AU2009266982B2 - A chimeric bacteriophage lysin with activity against staphylococci bacteria - Google Patents

A chimeric bacteriophage lysin with activity against staphylococci bacteria Download PDF

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Publication number
AU2009266982B2
AU2009266982B2 AU2009266982A AU2009266982A AU2009266982B2 AU 2009266982 B2 AU2009266982 B2 AU 2009266982B2 AU 2009266982 A AU2009266982 A AU 2009266982A AU 2009266982 A AU2009266982 A AU 2009266982A AU 2009266982 B2 AU2009266982 B2 AU 2009266982B2
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AU
Australia
Prior art keywords
lysin
bacteriophage lysin
chimeric
chimeric bacteriophage
domain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2009266982A
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English (en)
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AU2009266982A1 (en
Inventor
Anu Daniel
Chad Euler
Vincent A. Fischetti
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Rockefeller University
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Rockefeller University
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Filing date
Publication date
Application filed by Rockefeller University filed Critical Rockefeller University
Publication of AU2009266982A1 publication Critical patent/AU2009266982A1/en
Application granted granted Critical
Publication of AU2009266982B2 publication Critical patent/AU2009266982B2/en
Priority to AU2015230807A priority Critical patent/AU2015230807B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2462—Lysozyme (3.2.1.17)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
    • A01N63/50—Isolated enzymes; Isolated proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/10011—Details dsDNA Bacteriophages
    • C12N2795/10311—Siphoviridae
    • C12N2795/10322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Agronomy & Crop Science (AREA)
  • Environmental Sciences (AREA)
  • Dentistry (AREA)
  • Plant Pathology (AREA)
  • Pest Control & Pesticides (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
AU2009266982A 2008-07-03 2009-07-01 A chimeric bacteriophage lysin with activity against staphylococci bacteria Ceased AU2009266982B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2015230807A AU2015230807B2 (en) 2008-07-03 2015-09-25 A chimeric bacteriophage lysin with activity against staphylococci bacteria

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US7827708P 2008-07-03 2008-07-03
US61/078,277 2008-07-03
PCT/US2009/049349 WO2010002959A2 (en) 2008-07-03 2009-07-01 A chimeric bacteriophage lysin with activity against staphylococci bacteria

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2015230807A Division AU2015230807B2 (en) 2008-07-03 2015-09-25 A chimeric bacteriophage lysin with activity against staphylococci bacteria

Publications (2)

Publication Number Publication Date
AU2009266982A1 AU2009266982A1 (en) 2010-01-07
AU2009266982B2 true AU2009266982B2 (en) 2015-06-25

Family

ID=41466590

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2009266982A Ceased AU2009266982B2 (en) 2008-07-03 2009-07-01 A chimeric bacteriophage lysin with activity against staphylococci bacteria
AU2015230807A Ceased AU2015230807B2 (en) 2008-07-03 2015-09-25 A chimeric bacteriophage lysin with activity against staphylococci bacteria

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2015230807A Ceased AU2015230807B2 (en) 2008-07-03 2015-09-25 A chimeric bacteriophage lysin with activity against staphylococci bacteria

Country Status (8)

Country Link
US (4) US8840900B2 (enExample)
EP (2) EP2307557B1 (enExample)
JP (2) JP5758291B2 (enExample)
AU (2) AU2009266982B2 (enExample)
CA (2) CA2729160C (enExample)
ES (1) ES2627321T3 (enExample)
HK (1) HK1248722A1 (enExample)
WO (1) WO2010002959A2 (enExample)

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WO2008018854A2 (en) 2005-06-06 2008-02-14 The Rockefeller University Bactiophage lysins for bacillus anthracis
ES2357626T3 (es) 2005-08-24 2011-04-28 The Rockefeller University Lisinas mutantes de ply-gbs.
US9034322B2 (en) 2011-04-21 2015-05-19 The Rockefeller University Streptococcus bacteriophage lysins for detection and treatment of gram positive bacteria
DK2705144T4 (da) 2011-05-04 2019-10-21 Micreos Human Health Bv Polypeptid
WO2013052643A1 (en) 2011-10-05 2013-04-11 The Rockefeller University Dimeric bacteriophage lysins
ES2729123T3 (es) * 2012-05-09 2019-10-30 Contrafect Corp Rotura de biopelícula con lisina plyss2
MX389127B (es) * 2012-05-09 2025-03-19 Contrafect Corp Lisina de bacteriófago y combinaciones de antibióticos contra bacterias gram positivas.
CN103122347B (zh) * 2013-02-01 2015-04-22 中国科学院武汉病毒研究所 一种杀灭葡萄球菌的裂解酶及其应用
ES2525954B1 (es) * 2013-05-28 2015-10-23 Consejo Superior De Investigaciones Científicas (Csic) Enzibióticos bactericidas mejorados frente a neumococo y otras bacterias
CN104762285B (zh) * 2015-04-23 2017-10-27 武汉菲吉乐科生物科技有限公司 一种自内裂解大肠杆菌的裂解酶及其应用
CN104805066B (zh) * 2015-05-18 2018-04-24 武汉菲吉乐科生物科技有限公司 一种葡萄球菌裂解酶及其应用
RU2754667C2 (ru) 2016-05-12 2021-09-06 Контрафект Корпорейшн Способ микроразбавления в жидкой среде для оценки и определения минимальной ингибирующей концентрации антибактериальных полипептидов
JP2021527699A (ja) * 2018-06-22 2021-10-14 コントラフェクト コーポレイション 溶解素及びその誘導体がスタフィロコッカス・アウレウス及びグラム陽性細菌を抗生物質に再感作する
CN113038960A (zh) * 2018-08-10 2021-06-25 明治制果药业株式会社 噬菌体剂
CN109666667A (zh) * 2019-01-22 2019-04-23 上海交通大学 杀灭金黄色葡萄球菌的嵌合酶抗生素及其制备和应用
WO2021084558A2 (en) * 2019-10-31 2021-05-06 Bactoclear Holdings Pte. Ltd Chimeric proteins for selective lysis of bacteria
EP4114422A4 (en) * 2020-03-06 2024-09-18 Endolytix Technology, Inc. Compositions and methods for the treatment of intracellular bacterial infections
CN115605587B (zh) * 2020-03-11 2026-02-13 特卢姆治疗有限公司 新型重组溶素及其在治疗革兰氏阴性菌感染中的用途
CN111808837A (zh) * 2020-07-17 2020-10-23 青岛诺安百特生物技术有限公司 一种金黄色葡萄球菌噬菌体裂解酶及其制备方法和应用
CN115820616A (zh) * 2022-07-22 2023-03-21 昆明理工大学 一种带荧光标记的噬菌体裂解酶及其应用

Citations (1)

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WO2009024327A2 (en) * 2007-08-22 2009-02-26 Profos Ag New proteins for use in human and animal staphylococcus infections

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WO1997008553A1 (en) * 1995-08-22 1997-03-06 The Regents Of The University Of California Targeting of proteins to the cell wall of gram-positive bacteria
US6056954A (en) * 1997-10-31 2000-05-02 New Horizons Diagnostics Corp Use of bacterial phage associated lysing enzymers for the prophylactic and therapeutic treatment of various illnesses
US6703025B1 (en) * 1998-08-31 2004-03-09 Inhibitex, Inc. Multicomponent vaccines
US20020127215A1 (en) * 1999-09-14 2002-09-12 Lawrence Loomis Parenteral use of bacterial phage associated lysing enzymes for the therapeutic treatment of bacterial infections
GB0107661D0 (en) * 2001-03-27 2001-05-16 Chiron Spa Staphylococcus aureus
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ES2357626T3 (es) * 2005-08-24 2011-04-28 The Rockefeller University Lisinas mutantes de ply-gbs.
JP5732397B2 (ja) * 2008-10-10 2015-06-10 ルソメディカメンタ, エス.エー.Lusomedicamenta, S.A. 抗菌性ファージペプチド及びその使用法
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Non-Patent Citations (1)

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Also Published As

Publication number Publication date
JP5758291B2 (ja) 2015-08-05
JP2015126738A (ja) 2015-07-09
JP2011526920A (ja) 2011-10-20
JP6169632B2 (ja) 2017-07-26
US20150064156A1 (en) 2015-03-05
US11827911B2 (en) 2023-11-28
US20190055533A1 (en) 2019-02-21
US20120258088A1 (en) 2012-10-11
AU2015230807B2 (en) 2017-07-27
EP2307557A2 (en) 2011-04-13
CA2729160A1 (en) 2010-01-07
US8840900B2 (en) 2014-09-23
AU2009266982A1 (en) 2010-01-07
EP2307557A4 (en) 2012-04-11
CA2984933A1 (en) 2010-01-07
US10053681B2 (en) 2018-08-21
US11015182B2 (en) 2021-05-25
EP2307557B1 (en) 2017-03-01
AU2015230807A1 (en) 2015-10-15
WO2010002959A3 (en) 2010-05-06
ES2627321T3 (es) 2017-07-27
CA2984933C (en) 2020-07-07
US20210348146A1 (en) 2021-11-11
CA2729160C (en) 2017-11-14
EP3263588A1 (en) 2018-01-03
HK1248722A1 (en) 2018-10-19
WO2010002959A2 (en) 2010-01-07

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FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired