ES2656189T3 - Formas sólidas de un inhibidor macrocíclico de quinasa - Google Patents
Formas sólidas de un inhibidor macrocíclico de quinasa Download PDFInfo
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- ES2656189T3 ES2656189T3 ES14736454.1T ES14736454T ES2656189T3 ES 2656189 T3 ES2656189 T3 ES 2656189T3 ES 14736454 T ES14736454 T ES 14736454T ES 2656189 T3 ES2656189 T3 ES 2656189T3
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Classifications
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- C—CHEMISTRY; METALLURGY
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- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| US201361840703P | 2013-06-28 | 2013-06-28 | |
| US201361840703P | 2013-06-28 | ||
| PCT/IB2014/062296 WO2014207606A1 (en) | 2013-06-28 | 2014-06-17 | Solid forms of a macrocyclic kinase inhibitor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2656189T3 true ES2656189T3 (es) | 2018-02-26 |
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|---|---|
| US (1) | US9637500B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3013835B1 (cg-RX-API-DMAC7.html) |
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| AR (1) | AR096759A1 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2916605C (cg-RX-API-DMAC7.html) |
| ES (1) | ES2656189T3 (cg-RX-API-DMAC7.html) |
| TW (1) | TW201504246A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2014207606A1 (cg-RX-API-DMAC7.html) |
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| WO2016026423A1 (en) * | 2014-08-20 | 2016-02-25 | Teligene Ltd | Substituted macrocycles useful as kinases inhibitors and methods of use thereof |
| JP6609308B2 (ja) * | 2014-08-20 | 2019-11-20 | テリジーン リミテッド | キナーゼ阻害剤としての置換マクロサイクル |
| BR112017028604A2 (pt) * | 2015-07-31 | 2018-09-04 | Pfizer | forma cristalina de base livre de lorlatinibe |
| US20180282415A1 (en) | 2015-09-30 | 2018-10-04 | Merck Patent Gmbh | Combination of a PD-1 Axis Binding Antagonist and an ALK Inhibitor for Treating ALK-Negative Cancer |
| ES2812336T3 (es) | 2016-03-03 | 2021-03-16 | Shenzhen Targetrx Inc | Macrocíclico y composición que comprende el mismo |
| ES2819676T3 (es) * | 2016-04-08 | 2021-04-19 | Pfizer | Formas cristalinas de maleato de lorlatinib |
| HUE062926T2 (hu) * | 2017-10-10 | 2023-12-28 | Pfizer | Lorlatinib mint szabad bázis hidrátjának kristályos formája |
| US11179412B2 (en) | 2017-12-04 | 2021-11-23 | University of Pittsburgh—of the Commonwealth System of Higher Education | Methods of treating conditions involving elevated inflammatory response |
| US20210163498A1 (en) | 2018-04-23 | 2021-06-03 | Pliva Hrvatska D.O.O. | Solid state forms of lorlatinib and their preparation |
| WO2020108522A1 (zh) * | 2018-11-28 | 2020-06-04 | 深圳市塔吉瑞生物医药有限公司 | 一种氘代大环化合物的制备方法 |
| CN109651398B (zh) * | 2019-01-25 | 2021-07-30 | 安庆多辉生物科技有限公司 | 一种合成劳拉替尼的溴代物中间体及催化合成劳拉替尼的方法 |
| EP3999514A1 (en) | 2019-07-18 | 2022-05-25 | Pliva Hrvatska D.O.O. | Crystalline lorlatinib : fumaric acid and solid state form thereof |
| CN112321604A (zh) * | 2019-08-05 | 2021-02-05 | 华东理工大学 | 大环类jak2抑制剂及其应用 |
| CN110483551B (zh) * | 2019-08-30 | 2021-10-22 | 北京赛思源生物医药技术有限公司 | 一种劳拉替尼游离碱的晶体 |
| WO2021069571A1 (en) | 2019-10-10 | 2021-04-15 | Sandoz Ag | Polymorph of lorlatinib |
| CN112824417A (zh) * | 2019-11-21 | 2021-05-21 | 上海天慈国际药业有限公司 | 一种劳拉替尼的制备方法 |
| US20230117684A1 (en) | 2020-03-05 | 2023-04-20 | Pfizer Inc. | Combination of an anaplastic lymphoma kinase inhibitor and a cyclin dependent kinase inhibitor |
| PE20230608A1 (es) | 2020-05-05 | 2023-04-13 | Nuvalent Inc | Quimioterapicos de eter macrociclico heteroaromatico |
| EP4146205A4 (en) | 2020-05-05 | 2024-05-29 | Nuvalent, Inc. | HETEROAROMATIC MACROCYCLIC ETHERS AS CHEMOTHERAPEUTIC AGENTS |
| CN112724077B (zh) * | 2020-12-29 | 2023-07-11 | 武汉利昌医药科技有限公司 | 一种劳拉替尼中间体的合成方法 |
| CN113292496B (zh) * | 2021-05-17 | 2023-03-10 | 安徽联创生物医药股份有限公司 | 一种劳拉替尼中间体的合成方法 |
| CN118234725A (zh) | 2021-10-01 | 2024-06-21 | 纽威伦特公司 | 杂芳族大环醚化合物的固体形式、药物组合物及制备 |
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| CA2796967C (en) | 2010-05-04 | 2015-12-01 | Pfizer Inc. | Heterocyclic derivatives as alk inhibitors |
| AP2014007881A0 (en) | 2012-03-06 | 2014-08-31 | Pfizer | Macrocyclic derivatives for the treatment of proliferative diseases |
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2014
- 2014-06-17 WO PCT/IB2014/062296 patent/WO2014207606A1/en not_active Ceased
- 2014-06-17 ES ES14736454.1T patent/ES2656189T3/es active Active
- 2014-06-17 CA CA2916605A patent/CA2916605C/en active Active
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- 2014-06-26 AR ARP140102433A patent/AR096759A1/es unknown
- 2014-06-27 TW TW103122400A patent/TW201504246A/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US9637500B2 (en) | 2017-05-02 |
| JP2015010091A (ja) | 2015-01-19 |
| CA2916605C (en) | 2018-04-24 |
| AR096759A1 (es) | 2016-02-03 |
| CA2916605A1 (en) | 2014-12-31 |
| TW201504246A (zh) | 2015-02-01 |
| EP3013835B1 (en) | 2017-12-13 |
| EP3013835A1 (en) | 2016-05-04 |
| WO2014207606A1 (en) | 2014-12-31 |
| US20160115178A1 (en) | 2016-04-28 |
| JP6110817B2 (ja) | 2017-04-05 |
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