ES2667418T3 - Composiciones y métodos para el tratamiento de la enfermedad celíaca - Google Patents
Composiciones y métodos para el tratamiento de la enfermedad celíaca Download PDFInfo
- Publication number
- ES2667418T3 ES2667418T3 ES12748354.3T ES12748354T ES2667418T3 ES 2667418 T3 ES2667418 T3 ES 2667418T3 ES 12748354 T ES12748354 T ES 12748354T ES 2667418 T3 ES2667418 T3 ES 2667418T3
- Authority
- ES
- Spain
- Prior art keywords
- amino acid
- seq
- acid sequence
- wild
- kumamolysin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 208000015943 Coeliac disease Diseases 0.000 title description 8
- 238000000034 method Methods 0.000 title description 3
- 239000000203 mixture Substances 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract description 22
- 125000003275 alpha amino acid group Chemical group 0.000 abstract description 21
- 102000004196 processed proteins & peptides Human genes 0.000 abstract description 19
- 229920001184 polypeptide Polymers 0.000 abstract description 15
- 150000001413 amino acids Chemical class 0.000 abstract description 8
- 108091005804 Peptidases Proteins 0.000 description 14
- 239000004365 Protease Substances 0.000 description 13
- 102000004190 Enzymes Human genes 0.000 description 9
- 108090000790 Enzymes Proteins 0.000 description 9
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 9
- 230000035772 mutation Effects 0.000 description 9
- 235000019419 proteases Nutrition 0.000 description 9
- 108010068370 Glutens Proteins 0.000 description 8
- 235000021312 gluten Nutrition 0.000 description 8
- 108010038807 Oligopeptides Proteins 0.000 description 6
- 102000015636 Oligopeptides Human genes 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 108010061711 Gliadin Proteins 0.000 description 5
- 102000035195 Peptidases Human genes 0.000 description 5
- 230000002163 immunogen Effects 0.000 description 5
- 210000002784 stomach Anatomy 0.000 description 5
- 239000000758 substrate Substances 0.000 description 5
- 108010016626 Dipeptides Proteins 0.000 description 4
- 230000003197 catalytic effect Effects 0.000 description 4
- 206010061218 Inflammation Diseases 0.000 description 3
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 3
- 230000002496 gastric effect Effects 0.000 description 3
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 3
- 229910052739 hydrogen Inorganic materials 0.000 description 3
- 230000004054 inflammatory process Effects 0.000 description 3
- 235000018102 proteins Nutrition 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 230000017854 proteolysis Effects 0.000 description 3
- 239000004475 Arginine Substances 0.000 description 2
- 108010059378 Endopeptidases Proteins 0.000 description 2
- 102000005593 Endopeptidases Human genes 0.000 description 2
- 230000002378 acidificating effect Effects 0.000 description 2
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 238000006731 degradation reaction Methods 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 125000000404 glutamine group Chemical group N[C@@H](CCC(N)=O)C(=O)* 0.000 description 2
- 239000001257 hydrogen Substances 0.000 description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 108010049331 kumamolysin Proteins 0.000 description 2
- 230000007935 neutral effect Effects 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 241001442202 Alicyclobacillus sendaiensis Species 0.000 description 1
- 208000023275 Autoimmune disease Diseases 0.000 description 1
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 102000003886 Glycoproteins Human genes 0.000 description 1
- 108090000288 Glycoproteins Proteins 0.000 description 1
- 240000005979 Hordeum vulgare Species 0.000 description 1
- 235000007340 Hordeum vulgare Nutrition 0.000 description 1
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 description 1
- LCGISIDBXHGCDW-VKHMYHEASA-N L-glutamine amide Chemical compound NC(=O)[C@@H](N)CCC(N)=O LCGISIDBXHGCDW-VKHMYHEASA-N 0.000 description 1
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 description 1
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 description 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 1
- 241000209140 Triticum Species 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- 125000000539 amino acid group Chemical group 0.000 description 1
- 125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 description 1
- 238000003776 cleavage reaction Methods 0.000 description 1
- 230000006957 competitive inhibition Effects 0.000 description 1
- 238000005094 computer simulation Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 108091007735 digestive proteases Proteins 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 235000013312 flour Nutrition 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 239000008241 heterogeneous mixture Substances 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 238000002703 mutagenesis Methods 0.000 description 1
- 231100000350 mutagenesis Toxicity 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 235000019833 protease Nutrition 0.000 description 1
- 238000002731 protein assay Methods 0.000 description 1
- 230000002797 proteolythic effect Effects 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 229940124598 therapeutic candidate Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000014616 translation Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Transplantation (AREA)
- Pulmonology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161521899P | 2011-08-10 | 2011-08-10 | |
| US201161521899P | 2011-08-10 | ||
| PCT/US2012/050364 WO2013023151A2 (en) | 2011-08-10 | 2012-08-10 | Compositions and methods for treating celiac sprue disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2667418T3 true ES2667418T3 (es) | 2018-05-10 |
Family
ID=46690751
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES12748354.3T Active ES2667418T3 (es) | 2011-08-10 | 2012-08-10 | Composiciones y métodos para el tratamiento de la enfermedad celíaca |
| ES18162586T Active ES2896489T3 (es) | 2011-08-10 | 2012-08-10 | Composiciones y procedimientos para el tratamiento de la enfermedad esprúe celíaco |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES18162586T Active ES2896489T3 (es) | 2011-08-10 | 2012-08-10 | Composiciones y procedimientos para el tratamiento de la enfermedad esprúe celíaco |
Country Status (18)
| Country | Link |
|---|---|
| US (7) | US9289473B2 (enExample) |
| EP (3) | EP4023243A3 (enExample) |
| JP (5) | JP6342802B2 (enExample) |
| CA (1) | CA2882502A1 (enExample) |
| CY (1) | CY1120877T1 (enExample) |
| DK (1) | DK2718434T3 (enExample) |
| ES (2) | ES2667418T3 (enExample) |
| HR (1) | HRP20180687T1 (enExample) |
| HU (1) | HUE037870T2 (enExample) |
| LT (1) | LT2718434T (enExample) |
| NO (1) | NO2718434T3 (enExample) |
| PL (2) | PL3400958T3 (enExample) |
| PT (1) | PT2718434T (enExample) |
| RS (1) | RS57234B1 (enExample) |
| SI (1) | SI2718434T1 (enExample) |
| SM (1) | SMT201800249T1 (enExample) |
| TR (1) | TR201806885T4 (enExample) |
| WO (1) | WO2013023151A2 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE037870T2 (hu) | 2011-08-10 | 2018-09-28 | Univ Washington Through Its Center For Commercialization | Készítmények és módszerek lisztérzékenység kezelésére |
| EP3520808B1 (en) | 2013-08-14 | 2021-04-21 | University Of Washington Through Its Center For Commercialization | Compositions for treating celiac sprue disease |
| EP3081942A1 (en) * | 2015-04-17 | 2016-10-19 | Roche Diagniostics GmbH | Pressure transmission liquid for cellular analyzer, cellular analyzer and method for analyzing a liquid cellular sample |
| BR112017026142A2 (pt) | 2015-06-08 | 2018-08-14 | Univ California | composições e métodos para tratar doença sprue celíaca |
| AU2017380106B2 (en) * | 2016-12-22 | 2024-05-09 | Ew Nutrition Gmbh | Stable protease variants |
| WO2020087017A1 (en) * | 2018-10-26 | 2020-04-30 | The Regents Of The University Of California | Use of proteolytic enzymes to enhance protein bioavailability |
| US20240226248A9 (en) * | 2018-10-26 | 2024-07-11 | The Regents Of The University Of California | Methods and compositions for improving protein hydrolysis |
| AU2021368118A1 (en) | 2020-10-30 | 2023-05-11 | The Regents Of The University Of California | Compositions and methods for treating celiac sprue disease |
| WO2023147350A1 (en) | 2022-01-26 | 2023-08-03 | Digestiva, Inc. | Blood glucose stabilizing methods and compositions |
| WO2025068987A1 (en) | 2023-09-28 | 2025-04-03 | Takeda Pharmaceutical Company Limited | A method of producing a kumamolisin-as polypeptide |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2688229B1 (fr) | 1992-03-09 | 1995-06-23 | Ulice Soc | Procede de synthese enzymatique d'esters alkyliques de peptides, produits ainsi obtenus et utilisation desdits produits. |
| JP2002078489A (ja) | 2000-09-04 | 2002-03-19 | Daiwa Kasei Kk | セリン残基が活性発現に関与する新規酸性プロテアーゼ |
| US7303871B2 (en) | 2002-02-14 | 2007-12-04 | The Board Of Trustees Of The Leland Stanford Junior University | Enzyme treatment of foodstuffs for Celiac Sprue |
| US7320788B2 (en) | 2002-02-14 | 2008-01-22 | The Board Of Trustees Of The Leland Stanford Junior University | Enzyme treatment of foodstuffs for Celiac Sprue |
| US8143210B2 (en) | 2002-02-14 | 2012-03-27 | The Board Of Trustees Of The Leland Stanford Junior University | Enzyme treatment of foodstuffs for celiac sprue |
| US7265093B2 (en) | 2002-05-14 | 2007-09-04 | The Board Of Trustees Of The Leland Stanford Junior University | Drug therapy for Celiac Sprue |
| AU2003234597A1 (en) | 2002-05-14 | 2003-12-02 | The Board Of Trustees Of The Leland Stanford Junior University | Drug therapy for celiac sprue |
| US7462688B2 (en) | 2002-05-14 | 2008-12-09 | The Board Of Trustees Of The Leland Stanford Junior University | Peptides for diagnostic and therapeutic methods for celiac sprue |
| US7202216B2 (en) | 2002-05-14 | 2007-04-10 | The Board Of Trustees Of The Leland Stanford Junior University | Drug therapy for celiac sprue |
| WO2004045392A2 (en) | 2002-11-20 | 2004-06-03 | The Board Of Trustees Of The Leland Stanford Junior University | Diagnostic method for celiac sprue |
| US7579313B2 (en) | 2003-11-18 | 2009-08-25 | The Board Of Trustees Of The Leland Stanford Junior University | Transglutaminase inhibitors and methods of use thereof |
| US7563864B2 (en) | 2004-04-26 | 2009-07-21 | Celiac Sprue Research Foundation | Prolyl endopeptidase mediated destruction of T cell epitopes in whole gluten |
| US7534426B2 (en) | 2004-04-26 | 2009-05-19 | The Board Of Trustees Of The Leland Stanford Junior University | Glutenase enzyme assays |
| US7628985B2 (en) | 2004-04-26 | 2009-12-08 | The Board Of Regents Of The Leland Stanford Junior University | Therapeutic enzyme formulations and uses thereof in celiac sprue and/or dermatitis herpetoformis |
| EP1600141B1 (en) | 2004-05-24 | 2013-04-17 | 3M Deutschland GmbH | Collagenolytic active enzyme containing compositions for the treatment of dental caries |
| EP1726643A1 (en) * | 2005-05-27 | 2006-11-29 | Direvo Biotech AG | Method for the provision, identification and selection of proteases with altered sensitivity to activity-modulating substances |
| NZ591025A (en) | 2008-08-21 | 2013-01-25 | Alvine Pharmaceuticals Inc | Formulation for oral administration of proteins |
| HUE037870T2 (hu) * | 2011-08-10 | 2018-09-28 | Univ Washington Through Its Center For Commercialization | Készítmények és módszerek lisztérzékenység kezelésére |
| EP2788018B1 (en) | 2011-12-06 | 2016-06-29 | Fondazione Istituto Insubrico di Ricerca per la Vita | New proteases able to hydrolyze gluten peptides and proteins at acidic ph, from the actinomycete actinoallomurus |
| EP3520808B1 (en) | 2013-08-14 | 2021-04-21 | University Of Washington Through Its Center For Commercialization | Compositions for treating celiac sprue disease |
-
2012
- 2012-08-10 HU HUE12748354A patent/HUE037870T2/hu unknown
- 2012-08-10 LT LTEP12748354.3T patent/LT2718434T/lt unknown
- 2012-08-10 HR HRP20180687TT patent/HRP20180687T1/hr unknown
- 2012-08-10 DK DK12748354.3T patent/DK2718434T3/en active
- 2012-08-10 EP EP21187810.3A patent/EP4023243A3/en active Pending
- 2012-08-10 ES ES12748354.3T patent/ES2667418T3/es active Active
- 2012-08-10 RS RS20180609A patent/RS57234B1/sr unknown
- 2012-08-10 ES ES18162586T patent/ES2896489T3/es active Active
- 2012-08-10 NO NO12748354A patent/NO2718434T3/no unknown
- 2012-08-10 TR TR2018/06885T patent/TR201806885T4/tr unknown
- 2012-08-10 WO PCT/US2012/050364 patent/WO2013023151A2/en not_active Ceased
- 2012-08-10 US US14/131,601 patent/US9289473B2/en active Active
- 2012-08-10 CA CA2882502A patent/CA2882502A1/en active Pending
- 2012-08-10 PT PT127483543T patent/PT2718434T/pt unknown
- 2012-08-10 SM SM20180249T patent/SMT201800249T1/it unknown
- 2012-08-10 PL PL18162586T patent/PL3400958T3/pl unknown
- 2012-08-10 EP EP12748354.3A patent/EP2718434B1/en active Active
- 2012-08-10 JP JP2014525175A patent/JP6342802B2/ja active Active
- 2012-08-10 EP EP18162586.4A patent/EP3400958B1/en active Active
- 2012-08-10 SI SI201231269T patent/SI2718434T1/en unknown
- 2012-08-10 PL PL12748354T patent/PL2718434T3/pl unknown
-
2016
- 2016-01-26 US US15/006,341 patent/US9707280B2/en active Active
-
2017
- 2017-06-26 US US15/633,065 patent/US9925249B2/en active Active
- 2017-07-07 JP JP2017133615A patent/JP6502428B2/ja active Active
-
2018
- 2018-02-14 US US15/896,536 patent/US10149892B2/en active Active
- 2018-06-21 CY CY181100648T patent/CY1120877T1/el unknown
- 2018-11-28 US US16/203,109 patent/US10874720B2/en active Active
-
2019
- 2019-03-20 JP JP2019052599A patent/JP2019162107A/ja active Pending
-
2020
- 2020-12-07 US US17/114,294 patent/US20210085761A1/en not_active Abandoned
-
2021
- 2021-03-23 JP JP2021048356A patent/JP2021094031A/ja active Pending
-
2023
- 2023-11-20 US US18/513,879 patent/US20240207376A1/en active Pending
-
2024
- 2024-01-11 JP JP2024002401A patent/JP2024028452A/ja active Pending
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