ES2639063T3 - Desinfectante tópico de yodo bajo en tensioactivo - Google Patents
Desinfectante tópico de yodo bajo en tensioactivo Download PDFInfo
- Publication number
- ES2639063T3 ES2639063T3 ES12765400.2T ES12765400T ES2639063T3 ES 2639063 T3 ES2639063 T3 ES 2639063T3 ES 12765400 T ES12765400 T ES 12765400T ES 2639063 T3 ES2639063 T3 ES 2639063T3
- Authority
- ES
- Spain
- Prior art keywords
- iodine
- weight
- composition
- lanolin
- glycerin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000011630 iodine Substances 0.000 title claims abstract description 154
- 229910052740 iodine Inorganic materials 0.000 title claims abstract description 154
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 title claims abstract description 131
- 239000004094 surface-active agent Substances 0.000 title claims abstract description 17
- 239000000645 desinfectant Substances 0.000 title description 6
- 230000000699 topical effect Effects 0.000 title description 5
- 239000000203 mixture Substances 0.000 claims abstract description 165
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 86
- 235000011187 glycerol Nutrition 0.000 claims abstract description 43
- 239000004166 Lanolin Substances 0.000 claims abstract description 39
- 229940039717 lanolin Drugs 0.000 claims abstract description 39
- 235000019388 lanolin Nutrition 0.000 claims abstract description 39
- 239000003974 emollient agent Substances 0.000 claims abstract description 31
- 239000002562 thickening agent Substances 0.000 claims abstract description 28
- 230000002070 germicidal effect Effects 0.000 claims abstract description 27
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 claims abstract description 24
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims abstract description 21
- 230000000536 complexating effect Effects 0.000 claims abstract description 10
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims abstract description 7
- 229920000642 polymer Polymers 0.000 claims abstract description 7
- 239000000600 sorbitol Substances 0.000 claims abstract description 7
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims abstract description 6
- 239000002202 Polyethylene glycol Substances 0.000 claims abstract description 4
- 239000002253 acid Substances 0.000 claims abstract description 4
- 150000007513 acids Chemical class 0.000 claims abstract description 4
- 229940099367 lanolin alcohols Drugs 0.000 claims abstract description 4
- 229920001223 polyethylene glycol Polymers 0.000 claims abstract description 4
- 229920001285 xanthan gum Polymers 0.000 claims description 39
- 239000000230 xanthan gum Substances 0.000 claims description 38
- 235000010493 xanthan gum Nutrition 0.000 claims description 38
- 229940082509 xanthan gum Drugs 0.000 claims description 38
- 229920000084 Gum arabic Polymers 0.000 claims description 17
- 241000978776 Senegalia senegal Species 0.000 claims description 17
- 235000010489 acacia gum Nutrition 0.000 claims description 17
- 239000000205 acacia gum Substances 0.000 claims description 17
- 210000002445 nipple Anatomy 0.000 claims description 16
- 239000002245 particle Substances 0.000 claims description 12
- 241001465754 Metazoa Species 0.000 claims description 8
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 7
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 7
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 7
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims description 7
- 241000283690 Bos taurus Species 0.000 claims description 6
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims description 6
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims description 6
- 238000010790 dilution Methods 0.000 claims description 5
- 239000012895 dilution Substances 0.000 claims description 5
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims description 4
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 3
- 229920000615 alginic acid Polymers 0.000 claims description 2
- 239000011734 sodium Substances 0.000 claims description 2
- 229910052708 sodium Inorganic materials 0.000 claims description 2
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims 1
- 229940072056 alginate Drugs 0.000 claims 1
- 235000010443 alginic acid Nutrition 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 235000015424 sodium Nutrition 0.000 claims 1
- 229940023564 hydroxylated lanolin Drugs 0.000 abstract description 2
- 238000009472 formulation Methods 0.000 description 70
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 35
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 33
- 239000004615 ingredient Substances 0.000 description 23
- 239000000243 solution Substances 0.000 description 13
- 239000008139 complexing agent Substances 0.000 description 12
- 239000002244 precipitate Substances 0.000 description 12
- XMBWDFGMSWQBCA-UHFFFAOYSA-M iodide Chemical compound [I-] XMBWDFGMSWQBCA-UHFFFAOYSA-M 0.000 description 11
- 229940006461 iodide ion Drugs 0.000 description 11
- FVAUCKIRQBBSSJ-UHFFFAOYSA-M sodium iodide Chemical compound [Na+].[I-] FVAUCKIRQBBSSJ-UHFFFAOYSA-M 0.000 description 11
- YASYEJJMZJALEJ-UHFFFAOYSA-N Citric acid monohydrate Chemical compound O.OC(=O)CC(O)(C(O)=O)CC(O)=O YASYEJJMZJALEJ-UHFFFAOYSA-N 0.000 description 9
- 229960002303 citric acid monohydrate Drugs 0.000 description 9
- 230000000694 effects Effects 0.000 description 9
- 239000011550 stock solution Substances 0.000 description 9
- 238000012360 testing method Methods 0.000 description 9
- 239000000080 wetting agent Substances 0.000 description 9
- 238000002296 dynamic light scattering Methods 0.000 description 8
- 239000000872 buffer Substances 0.000 description 7
- 239000012141 concentrate Substances 0.000 description 7
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
- 239000000839 emulsion Substances 0.000 description 6
- 238000006116 polymerization reaction Methods 0.000 description 6
- 239000003795 chemical substances by application Substances 0.000 description 5
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 description 5
- APSBXTVYXVQYAB-UHFFFAOYSA-M sodium docusate Chemical compound [Na+].CCCCC(CC)COC(=O)CC(S([O-])(=O)=O)C(=O)OCC(CC)CCCC APSBXTVYXVQYAB-UHFFFAOYSA-M 0.000 description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- NALMPLUMOWIVJC-UHFFFAOYSA-N n,n,4-trimethylbenzeneamine oxide Chemical compound CC1=CC=C([N+](C)(C)[O-])C=C1 NALMPLUMOWIVJC-UHFFFAOYSA-N 0.000 description 4
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 4
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 4
- 239000011697 sodium iodate Substances 0.000 description 4
- 235000015281 sodium iodate Nutrition 0.000 description 4
- 229940032753 sodium iodate Drugs 0.000 description 4
- 235000009518 sodium iodide Nutrition 0.000 description 4
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 3
- 235000010418 carrageenan Nutrition 0.000 description 3
- 239000000679 carrageenan Substances 0.000 description 3
- 229920001525 carrageenan Polymers 0.000 description 3
- 229940113118 carrageenan Drugs 0.000 description 3
- 239000006185 dispersion Substances 0.000 description 3
- ICIWUVCWSCSTAQ-UHFFFAOYSA-M iodate Chemical compound [O-]I(=O)=O ICIWUVCWSCSTAQ-UHFFFAOYSA-M 0.000 description 3
- -1 isopropyl alcohol Chemical class 0.000 description 3
- NLKNQRATVPKPDG-UHFFFAOYSA-M potassium iodide Chemical compound [K+].[I-] NLKNQRATVPKPDG-UHFFFAOYSA-M 0.000 description 3
- 239000012088 reference solution Substances 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 3
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 229960004106 citric acid Drugs 0.000 description 2
- 239000000084 colloidal system Substances 0.000 description 2
- 235000019329 dioctyl sodium sulphosuccinate Nutrition 0.000 description 2
- YHAIUSTWZPMYGG-UHFFFAOYSA-L disodium;2,2-dioctyl-3-sulfobutanedioate Chemical compound [Na+].[Na+].CCCCCCCCC(C([O-])=O)(C(C([O-])=O)S(O)(=O)=O)CCCCCCCC YHAIUSTWZPMYGG-UHFFFAOYSA-L 0.000 description 2
- 229940005633 iodate ion Drugs 0.000 description 2
- 230000007794 irritation Effects 0.000 description 2
- 208000004396 mastitis Diseases 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 230000003287 optical effect Effects 0.000 description 2
- 235000010413 sodium alginate Nutrition 0.000 description 2
- 239000000661 sodium alginate Substances 0.000 description 2
- 229940005550 sodium alginate Drugs 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 230000007928 solubilization Effects 0.000 description 2
- 238000005063 solubilization Methods 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 230000008719 thickening Effects 0.000 description 2
- IEORSVTYLWZQJQ-UHFFFAOYSA-N 2-(2-nonylphenoxy)ethanol Chemical compound CCCCCCCCCC1=CC=CC=C1OCCO IEORSVTYLWZQJQ-UHFFFAOYSA-N 0.000 description 1
- GJCOSYZMQJWQCA-UHFFFAOYSA-N 9H-xanthene Chemical compound C1=CC=C2CC3=CC=CC=C3OC2=C1 GJCOSYZMQJWQCA-UHFFFAOYSA-N 0.000 description 1
- 229920002065 Pluronic® P 105 Polymers 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
- ULUAUXLGCMPNKK-UHFFFAOYSA-N Sulfobutanedioic acid Chemical class OC(=O)CC(C(O)=O)S(O)(=O)=O ULUAUXLGCMPNKK-UHFFFAOYSA-N 0.000 description 1
- KZENBFUSKMWCJF-UHFFFAOYSA-N [5-[5-[5-(hydroxymethyl)-2-thiophenyl]-2-furanyl]-2-thiophenyl]methanol Chemical compound S1C(CO)=CC=C1C1=CC=C(C=2SC(CO)=CC=2)O1 KZENBFUSKMWCJF-UHFFFAOYSA-N 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 239000000443 aerosol Substances 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 150000008055 alkyl aryl sulfonates Chemical class 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 229940045714 alkyl sulfonate alkylating agent Drugs 0.000 description 1
- 150000008052 alkyl sulfonates Chemical class 0.000 description 1
- 239000013011 aqueous formulation Substances 0.000 description 1
- 125000005228 aryl sulfonate group Chemical group 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229940105329 carboxymethylcellulose Drugs 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 235000013365 dairy product Nutrition 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 239000003752 hydrotrope Substances 0.000 description 1
- 229940071826 hydroxyethyl cellulose Drugs 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 229940035535 iodophors Drugs 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 229920000847 nonoxynol Polymers 0.000 description 1
- 239000003002 pH adjusting agent Substances 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 229920001983 poloxamer Polymers 0.000 description 1
- 229940069328 povidone Drugs 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- KCXFHTAICRTXLI-UHFFFAOYSA-N propane-1-sulfonic acid Chemical compound CCCS(O)(=O)=O KCXFHTAICRTXLI-UHFFFAOYSA-N 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000013517 stratification Methods 0.000 description 1
- 150000003871 sulfonates Chemical class 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
- A01N59/12—Iodine, e.g. iodophors; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/18—Iodine; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Inorganic Chemistry (AREA)
- Epidemiology (AREA)
- Environmental Sciences (AREA)
- Dentistry (AREA)
- Zoology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Wood Science & Technology (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dermatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
- Dispersion Chemistry (AREA)
- Toxicology (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161467874P | 2011-03-25 | 2011-03-25 | |
| US201161467874P | 2011-03-25 | ||
| PCT/US2012/030417 WO2012135055A2 (en) | 2011-03-25 | 2012-03-23 | Low surfactant iodine topical disinfectant |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2639063T3 true ES2639063T3 (es) | 2017-10-25 |
Family
ID=46932258
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES12765400.2T Active ES2639063T3 (es) | 2011-03-25 | 2012-03-23 | Desinfectante tópico de yodo bajo en tensioactivo |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US9302007B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2688410B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP6203172B2 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2639063T3 (cg-RX-API-DMAC7.html) |
| LT (1) | LT2688410T (cg-RX-API-DMAC7.html) |
| RU (1) | RU2590825C2 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2012135055A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9166959B2 (en) * | 2012-03-31 | 2015-10-20 | Intel Corporation | Secure communication using physical proximity |
| EP2799068A1 (en) * | 2013-05-01 | 2014-11-05 | National University of Ireland, Galway | Antimicrobial compositions and methods for their production |
| AU2015241297B2 (en) | 2014-03-31 | 2019-03-28 | Iotech International, Inc. | Stable compositions of uncomplexed iodine and methods of use |
| WO2018017645A1 (en) * | 2016-07-21 | 2018-01-25 | Iogen, Llc | Emollient topical disinfectants |
| EP4196094A4 (en) | 2020-08-13 | 2024-11-13 | I2Pure Corp. | High molecular iodine concentration compositions, pharmaceutical formulations, preparation and uses |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3728449A (en) * | 1972-05-01 | 1973-04-17 | West Laboratories Inc | Germicidal iodine compositions for application to skin tissue including teats of milk animals |
| US4125602A (en) * | 1974-12-02 | 1978-11-14 | Ciba-Geigy Corporation | Process for the production of iodophors |
| US4271149A (en) | 1979-09-21 | 1981-06-02 | West Agro-Chemical, Inc. | Germicidal iodine compositions with enhanced iodine stability |
| EP0094219A1 (en) * | 1982-05-07 | 1983-11-16 | Diversey Corporation | Germicidal iodine compositions |
| US5302392A (en) * | 1990-08-20 | 1994-04-12 | Becton, Dickinson And Company | Polyurethane sponge having rapid iodine release |
| US5616348A (en) * | 1992-09-18 | 1997-04-01 | West Agro, Inc. | Germicidal detergent-iodine compositions including polyvinyl pyrrolidone and compatible nonionic surfactant complexors |
| MX9305535A (es) * | 1992-09-18 | 1994-03-31 | West Agro Inc | Composiciones y concentrados germicidas a base de yodo-detergente, acuosos y estables. |
| US5853768A (en) * | 1995-03-01 | 1998-12-29 | Altadonna; James | Topical preparation and method for pain relief |
| US5607699A (en) * | 1995-05-12 | 1997-03-04 | Becton Dickinson And Company | Non-aqueous emiollient iodophor formulations |
| US5643608A (en) * | 1996-03-01 | 1997-07-01 | West Agro, Inc. | Low pH germicidal iodine compositions having enhanced stability |
| US6153229A (en) | 1997-04-02 | 2000-11-28 | West Agro, Inc. | Stable glycerine iodine concentrate compositions |
| US5885620A (en) * | 1997-04-02 | 1999-03-23 | West Agro, Inc. | Stable glycerin iodine concentrate compositions |
| US6436444B1 (en) * | 1997-09-26 | 2002-08-20 | Ecolab Inc. | Acidic aqueous chlorite teat dip providing shelf life sanitizing capacity and tissue protection |
| US6395289B1 (en) * | 1998-06-29 | 2002-05-28 | Hydromer, Inc. | Hydrophilic polymer blends used to prevent cow skin infections |
| US6107344A (en) | 1999-02-16 | 2000-08-22 | Webco Chemical Corporation | Aqueous germicidal film forming composition for applying to teats of dairy cows |
| US20010036482A1 (en) * | 1999-10-15 | 2001-11-01 | Dale Lind Fredell | Antimicrobial compositions for mastitis control |
| US20030235560A1 (en) * | 2000-05-12 | 2003-12-25 | Harrison Richard J. | Mastitis prevention |
| US6663902B1 (en) * | 2000-09-19 | 2003-12-16 | Ecolab Inc. | Method and composition for the generation of chlorine dioxide using Iodo-Compounds, and methods of use |
| US6586477B1 (en) * | 2002-10-31 | 2003-07-01 | Sporicidin Company | Teat dip composition containing phenol and phenate |
| US20040091553A1 (en) | 2002-11-12 | 2004-05-13 | West Agro, Inc | Composition and method for mammary disinfection during winter conditions |
| US7182948B2 (en) * | 2003-08-04 | 2007-02-27 | Ko Manufacturing, Inc. | Topical veterinary compositions and methods for the treatment and prevention of infection |
| RU2240780C1 (ru) * | 2003-09-05 | 2004-11-27 | Фаизов Тагир Хадиевич | Бактерицидное и противовоспалительное средство в виде мази |
| WO2005048709A1 (en) * | 2003-11-05 | 2005-06-02 | Dsm Ip Assets B.V. | Use of panthenol in teat dip/spray preparations |
| US7845351B2 (en) * | 2005-08-31 | 2010-12-07 | Kimberly-Clark Worldwide Inc. | Germicidal face mask |
| US9511040B2 (en) * | 2007-06-20 | 2016-12-06 | The Trustees Of Columbia University In The City Of New York | Skin and surface disinfectant compositions containing botanicals |
| EP2773201B1 (en) * | 2011-10-31 | 2017-12-06 | Microdermis Corporation | Improved compositions comprising povidone-iodine complex |
-
2012
- 2012-03-23 RU RU2013147613/13A patent/RU2590825C2/ru active
- 2012-03-23 WO PCT/US2012/030417 patent/WO2012135055A2/en not_active Ceased
- 2012-03-23 ES ES12765400.2T patent/ES2639063T3/es active Active
- 2012-03-23 EP EP12765400.2A patent/EP2688410B1/en active Active
- 2012-03-23 LT LTEP12765400.2T patent/LT2688410T/lt unknown
- 2012-03-23 JP JP2014501284A patent/JP6203172B2/ja active Active
- 2012-03-23 US US14/005,725 patent/US9302007B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP2014510109A (ja) | 2014-04-24 |
| WO2012135055A9 (en) | 2013-02-21 |
| US20140010881A1 (en) | 2014-01-09 |
| JP6203172B2 (ja) | 2017-09-27 |
| LT2688410T (lt) | 2017-10-10 |
| EP2688410B1 (en) | 2017-08-09 |
| US9302007B2 (en) | 2016-04-05 |
| EP2688410A2 (en) | 2014-01-29 |
| RU2013147613A (ru) | 2015-04-27 |
| EP2688410A4 (en) | 2014-11-12 |
| WO2012135055A3 (en) | 2012-12-27 |
| RU2590825C2 (ru) | 2016-07-10 |
| WO2012135055A2 (en) | 2012-10-04 |
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