ES2620751T3 - Nuevos compuestos útiles como inhibidores de S100 - Google Patents
Nuevos compuestos útiles como inhibidores de S100 Download PDFInfo
- Publication number
- ES2620751T3 ES2620751T3 ES15724640.6T ES15724640T ES2620751T3 ES 2620751 T3 ES2620751 T3 ES 2620751T3 ES 15724640 T ES15724640 T ES 15724640T ES 2620751 T3 ES2620751 T3 ES 2620751T3
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- optionally substituted
- cycloalkyl
- independently selected
- attached
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 18
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 12
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 5
- 125000005842 heteroatom Chemical group 0.000 abstract 5
- 125000006661 (C4-C6) heterocyclic group Chemical group 0.000 abstract 4
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 4
- 229910052736 halogen Inorganic materials 0.000 abstract 4
- 150000002367 halogens Chemical class 0.000 abstract 4
- 125000000623 heterocyclic group Chemical group 0.000 abstract 4
- 229910052757 nitrogen Inorganic materials 0.000 abstract 4
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 4
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 3
- 125000002947 alkylene group Chemical group 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 125000004122 cyclic group Chemical group 0.000 abstract 2
- 102200080066 rs122460151 Human genes 0.000 abstract 2
- 102220264985 rs182760732 Human genes 0.000 abstract 2
- PTUCPHGSAFOJAU-MGONOCMRSA-N (4s)-5-amino-4-[[(2s)-2-[[(2s)-2-[[(4-bromophenyl)-hydroxyphosphoryl]methyl]-3-[3-[4-(3-chlorophenyl)phenyl]-1,2-oxazol-5-yl]propanoyl]amino]-4-carboxybutanoyl]amino]-5-oxopentanoic acid Chemical compound C([C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N)CP(O)(=O)C=1C=CC(Br)=CC=1)C(ON=1)=CC=1C(C=C1)=CC=C1C1=CC=CC(Cl)=C1 PTUCPHGSAFOJAU-MGONOCMRSA-N 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 102200012954 rs121918642 Human genes 0.000 abstract 1
- 102200078752 rs201827340 Human genes 0.000 abstract 1
- 102200040459 rs3087473 Human genes 0.000 abstract 1
- 102200029950 rs35898499 Human genes 0.000 abstract 1
- 102220139548 rs61735306 Human genes 0.000 abstract 1
- 102220308785 rs749697322 Human genes 0.000 abstract 1
- 102200140336 rs786204767 Human genes 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14169757 | 2014-05-23 | ||
| EP14169757 | 2014-05-23 | ||
| PCT/EP2015/061468 WO2015177367A1 (en) | 2014-05-23 | 2015-05-22 | Novel compounds useful as s100-inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2620751T3 true ES2620751T3 (es) | 2017-06-29 |
Family
ID=50774707
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES15724640.6T Active ES2620751T3 (es) | 2014-05-23 | 2015-05-22 | Nuevos compuestos útiles como inhibidores de S100 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US9771372B2 (Direct) |
| EP (1) | EP2991990B1 (Direct) |
| JP (1) | JP6580074B2 (Direct) |
| KR (1) | KR20170005868A (Direct) |
| CN (1) | CN106414448B (Direct) |
| AU (1) | AU2015261775B2 (Direct) |
| BR (1) | BR112016024749A2 (Direct) |
| CA (1) | CA2948436A1 (Direct) |
| EA (1) | EA030604B1 (Direct) |
| ES (1) | ES2620751T3 (Direct) |
| MX (1) | MX2016014483A (Direct) |
| WO (1) | WO2015177367A1 (Direct) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112040982A (zh) | 2018-04-27 | 2020-12-04 | 国立大学法人冈山大学 | 抗s100a8/a9抗体及其用途 |
| US11197908B2 (en) | 2018-07-17 | 2021-12-14 | The Board Of Trustees Of The University Of Arkansas | Peptoids and methods for attenuating inflammatory response |
| EP4052725A4 (en) | 2019-10-30 | 2024-07-17 | National University Corporation Okayama University | PROPHYLACTIC AND/OR THERAPEUTIC AGENT FOR INFLAMMATORY LUNG DISEASE |
| WO2023209141A1 (en) | 2022-04-29 | 2023-11-02 | Westfälische Wilhelms-Universität Münster | Benzo[d]imidazo[1,2-a]imidazoles and their use in diagnosis |
| WO2025132458A1 (en) | 2023-12-18 | 2025-06-26 | Chiesi Farmaceutici S.P.A. | Pyridazinyl amino derivatives as alk5 inhibitors |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6248755B1 (en) | 1999-04-06 | 2001-06-19 | Merck & Co., Inc. | Pyrrolidine modulators of chemokine receptor activity |
| AR029489A1 (es) | 2000-03-10 | 2003-07-02 | Euro Celtique Sa | Piridinas, pirimidinas, pirazinas, triazinas sustituidas por arilo, composiciones farmaceuticas y el uso de las mismas para la manufactura de un medicamento |
| US7087632B2 (en) * | 2001-03-05 | 2006-08-08 | Transtech Pharma, Inc. | Benzimidazole derivatives as therapeutic agents |
| IL154107A0 (en) | 2000-07-26 | 2003-07-31 | Smithkline Beecham Plc | Aminopiperidine quinolines and their azaisosteric analogues with antibacterial activity |
| GB0117506D0 (en) | 2001-07-18 | 2001-09-12 | Bayer Ag | Imidazopyridinones |
| SE0104331D0 (sv) | 2001-12-19 | 2001-12-19 | Astrazeneca Ab | Novel compounds |
| JP4481011B2 (ja) * | 2002-03-05 | 2010-06-16 | トランス テック ファーマ，インコーポレイテッド | リガンドのｒａｇｅとの相互作用を阻害する単環式および二環式アゾール誘導体 |
| US20060111416A1 (en) | 2004-11-24 | 2006-05-25 | Lane Charlotte A L | Octahydropyrrolo[3,4-C]pyrrole derivatives |
| WO2008042282A2 (en) | 2006-09-28 | 2008-04-10 | Exelixis, Inc. | Imidazole-4, 5-dicarboxamide derivatives as jak-2 modulators |
| EP2132207A2 (en) | 2007-03-23 | 2009-12-16 | Amgen Inc. | Heterocyclic compounds and their uses |
| EP1986009A1 (en) * | 2007-04-26 | 2008-10-29 | Active Biotech AB | Screening method |
| CN101977505A (zh) | 2007-06-13 | 2011-02-16 | 葛兰素史密丝克莱恩有限责任公司 | 类法尼醇x受体激动剂 |
| CL2009000116A1 (es) * | 2008-01-22 | 2010-08-27 | Takeda Pharmaceutical Compnany Ltd | Compuestos derivados de heterotriciclos sustituidos, antagonistas del receptor crf; sus composiciones farmaceuticas; y uso de dichos compuestos para el tratamiento de trastornos afectivos, depresion, ansiedad y sindrome del colon irritable. |
| TW201004941A (en) | 2008-07-16 | 2010-02-01 | Wyeth Corp | Alpha7 nicotinic acetylcholine receptor inhibitors |
| CN102414180A (zh) | 2009-03-02 | 2012-04-11 | 西特里斯药业公司 | 作为沉默调节蛋白调节剂的8-取代的喹啉及相关的类似物 |
| JP5808869B2 (ja) | 2011-11-03 | 2015-11-10 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | 二環式ピペラジン化合物 |
| GB201321728D0 (en) * | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic agents |
-
2015
- 2015-05-22 CA CA2948436A patent/CA2948436A1/en not_active Abandoned
- 2015-05-22 BR BR112016024749A patent/BR112016024749A2/pt not_active IP Right Cessation
- 2015-05-22 AU AU2015261775A patent/AU2015261775B2/en not_active Ceased
- 2015-05-22 US US15/312,762 patent/US9771372B2/en not_active Expired - Fee Related
- 2015-05-22 KR KR1020167035803A patent/KR20170005868A/ko not_active Withdrawn
- 2015-05-22 EP EP15724640.6A patent/EP2991990B1/en active Active
- 2015-05-22 EA EA201692405A patent/EA030604B1/ru not_active IP Right Cessation
- 2015-05-22 WO PCT/EP2015/061468 patent/WO2015177367A1/en not_active Ceased
- 2015-05-22 CN CN201580026356.5A patent/CN106414448B/zh not_active Expired - Fee Related
- 2015-05-22 ES ES15724640.6T patent/ES2620751T3/es active Active
- 2015-05-22 MX MX2016014483A patent/MX2016014483A/es unknown
- 2015-05-22 JP JP2016568812A patent/JP6580074B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN106414448A (zh) | 2017-02-15 |
| MX2016014483A (es) | 2017-01-23 |
| HK1221463A1 (en) | 2017-06-02 |
| US20170204098A1 (en) | 2017-07-20 |
| CA2948436A1 (en) | 2015-11-26 |
| JP2017516772A (ja) | 2017-06-22 |
| BR112016024749A2 (pt) | 2017-08-15 |
| KR20170005868A (ko) | 2017-01-16 |
| EP2991990B1 (en) | 2017-02-01 |
| EA201692405A1 (ru) | 2017-06-30 |
| EA030604B1 (ru) | 2018-08-31 |
| WO2015177367A1 (en) | 2015-11-26 |
| CN106414448B (zh) | 2019-04-19 |
| JP6580074B2 (ja) | 2019-09-25 |
| EP2991990A1 (en) | 2016-03-09 |
| US9771372B2 (en) | 2017-09-26 |
| AU2015261775A1 (en) | 2016-12-08 |
| AU2015261775B2 (en) | 2019-07-11 |
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