MX2016014483A - Nuevos compuestos utiles como inhibidores de s100. - Google Patents
Nuevos compuestos utiles como inhibidores de s100.Info
- Publication number
- MX2016014483A MX2016014483A MX2016014483A MX2016014483A MX2016014483A MX 2016014483 A MX2016014483 A MX 2016014483A MX 2016014483 A MX2016014483 A MX 2016014483A MX 2016014483 A MX2016014483 A MX 2016014483A MX 2016014483 A MX2016014483 A MX 2016014483A
- Authority
- MX
- Mexico
- Prior art keywords
- inhibitors
- novel compounds
- compounds useful
- disorders
- compound
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 230000003993 interaction Effects 0.000 abstract 2
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 102000015279 Basigin Human genes 0.000 abstract 1
- 108010064528 Basigin Proteins 0.000 abstract 1
- 101000669447 Homo sapiens Toll-like receptor 4 Proteins 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 102100039360 Toll-like receptor 4 Human genes 0.000 abstract 1
- 208000037979 autoimmune inflammatory disease Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14169757 | 2014-05-23 | ||
| PCT/EP2015/061468 WO2015177367A1 (en) | 2014-05-23 | 2015-05-22 | Novel compounds useful as s100-inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2016014483A true MX2016014483A (es) | 2017-01-23 |
Family
ID=50774707
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2016014483A MX2016014483A (es) | 2014-05-23 | 2015-05-22 | Nuevos compuestos utiles como inhibidores de s100. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US9771372B2 (Direct) |
| EP (1) | EP2991990B1 (Direct) |
| JP (1) | JP6580074B2 (Direct) |
| KR (1) | KR20170005868A (Direct) |
| CN (1) | CN106414448B (Direct) |
| AU (1) | AU2015261775B2 (Direct) |
| BR (1) | BR112016024749A2 (Direct) |
| CA (1) | CA2948436A1 (Direct) |
| EA (1) | EA030604B1 (Direct) |
| ES (1) | ES2620751T3 (Direct) |
| MX (1) | MX2016014483A (Direct) |
| WO (1) | WO2015177367A1 (Direct) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112040982A (zh) | 2018-04-27 | 2020-12-04 | 国立大学法人冈山大学 | 抗s100a8/a9抗体及其用途 |
| US11197908B2 (en) | 2018-07-17 | 2021-12-14 | The Board Of Trustees Of The University Of Arkansas | Peptoids and methods for attenuating inflammatory response |
| EP4052725A4 (en) | 2019-10-30 | 2024-07-17 | National University Corporation Okayama University | PROPHYLACTIC AND/OR THERAPEUTIC AGENT FOR INFLAMMATORY LUNG DISEASE |
| WO2023209141A1 (en) | 2022-04-29 | 2023-11-02 | Westfälische Wilhelms-Universität Münster | Benzo[d]imidazo[1,2-a]imidazoles and their use in diagnosis |
| WO2025132458A1 (en) | 2023-12-18 | 2025-06-26 | Chiesi Farmaceutici S.P.A. | Pyridazinyl amino derivatives as alk5 inhibitors |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6248755B1 (en) | 1999-04-06 | 2001-06-19 | Merck & Co., Inc. | Pyrrolidine modulators of chemokine receptor activity |
| AR029489A1 (es) | 2000-03-10 | 2003-07-02 | Euro Celtique Sa | Piridinas, pirimidinas, pirazinas, triazinas sustituidas por arilo, composiciones farmaceuticas y el uso de las mismas para la manufactura de un medicamento |
| US7087632B2 (en) * | 2001-03-05 | 2006-08-08 | Transtech Pharma, Inc. | Benzimidazole derivatives as therapeutic agents |
| IL154107A0 (en) | 2000-07-26 | 2003-07-31 | Smithkline Beecham Plc | Aminopiperidine quinolines and their azaisosteric analogues with antibacterial activity |
| GB0117506D0 (en) | 2001-07-18 | 2001-09-12 | Bayer Ag | Imidazopyridinones |
| SE0104331D0 (sv) | 2001-12-19 | 2001-12-19 | Astrazeneca Ab | Novel compounds |
| JP4481011B2 (ja) * | 2002-03-05 | 2010-06-16 | トランス テック ファーマ，インコーポレイテッド | リガンドのｒａｇｅとの相互作用を阻害する単環式および二環式アゾール誘導体 |
| US20060111416A1 (en) | 2004-11-24 | 2006-05-25 | Lane Charlotte A L | Octahydropyrrolo[3,4-C]pyrrole derivatives |
| WO2008042282A2 (en) | 2006-09-28 | 2008-04-10 | Exelixis, Inc. | Imidazole-4, 5-dicarboxamide derivatives as jak-2 modulators |
| EP2132207A2 (en) | 2007-03-23 | 2009-12-16 | Amgen Inc. | Heterocyclic compounds and their uses |
| EP1986009A1 (en) * | 2007-04-26 | 2008-10-29 | Active Biotech AB | Screening method |
| CN101977505A (zh) | 2007-06-13 | 2011-02-16 | 葛兰素史密丝克莱恩有限责任公司 | 类法尼醇x受体激动剂 |
| CL2009000116A1 (es) * | 2008-01-22 | 2010-08-27 | Takeda Pharmaceutical Compnany Ltd | Compuestos derivados de heterotriciclos sustituidos, antagonistas del receptor crf; sus composiciones farmaceuticas; y uso de dichos compuestos para el tratamiento de trastornos afectivos, depresion, ansiedad y sindrome del colon irritable. |
| TW201004941A (en) | 2008-07-16 | 2010-02-01 | Wyeth Corp | Alpha7 nicotinic acetylcholine receptor inhibitors |
| CN102414180A (zh) | 2009-03-02 | 2012-04-11 | 西特里斯药业公司 | 作为沉默调节蛋白调节剂的8-取代的喹啉及相关的类似物 |
| JP5808869B2 (ja) | 2011-11-03 | 2015-11-10 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | 二環式ピペラジン化合物 |
| GB201321728D0 (en) * | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic agents |
-
2015
- 2015-05-22 CA CA2948436A patent/CA2948436A1/en not_active Abandoned
- 2015-05-22 BR BR112016024749A patent/BR112016024749A2/pt not_active IP Right Cessation
- 2015-05-22 AU AU2015261775A patent/AU2015261775B2/en not_active Ceased
- 2015-05-22 US US15/312,762 patent/US9771372B2/en not_active Expired - Fee Related
- 2015-05-22 KR KR1020167035803A patent/KR20170005868A/ko not_active Withdrawn
- 2015-05-22 EP EP15724640.6A patent/EP2991990B1/en active Active
- 2015-05-22 EA EA201692405A patent/EA030604B1/ru not_active IP Right Cessation
- 2015-05-22 WO PCT/EP2015/061468 patent/WO2015177367A1/en not_active Ceased
- 2015-05-22 CN CN201580026356.5A patent/CN106414448B/zh not_active Expired - Fee Related
- 2015-05-22 ES ES15724640.6T patent/ES2620751T3/es active Active
- 2015-05-22 MX MX2016014483A patent/MX2016014483A/es unknown
- 2015-05-22 JP JP2016568812A patent/JP6580074B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN106414448A (zh) | 2017-02-15 |
| HK1221463A1 (en) | 2017-06-02 |
| US20170204098A1 (en) | 2017-07-20 |
| CA2948436A1 (en) | 2015-11-26 |
| JP2017516772A (ja) | 2017-06-22 |
| BR112016024749A2 (pt) | 2017-08-15 |
| KR20170005868A (ko) | 2017-01-16 |
| EP2991990B1 (en) | 2017-02-01 |
| EA201692405A1 (ru) | 2017-06-30 |
| EA030604B1 (ru) | 2018-08-31 |
| ES2620751T3 (es) | 2017-06-29 |
| WO2015177367A1 (en) | 2015-11-26 |
| CN106414448B (zh) | 2019-04-19 |
| JP6580074B2 (ja) | 2019-09-25 |
| EP2991990A1 (en) | 2016-03-09 |
| US9771372B2 (en) | 2017-09-26 |
| AU2015261775A1 (en) | 2016-12-08 |
| AU2015261775B2 (en) | 2019-07-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EA201790528A1 (ru) | Дигидропирролопиридиновые ингибиторы ror-гамма | |
| PH12017500509A1 (en) | Benzyl substituted indazoles as bub1 inhibitors | |
| PH12016501457A1 (en) | Dihydropyrrolopyridine inhibitors of ror-gamma | |
| PH12016501702B1 (en) | Pyrazole amide derivative | |
| EP4230264A3 (en) | Prodrugs of fumarates and their use in treating various deseases | |
| NZ729005A (en) | Aminopyrimidinyl compounds as jak inhibitors | |
| MX2018001990A (es) | Composiciones que comprenden un inhibidor de p13k y un inhibidor de hdac. | |
| PH12017501669A1 (en) | Alpha-cinnamide compounds and compositions as hdac8 inhibitors | |
| EA201691421A1 (ru) | Гетероарилы и их применение | |
| WO2015054642A3 (en) | Use of cbp/ep300 bromodomain inhibitors for cancer immunotherapy | |
| PH12016500330B1 (en) | Certain chemical entities, compositions, and methods | |
| WO2014179564A8 (en) | Thiazolopyrrolidine inhibitors of ror-gamma | |
| EA201692091A1 (ru) | Хиноксалиновые соединения и их применение | |
| EA201591509A1 (ru) | Ингибиторы cdc7 | |
| CL2016003074A1 (es) | Compuestos derivados de 2-oxi-2-fenil-n-5-pirrolidin-3-ilamino-1,3,4-tiadiazol-2-ilacetamida, inhibidores gls1 composición farmacéutica y su uso para tratar el cáncer. | |
| EA201690783A1 (ru) | Вещества, фармацевтическая композиция и методы применения при лечении воспалительных заболеваний | |
| CL2018000565A1 (es) | Compuestos derivados de piridinona dicarboxamida, inhibidores de bromodominio; composicion farmaceutica; combinacion farmaceutica; utiles en el tratamiento de enfermedades autoinmunitarias, inflamatorias, virales y cancer, entre otras. | |
| MX2015017035A (es) | Inhibidor de la señalizacion de cd40 y un compuesto adicional, en donde el compuesto adicional es un acido labil, un derivado de acido labil, un agonista del receptor tgr5, un agonista del fxr o una combinacion de los mismos, para el tratamiento de inflamacion cronica, y la prevencion de cancer gastrointestinal o fibrosis. | |
| EA031679B9 (ru) | Производные тетрагидрохинолина в качестве ингибиторов бромодомена | |
| EA201890364A1 (ru) | СОЕДИНЕНИЯ, ПРИГОДНЫЕ ДЛЯ ИНГИБИРОВАНИЯ ROR-ГАММА-t | |
| MX2016014483A (es) | Nuevos compuestos utiles como inhibidores de s100. | |
| EA201790687A1 (ru) | Хинолинкарбоксамиды для применения в лечении множественной миеломы | |
| EA201500736A1 (ru) | Пиразолилкарбоксамиды i в качестве ингибиторов crac каналов | |
| EA201791099A1 (ru) | Хинолин карбоксамиды для применения в лечении лейкоза | |
| MX360455B (es) | Derivados de n-(heteroaril)-sulfonamida utiles como inhibidores de s100. |