CN105377814B - 作为甲酰基肽受体调节剂的n‑脲取代的氨基酸的衍生物 - Google Patents

作为甲酰基肽受体调节剂的n‑脲取代的氨基酸的衍生物 Download PDF

Info

Publication number
CN105377814B
CN105377814B CN201480040132.5A CN201480040132A CN105377814B CN 105377814 B CN105377814 B CN 105377814B CN 201480040132 A CN201480040132 A CN 201480040132A CN 105377814 B CN105377814 B CN 105377814B
Authority
CN
China
Prior art keywords
amino
alkyl
group
optionally substituted
carbamoyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201480040132.5A
Other languages
English (en)
Chinese (zh)
Other versions
CN105377814A (zh
Inventor
R·L·比尔德
T·T·杜昂
J·E·多纳罗
V·维斯瓦纳斯
M·E·贾斯特
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Allergan Inc
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allergan Inc filed Critical Allergan Inc
Publication of CN105377814A publication Critical patent/CN105377814A/zh
Application granted granted Critical
Publication of CN105377814B publication Critical patent/CN105377814B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06043—Leu-amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/30—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by halogen atoms, or by nitro or nitroso groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201480040132.5A 2013-07-16 2014-07-10 作为甲酰基肽受体调节剂的n‑脲取代的氨基酸的衍生物 Expired - Fee Related CN105377814B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361846787P 2013-07-16 2013-07-16
US61/846,787 2013-07-16
PCT/US2014/046203 WO2015009545A1 (en) 2013-07-16 2014-07-10 Derivatives of n-urea substituted amino acids as formyl peptide receptor modulators

Publications (2)

Publication Number Publication Date
CN105377814A CN105377814A (zh) 2016-03-02
CN105377814B true CN105377814B (zh) 2018-04-03

Family

ID=51230227

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201480040132.5A Expired - Fee Related CN105377814B (zh) 2013-07-16 2014-07-10 作为甲酰基肽受体调节剂的n‑脲取代的氨基酸的衍生物

Country Status (11)

Country Link
US (1) US9428549B2 (enExample)
EP (1) EP3022174B1 (enExample)
JP (1) JP6653253B2 (enExample)
KR (1) KR102313757B1 (enExample)
CN (1) CN105377814B (enExample)
AU (1) AU2014290618B2 (enExample)
CA (1) CA2917811C (enExample)
DK (1) DK3022174T3 (enExample)
ES (1) ES2708571T3 (enExample)
RU (1) RU2696581C2 (enExample)
WO (1) WO2015009545A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106518742B (zh) 2011-10-26 2020-01-21 阿勒根公司 作为甲酰肽受体样-1(fprl-1)受体调节剂的n-脲取代的氨基酸的酰胺衍生物
BR112015021392B1 (pt) 2013-03-06 2021-11-16 Allergan, Inc Uso de agonistas do receptor de peptídeo formil 2 para tratar doenças dermatológicas
WO2015077451A1 (en) 2013-11-21 2015-05-28 Allergan, Inc. Phenylcarbamate derivatives as formyl peptide receptor modulators
BR112016011755B1 (pt) 2013-11-28 2023-05-02 Kyorin Pharmaceutical Co., Ltd Derivado de ureia ou sal farmacologicamente aceitável do mesmo, seu uso e composição farmacêutica que os compreende
US9663457B2 (en) 2014-04-09 2017-05-30 Allergan, Inc. Carbamoyl hydrazine derivatives as formyl peptide modulators
AU2015264021B2 (en) 2014-05-21 2020-02-27 Allergan, Inc. Imidazole derivatives as formyl peptide receptor modulators
WO2016189877A1 (en) 2015-05-27 2016-12-01 Kyorin Pharmaceutical Co., Ltd. Urea derivative or pharmacologically acceptable salt thereof
BR112017024966A2 (pt) 2015-05-27 2018-08-07 Kyorin Seiyaku Kk derivado de ureia ou sal farmacologicamente aceitável do mesmo
WO2017023907A1 (en) * 2015-08-05 2017-02-09 Allergan, Inc. Phenyl urea analogs as formyl peptide repceptor 1 (fpr1) selective agonists
KR102803660B1 (ko) 2018-03-05 2025-05-02 브리스톨-마이어스 스큅 컴퍼니 페닐피롤리디논 포르밀 펩티드 2 수용체 효능제

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0107597A1 (fr) * 1982-09-17 1984-05-02 Universite Claude Bernard - Lyon 1 Composés chimiques et utilisation comme édulcorants
CN1057269A (zh) * 1990-05-14 1991-12-25 藤泽药品工业株式会社 肽化合物及其制备
JPH06172288A (ja) * 1992-12-04 1994-06-21 Toyama Chem Co Ltd 新規なフェニルアラニン誘導体またはその塩
WO1999065932A1 (en) * 1998-06-18 1999-12-23 Sepracor, Inc. Tetrapeptides, analogs and peptidomimetics which bind selectively mammalian opioid receptors
US20130109866A1 (en) * 2011-10-26 2013-05-02 Allergan, Inc. Amide derivatives of n-urea substituted amino acids as formyl peptide receptor like-1 (fprl-1) receptor modulators
CN105007908A (zh) * 2013-03-06 2015-10-28 阿勒根公司 用于治疗皮肤病的甲酰基肽受体2的激动剂的用途
CN105007909A (zh) * 2013-03-06 2015-10-28 阿勒根公司 用于治疗眼部炎性疾病的甲酰基肽受体2激动剂的用途

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030009022A1 (en) * 1993-03-31 2003-01-09 Cadus Pharmaceutical Corporation Methods and compositions for identifying receptor effectors
JP2968842B2 (ja) * 1994-02-09 1999-11-02 塩野義製薬株式会社 カルバモイルメチルウレア誘導体
ATE212356T1 (de) * 1994-02-09 2002-02-15 Shionogi & Co Carbamoylmethylharnstoffderivate
US6423689B1 (en) * 1997-12-22 2002-07-23 Warner-Lambert Company Peptidyl calcium channel blockers
WO2003082314A2 (en) * 2002-04-03 2003-10-09 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with n-formyl peptide receptor like 1 (fprl1)
EP1692502A2 (en) * 2003-11-07 2006-08-23 Acadia Pharmaceuticals Inc. Use of the lipoxin receptor, fprl1, as a tool for identifying compounds effective in the treatment of pain and inflammation
HRP20130972T1 (hr) * 2009-05-18 2013-11-22 Actelion Pharmaceuticals Ltd. Premošteni derivati spiro [2,4] heptana kao alx-receptori i/ili fprl2-agonisti
AU2011336973A1 (en) * 2010-12-03 2013-07-11 Allergan, Inc. Pharmaceutical compositions comprising 3,4- dihydroisoquinolin-2(1 H)-yl-3-phenylurea derivatives having formyl peptide receptor like-1 (FPRL-1) agonist or antagonist activity
US8541577B2 (en) * 2011-11-10 2013-09-24 Allergan, Inc. Aryl urea derivatives as N-formyl peptide receptors like-1 (FPRL-1) receptor modulators
US8735622B2 (en) * 2011-11-30 2014-05-27 The Regents Of The University Of Colorado, A Body Corporate Histone demethylase inhibitors and methods for using the same

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0107597A1 (fr) * 1982-09-17 1984-05-02 Universite Claude Bernard - Lyon 1 Composés chimiques et utilisation comme édulcorants
CN1057269A (zh) * 1990-05-14 1991-12-25 藤泽药品工业株式会社 肽化合物及其制备
JPH06172288A (ja) * 1992-12-04 1994-06-21 Toyama Chem Co Ltd 新規なフェニルアラニン誘導体またはその塩
WO1999065932A1 (en) * 1998-06-18 1999-12-23 Sepracor, Inc. Tetrapeptides, analogs and peptidomimetics which bind selectively mammalian opioid receptors
US20130109866A1 (en) * 2011-10-26 2013-05-02 Allergan, Inc. Amide derivatives of n-urea substituted amino acids as formyl peptide receptor like-1 (fprl-1) receptor modulators
CN105007908A (zh) * 2013-03-06 2015-10-28 阿勒根公司 用于治疗皮肤病的甲酰基肽受体2的激动剂的用途
CN105007909A (zh) * 2013-03-06 2015-10-28 阿勒根公司 用于治疗眼部炎性疾病的甲酰基肽受体2激动剂的用途

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
二肽和三肽甜味剂的结构性能关系;曾广植;《应用化学》;19901231;第7卷(第1期);1-9 *

Also Published As

Publication number Publication date
RU2696581C2 (ru) 2019-08-05
ES2708571T3 (es) 2019-04-10
CA2917811C (en) 2021-08-31
EP3022174A1 (en) 2016-05-25
DK3022174T3 (da) 2019-01-02
KR20160031007A (ko) 2016-03-21
KR102313757B1 (ko) 2021-10-18
EP3022174B1 (en) 2018-09-05
US20150025021A1 (en) 2015-01-22
RU2016104844A (ru) 2017-08-21
CN105377814A (zh) 2016-03-02
JP6653253B2 (ja) 2020-02-26
WO2015009545A1 (en) 2015-01-22
AU2014290618A1 (en) 2016-02-18
US9428549B2 (en) 2016-08-30
AU2014290618B2 (en) 2018-04-05
CA2917811A1 (en) 2015-01-22
JP2016529235A (ja) 2016-09-23

Similar Documents

Publication Publication Date Title
CN105377814B (zh) 作为甲酰基肽受体调节剂的n‑脲取代的氨基酸的衍生物
CN104114164B (zh) 作为甲酰肽受体样-1(fprl-1)受体调节剂的n-脲取代的氨基酸的酰胺衍生物
CN104169254A (zh) 作为n-甲酰肽样受体-1(fprl-1)受体的调节剂的芳基脲衍生物
CN104302630A (zh) 作为甲酰肽受体2调节剂的(2-脲基乙酰氨基)烷基衍生物
WO2015042071A1 (en) Diphenyl urea derivatives as formyl peptide receptor modulators
CN105705484A (zh) 作为甲酰肽受体调节剂的苯基氨基甲酸酯衍生物
US9868700B2 (en) Carbamoyl hydrazine derivatives as formyl peptide modulators
HK1225012B (en) Derivatives of n-urea substituted amino acids as formyl peptide receptor modulators
HK1225012A1 (en) Derivatives of n-urea substituted amino acids as formyl peptide receptor modulators
HK1228885A (en) Amide derivatives of n-urea substituted amino acids as formyl peptide receptor like-1 (fprl-1) receptor modulators
HK1228885A1 (en) Amide derivatives of n-urea substituted amino acids as formyl peptide receptor like-1 (fprl-1) receptor modulators
HK1199622B (en) Amide derivatives of n-urea substituted amino acids as formyl peptide receptor like-1 (fprl-1) receptor modulators

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20180403