ES2708571T3 - Derivados de aminoácidos sustituidos con N-urea como moduladores del receptor de péptido formilado - Google Patents
Derivados de aminoácidos sustituidos con N-urea como moduladores del receptor de péptido formilado Download PDFInfo
- Publication number
- ES2708571T3 ES2708571T3 ES14744725T ES14744725T ES2708571T3 ES 2708571 T3 ES2708571 T3 ES 2708571T3 ES 14744725 T ES14744725 T ES 14744725T ES 14744725 T ES14744725 T ES 14744725T ES 2708571 T3 ES2708571 T3 ES 2708571T3
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- alkyl
- amino
- carbamoyl
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
- C07K5/06043—Leu-amino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/30—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by halogen atoms, or by nitro or nitroso groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Pain & Pain Management (AREA)
- Ophthalmology & Optometry (AREA)
- Rheumatology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361846787P | 2013-07-16 | 2013-07-16 | |
| PCT/US2014/046203 WO2015009545A1 (en) | 2013-07-16 | 2014-07-10 | Derivatives of n-urea substituted amino acids as formyl peptide receptor modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2708571T3 true ES2708571T3 (es) | 2019-04-10 |
Family
ID=51230227
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES14744725T Active ES2708571T3 (es) | 2013-07-16 | 2014-07-10 | Derivados de aminoácidos sustituidos con N-urea como moduladores del receptor de péptido formilado |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US9428549B2 (OSRAM) |
| EP (1) | EP3022174B1 (OSRAM) |
| JP (1) | JP6653253B2 (OSRAM) |
| KR (1) | KR102313757B1 (OSRAM) |
| CN (1) | CN105377814B (OSRAM) |
| AU (1) | AU2014290618B2 (OSRAM) |
| CA (1) | CA2917811C (OSRAM) |
| DK (1) | DK3022174T3 (OSRAM) |
| ES (1) | ES2708571T3 (OSRAM) |
| RU (1) | RU2696581C2 (OSRAM) |
| WO (1) | WO2015009545A1 (OSRAM) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX376348B (es) | 2011-10-26 | 2025-03-07 | Allergan Inc | Derivados de amida de aminoacidos sustituidos con n-urea como moduladores de receptor de tipo peptido receptor de formilo-1 (fprl-1). |
| KR20210024691A (ko) * | 2013-03-06 | 2021-03-05 | 알러간, 인코포레이티드 | 피부 질환 치료용 포르밀 펩티드 수용체 2의 항진제의 용도 |
| RU2703725C1 (ru) | 2013-11-21 | 2019-10-22 | Аллерган, Инк. | Производные фенилкарбамата в качестве модуляторов формилпептидного рецептора |
| PE20161206A1 (es) | 2013-11-28 | 2016-11-05 | Kyorin Seiyaku Kk | Derivado de urea o sal farmacologicamente aceptable del mismo |
| US9663457B2 (en) | 2014-04-09 | 2017-05-30 | Allergan, Inc. | Carbamoyl hydrazine derivatives as formyl peptide modulators |
| EP3145916B1 (en) | 2014-05-21 | 2020-02-12 | Allergan, Inc. | Imidazole derivatives as formyl peptide receptor modulators |
| EA201792382A1 (ru) | 2015-05-27 | 2018-04-30 | Киорин Фармасютикал Ко., Лтд. | Производное мочевины или его фармакологически приемлемая соль |
| US10858314B2 (en) | 2015-05-27 | 2020-12-08 | Kyorin Pharmaceutical Co., Ltd. | Urea derivative or pharmacologically acceptable salt thereof |
| WO2017023907A1 (en) * | 2015-08-05 | 2017-02-09 | Allergan, Inc. | Phenyl urea analogs as formyl peptide repceptor 1 (fpr1) selective agonists |
| MY204384A (en) | 2018-03-05 | 2024-08-27 | Bristol Myers Squibb Co | Phenylpyrrolidinone formyl peptide 2 receptor agonists |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2533210A1 (fr) | 1982-09-17 | 1984-03-23 | Lyon I Universite Claude | Edulcorants de synthese |
| US5284828A (en) * | 1990-05-14 | 1994-02-08 | Fujisawa Pharmaceutical Co. Ltd. | Peptide compound and its preparation |
| JP3387948B2 (ja) * | 1992-12-04 | 2003-03-17 | 富山化学工業株式会社 | 新規なフェニルアラニン誘導体またはその塩 |
| US20030009022A1 (en) * | 1993-03-31 | 2003-01-09 | Cadus Pharmaceutical Corporation | Methods and compositions for identifying receptor effectors |
| PT739903E (pt) * | 1994-02-09 | 2002-05-31 | Shionogi & Co | Derivado carbamoilmetilureia |
| JP2968842B2 (ja) * | 1994-02-09 | 1999-11-02 | 塩野義製薬株式会社 | カルバモイルメチルウレア誘導体 |
| US6423689B1 (en) * | 1997-12-22 | 2002-07-23 | Warner-Lambert Company | Peptidyl calcium channel blockers |
| US6548637B1 (en) * | 1998-06-18 | 2003-04-15 | Sepracor, Inc. | Ligands for opioid receptors |
| EP1492552A2 (en) * | 2002-04-03 | 2005-01-05 | Bayer Aktiengesellschaft | Diagnostics and therapeutics for diseases associated with n-formyl peptide receptor like 1 (fprl1) |
| JP2007516434A (ja) * | 2003-11-07 | 2007-06-21 | アカディア ファーマシューティカルズ インコーポレイティド | リポキシン受容体ｆｐｒｌ１の、疼痛および炎症の治療に有効な化合物を識別する手段としての使用 |
| PT2432760E (pt) * | 2009-05-18 | 2013-10-21 | Actelion Pharmaceuticals Ltd | Derivados de espiro [2,4] heptano ligados em ponte como agonistas do receptor fprl2 e/ou receptor alx |
| CA2819457A1 (en) * | 2010-12-03 | 2012-06-07 | Allergan, Inc. | Pharmaceutical compositions comprising 3,4-dihydroisoquinolin-2(1h)-yl-3-phenylurea derivatives having formyl peptide receptor like-1 (fprl-1) agonist or antagonist activity |
| MX376348B (es) * | 2011-10-26 | 2025-03-07 | Allergan Inc | Derivados de amida de aminoacidos sustituidos con n-urea como moduladores de receptor de tipo peptido receptor de formilo-1 (fprl-1). |
| US8541577B2 (en) * | 2011-11-10 | 2013-09-24 | Allergan, Inc. | Aryl urea derivatives as N-formyl peptide receptors like-1 (FPRL-1) receptor modulators |
| US8735622B2 (en) * | 2011-11-30 | 2014-05-27 | The Regents Of The University Of Colorado, A Body Corporate | Histone demethylase inhibitors and methods for using the same |
| US9850264B2 (en) * | 2013-03-06 | 2017-12-26 | Allergan, Inc. | Use of agonists of formyl peptide receptor 2 for treating ocular inflammatory diseases |
| KR20210024691A (ko) * | 2013-03-06 | 2021-03-05 | 알러간, 인코포레이티드 | 피부 질환 치료용 포르밀 펩티드 수용체 2의 항진제의 용도 |
-
2014
- 2014-07-10 EP EP14744725.4A patent/EP3022174B1/en active Active
- 2014-07-10 RU RU2016104844A patent/RU2696581C2/ru active
- 2014-07-10 CN CN201480040132.5A patent/CN105377814B/zh not_active Expired - Fee Related
- 2014-07-10 CA CA2917811A patent/CA2917811C/en active Active
- 2014-07-10 AU AU2014290618A patent/AU2014290618B2/en not_active Ceased
- 2014-07-10 KR KR1020167003770A patent/KR102313757B1/ko not_active Expired - Fee Related
- 2014-07-10 JP JP2016526992A patent/JP6653253B2/ja not_active Expired - Fee Related
- 2014-07-10 WO PCT/US2014/046203 patent/WO2015009545A1/en not_active Ceased
- 2014-07-10 ES ES14744725T patent/ES2708571T3/es active Active
- 2014-07-10 US US14/328,540 patent/US9428549B2/en active Active
- 2014-07-10 DK DK14744725.4T patent/DK3022174T3/da active
Also Published As
| Publication number | Publication date |
|---|---|
| AU2014290618A1 (en) | 2016-02-18 |
| RU2016104844A (ru) | 2017-08-21 |
| CN105377814B (zh) | 2018-04-03 |
| WO2015009545A1 (en) | 2015-01-22 |
| CA2917811C (en) | 2021-08-31 |
| EP3022174A1 (en) | 2016-05-25 |
| US20150025021A1 (en) | 2015-01-22 |
| DK3022174T3 (da) | 2019-01-02 |
| KR102313757B1 (ko) | 2021-10-18 |
| EP3022174B1 (en) | 2018-09-05 |
| US9428549B2 (en) | 2016-08-30 |
| KR20160031007A (ko) | 2016-03-21 |
| JP6653253B2 (ja) | 2020-02-26 |
| JP2016529235A (ja) | 2016-09-23 |
| AU2014290618B2 (en) | 2018-04-05 |
| CA2917811A1 (en) | 2015-01-22 |
| CN105377814A (zh) | 2016-03-02 |
| RU2696581C2 (ru) | 2019-08-05 |
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