ES270275A1 - An improved process for the industrial manufacture of hydroxocobalamin - Google Patents
An improved process for the industrial manufacture of hydroxocobalaminInfo
- Publication number
- ES270275A1 ES270275A1 ES0270275A ES270275A ES270275A1 ES 270275 A1 ES270275 A1 ES 270275A1 ES 0270275 A ES0270275 A ES 0270275A ES 270275 A ES270275 A ES 270275A ES 270275 A1 ES270275 A1 ES 270275A1
- Authority
- ES
- Spain
- Prior art keywords
- hydroxocobalamin
- zinc
- acid
- addition
- improved process
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H23/00—Compounds containing boron, silicon, or a metal, e.g. chelates, vitamin B12
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/84—Preparation of the fraction to be distributed
Landscapes
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- General Physics & Mathematics (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Hydroxocobalamin is obtained by reducing cyanocobalamin in acid solution by means of nascent hydrogen produced by adding granular zinc and then blowing an oxidising gas through the resultant liquid after it has been diluted with water. The grain size of the zinc may be from 200 to 1400 microns and the acid may be hydrochloric, hydrobromic, hydriodic or sulphuric acid. Reaction is preferably effected at ambient temperature and at atmospheric pressure using air as the oxidising gas. The zinc may be rendered insoluble by the addition of soda, potash, baryta or ammonia and the hydroxocobalamin crystallised from aqueous solution by the addition of tetrahydrofuran, dioxan or acetone.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MC252A MC320A1 (en) | 1960-09-22 | 1960-09-22 | Process for preparing hydroxocobalamin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES270275A1 true ES270275A1 (en) | 1962-02-01 |
Family
ID=19737440
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES0269988A Expired ES269988A1 (en) | 1960-09-22 | 1961-08-18 | An improved process for the industrial manufacture of hydroxocobalamin |
| ES0270275A Expired ES270275A1 (en) | 1960-09-22 | 1961-09-06 | An improved process for the industrial manufacture of hydroxocobalamin |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES0269988A Expired ES269988A1 (en) | 1960-09-22 | 1961-08-18 | An improved process for the industrial manufacture of hydroxocobalamin |
Country Status (8)
| Country | Link |
|---|---|
| BE (1) | BE642487A (en) |
| CH (2) | CH396921A (en) |
| DE (1) | DE1182666B (en) |
| ES (2) | ES269988A1 (en) |
| FR (2) | FR1346256A (en) |
| GB (2) | GB916186A (en) |
| MC (1) | MC320A1 (en) |
| OA (2) | OA00124A (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2015012710A (en) * | 2013-03-13 | 2018-03-23 | Interquim S A De C V | Improvements to the method for preparing hydroxocobalamin and the high-purity salts thereof. |
-
1960
- 1960-09-22 MC MC252A patent/MC320A1/en unknown
-
1961
- 1961-07-28 FR FR869338A patent/FR1346256A/en not_active Expired
- 1961-08-02 FR FR869812A patent/FR1346257A/en not_active Expired
- 1961-08-18 ES ES0269988A patent/ES269988A1/en not_active Expired
- 1961-08-22 CH CH977361A patent/CH396921A/en unknown
- 1961-08-25 DE DEB63779A patent/DE1182666B/en active Pending
- 1961-08-30 GB GB31271/61A patent/GB916186A/en not_active Expired
- 1961-09-05 CH CH1028461A patent/CH398623A/en unknown
- 1961-09-06 ES ES0270275A patent/ES270275A1/en not_active Expired
- 1961-09-07 GB GB32222/61A patent/GB934462A/en not_active Expired
-
1964
- 1964-01-14 BE BE642487A patent/BE642487A/xx unknown
- 1964-05-02 OA OA50089A patent/OA00124A/en unknown
- 1964-06-30 OA OA50171A patent/OA00146A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FR1346257A (en) | 1963-12-20 |
| OA00146A (en) | 1966-03-15 |
| FR1346256A (en) | 1963-12-20 |
| GB934462A (en) | 1963-08-21 |
| OA00124A (en) | 1966-01-15 |
| CH398623A (en) | 1966-03-15 |
| GB916186A (en) | 1963-01-23 |
| CH396921A (en) | 1965-08-15 |
| MC320A1 (en) | 1962-04-12 |
| ES269988A1 (en) | 1961-12-16 |
| DE1182666B (en) | 1964-12-03 |
| BE642487A (en) | 1964-05-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GB980596A (en) | Regeneration of primary oxidants in electrochemical cells | |
| ES270275A1 (en) | An improved process for the industrial manufacture of hydroxocobalamin | |
| ES376742A1 (en) | Process for the production of nitric acid with a concentration of over 70 percent by weight | |
| GB1434061A (en) | Process for purification | |
| GB891094A (en) | Improvements in and relating to per-compounds | |
| GB1384776A (en) | Process for producing potassium superoxide | |
| ES296157A1 (en) | Process for hydrating propylene | |
| GB922679A (en) | Improvements in and relating to the preparation of 2:2- dihydroxydiphenyls | |
| GB1396358A (en) | Method of removing mercury vapour from gases contaminated therewith | |
| GB909945A (en) | Stabilized hydrogen peroxide | |
| GB1130127A (en) | Process for the removal of hydrogen sulphide from carbon dioxide and gas mixtures containing carbon dioxide | |
| GB1204029A (en) | Process for the production of dinitrogen tetroxide | |
| GB1269873A (en) | Process for producing ferrous sulphate | |
| GB1000676A (en) | Water electrolysis process | |
| GB866040A (en) | Improvements in or relating to the recovery of germanium | |
| GB1012782A (en) | Process for the manufacture of phloroglucinol | |
| GB769211A (en) | Process for fractionating starch | |
| GB795424A (en) | Improvements in or relating to sodium cyanide | |
| GB956598A (en) | Chlorine manufacture | |
| ES280122A1 (en) | Procedure for the direct and simultaneous production of inorganic salts of alkaline metals, chlorine gas and cathodic products (Machine-translation by Google Translate, not legally binding) | |
| GB928080A (en) | Process for the activation of oxygen electrodes | |
| GB750355A (en) | Improvements in or relating to the manufacture of titanium | |
| GB866041A (en) | Improvements in or relating to the recovery of germanium | |
| GB836666A (en) | Production of chloroprene | |
| GB910207A (en) | Preparation of potassium hydrogen fluoride |