JP6110817B2 - 大環状キナーゼ阻害剤の固体形態 - Google Patents

大環状キナーゼ阻害剤の固体形態 Download PDF

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JP6110817B2
JP6110817B2 JP2014124999A JP2014124999A JP6110817B2 JP 6110817 B2 JP6110817 B2 JP 6110817B2 JP 2014124999 A JP2014124999 A JP 2014124999A JP 2014124999 A JP2014124999 A JP 2014124999A JP 6110817 B2 JP6110817 B2 JP 6110817B2
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value
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JP2015010091A (ja
JP2015010091A5 (cg-RX-API-DMAC7.html
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ジェームス ジェンセン アンドリュー
ジェームス ジェンセン アンドリュー
ルスラ スマン
ルスラ スマン
フランシス リチャードソン ポール
フランシス リチャードソン ポール
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ファイザー・インク
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP2014124999A 2013-06-28 2014-06-18 大環状キナーゼ阻害剤の固体形態 Expired - Fee Related JP6110817B2 (ja)

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US201361840703P 2013-06-28 2013-06-28
US61/840,703 2013-06-28

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JP2015010091A JP2015010091A (ja) 2015-01-19
JP2015010091A5 JP2015010091A5 (cg-RX-API-DMAC7.html) 2016-08-04
JP6110817B2 true JP6110817B2 (ja) 2017-04-05

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JP2014124999A Expired - Fee Related JP6110817B2 (ja) 2013-06-28 2014-06-18 大環状キナーゼ阻害剤の固体形態

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US (1) US9637500B2 (cg-RX-API-DMAC7.html)
EP (1) EP3013835B1 (cg-RX-API-DMAC7.html)
JP (1) JP6110817B2 (cg-RX-API-DMAC7.html)
AR (1) AR096759A1 (cg-RX-API-DMAC7.html)
CA (1) CA2916605C (cg-RX-API-DMAC7.html)
ES (1) ES2656189T3 (cg-RX-API-DMAC7.html)
TW (1) TW201504246A (cg-RX-API-DMAC7.html)
WO (1) WO2014207606A1 (cg-RX-API-DMAC7.html)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016026423A1 (en) * 2014-08-20 2016-02-25 Teligene Ltd Substituted macrocycles useful as kinases inhibitors and methods of use thereof
JP6609308B2 (ja) * 2014-08-20 2019-11-20 テリジーン リミテッド キナーゼ阻害剤としての置換マクロサイクル
BR112017028604A2 (pt) * 2015-07-31 2018-09-04 Pfizer forma cristalina de base livre de lorlatinibe
US20180282415A1 (en) 2015-09-30 2018-10-04 Merck Patent Gmbh Combination of a PD-1 Axis Binding Antagonist and an ALK Inhibitor for Treating ALK-Negative Cancer
ES2812336T3 (es) 2016-03-03 2021-03-16 Shenzhen Targetrx Inc Macrocíclico y composición que comprende el mismo
ES2819676T3 (es) * 2016-04-08 2021-04-19 Pfizer Formas cristalinas de maleato de lorlatinib
HUE062926T2 (hu) * 2017-10-10 2023-12-28 Pfizer Lorlatinib mint szabad bázis hidrátjának kristályos formája
US11179412B2 (en) 2017-12-04 2021-11-23 University of Pittsburgh—of the Commonwealth System of Higher Education Methods of treating conditions involving elevated inflammatory response
US20210163498A1 (en) 2018-04-23 2021-06-03 Pliva Hrvatska D.O.O. Solid state forms of lorlatinib and their preparation
WO2020108522A1 (zh) * 2018-11-28 2020-06-04 深圳市塔吉瑞生物医药有限公司 一种氘代大环化合物的制备方法
CN109651398B (zh) * 2019-01-25 2021-07-30 安庆多辉生物科技有限公司 一种合成劳拉替尼的溴代物中间体及催化合成劳拉替尼的方法
EP3999514A1 (en) 2019-07-18 2022-05-25 Pliva Hrvatska D.O.O. Crystalline lorlatinib : fumaric acid and solid state form thereof
CN112321604A (zh) * 2019-08-05 2021-02-05 华东理工大学 大环类jak2抑制剂及其应用
CN110483551B (zh) * 2019-08-30 2021-10-22 北京赛思源生物医药技术有限公司 一种劳拉替尼游离碱的晶体
WO2021069571A1 (en) 2019-10-10 2021-04-15 Sandoz Ag Polymorph of lorlatinib
CN112824417A (zh) * 2019-11-21 2021-05-21 上海天慈国际药业有限公司 一种劳拉替尼的制备方法
US20230117684A1 (en) 2020-03-05 2023-04-20 Pfizer Inc. Combination of an anaplastic lymphoma kinase inhibitor and a cyclin dependent kinase inhibitor
PE20230608A1 (es) 2020-05-05 2023-04-13 Nuvalent Inc Quimioterapicos de eter macrociclico heteroaromatico
EP4146205A4 (en) 2020-05-05 2024-05-29 Nuvalent, Inc. HETEROAROMATIC MACROCYCLIC ETHERS AS CHEMOTHERAPEUTIC AGENTS
CN112724077B (zh) * 2020-12-29 2023-07-11 武汉利昌医药科技有限公司 一种劳拉替尼中间体的合成方法
CN113292496B (zh) * 2021-05-17 2023-03-10 安徽联创生物医药股份有限公司 一种劳拉替尼中间体的合成方法
CN118234725A (zh) 2021-10-01 2024-06-21 纽威伦特公司 杂芳族大环醚化合物的固体形式、药物组合物及制备

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2796967C (en) 2010-05-04 2015-12-01 Pfizer Inc. Heterocyclic derivatives as alk inhibitors
AP2014007881A0 (en) 2012-03-06 2014-08-31 Pfizer Macrocyclic derivatives for the treatment of proliferative diseases

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Publication number Publication date
US9637500B2 (en) 2017-05-02
JP2015010091A (ja) 2015-01-19
CA2916605C (en) 2018-04-24
AR096759A1 (es) 2016-02-03
CA2916605A1 (en) 2014-12-31
TW201504246A (zh) 2015-02-01
EP3013835B1 (en) 2017-12-13
EP3013835A1 (en) 2016-05-04
WO2014207606A1 (en) 2014-12-31
US20160115178A1 (en) 2016-04-28
ES2656189T3 (es) 2018-02-26

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