ES2680942T3 - Variante de polipéptidos del factor VIII y procedimientos para su producción y utilización - Google Patents
Variante de polipéptidos del factor VIII y procedimientos para su producción y utilización Download PDFInfo
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- ES2680942T3 ES2680942T3 ES14770221.1T ES14770221T ES2680942T3 ES 2680942 T3 ES2680942 T3 ES 2680942T3 ES 14770221 T ES14770221 T ES 14770221T ES 2680942 T3 ES2680942 T3 ES 2680942T3
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- 238000009826 distribution Methods 0.000 description 1
- PMMYEEVYMWASQN-UHFFFAOYSA-N dl-hydroxyproline Natural products OC1C[NH2+]C(C([O-])=O)C1 PMMYEEVYMWASQN-UHFFFAOYSA-N 0.000 description 1
- 238000002283 elective surgery Methods 0.000 description 1
- 238000004520 electroporation Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 229960004222 factor ix Drugs 0.000 description 1
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- 238000010353 genetic engineering Methods 0.000 description 1
- 235000013922 glutamic acid Nutrition 0.000 description 1
- 239000004220 glutamic acid Substances 0.000 description 1
- 125000000291 glutamic acid group Chemical group N[C@@H](CCC(O)=O)C(=O)* 0.000 description 1
- 230000013595 glycosylation Effects 0.000 description 1
- 238000006206 glycosylation reaction Methods 0.000 description 1
- 210000002288 golgi apparatus Anatomy 0.000 description 1
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- 229960002897 heparin Drugs 0.000 description 1
- 239000000833 heterodimer Substances 0.000 description 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
- 229940052349 human coagulation factor ix Drugs 0.000 description 1
- 229940099813 human coagulation factor x Drugs 0.000 description 1
- 238000009396 hybridization Methods 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 description 1
- 229960002591 hydroxyproline Drugs 0.000 description 1
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- 230000001771 impaired effect Effects 0.000 description 1
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- 230000001939 inductive effect Effects 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 208000018592 inherited blood coagulation disease Diseases 0.000 description 1
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- LSDPWZHWYPCBBB-UHFFFAOYSA-O methylsulfide anion Chemical compound [SH2+]C LSDPWZHWYPCBBB-UHFFFAOYSA-O 0.000 description 1
- 108091005601 modified peptides Proteins 0.000 description 1
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- 239000000178 monomer Substances 0.000 description 1
- 108091027963 non-coding RNA Proteins 0.000 description 1
- 102000042567 non-coding RNA Human genes 0.000 description 1
- 230000000771 oncological effect Effects 0.000 description 1
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- 239000002245 particle Substances 0.000 description 1
- 230000006320 pegylation Effects 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 230000010412 perfusion Effects 0.000 description 1
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 description 1
- 150000008104 phosphatidylethanolamines Chemical class 0.000 description 1
- BZQFBWGGLXLEPQ-REOHCLBHSA-N phosphoserine Chemical compound OC(=O)[C@@H](N)COP(O)(O)=O BZQFBWGGLXLEPQ-REOHCLBHSA-N 0.000 description 1
- 238000007842 plasma-based assay Methods 0.000 description 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
- 238000009117 preventive therapy Methods 0.000 description 1
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- 229960003766 thrombin (human) Drugs 0.000 description 1
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- 231100000759 toxicological effect Toxicity 0.000 description 1
- FGMPLJWBKKVCDB-UHFFFAOYSA-N trans-L-hydroxy-proline Natural products ON1CCCC1C(O)=O FGMPLJWBKKVCDB-UHFFFAOYSA-N 0.000 description 1
- 230000009529 traumatic brain injury Effects 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- 125000002987 valine group Chemical group [H]N([H])C([H])(C(*)=O)C([H])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
- A61K38/37—Factors VIII
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Hematology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Toxicology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361789112P | 2013-03-15 | 2013-03-15 | |
| US201361789112P | 2013-03-15 | ||
| PCT/US2014/027443 WO2014152530A1 (en) | 2013-03-15 | 2014-03-14 | Variant factor viii polypeptides and methods of their production and use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2680942T3 true ES2680942T3 (es) | 2018-09-11 |
Family
ID=51581235
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES14770221.1T Active ES2680942T3 (es) | 2013-03-15 | 2014-03-14 | Variante de polipéptidos del factor VIII y procedimientos para su producción y utilización |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US9914764B2 (OSRAM) |
| EP (2) | EP2988758B1 (OSRAM) |
| JP (1) | JP6523244B2 (OSRAM) |
| CN (1) | CN105209488A (OSRAM) |
| CA (1) | CA2906602A1 (OSRAM) |
| ES (1) | ES2680942T3 (OSRAM) |
| HK (1) | HK1213274A1 (OSRAM) |
| WO (1) | WO2014152530A1 (OSRAM) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112119158A (zh) * | 2018-04-12 | 2020-12-22 | 生物测试股份公司 | 去免疫化的因子viii分子以及包含其的药物组合物 |
| AU2020395323A1 (en) * | 2019-12-06 | 2022-06-30 | The Children's Hospital Of Philadelphia | Compositions and methods for modulating factor VIII function |
| EP4514837A1 (en) * | 2022-04-25 | 2025-03-05 | The Children's Hospital Of Philadelphia | Compositions and methods for modulating factor viii function |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5451521A (en) * | 1986-05-29 | 1995-09-19 | Genetics Institute, Inc. | Procoagulant proteins |
| US5004803A (en) * | 1988-11-14 | 1991-04-02 | Genetics Institute, Inc. | Production of procoagulant proteins |
| JP3987114B2 (ja) | 1996-04-24 | 2007-10-03 | ザ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・ミシガン | 不活性化耐性第▲８▼因子 |
| US8183344B2 (en) | 1996-04-24 | 2012-05-22 | University Of Michigan | Inactivation resistant factor VIII |
| US5763401A (en) | 1996-07-12 | 1998-06-09 | Bayer Corporation | Stabilized albumin-free recombinant factor VIII preparation having a low sugar content |
| KR20040103970A (ko) * | 2002-04-18 | 2004-12-09 | 메르크 파텐트 게엠베하 | 변형된 펙터 ⅷ |
| WO2006027111A1 (en) * | 2004-09-06 | 2006-03-16 | Zlb Behring Gmbh | Modified coagulation factor viii with enhanced stability |
| WO2006103298A2 (en) | 2005-04-01 | 2006-10-05 | Novo Nordisk Health Care Ag | Blood coagulation fviii analogues |
| WO2006108590A1 (en) * | 2005-04-14 | 2006-10-19 | Csl Behring Gmbh | Modified coagulation factor viii with enhanced stability and its derivates |
| EP2520586A1 (en) * | 2006-06-30 | 2012-11-07 | The Regents of the University of Michigan | Method of producing factor VIII proteins by recombinant methods |
| US20120028900A1 (en) * | 2006-06-30 | 2012-02-02 | Kaufman Randal J | Method of producing factor viii proteins by recombinant methods |
| US20090203077A1 (en) * | 2006-06-30 | 2009-08-13 | The Regents Of The University Of Michigan | Method of producing factor viii proteins by recombinant methods |
| CN104152489A (zh) | 2007-11-01 | 2014-11-19 | 罗切斯特大学 | 具有增加的稳定性的重组因子viii |
| US8637448B2 (en) | 2010-09-14 | 2014-01-28 | University Of Rochester | Recombinant factor VIII having enhanced stability following mutation at the A1-C2 domain interface |
-
2014
- 2014-03-14 EP EP14770221.1A patent/EP2988758B1/en not_active Not-in-force
- 2014-03-14 US US14/773,702 patent/US9914764B2/en not_active Expired - Fee Related
- 2014-03-14 CA CA2906602A patent/CA2906602A1/en not_active Abandoned
- 2014-03-14 JP JP2016502439A patent/JP6523244B2/ja not_active Expired - Fee Related
- 2014-03-14 WO PCT/US2014/027443 patent/WO2014152530A1/en not_active Ceased
- 2014-03-14 HK HK16101335.4A patent/HK1213274A1/zh unknown
- 2014-03-14 EP EP18159477.1A patent/EP3427744A1/en not_active Withdrawn
- 2014-03-14 CN CN201480027204.2A patent/CN105209488A/zh active Pending
- 2014-03-14 ES ES14770221.1T patent/ES2680942T3/es active Active
-
2018
- 2018-01-23 US US15/878,012 patent/US10266583B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP2016513697A (ja) | 2016-05-16 |
| WO2014152530A1 (en) | 2014-09-25 |
| JP6523244B2 (ja) | 2019-05-29 |
| EP2988758A4 (en) | 2016-04-27 |
| HK1213274A1 (zh) | 2016-06-30 |
| EP3427744A1 (en) | 2019-01-16 |
| EP2988758A1 (en) | 2016-03-02 |
| CA2906602A1 (en) | 2014-09-25 |
| EP2988758B1 (en) | 2018-04-25 |
| US20160031968A1 (en) | 2016-02-04 |
| US20180148495A1 (en) | 2018-05-31 |
| CN105209488A (zh) | 2015-12-30 |
| US10266583B2 (en) | 2019-04-23 |
| US9914764B2 (en) | 2018-03-13 |
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