ES2613666T3 - Uso de un inhibidor de aromatasa para el tratamiento del hipogonadismo y enfermedades relacionadas - Google Patents

Uso de un inhibidor de aromatasa para el tratamiento del hipogonadismo y enfermedades relacionadas Download PDF

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Publication number
ES2613666T3
ES2613666T3 ES12758965.3T ES12758965T ES2613666T3 ES 2613666 T3 ES2613666 T3 ES 2613666T3 ES 12758965 T ES12758965 T ES 12758965T ES 2613666 T3 ES2613666 T3 ES 2613666T3
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ES
Spain
Prior art keywords
once
dose
days
hypogonadism
compound
Prior art date
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ES12758965.3T
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English (en)
Spanish (es)
Inventor
Ann Taylor
Lloyd B. Klickstein
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Mereo Biopharma 2 Ltd
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Mereo Biopharma 2 Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4833—Encapsulating processes; Filling of capsules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/485—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/06—Anabolic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/26—Androgens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Reproductive Health (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Inorganic Chemistry (AREA)
  • Gynecology & Obstetrics (AREA)
  • Psychiatry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ES12758965.3T 2011-09-08 2012-09-06 Uso de un inhibidor de aromatasa para el tratamiento del hipogonadismo y enfermedades relacionadas Active ES2613666T3 (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161532459P 2011-09-08 2011-09-08
US201161532459P 2011-09-08
US201261638588P 2012-04-26 2012-04-26
US201261638588P 2012-04-26
PCT/US2012/053844 WO2013036562A1 (en) 2011-09-08 2012-09-06 Use of an aromatase inhibitor for the treatment of hypogonadism and related diseases

Publications (1)

Publication Number Publication Date
ES2613666T3 true ES2613666T3 (es) 2017-05-25

Family

ID=46846026

Family Applications (2)

Application Number Title Priority Date Filing Date
ES12758965.3T Active ES2613666T3 (es) 2011-09-08 2012-09-06 Uso de un inhibidor de aromatasa para el tratamiento del hipogonadismo y enfermedades relacionadas
ES12758966.1T Active ES2613667T3 (es) 2011-09-08 2012-09-06 Composiciones farmacéuticas que comprenden un inhibidor de aromatasa

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES12758966.1T Active ES2613667T3 (es) 2011-09-08 2012-09-06 Composiciones farmacéuticas que comprenden un inhibidor de aromatasa

Country Status (31)

Country Link
US (4) US9295668B2 (OSRAM)
EP (2) EP2753312B1 (OSRAM)
JP (2) JP6280501B2 (OSRAM)
KR (3) KR20180030254A (OSRAM)
CN (2) CN103796644B (OSRAM)
AR (1) AR087790A1 (OSRAM)
AU (2) AU2012304693B2 (OSRAM)
BR (2) BR112014005434B1 (OSRAM)
CA (2) CA2846884C (OSRAM)
CL (1) CL2014000552A1 (OSRAM)
CY (2) CY1118461T1 (OSRAM)
DK (2) DK2753312T3 (OSRAM)
ES (2) ES2613666T3 (OSRAM)
HR (2) HRP20170002T1 (OSRAM)
HU (2) HUE031478T2 (OSRAM)
IL (1) IL231234A (OSRAM)
IN (1) IN2014DN01619A (OSRAM)
LT (2) LT2753312T (OSRAM)
MX (2) MX343902B (OSRAM)
PE (1) PE20141584A1 (OSRAM)
PH (1) PH12014500435A1 (OSRAM)
PL (2) PL2753312T3 (OSRAM)
PT (2) PT2753312T (OSRAM)
RU (2) RU2617510C2 (OSRAM)
SG (2) SG2014012132A (OSRAM)
SI (2) SI2753312T1 (OSRAM)
TN (1) TN2014000059A1 (OSRAM)
TW (1) TW201316987A (OSRAM)
UY (1) UY34315A (OSRAM)
WO (2) WO2013036562A1 (OSRAM)
ZA (1) ZA201401040B (OSRAM)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6280501B2 (ja) * 2011-09-08 2018-02-14 メレオ バイオファーマ 2 リミテッド 性腺機能低下症および関連疾患の処置ためのアロマターゼ阻害剤の使用
WO2015148549A1 (en) * 2014-03-26 2015-10-01 The Regents Of The University Of California Ultrasensitive androgen receptor bioassay
SI3166596T1 (sl) * 2014-07-07 2018-10-30 Novartis Ag Farmacevtske odmerne oblike
GB201614179D0 (en) * 2016-08-19 2016-10-05 Mereo Biopharma 2 Ltd Dosage regimen for the treatment of endometriosis
CN110520110A (zh) * 2017-03-08 2019-11-29 阿瑞雅德制药公司 包含5-氯-n4-[2-(二甲基磷酰基)苯基]-n2-{2-甲氧基-4-[4-(4-甲基哌嗪-1-基)哌啶-1-基]苯基}嘧啶-2,4-二胺的药物制剂
IL322969A (en) 2017-10-12 2025-10-01 Novo Nordisk As Semaglutide in medical therapy
USD894149S1 (en) * 2018-08-16 2020-08-25 Alibaba Group Holding Limited Information terminal for payment
USD894148S1 (en) * 2018-08-16 2020-08-25 Alibaba Group Holding Limited Information terminal for payment
JP7121999B2 (ja) * 2019-09-26 2022-08-19 学校法人九州文化学園 男性性腺機能低下症治療剤
US12552754B1 (en) 2025-06-11 2026-02-17 ReproNovo SA Leflutrozole compositions of matter and processes for preparation

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4749713A (en) 1986-03-07 1988-06-07 Ciba-Geigy Corporation Alpha-heterocycle substituted tolunitriles
TW210334B (OSRAM) 1990-12-12 1993-08-01 Ciba Geigy Ag
DE4435368A1 (de) * 1994-09-22 1996-03-28 Schering Ag Verwendung von Aromatasehemmern zur Herstellung eines Arzneimittels zur Behandlung eines relativen Androgenmangels beim Mann
US5972921A (en) * 1997-12-12 1999-10-26 Hormos Medical Oy Ltd. Use of an aromatase inhibitor in the treatment of decreased androgen to estrogen ratio and detrusor urethral sphincter dyssynergia in men
AU2001271162A1 (en) * 2000-07-05 2002-01-14 Astrazeneca Ab Pharmaceutical combination of an anti-androgen and letrozole for providing an anit-androgenic effect and aromatase inhibition
CZ299735B6 (cs) * 2001-04-17 2008-11-05 Ares Trading S. A. Farmaceutický prostredek
US7101573B2 (en) 2001-09-28 2006-09-05 Mcneil-Pcc, Inc. Simethicone solid oral dosage form
EP1492515A1 (en) * 2002-04-03 2005-01-05 Jencap Research Ltd. Pharmaceutical composition comprising an aromatase inhibitor and an estrogen suitable for hormone replacement therapy for a male
EP1937251A2 (en) 2005-04-25 2008-07-02 Pfizer Products Inc. Pharmaceutical compositions and methods comprising a combination of a selective estrogen receptor modulator and an aromatase inhibitor
JPWO2009066712A1 (ja) 2007-11-21 2011-04-07 クラシエ製薬株式会社 アロマターゼ阻害剤
JP6280501B2 (ja) * 2011-09-08 2018-02-14 メレオ バイオファーマ 2 リミテッド 性腺機能低下症および関連疾患の処置ためのアロマターゼ阻害剤の使用

Also Published As

Publication number Publication date
JP2014526465A (ja) 2014-10-06
US20140213622A1 (en) 2014-07-31
PL2753312T3 (pl) 2017-06-30
HUE031478T2 (hu) 2017-07-28
MX343902B (es) 2016-11-28
WO2013036562A1 (en) 2013-03-14
SG2014012132A (en) 2014-06-27
LT2753313T (lt) 2017-02-10
KR101872561B1 (ko) 2018-06-28
JP6051467B2 (ja) 2016-12-27
JP6280501B2 (ja) 2018-02-14
US9370505B2 (en) 2016-06-21
CA2846884A1 (en) 2013-03-14
BR112014005434A2 (pt) 2017-04-04
CL2014000552A1 (es) 2014-09-12
TN2014000059A1 (en) 2015-07-01
HRP20170003T1 (hr) 2017-03-10
CN103796644B (zh) 2017-05-03
CA2846884C (en) 2019-04-09
US9750724B2 (en) 2017-09-05
DK2753313T3 (en) 2017-02-13
BR112014005434B1 (pt) 2021-01-05
MX360315B (es) 2018-10-29
MX2014002773A (es) 2014-06-05
US20140309267A1 (en) 2014-10-16
EP2753313B1 (en) 2016-12-14
CY1118499T1 (el) 2017-07-12
EP2753313A1 (en) 2014-07-16
LT2753312T (lt) 2017-01-25
US20160346257A1 (en) 2016-12-01
WO2013036563A1 (en) 2013-03-14
AU2012304694B2 (en) 2016-04-07
DK2753312T3 (da) 2017-02-13
US10064844B2 (en) 2018-09-04
CN103781476B (zh) 2016-12-07
AU2012304693B2 (en) 2016-03-31
AR087790A1 (es) 2014-04-16
CN103781476A (zh) 2014-05-07
SG10201607503WA (en) 2016-10-28
BR112014004879B1 (pt) 2020-01-28
KR20140058619A (ko) 2014-05-14
EP2753312B1 (en) 2016-12-14
CN103796644A (zh) 2014-05-14
PT2753312T (pt) 2017-02-03
RU2014113575A (ru) 2015-10-20
ES2613667T3 (es) 2017-05-25
JP2014528932A (ja) 2014-10-30
MX2014002780A (es) 2014-06-05
HRP20170002T1 (hr) 2017-02-24
RU2628808C2 (ru) 2017-08-22
KR20140071358A (ko) 2014-06-11
US9295668B2 (en) 2016-03-29
CA2845929C (en) 2018-06-19
IN2014DN01619A (OSRAM) 2015-05-15
PL2753313T3 (pl) 2017-07-31
EP2753312A1 (en) 2014-07-16
RU2617510C2 (ru) 2017-04-25
RU2014113334A (ru) 2015-10-20
AU2012304694A1 (en) 2014-03-20
UY34315A (es) 2013-04-30
SI2753312T1 (sl) 2017-10-30
AU2012304693A1 (en) 2014-03-13
BR112014004879A2 (pt) 2017-03-14
TW201316987A (zh) 2013-05-01
US20160243084A1 (en) 2016-08-25
ZA201401040B (en) 2015-12-23
IL231234A (en) 2016-12-29
PT2753313T (pt) 2017-02-02
CA2845929A1 (en) 2013-03-14
NZ621476A (en) 2016-02-26
IL231234A0 (en) 2014-04-30
HUE031435T2 (en) 2017-07-28
KR20180030254A (ko) 2018-03-21
PH12014500435A1 (en) 2019-03-22
CY1118461T1 (el) 2017-07-12
SI2753313T1 (sl) 2017-04-26
PE20141584A1 (es) 2014-11-13

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