RU2696581C2 - Производные n-мочевинозамещенных аминокислот как модуляторы формил-пептидного рецептора - Google Patents

Производные n-мочевинозамещенных аминокислот как модуляторы формил-пептидного рецептора Download PDF

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Publication number
RU2696581C2
RU2696581C2 RU2016104844A RU2016104844A RU2696581C2 RU 2696581 C2 RU2696581 C2 RU 2696581C2 RU 2016104844 A RU2016104844 A RU 2016104844A RU 2016104844 A RU2016104844 A RU 2016104844A RU 2696581 C2 RU2696581 C2 RU 2696581C2
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Russia
Prior art keywords
amino
carbamoyl
methyl
alkyl
bromophenyl
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RU2016104844A
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English (en)
Russian (ru)
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RU2016104844A (ru
Inventor
Ричард Л. БИРД
Тьен Т. ДУОНГ
Джон Е. ДОНЕЛЛО
Вина ВИСВАНАТ
Майкл Е. ГАРСТ
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Аллерган, Инк.
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Publication of RU2016104844A publication Critical patent/RU2016104844A/ru
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06043—Leu-amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/30—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by halogen atoms, or by nitro or nitroso groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
  • Rheumatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
RU2016104844A 2013-07-16 2014-07-10 Производные n-мочевинозамещенных аминокислот как модуляторы формил-пептидного рецептора RU2696581C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361846787P 2013-07-16 2013-07-16
US61/846,787 2013-07-16
PCT/US2014/046203 WO2015009545A1 (en) 2013-07-16 2014-07-10 Derivatives of n-urea substituted amino acids as formyl peptide receptor modulators

Publications (2)

Publication Number Publication Date
RU2016104844A RU2016104844A (ru) 2017-08-21
RU2696581C2 true RU2696581C2 (ru) 2019-08-05

Family

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Family Applications (1)

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RU2016104844A RU2696581C2 (ru) 2013-07-16 2014-07-10 Производные n-мочевинозамещенных аминокислот как модуляторы формил-пептидного рецептора

Country Status (11)

Country Link
US (1) US9428549B2 (OSRAM)
EP (1) EP3022174B1 (OSRAM)
JP (1) JP6653253B2 (OSRAM)
KR (1) KR102313757B1 (OSRAM)
CN (1) CN105377814B (OSRAM)
AU (1) AU2014290618B2 (OSRAM)
CA (1) CA2917811C (OSRAM)
DK (1) DK3022174T3 (OSRAM)
ES (1) ES2708571T3 (OSRAM)
RU (1) RU2696581C2 (OSRAM)
WO (1) WO2015009545A1 (OSRAM)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2012329098B2 (en) 2011-10-26 2017-08-03 Allergan, Inc. Amide derivatives of N-urea substituted amino acids as formyl peptide receptor like-1 (FPRL-1) receptor modulators
CA3114477A1 (en) 2013-03-06 2014-09-12 Allergan, Inc. Use of agonists of formyl peptide receptor 2 for treating dermatological diseases
CN105705484B (zh) 2013-11-21 2018-09-14 阿勒根公司 作为甲酰肽受体调节剂的苯基氨基甲酸酯衍生物
NZ752095A (en) 2013-11-28 2022-07-01 Kyorin Seiyaku Kk Urea derivative or pharmacologically acceptable salt thereof
US9663457B2 (en) 2014-04-09 2017-05-30 Allergan, Inc. Carbamoyl hydrazine derivatives as formyl peptide modulators
RU2748652C2 (ru) 2014-05-21 2021-05-28 Аллерган, Инк. Производные имидазола как модуляторы формилпептидного рецептора
CN107848962B (zh) 2015-05-27 2021-04-09 杏林制药株式会社 脲衍生物或其药理学上可接受的盐
MX2017015040A (es) 2015-05-27 2018-08-14 Kyorin Seiyaku Kk Derivado de urea o sal farmacologicamente aceptable del mismo.
EP3331897B1 (en) * 2015-08-05 2021-03-24 Allergan, Inc. Phenyl urea analogs as formyl peptide receptor 1 (fpr1) selective agonists
MY204384A (en) 2018-03-05 2024-08-27 Bristol Myers Squibb Co Phenylpyrrolidinone formyl peptide 2 receptor agonists

Citations (3)

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WO2005047899A2 (en) * 2003-11-07 2005-05-26 Acadia Pharmaceuticals Inc. Use of the lipoxin receptor, fprl1, as a tool for identifying compounds effective in the treatment of pain and inflammation
US20130109866A1 (en) * 2011-10-26 2013-05-02 Allergan, Inc. Amide derivatives of n-urea substituted amino acids as formyl peptide receptor like-1 (fprl-1) receptor modulators
RU2011151277A (ru) * 2009-05-18 2013-06-27 Актелион Фармасьютиклз Лтд Мостиковые производные спиро[2.4]гептана в качестве агонистов рецептора alx и/или fprl2

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US5284828A (en) * 1990-05-14 1994-02-08 Fujisawa Pharmaceutical Co. Ltd. Peptide compound and its preparation
JP3387948B2 (ja) * 1992-12-04 2003-03-17 富山化学工業株式会社 新規なフェニルアラニン誘導体またはその塩
US20030009022A1 (en) * 1993-03-31 2003-01-09 Cadus Pharmaceutical Corporation Methods and compositions for identifying receptor effectors
DE69525145T2 (de) * 1994-02-09 2002-08-29 SHIONOGI & CO., LTD. Carbamoylmethylharnstoffderivate
JP2968842B2 (ja) * 1994-02-09 1999-11-02 塩野義製薬株式会社 カルバモイルメチルウレア誘導体
US6423689B1 (en) * 1997-12-22 2002-07-23 Warner-Lambert Company Peptidyl calcium channel blockers
WO1999065932A1 (en) * 1998-06-18 1999-12-23 Sepracor, Inc. Tetrapeptides, analogs and peptidomimetics which bind selectively mammalian opioid receptors
WO2003082314A2 (en) * 2002-04-03 2003-10-09 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with n-formyl peptide receptor like 1 (fprl1)
EP2646030A1 (en) * 2010-12-03 2013-10-09 Allergan, Inc. Pharmaceutical compositions comprising 3,4- dihydroisoquinolin-2(1 h)-yl-3-phenylurea derivatives having formyl peptide receptor like-1 (fprl-1) agonist or antagonist activity
US8541577B2 (en) * 2011-11-10 2013-09-24 Allergan, Inc. Aryl urea derivatives as N-formyl peptide receptors like-1 (FPRL-1) receptor modulators
US8735622B2 (en) * 2011-11-30 2014-05-27 The Regents Of The University Of Colorado, A Body Corporate Histone demethylase inhibitors and methods for using the same
CA3114477A1 (en) * 2013-03-06 2014-09-12 Allergan, Inc. Use of agonists of formyl peptide receptor 2 for treating dermatological diseases
KR102290134B1 (ko) * 2013-03-06 2021-08-17 알러간, 인코포레이티드 안구 염증성 질환을 치료하기 위한 포르밀 펩타이드 수용체 2의 작용제의 용도

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005047899A2 (en) * 2003-11-07 2005-05-26 Acadia Pharmaceuticals Inc. Use of the lipoxin receptor, fprl1, as a tool for identifying compounds effective in the treatment of pain and inflammation
RU2011151277A (ru) * 2009-05-18 2013-06-27 Актелион Фармасьютиклз Лтд Мостиковые производные спиро[2.4]гептана в качестве агонистов рецептора alx и/или fprl2
US20130109866A1 (en) * 2011-10-26 2013-05-02 Allergan, Inc. Amide derivatives of n-urea substituted amino acids as formyl peptide receptor like-1 (fprl-1) receptor modulators

Also Published As

Publication number Publication date
AU2014290618A1 (en) 2016-02-18
US20150025021A1 (en) 2015-01-22
AU2014290618B2 (en) 2018-04-05
KR20160031007A (ko) 2016-03-21
RU2016104844A (ru) 2017-08-21
CA2917811A1 (en) 2015-01-22
CN105377814A (zh) 2016-03-02
EP3022174B1 (en) 2018-09-05
EP3022174A1 (en) 2016-05-25
CN105377814B (zh) 2018-04-03
DK3022174T3 (da) 2019-01-02
ES2708571T3 (es) 2019-04-10
WO2015009545A1 (en) 2015-01-22
CA2917811C (en) 2021-08-31
JP2016529235A (ja) 2016-09-23
US9428549B2 (en) 2016-08-30
JP6653253B2 (ja) 2020-02-26
KR102313757B1 (ko) 2021-10-18

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