ES2616295T3 - Agente para aplicar a mucosa y procedimiento para la producción del mismo - Google Patents
Agente para aplicar a mucosa y procedimiento para la producción del mismo Download PDFInfo
- Publication number
- ES2616295T3 ES2616295T3 ES06811990.8T ES06811990T ES2616295T3 ES 2616295 T3 ES2616295 T3 ES 2616295T3 ES 06811990 T ES06811990 T ES 06811990T ES 2616295 T3 ES2616295 T3 ES 2616295T3
- Authority
- ES
- Spain
- Prior art keywords
- group
- administration
- chain
- introduction
- mucosa
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 210000004877 mucosa Anatomy 0.000 title claims abstract description 59
- 238000000034 method Methods 0.000 title description 31
- 238000004519 manufacturing process Methods 0.000 title description 8
- 125000001165 hydrophobic group Chemical group 0.000 claims abstract description 80
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 69
- 208000035475 disorder Diseases 0.000 claims abstract description 68
- 210000005081 epithelial layer Anatomy 0.000 claims abstract description 61
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 56
- 230000002265 prevention Effects 0.000 claims abstract description 46
- 125000006850 spacer group Chemical group 0.000 claims abstract description 16
- 229920002683 Glycosaminoglycan Polymers 0.000 claims abstract description 15
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims abstract description 14
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- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims description 13
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims description 2
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- YQEZLKZALYSWHR-UHFFFAOYSA-N Ketamine Chemical compound C=1C=CC=C(Cl)C=1C1(NC)CCCCC1=O YQEZLKZALYSWHR-UHFFFAOYSA-N 0.000 description 18
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- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 14
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- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 10
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- FJLUATLTXUNBOT-UHFFFAOYSA-N 1-Hexadecylamine Chemical compound CCCCCCCCCCCCCCCCN FJLUATLTXUNBOT-UHFFFAOYSA-N 0.000 description 9
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- 125000001273 sulfonato group Chemical group [O-]S(*)(=O)=O 0.000 description 9
- 238000002834 transmittance Methods 0.000 description 9
- FPQQSJJWHUJYPU-UHFFFAOYSA-N 3-(dimethylamino)propyliminomethylidene-ethylazanium;chloride Chemical compound Cl.CCN=C=NCCCN(C)C FPQQSJJWHUJYPU-UHFFFAOYSA-N 0.000 description 8
- 241000699800 Cricetinae Species 0.000 description 8
- 241001465754 Metazoa Species 0.000 description 8
- NQTADLQHYWFPDB-UHFFFAOYSA-N N-Hydroxysuccinimide Chemical compound ON1C(=O)CCC1=O NQTADLQHYWFPDB-UHFFFAOYSA-N 0.000 description 8
- 210000000214 mouth Anatomy 0.000 description 8
- 125000004432 carbon atom Chemical group C* 0.000 description 7
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- 239000002244 precipitate Substances 0.000 description 7
- 235000017557 sodium bicarbonate Nutrition 0.000 description 7
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 7
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 6
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- BFMYDTVEBKDAKJ-UHFFFAOYSA-L disodium;(2',7'-dibromo-3',6'-dioxido-3-oxospiro[2-benzofuran-1,9'-xanthene]-4'-yl)mercury;hydrate Chemical compound O.[Na+].[Na+].O1C(=O)C2=CC=CC=C2C21C1=CC(Br)=C([O-])C([Hg])=C1OC1=C2C=C(Br)C([O-])=C1 BFMYDTVEBKDAKJ-UHFFFAOYSA-L 0.000 description 4
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- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 3
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- WCDDVEOXEIYWFB-VXORFPGASA-N (2s,3s,4r,5r,6r)-3-[(2s,3r,5s,6r)-3-acetamido-5-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5,6-trihydroxyoxane-2-carboxylic acid Chemical class CC(=O)N[C@@H]1C[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O)[C@H](O)[C@H]1O WCDDVEOXEIYWFB-VXORFPGASA-N 0.000 description 2
- LMDZBCPBFSXMTL-UHFFFAOYSA-N 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide Substances CCN=C=NCCCN(C)C LMDZBCPBFSXMTL-UHFFFAOYSA-N 0.000 description 2
- BMTZEAOGFDXDAD-UHFFFAOYSA-M 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholin-4-ium;chloride Chemical compound [Cl-].COC1=NC(OC)=NC([N+]2(C)CCOCC2)=N1 BMTZEAOGFDXDAD-UHFFFAOYSA-M 0.000 description 2
- WBYWAXJHAXSJNI-SREVYHEPSA-N Cinnamic acid Chemical compound OC(=O)\C=C/C1=CC=CC=C1 WBYWAXJHAXSJNI-SREVYHEPSA-N 0.000 description 2
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- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 2
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- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
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- 235000011164 potassium chloride Nutrition 0.000 description 1
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- GNSKLFRGEWLPPA-UHFFFAOYSA-M potassium dihydrogen phosphate Chemical compound [K+].OP(O)([O-])=O GNSKLFRGEWLPPA-UHFFFAOYSA-M 0.000 description 1
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Classifications
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- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
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- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Biomedical Technology (AREA)
- Ophthalmology & Optometry (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Gynecology & Obstetrics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Otolaryngology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2005297170 | 2005-10-12 | ||
| JP2005297170 | 2005-10-12 | ||
| JP2006160478 | 2006-06-09 | ||
| JP2006160478 | 2006-06-09 | ||
| PCT/JP2006/320801 WO2007043702A1 (en) | 2005-10-12 | 2006-10-12 | Agent for applying to mucosa and method for production thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2616295T3 true ES2616295T3 (es) | 2017-06-12 |
Family
ID=37942916
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES06811990.8T Active ES2616295T3 (es) | 2005-10-12 | 2006-10-12 | Agente para aplicar a mucosa y procedimiento para la producción del mismo |
Country Status (9)
| Country | Link |
|---|---|
| US (4) | US20080306022A1 (https=) |
| EP (1) | EP1942912B1 (https=) |
| JP (3) | JP4387445B2 (https=) |
| KR (4) | KR101554834B1 (https=) |
| CN (3) | CN103120701B (https=) |
| AU (1) | AU2006300207C1 (https=) |
| CA (1) | CA2625532C (https=) |
| ES (1) | ES2616295T3 (https=) |
| WO (1) | WO2007043702A1 (https=) |
Families Citing this family (22)
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| GB0327723D0 (en) | 2003-09-15 | 2003-12-31 | Vectura Ltd | Pharmaceutical compositions |
| CA2625532C (en) * | 2005-10-12 | 2013-10-01 | Seikagaku Corporation | Agent for applying to mucosa containing a hydrophobic group binding type glycosaminoglycan |
| AU2007328871B2 (en) | 2006-12-06 | 2013-11-21 | Seikagaku Corporation | Pharmaceutical agent having long-lasting effect of treating arthritic disorders |
| JP2009046454A (ja) * | 2007-08-22 | 2009-03-05 | Shiseido Co Ltd | 口腔内用組成物 |
| ITMI20072237A1 (it) * | 2007-11-27 | 2009-05-28 | Sigea Srl | Esteri misti butirrico-formico di polisaccaridi acidi, loro preparazione ed uso come dermocosmetici |
| CA2719666C (en) | 2008-04-04 | 2016-08-16 | Glenn Prestwich | Alkylated semi-synthetic glycosaminoglycosan ethers, and methods for making and using thereof |
| WO2010053140A1 (ja) * | 2008-11-05 | 2010-05-14 | 国立大学法人 東京医科歯科大学 | ヒアルロン酸誘導体、およびその医薬組成物 |
| FR2958646B1 (fr) | 2010-04-07 | 2012-05-18 | Adocia | Polysaccharides comportant des groupes fonctionnels carboxyles substitues par un derive d'acide hydrophobe. |
| CA2703532C (en) * | 2010-05-10 | 2018-05-01 | Eva Turley | Topically administered, skin-penetrating glycosaminoglycan formulations suitable for use in cosmetic and pharmaceutical applications |
| WO2012129461A1 (en) | 2011-03-23 | 2012-09-27 | University Of Utah Research Foundation | Methods for treating or preventing urological inflammation |
| US9067299B2 (en) | 2012-04-25 | 2015-06-30 | Applied Materials, Inc. | Printed chemical mechanical polishing pad |
| CA2972212C (en) * | 2014-12-26 | 2024-10-29 | Seikagaku Corporation | AGENT AND IMPROVEMENT OF SUBJECTIVE OCULAR SYMPTOMS AND ASSOCIATED METHOD |
| CN104940221A (zh) * | 2015-05-13 | 2015-09-30 | 北京大清生物技术有限公司 | 一种用于膀胱和尿道上皮损伤修复的组合物 |
| EP3305304A4 (en) * | 2015-05-29 | 2019-01-23 | Seikagaku Corporation | COMPOSITION WITH GLUCOSAMINATE SCANDERIVATE AND CHEMOKIN RECEPTOR ACTIVITY CONTROLLER |
| JP6757731B2 (ja) * | 2015-08-20 | 2020-09-23 | 生化学工業株式会社 | 眼用デバイス適用剤 |
| US10525159B2 (en) | 2016-05-26 | 2020-01-07 | Ophtecs Corporation | Liquid preparation for contact lenses comprising hydrolyzed hyaluronic acid derivative and cationic bactericide |
| US11337994B2 (en) | 2016-09-15 | 2022-05-24 | University Of Utah Research Foundation | In situ gelling compositions for the treatment or prevention of inflammation and tissue damage |
| US20190240251A1 (en) * | 2016-10-14 | 2019-08-08 | i.com medical GmbH | Method for establishing, restoring, and preserving homeostasis of the ocular surface |
| SG10202107829YA (en) | 2017-03-22 | 2021-08-30 | Genentech Inc | Hydrogel cross-linked hyaluronic acid prodrug compositions and methods |
| RU2652581C1 (ru) * | 2017-07-03 | 2018-04-26 | федеральное государственное бюджетное образовательное учреждение высшего образования "Приволжский исследовательский медицинский университет" Министерства здравоохранения Российской Федерации | Способ лечения роговично-конъюнктивального ксероза |
| CN111228653A (zh) | 2018-11-13 | 2020-06-05 | 格莱科米拉治疗公司 | 用电离辐射加强癌症治疗的方法 |
| EP4039279A4 (en) | 2019-10-03 | 2023-11-01 | Seikagaku Corporation | TRANSMUCOSAL MEDICINAL ACTIVE DELIVERY SYSTEM FOR THE BLADDER SUBMUCOSA |
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| US4851521A (en) * | 1985-07-08 | 1989-07-25 | Fidia, S.P.A. | Esters of hyaluronic acid |
| JPH0723317B2 (ja) | 1988-03-17 | 1995-03-15 | 生化学工業株式会社 | 角膜上皮層障害症治療剤 |
| US5733892A (en) * | 1990-07-24 | 1998-03-31 | Seikagaku Corporation | Metastasis inhibitor composition comprising a phospholipid-linked glycosaminoglycan and method for inhibiting metastasis employing the same |
| JP2855307B2 (ja) * | 1992-02-05 | 1999-02-10 | 生化学工業株式会社 | 光反応性グリコサミノグリカン、架橋グリコサミノグリカン及びそれらの製造方法 |
| DE4203529A1 (de) * | 1992-02-07 | 1993-08-12 | Wolff Walsrode Ag | Wasserloesliche sulfoalkylhydroxyalkylderivate der cellulose und deren verwendung in gips- und zementhaltigen massen |
| WO1995025287A1 (en) * | 1994-03-14 | 1995-09-21 | Seikagaku Corporation | Material to be worn on the eyeball |
| CA2162957C (en) * | 1994-11-17 | 2011-08-02 | Michinori Waki | Cinnamic acid derivative |
| US6025444A (en) * | 1994-11-17 | 2000-02-15 | Seikagaku Kogyo Kabushiki Kaisha (Seikagaku Corporation) | Cinnamic acid derivative |
| JP3308742B2 (ja) * | 1994-11-17 | 2002-07-29 | 生化学工業株式会社 | 光架橋性ヒアルロン酸誘導体とその架橋体およびそれらの製造方法 |
| JP3955107B2 (ja) * | 1995-05-01 | 2007-08-08 | 生化学工業株式会社 | 架橋多糖の製造法 |
| JP4006039B2 (ja) * | 1995-09-13 | 2007-11-14 | 生化学工業株式会社 | 光架橋ヒアルロン酸コンタクトレンズ |
| US5789462A (en) * | 1995-09-13 | 1998-08-04 | Seikagaku Kogyo Kabushiki Kaisha (Seikagaku Corporation) | Photocured crosslinked-hyaluronic acid contact lens |
| JP3439481B2 (ja) * | 1995-11-15 | 2003-08-25 | 生化学工業株式会社 | 光架橋ヒアルロン酸ゲルおよびその製造法 |
| WO1998029125A1 (fr) | 1996-12-27 | 1998-07-09 | Seikagaku Corporation | Remedes contre des troubles de la vessie |
| US6548487B2 (en) * | 1996-12-27 | 2003-04-15 | Seikagaku Corporation | Agent for treatment of bladder troubles |
| JPH1171282A (ja) | 1997-09-01 | 1999-03-16 | Senju Pharmaceut Co Ltd | 点眼用水性製剤 |
| JP3014357B2 (ja) | 1998-01-26 | 2000-02-28 | 生化学工業株式会社 | 角膜上皮層伸展促進剤 |
| ITPD980169A1 (it) * | 1998-07-06 | 2000-01-06 | Fidia Advanced Biopolymers Srl | Ammidi dell'acido ialuronico e dei suoi derivati e processo per la loro preparazione. |
| AU3327000A (en) * | 1999-03-24 | 2000-10-09 | Seikagaku Corporation | Artificial saliva |
| EP1142566B1 (fr) | 2000-04-07 | 2003-10-01 | Laboratoire Medidom S.A. | Formulations ophtalmiques à base de ciclosporine, d'acide hyaluronique et du polysorbate |
| JP2001329002A (ja) * | 2000-05-25 | 2001-11-27 | Denki Kagaku Kogyo Kk | 修飾ヒアルロン酸ゲルとその製造方法及びそれを含有する医用材料 |
| JP2002037746A (ja) | 2000-07-24 | 2002-02-06 | Fuji Yakuhin:Kk | キノロンカルボン酸系抗菌剤を含有する液剤 |
| EP1217008B1 (en) * | 2000-12-19 | 2006-03-01 | Seikagaku Corporation | Photocurable hyaluronic acid derivative and process for producing the same, and photocured crosslinked hyaluronic acid derivative and medical material using the same |
| JP4172176B2 (ja) | 2000-12-19 | 2008-10-29 | 生化学工業株式会社 | 光反応性ヒアルロン酸およびその製造方法ならびに光架橋ヒアルロン酸および医用材料 |
| AU2002243630A1 (en) * | 2001-01-23 | 2002-08-06 | Massachusetts Institute Of Technology | Solid- and solution -phase synthesis of heparin and other glycosaminoglycans |
| JP4273208B2 (ja) * | 2001-03-30 | 2009-06-03 | チッソ株式会社 | 婦人科疾患治療剤 |
| WO2006030965A1 (en) * | 2004-09-15 | 2006-03-23 | Seikagaku Corporation | Photoreactive polysaccharide, photocrosslinked polysaccharide products, the method of making them and medical materials therefrom |
| CA2625532C (en) * | 2005-10-12 | 2013-10-01 | Seikagaku Corporation | Agent for applying to mucosa containing a hydrophobic group binding type glycosaminoglycan |
| JP7023317B2 (ja) * | 2020-05-12 | 2022-02-21 | 沖電気工業株式会社 | 光波長フィルタ及び波長分離光回路 |
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- 2006-10-12 KR KR1020147008031A patent/KR101554834B1/ko not_active Expired - Fee Related
- 2006-10-12 AU AU2006300207A patent/AU2006300207C1/en not_active Ceased
- 2006-10-12 CN CN2006800380199A patent/CN101287473B/zh not_active Expired - Fee Related
- 2006-10-12 KR KR1020137024561A patent/KR20130109259A/ko not_active Ceased
- 2006-10-12 JP JP2008519554A patent/JP4387445B2/ja active Active
- 2006-10-12 EP EP06811990.8A patent/EP1942912B1/en not_active Not-in-force
- 2006-10-12 KR KR1020117023949A patent/KR101428153B1/ko not_active Expired - Fee Related
- 2006-10-12 ES ES06811990.8T patent/ES2616295T3/es active Active
- 2006-10-12 CN CN201210562963.1A patent/CN103120702B/zh not_active Expired - Fee Related
- 2006-10-12 WO PCT/JP2006/320801 patent/WO2007043702A1/en not_active Ceased
- 2006-10-12 KR KR1020087011277A patent/KR101411067B1/ko not_active Expired - Fee Related
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2009
- 2009-08-11 JP JP2009186548A patent/JP5094799B2/ja not_active Expired - Fee Related
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2011
- 2011-03-23 US US13/070,210 patent/US8969319B2/en active Active
-
2012
- 2012-06-27 JP JP2012144630A patent/JP2012211171A/ja active Pending
-
2015
- 2015-01-20 US US14/600,558 patent/US20150196574A1/en not_active Abandoned
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2018
- 2018-03-30 US US15/941,443 patent/US20180289730A1/en not_active Abandoned
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