PE20161206A1 - Derivado de urea o sal farmacologicamente aceptable del mismo - Google Patents
Derivado de urea o sal farmacologicamente aceptable del mismoInfo
- Publication number
- PE20161206A1 PE20161206A1 PE2016000697A PE2016000697A PE20161206A1 PE 20161206 A1 PE20161206 A1 PE 20161206A1 PE 2016000697 A PE2016000697 A PE 2016000697A PE 2016000697 A PE2016000697 A PE 2016000697A PE 20161206 A1 PE20161206 A1 PE 20161206A1
- Authority
- PE
- Peru
- Prior art keywords
- urea
- hydrogen
- optionally substituted
- acceptable salt
- pharmacologically acceptable
- Prior art date
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- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
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- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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Abstract
La presente invencion se refiere a un compuesto de formula I o una sal de esta farmacologicamente aceptable donde Ar1 y Ar2 son grupos fenilo, heterociclo aromatico de 5 miembros cualquiera de ellos opcionalmente sustituido, entre otros; X es NR4, NOR4, oxigeno o azufre donde, cuando X es NR4 o NOR4 entonces R4 es hidrogeno, fenilo opcionalmente sustituido, entre otros; R1 es hidrogeno, hidroxi, entre otros; R2 y R3 son hidrogeno, alquilo opcionalmente sustituido, entre otros; y cada carbono con asterisco es un carbono asimetrico. Son preferentes, (-)-1-(4-fluorofenil)-3-[(3S*,4R*)-4-(4-metoxifenil)-2-oxopirrolidin-3-il]urea , (-)-1-(4-clorofenil)-3-[(3S*,4R*)-4-(4-metoxifenil)-2-oxopirrolidin-3-il]urea,entre otros. Tambien se refiere a una composicion farmaceutica y un metodo de tratamiento. Dicho compuesto es un derivado de urea con efecto agonista sobre el receptor similar al de peptidos formilados 1 (FPRL1) siendo utiles en el tratamiento, prevencion o supresion de la enfermedad de Behcet, enfermedad de Sweet, lupus eritematoso, entre otros.
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CN (1) | CN105814019B (es) |
AU (2) | AU2014355887B2 (es) |
BR (1) | BR112016011755B1 (es) |
CA (1) | CA2932010C (es) |
CL (1) | CL2016001283A1 (es) |
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PE (1) | PE20161206A1 (es) |
PH (1) | PH12016500806A1 (es) |
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