ES2644082T3 - 2-alquil-1-oxo-n-fenil-3-heteroaril-1,2,3,4-tetrahidroisoquinolina-4-carboxamidas sustituidas para tratamientos antipalúdicos - Google Patents
2-alquil-1-oxo-n-fenil-3-heteroaril-1,2,3,4-tetrahidroisoquinolina-4-carboxamidas sustituidas para tratamientos antipalúdicos Download PDFInfo
- Publication number
- ES2644082T3 ES2644082T3 ES12772470.6T ES12772470T ES2644082T3 ES 2644082 T3 ES2644082 T3 ES 2644082T3 ES 12772470 T ES12772470 T ES 12772470T ES 2644082 T3 ES2644082 T3 ES 2644082T3
- Authority
- ES
- Spain
- Prior art keywords
- oxo
- tetrahydroisoquinoline
- carboxamide
- pyrazol
- isobutyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Tropical Medicine & Parasitology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161527594P | 2011-08-25 | 2011-08-25 | |
| US201161527594P | 2011-08-25 | ||
| PCT/IB2012/054305 WO2013027196A1 (en) | 2011-08-25 | 2012-08-24 | Substituted 2-alkyl-1-oxo-n-phenyl-3-heteroaryl-1,2,3,4- tetrahydroisoquinoline-4-carboxamides for antimalarial therapies |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2644082T3 true ES2644082T3 (es) | 2017-11-27 |
Family
ID=47018313
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES12772470.6T Active ES2644082T3 (es) | 2011-08-25 | 2012-08-24 | 2-alquil-1-oxo-n-fenil-3-heteroaril-1,2,3,4-tetrahidroisoquinolina-4-carboxamidas sustituidas para tratamientos antipalúdicos |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US9416124B2 (enExample) |
| EP (1) | EP2748147B1 (enExample) |
| JP (1) | JP6035334B2 (enExample) |
| CN (1) | CN103930404B (enExample) |
| BR (1) | BR112014004437B1 (enExample) |
| CA (1) | CA2846507C (enExample) |
| CY (1) | CY1119748T1 (enExample) |
| DK (1) | DK2748147T3 (enExample) |
| ES (1) | ES2644082T3 (enExample) |
| HR (1) | HRP20171567T1 (enExample) |
| HU (1) | HUE034721T2 (enExample) |
| LT (1) | LT2748147T (enExample) |
| ME (1) | ME02908B (enExample) |
| PL (1) | PL2748147T3 (enExample) |
| PT (1) | PT2748147T (enExample) |
| RS (1) | RS56544B1 (enExample) |
| SI (1) | SI2748147T1 (enExample) |
| SM (1) | SMT201700528T1 (enExample) |
| WO (1) | WO2013027196A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111886225A (zh) * | 2017-08-21 | 2020-11-03 | 纳维根公司 | Arf6抑制剂及相关方法 |
| EP3892332A1 (en) * | 2020-04-09 | 2021-10-13 | University Of Kentucky Research Foundation | New anti-malarial agents |
| MX2023012143A (es) | 2021-04-15 | 2024-01-11 | Rdp Pharma Ag | Derivados de isoquinolina para usarse como agentes antivirales y antitumorales. |
| EP4074314A1 (en) | 2021-04-15 | 2022-10-19 | Valdospan GmbH | Isoquinoline derivatives for use as antiviral and antitumour agents |
| AU2023363824A1 (en) | 2022-10-17 | 2025-04-17 | Rdp Pharma Ag | Isoquinoline derivatives as protein degraders, e7 degraders, antivirals, tumor therapeutics and immune suppressives |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5409938A (en) * | 1994-02-14 | 1995-04-25 | The United States Of America As Represented By The Secretary, Department Of Health And Human Services | Antimalarial korupensamines and pharmaceutical compositions and medical uses thereof |
| US5639761A (en) | 1994-02-14 | 1997-06-17 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Antimalarial naphthylisoquinoline alkaloids and pharmaceutical compositions and medical uses thereof |
| US6921762B2 (en) * | 2001-11-16 | 2005-07-26 | Amgen Inc. | Substituted indolizine-like compounds and methods of use |
| US20050124614A1 (en) | 2002-07-03 | 2005-06-09 | Axys Pharmaceuticals, Inc. | 3,4-Dihydroisoquinolin-1-one derivatives as inducers of apoptosis |
| DE10237722A1 (de) * | 2002-08-17 | 2004-08-19 | Aventis Pharma Deutschland Gmbh | Indol- oder Benzimidazolderivate zur Modulation der IKappaB-Kinase |
| DE10312963A1 (de) | 2003-03-24 | 2004-10-07 | Aventis Pharma Deutschland Gmbh | Substituierte 4-Phenyltetrahydroisochinoline, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament, sowie sie enthaltendes Medikament |
| PE20061351A1 (es) * | 2005-03-25 | 2007-01-14 | Glaxo Group Ltd | COMPUESTOS 8H-PIRIDO[2,3-d]PIRIMIDIN-7-ONA 2,4,8-TRISUSTITUIDOS COMO INHIBIDORES DE LA QUINASA CSBP/RK/p38 |
| RU2302417C1 (ru) * | 2006-03-14 | 2007-07-10 | Иващенко Андрей Александрович | 1-оксо-3-(1н-индол-3-ил)-1,2,3,4-тетрагидроизохинолины, способы их получения, комбинаторная библиотека и фокусированная библиотека |
| EP2282996A1 (en) * | 2008-05-19 | 2011-02-16 | Actelion Pharmaceuticals Ltd. | Tetrahydroisoquinolines as antimalarial agents |
| GB0820856D0 (en) | 2008-11-14 | 2008-12-24 | Univ Leuven Kath | Novel inhibitors of flavivirus replication |
-
2012
- 2012-08-24 DK DK12772470.6T patent/DK2748147T3/da active
- 2012-08-24 CA CA2846507A patent/CA2846507C/en active Active
- 2012-08-24 PT PT127724706T patent/PT2748147T/pt unknown
- 2012-08-24 ME MEP-2017-250A patent/ME02908B/me unknown
- 2012-08-24 ES ES12772470.6T patent/ES2644082T3/es active Active
- 2012-08-24 LT LTEP12772470.6T patent/LT2748147T/lt unknown
- 2012-08-24 SM SM20170528T patent/SMT201700528T1/it unknown
- 2012-08-24 JP JP2014526594A patent/JP6035334B2/ja not_active Expired - Fee Related
- 2012-08-24 BR BR112014004437-6A patent/BR112014004437B1/pt active IP Right Grant
- 2012-08-24 CN CN201280041436.4A patent/CN103930404B/zh active Active
- 2012-08-24 SI SI201231080T patent/SI2748147T1/sl unknown
- 2012-08-24 HR HRP20171567TT patent/HRP20171567T1/hr unknown
- 2012-08-24 PL PL12772470T patent/PL2748147T3/pl unknown
- 2012-08-24 RS RS20171090A patent/RS56544B1/sr unknown
- 2012-08-24 EP EP12772470.6A patent/EP2748147B1/en active Active
- 2012-08-24 WO PCT/IB2012/054305 patent/WO2013027196A1/en not_active Ceased
- 2012-08-24 HU HUE12772470A patent/HUE034721T2/hu unknown
- 2012-08-24 US US14/240,994 patent/US9416124B2/en active Active
-
2017
- 2017-10-20 CY CY20171101092T patent/CY1119748T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HUE034721T2 (hu) | 2018-02-28 |
| EP2748147A1 (en) | 2014-07-02 |
| BR112014004437B1 (pt) | 2021-12-14 |
| CN103930404B (zh) | 2016-08-24 |
| HRP20171567T1 (hr) | 2017-11-17 |
| WO2013027196A1 (en) | 2013-02-28 |
| SI2748147T1 (sl) | 2017-11-30 |
| PL2748147T3 (pl) | 2018-01-31 |
| US20140235593A1 (en) | 2014-08-21 |
| CA2846507A1 (en) | 2013-02-28 |
| PT2748147T (pt) | 2017-11-14 |
| JP2014524464A (ja) | 2014-09-22 |
| CN103930404A (zh) | 2014-07-16 |
| SMT201700528T1 (it) | 2018-01-11 |
| RS56544B1 (sr) | 2018-02-28 |
| BR112014004437A8 (pt) | 2018-01-23 |
| CA2846507C (en) | 2020-03-10 |
| JP6035334B2 (ja) | 2016-11-30 |
| US9416124B2 (en) | 2016-08-16 |
| HK1199443A1 (en) | 2015-07-03 |
| CY1119748T1 (el) | 2018-06-27 |
| BR112014004437A2 (pt) | 2017-03-28 |
| LT2748147T (lt) | 2017-10-25 |
| ME02908B (me) | 2018-10-20 |
| WO2013027196A9 (en) | 2013-04-18 |
| DK2748147T3 (da) | 2017-11-13 |
| EP2748147B1 (en) | 2017-08-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US11396495B2 (en) | Amine compound for inhibiting SSAO/VAP-1 and use thereof | |
| EA026654B1 (ru) | Производные тиазола | |
| TW201629065A (zh) | 三唑并嘧啶化合物及其用途 | |
| NZ617987A (en) | Fused heterocyclic compounds as sodium channel modulators | |
| EA023364B1 (ru) | Производные пиридина и пиразина | |
| TWI688565B (zh) | 萘啶二酮（ｎａｐｈｔｈｙｒｉｄｉｎｅｄｉｏｎｅ）衍生物 | |
| US11992487B2 (en) | Quinolines that modulate SERCA and their use for treating disease | |
| CN114149432A (zh) | 用于癌症治疗的双重clk/cdk1抑制剂 | |
| ES2740428T3 (es) | Dihidropirimidinonas bicíclicas sustituidas y su uso como inhibidores de la actividad de la elastasa de neutrófilos | |
| US11827626B2 (en) | Quinolines that modulate SERCA and their use for treating disease | |
| JP6035334B2 (ja) | 抗マラリア療法のための置換２−アルキル−１−オキソ−ｎ−フェニル−３−ヘテロアリール−１，２，３，４−テトラヒドロイソキノリン−４−カルボキサミド | |
| US10772881B2 (en) | Quinolines that modulate SERCA and their use for treating disease | |
| US10336765B2 (en) | Dihydropyranopyrimidinone derivatives, and use thereof | |
| US20230310445A1 (en) | Lox enzyme inhibiting methods and compositions | |
| JP7863272B2 (ja) | フルオロアルコキシアルキレン－ジヒドロイミダゾ［５，１－ｄ］テトラジノン化合物および関連化合物ならびに医学的症状の治療におけるそれらの使用 | |
| US12016864B2 (en) | LOX enzyme inhibiting methods and compositions | |
| JP2026514636A (ja) | フルオロアルコキシアルキレン－ジヒドロイミダゾ［５，１－ｄ］テトラジノン化合物および関連化合物ならびに医学的症状の治療におけるそれらの使用 | |
| WO2024249604A2 (en) | Covalent inhibitors as anti-malarial agents | |
| HK1199443B (en) | Substituted 2-alkyl-1-oxo-n-phenyl-3-heteroaryl-1,2,3,4-tetrahyd roisoquinoline-4-carboxamides for antimalarial therapies | |
| KR20260047607A (ko) | 플루오로알콕시알킬렌-디히드로이미다조[5,1-d]테트라지논 화합물 및 관련 화합물 및 의학적 상태의 치료에서의 그의 용도 |