ES2627321T3 - Una lisina de bacteriófago quimérica con actividad contra bacterias estafilocócicas - Google Patents
Una lisina de bacteriófago quimérica con actividad contra bacterias estafilocócicas Download PDFInfo
- Publication number
- ES2627321T3 ES2627321T3 ES09774409.8T ES09774409T ES2627321T3 ES 2627321 T3 ES2627321 T3 ES 2627321T3 ES 09774409 T ES09774409 T ES 09774409T ES 2627321 T3 ES2627321 T3 ES 2627321T3
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2795/00—Bacteriophages
- C12N2795/00011—Details
- C12N2795/10011—Details dsDNA Bacteriophages
- C12N2795/10311—Siphoviridae
- C12N2795/10322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Agronomy & Crop Science (AREA)
- Environmental Sciences (AREA)
- Dentistry (AREA)
- Plant Pathology (AREA)
- Pest Control & Pesticides (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7827708P | 2008-07-03 | 2008-07-03 | |
| US78277P | 2008-07-03 | ||
| PCT/US2009/049349 WO2010002959A2 (en) | 2008-07-03 | 2009-07-01 | A chimeric bacteriophage lysin with activity against staphylococci bacteria |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2627321T3 true ES2627321T3 (es) | 2017-07-27 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES09774409.8T Active ES2627321T3 (es) | 2008-07-03 | 2009-07-01 | Una lisina de bacteriófago quimérica con actividad contra bacterias estafilocócicas |
Country Status (8)
| Country | Link |
|---|---|
| US (4) | US8840900B2 (enExample) |
| EP (2) | EP2307557B1 (enExample) |
| JP (2) | JP5758291B2 (enExample) |
| AU (2) | AU2009266982B2 (enExample) |
| CA (2) | CA2729160C (enExample) |
| ES (1) | ES2627321T3 (enExample) |
| HK (1) | HK1248722A1 (enExample) |
| WO (1) | WO2010002959A2 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008018854A2 (en) | 2005-06-06 | 2008-02-14 | The Rockefeller University | Bactiophage lysins for bacillus anthracis |
| ES2357626T3 (es) | 2005-08-24 | 2011-04-28 | The Rockefeller University | Lisinas mutantes de ply-gbs. |
| US9034322B2 (en) | 2011-04-21 | 2015-05-19 | The Rockefeller University | Streptococcus bacteriophage lysins for detection and treatment of gram positive bacteria |
| DK2705144T4 (da) | 2011-05-04 | 2019-10-21 | Micreos Human Health Bv | Polypeptid |
| WO2013052643A1 (en) | 2011-10-05 | 2013-04-11 | The Rockefeller University | Dimeric bacteriophage lysins |
| ES2729123T3 (es) * | 2012-05-09 | 2019-10-30 | Contrafect Corp | Rotura de biopelícula con lisina plyss2 |
| MX389127B (es) * | 2012-05-09 | 2025-03-19 | Contrafect Corp | Lisina de bacteriófago y combinaciones de antibióticos contra bacterias gram positivas. |
| CN103122347B (zh) * | 2013-02-01 | 2015-04-22 | 中国科学院武汉病毒研究所 | 一种杀灭葡萄球菌的裂解酶及其应用 |
| ES2525954B1 (es) * | 2013-05-28 | 2015-10-23 | Consejo Superior De Investigaciones Científicas (Csic) | Enzibióticos bactericidas mejorados frente a neumococo y otras bacterias |
| CN104762285B (zh) * | 2015-04-23 | 2017-10-27 | 武汉菲吉乐科生物科技有限公司 | 一种自内裂解大肠杆菌的裂解酶及其应用 |
| CN104805066B (zh) * | 2015-05-18 | 2018-04-24 | 武汉菲吉乐科生物科技有限公司 | 一种葡萄球菌裂解酶及其应用 |
| RU2754667C2 (ru) | 2016-05-12 | 2021-09-06 | Контрафект Корпорейшн | Способ микроразбавления в жидкой среде для оценки и определения минимальной ингибирующей концентрации антибактериальных полипептидов |
| JP2021527699A (ja) * | 2018-06-22 | 2021-10-14 | コントラフェクト コーポレイション | 溶解素及びその誘導体がスタフィロコッカス・アウレウス及びグラム陽性細菌を抗生物質に再感作する |
| CN113038960A (zh) * | 2018-08-10 | 2021-06-25 | 明治制果药业株式会社 | 噬菌体剂 |
| CN109666667A (zh) * | 2019-01-22 | 2019-04-23 | 上海交通大学 | 杀灭金黄色葡萄球菌的嵌合酶抗生素及其制备和应用 |
| WO2021084558A2 (en) * | 2019-10-31 | 2021-05-06 | Bactoclear Holdings Pte. Ltd | Chimeric proteins for selective lysis of bacteria |
| EP4114422A4 (en) * | 2020-03-06 | 2024-09-18 | Endolytix Technology, Inc. | Compositions and methods for the treatment of intracellular bacterial infections |
| CN115605587B (zh) * | 2020-03-11 | 2026-02-13 | 特卢姆治疗有限公司 | 新型重组溶素及其在治疗革兰氏阴性菌感染中的用途 |
| CN111808837A (zh) * | 2020-07-17 | 2020-10-23 | 青岛诺安百特生物技术有限公司 | 一种金黄色葡萄球菌噬菌体裂解酶及其制备方法和应用 |
| CN115820616A (zh) * | 2022-07-22 | 2023-03-21 | 昆明理工大学 | 一种带荧光标记的噬菌体裂解酶及其应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997008553A1 (en) * | 1995-08-22 | 1997-03-06 | The Regents Of The University Of California | Targeting of proteins to the cell wall of gram-positive bacteria |
| US6056954A (en) * | 1997-10-31 | 2000-05-02 | New Horizons Diagnostics Corp | Use of bacterial phage associated lysing enzymers for the prophylactic and therapeutic treatment of various illnesses |
| US6703025B1 (en) * | 1998-08-31 | 2004-03-09 | Inhibitex, Inc. | Multicomponent vaccines |
| US20020127215A1 (en) * | 1999-09-14 | 2002-09-12 | Lawrence Loomis | Parenteral use of bacterial phage associated lysing enzymes for the therapeutic treatment of bacterial infections |
| GB0107661D0 (en) * | 2001-03-27 | 2001-05-16 | Chiron Spa | Staphylococcus aureus |
| US20040213765A1 (en) * | 2001-07-13 | 2004-10-28 | Vincent Fischetti | Use of bacterial phage associated lytic enzymes to prevent food poisoning |
| CN1643139A (zh) * | 2002-03-25 | 2005-07-20 | 沃里克大学 | 抗菌剂 |
| AU2003261782A1 (en) * | 2002-08-28 | 2004-03-19 | Techno Network Shikoku Co., Ltd. | Bacteriophages and remedies for bacterial infection |
| ES2357626T3 (es) * | 2005-08-24 | 2011-04-28 | The Rockefeller University | Lisinas mutantes de ply-gbs. |
| WO2009024327A2 (en) | 2007-08-22 | 2009-02-26 | Profos Ag | New proteins for use in human and animal staphylococcus infections |
| JP5732397B2 (ja) * | 2008-10-10 | 2015-06-10 | ルソメディカメンタ, エス.エー.Lusomedicamenta, S.A. | 抗菌性ファージペプチド及びその使用法 |
| EP3115054B1 (en) * | 2009-02-06 | 2019-11-20 | Technophage, Investigação E Desenvolvimento Em Biotecnologia, SA | Antibacterial phage, phage peptides and methods of use thereof |
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2009
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- 2009-07-01 EP EP09774409.8A patent/EP2307557B1/en active Active
- 2009-07-01 US US13/502,912 patent/US8840900B2/en active Active
- 2009-07-01 AU AU2009266982A patent/AU2009266982B2/en not_active Ceased
- 2009-07-01 WO PCT/US2009/049349 patent/WO2010002959A2/en not_active Ceased
- 2009-07-01 ES ES09774409.8T patent/ES2627321T3/es active Active
- 2009-07-01 CA CA2984933A patent/CA2984933C/en active Active
- 2009-07-01 JP JP2011516843A patent/JP5758291B2/ja not_active Expired - Fee Related
- 2009-07-01 EP EP17158578.9A patent/EP3263588A1/en not_active Withdrawn
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2014
- 2014-09-09 US US14/480,822 patent/US10053681B2/en active Active
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2015
- 2015-02-24 JP JP2015033626A patent/JP6169632B2/ja not_active Expired - Fee Related
- 2015-09-25 AU AU2015230807A patent/AU2015230807B2/en not_active Ceased
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2018
- 2018-06-27 HK HK18108284.8A patent/HK1248722A1/en unknown
- 2018-08-20 US US16/105,155 patent/US11015182B2/en active Active
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2021
- 2021-05-24 US US17/328,299 patent/US11827911B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP5758291B2 (ja) | 2015-08-05 |
| AU2009266982B2 (en) | 2015-06-25 |
| JP2015126738A (ja) | 2015-07-09 |
| JP2011526920A (ja) | 2011-10-20 |
| JP6169632B2 (ja) | 2017-07-26 |
| US20150064156A1 (en) | 2015-03-05 |
| US11827911B2 (en) | 2023-11-28 |
| US20190055533A1 (en) | 2019-02-21 |
| US20120258088A1 (en) | 2012-10-11 |
| AU2015230807B2 (en) | 2017-07-27 |
| EP2307557A2 (en) | 2011-04-13 |
| CA2729160A1 (en) | 2010-01-07 |
| US8840900B2 (en) | 2014-09-23 |
| AU2009266982A1 (en) | 2010-01-07 |
| EP2307557A4 (en) | 2012-04-11 |
| CA2984933A1 (en) | 2010-01-07 |
| US10053681B2 (en) | 2018-08-21 |
| US11015182B2 (en) | 2021-05-25 |
| EP2307557B1 (en) | 2017-03-01 |
| AU2015230807A1 (en) | 2015-10-15 |
| WO2010002959A3 (en) | 2010-05-06 |
| CA2984933C (en) | 2020-07-07 |
| US20210348146A1 (en) | 2021-11-11 |
| CA2729160C (en) | 2017-11-14 |
| EP3263588A1 (en) | 2018-01-03 |
| HK1248722A1 (en) | 2018-10-19 |
| WO2010002959A2 (en) | 2010-01-07 |
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