
- receptor modulators
- Prior art date
Links
- 102000011652 Formyl peptide receptors Human genes 0.000 title 1
- 108010076288 Formyl peptide receptors Proteins 0.000 title 1
- 150000001413 amino acids Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
- C07K5/06043—Leu-amino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/30—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by halogen atoms, or by nitro or nitroso groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Ophthalmology & Optometry (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361846787P | 2013-07-16 | 2013-07-16 | |
| PCT/US2014/046203 WO2015009545A1 (en) | 2013-07-16 | 2014-07-10 | Derivatives of n-urea substituted amino acids as formyl peptide receptor modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3022174T3 true DK3022174T3 (da) | 2019-01-02 |
Family
ID=51230227
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK14744725.4T DK3022174T3 (da) | 2013-07-16 | 2014-07-10 | Derivater af n-urinstof-substituerede aminosyrer som formylpeptidreceptormodulatorer |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US9428549B2 (enExample) |
| EP (1) | EP3022174B1 (enExample) |
| JP (1) | JP6653253B2 (enExample) |
| KR (1) | KR102313757B1 (enExample) |
| CN (1) | CN105377814B (enExample) |
| AU (1) | AU2014290618B2 (enExample) |
| CA (1) | CA2917811C (enExample) |
| DK (1) | DK3022174T3 (enExample) |
| ES (1) | ES2708571T3 (enExample) |
| RU (1) | RU2696581C2 (enExample) |
| WO (1) | WO2015009545A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2012329098B2 (en) | 2011-10-26 | 2017-08-03 | Allergan, Inc. | Amide derivatives of N-urea substituted amino acids as formyl peptide receptor like-1 (FPRL-1) receptor modulators |
| JP6196328B2 (ja) | 2013-03-06 | 2017-09-13 | アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ | 皮膚疾患を治療するためのホルミルペプチド受容体２アゴニストの使用 |
| JP6496728B2 (ja) | 2013-11-21 | 2019-04-03 | アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ | ホルミルペプチド受容体の調節因子としてのカルバミン酸フェニル誘導体 |
| WO2015079692A1 (ja) | 2013-11-28 | 2015-06-04 | 杏林製薬株式会社 | ウレア誘導体、またはその薬理学的に許容される塩 |
| US9663457B2 (en) | 2014-04-09 | 2017-05-30 | Allergan, Inc. | Carbamoyl hydrazine derivatives as formyl peptide modulators |
| ES2788700T3 (es) | 2014-05-21 | 2020-10-22 | Allergan Inc | Derivados de imidazol como moduladores del receptor de péptido formilado |
| EP3303284B1 (en) | 2015-05-27 | 2020-04-08 | Kyorin Pharmaceutical Co., Ltd. | Urea derivative or pharmacologically acceptable salt thereof |
| US10525058B2 (en) | 2015-05-27 | 2020-01-07 | Kyorin Pharmaceutical Co., Ltd | Urea derivative or pharmacologically acceptable salt thereof |
| WO2017023907A1 (en) * | 2015-08-05 | 2017-02-09 | Allergan, Inc. | Phenyl urea analogs as formyl peptide repceptor 1 (fpr1) selective agonists |
| SG11202008504SA (en) | 2018-03-05 | 2020-10-29 | Bristol Myers Squibb Co | Phenylpyrrolidinone formyl peptide 2 receptor agonists |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2533210A1 (fr) | 1982-09-17 | 1984-03-23 | Lyon I Universite Claude | Edulcorants de synthese |
| US5284828A (en) * | 1990-05-14 | 1994-02-08 | Fujisawa Pharmaceutical Co. Ltd. | Peptide compound and its preparation |
| JP3387948B2 (ja) * | 1992-12-04 | 2003-03-17 | 富山化学工業株式会社 | 新規なフェニルアラニン誘導体またはその塩 |
| US20030009022A1 (en) * | 1993-03-31 | 2003-01-09 | Cadus Pharmaceutical Corporation | Methods and compositions for identifying receptor effectors |
| JP2968842B2 (ja) * | 1994-02-09 | 1999-11-02 | 塩野義製薬株式会社 | カルバモイルメチルウレア誘導体 |
| PT739903E (pt) * | 1994-02-09 | 2002-05-31 | Shionogi & Co | Derivado carbamoilmetilureia |
| US6423689B1 (en) * | 1997-12-22 | 2002-07-23 | Warner-Lambert Company | Peptidyl calcium channel blockers |
| US6548637B1 (en) * | 1998-06-18 | 2003-04-15 | Sepracor, Inc. | Ligands for opioid receptors |
| WO2003082314A2 (en) * | 2002-04-03 | 2003-10-09 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with n-formyl peptide receptor like 1 (fprl1) |
| KR20060130064A (ko) * | 2003-11-07 | 2006-12-18 | 아카디아 파마슈티칼스 인코포레이티드 | 통증 및 염증 치료에 효과적인 화합물을 동정하기 위한도구로서의 리폭신 수용체, ｆｐｒｌ1의 용도 |
| CN102414168B (zh) * | 2009-05-18 | 2014-05-21 | 埃科特莱茵药品有限公司 | 用作为alx受体和/或fprl2激动剂的桥联螺[2.4]庚烷衍生物 |
| AU2011336973A1 (en) * | 2010-12-03 | 2013-07-11 | Allergan, Inc. | Pharmaceutical compositions comprising 3,4- dihydroisoquinolin-2(1 H)-yl-3-phenylurea derivatives having formyl peptide receptor like-1 (FPRL-1) agonist or antagonist activity |
| AU2012329098B2 (en) * | 2011-10-26 | 2017-08-03 | Allergan, Inc. | Amide derivatives of N-urea substituted amino acids as formyl peptide receptor like-1 (FPRL-1) receptor modulators |
| US8541577B2 (en) * | 2011-11-10 | 2013-09-24 | Allergan, Inc. | Aryl urea derivatives as N-formyl peptide receptors like-1 (FPRL-1) receptor modulators |
| US8735622B2 (en) * | 2011-11-30 | 2014-05-27 | The Regents Of The University Of Colorado, A Body Corporate | Histone demethylase inhibitors and methods for using the same |
| CN110279684B (zh) * | 2013-03-06 | 2023-02-28 | 阿勒根公司 | 用于治疗眼部炎性疾病的甲酰基肽受体2激动剂的用途 |
| JP6196328B2 (ja) * | 2013-03-06 | 2017-09-13 | アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ | 皮膚疾患を治療するためのホルミルペプチド受容体２アゴニストの使用 |
-
2014
- 2014-07-10 US US14/328,540 patent/US9428549B2/en active Active
- 2014-07-10 KR KR1020167003770A patent/KR102313757B1/ko not_active Expired - Fee Related
- 2014-07-10 CN CN201480040132.5A patent/CN105377814B/zh not_active Expired - Fee Related
- 2014-07-10 ES ES14744725T patent/ES2708571T3/es active Active
- 2014-07-10 EP EP14744725.4A patent/EP3022174B1/en active Active
- 2014-07-10 AU AU2014290618A patent/AU2014290618B2/en not_active Ceased
- 2014-07-10 JP JP2016526992A patent/JP6653253B2/ja not_active Expired - Fee Related
- 2014-07-10 RU RU2016104844A patent/RU2696581C2/ru active
- 2014-07-10 DK DK14744725.4T patent/DK3022174T3/da active
- 2014-07-10 WO PCT/US2014/046203 patent/WO2015009545A1/en not_active Ceased
- 2014-07-10 CA CA2917811A patent/CA2917811C/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| AU2014290618A1 (en) | 2016-02-18 |
| CN105377814A (zh) | 2016-03-02 |
| RU2696581C2 (ru) | 2019-08-05 |
| JP6653253B2 (ja) | 2020-02-26 |
| CN105377814B (zh) | 2018-04-03 |
| WO2015009545A1 (en) | 2015-01-22 |
| JP2016529235A (ja) | 2016-09-23 |
| US9428549B2 (en) | 2016-08-30 |
| CA2917811C (en) | 2021-08-31 |
| EP3022174B1 (en) | 2018-09-05 |
| KR102313757B1 (ko) | 2021-10-18 |
| KR20160031007A (ko) | 2016-03-21 |
| RU2016104844A (ru) | 2017-08-21 |
| AU2014290618B2 (en) | 2018-04-05 |
| ES2708571T3 (es) | 2019-04-10 |
| US20150025021A1 (en) | 2015-01-22 |
| EP3022174A1 (en) | 2016-05-25 |
| CA2917811A1 (en) | 2015-01-22 |
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