ES2606947T3 - Composición para combatir epistaxis - Google Patents
Composición para combatir epistaxis Download PDFInfo
- Publication number
- ES2606947T3 ES2606947T3 ES08709491.8T ES08709491T ES2606947T3 ES 2606947 T3 ES2606947 T3 ES 2606947T3 ES 08709491 T ES08709491 T ES 08709491T ES 2606947 T3 ES2606947 T3 ES 2606947T3
- Authority
- ES
- Spain
- Prior art keywords
- gel
- composition
- per liter
- concentration
- glycine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 42
- 208000001780 epistaxis Diseases 0.000 title claims description 18
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims abstract description 35
- 229920000642 polymer Polymers 0.000 claims abstract description 23
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical group OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims abstract description 22
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 claims abstract description 19
- 229910001424 calcium ion Inorganic materials 0.000 claims abstract description 19
- 229940096529 carboxypolymethylene Drugs 0.000 claims abstract description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 16
- 239000004471 Glycine Substances 0.000 claims abstract description 15
- 238000011282 treatment Methods 0.000 claims description 10
- 238000002560 therapeutic procedure Methods 0.000 claims description 7
- 238000011321 prophylaxis Methods 0.000 claims description 5
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 3
- 239000003814 drug Substances 0.000 claims 1
- 239000000499 gel Substances 0.000 description 42
- 229920002125 Sokalan® Polymers 0.000 description 9
- 229960002449 glycine Drugs 0.000 description 9
- 208000032843 Hemorrhage Diseases 0.000 description 8
- 230000000740 bleeding effect Effects 0.000 description 7
- 238000003756 stirring Methods 0.000 description 7
- 238000000034 method Methods 0.000 description 6
- 210000002850 nasal mucosa Anatomy 0.000 description 6
- 239000000463 material Substances 0.000 description 5
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 4
- 102000009123 Fibrin Human genes 0.000 description 4
- 108010073385 Fibrin Proteins 0.000 description 4
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 4
- 239000001110 calcium chloride Substances 0.000 description 4
- 229910001628 calcium chloride Inorganic materials 0.000 description 4
- 229950003499 fibrin Drugs 0.000 description 4
- 210000004877 mucosa Anatomy 0.000 description 4
- 210000001331 nose Anatomy 0.000 description 4
- 229920000742 Cotton Polymers 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 239000000872 buffer Substances 0.000 description 3
- 229960001631 carbomer Drugs 0.000 description 3
- 229940068196 placebo Drugs 0.000 description 3
- 239000000902 placebo Substances 0.000 description 3
- 230000000306 recurrent effect Effects 0.000 description 3
- 235000002639 sodium chloride Nutrition 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 239000002253 acid Substances 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 238000003825 pressing Methods 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- GYDJEQRTZSCIOI-LJGSYFOKSA-N tranexamic acid Chemical compound NC[C@H]1CC[C@H](C(O)=O)CC1 GYDJEQRTZSCIOI-LJGSYFOKSA-N 0.000 description 2
- 229960000401 tranexamic acid Drugs 0.000 description 2
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 1
- JVTIXNMXDLQEJE-UHFFFAOYSA-N 2-decanoyloxypropyl decanoate 2-octanoyloxypropyl octanoate Chemical compound C(CCCCCCC)(=O)OCC(C)OC(CCCCCCC)=O.C(=O)(CCCCCCCCC)OCC(C)OC(=O)CCCCCCCCC JVTIXNMXDLQEJE-UHFFFAOYSA-N 0.000 description 1
- WLAMNBDJUVNPJU-UHFFFAOYSA-N 2-methylbutyric acid Chemical compound CCC(C)C(O)=O WLAMNBDJUVNPJU-UHFFFAOYSA-N 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- RGHNJXZEOKUKBD-SQOUGZDYSA-M D-gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O RGHNJXZEOKUKBD-SQOUGZDYSA-M 0.000 description 1
- 108010049003 Fibrinogen Proteins 0.000 description 1
- 102000008946 Fibrinogen Human genes 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 108090000190 Thrombin Proteins 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 230000001464 adherent effect Effects 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- -1 alkalis Substances 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 230000023555 blood coagulation Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 238000007664 blowing Methods 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- GICLSALZHXCILJ-UHFFFAOYSA-N ctk5a5089 Chemical compound NCC(O)=O.NCC(O)=O GICLSALZHXCILJ-UHFFFAOYSA-N 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 239000003797 essential amino acid Substances 0.000 description 1
- 235000020776 essential amino acid Nutrition 0.000 description 1
- 230000020764 fibrinolysis Effects 0.000 description 1
- 239000003527 fibrinolytic agent Substances 0.000 description 1
- 230000003480 fibrinolytic effect Effects 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 229940050410 gluconate Drugs 0.000 description 1
- 230000002439 hemostatic effect Effects 0.000 description 1
- KUQWZSZYIQGTHT-UHFFFAOYSA-N hexa-1,5-diene-3,4-diol Chemical compound C=CC(O)C(O)C=C KUQWZSZYIQGTHT-UHFFFAOYSA-N 0.000 description 1
- 210000005260 human cell Anatomy 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000006241 metabolic reaction Methods 0.000 description 1
- 230000000420 mucociliary effect Effects 0.000 description 1
- 229940100652 nasal gel Drugs 0.000 description 1
- 229940097496 nasal spray Drugs 0.000 description 1
- 239000007922 nasal spray Substances 0.000 description 1
- 239000003002 pH adjusting agent Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 229940071643 prefilled syringe Drugs 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 206010039083 rhinitis Diseases 0.000 description 1
- 201000009890 sinusitis Diseases 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 229960004072 thrombin Drugs 0.000 description 1
- 239000012049 topical pharmaceutical composition Substances 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000005526 vasoconstrictor agent Substances 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/765—Polymers containing oxygen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Otolaryngology (AREA)
- Inorganic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0703377A GB2447012B (en) | 2007-02-21 | 2007-02-21 | Composition for combating epistaxis |
| GB0703377 | 2007-02-21 | ||
| PCT/GB2008/000608 WO2008102150A2 (en) | 2007-02-21 | 2008-02-21 | Composition for combating epistaxis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2606947T3 true ES2606947T3 (es) | 2017-03-28 |
Family
ID=37909023
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES08709491.8T Active ES2606947T3 (es) | 2007-02-21 | 2008-02-21 | Composición para combatir epistaxis |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US9138406B2 (enExample) |
| EP (1) | EP2117502B1 (enExample) |
| JP (1) | JP2010519285A (enExample) |
| KR (1) | KR20090130001A (enExample) |
| CN (1) | CN101677940B (enExample) |
| AU (1) | AU2008217608B2 (enExample) |
| BR (1) | BRPI0807732B8 (enExample) |
| CA (1) | CA2678706C (enExample) |
| DK (1) | DK2117502T3 (enExample) |
| ES (1) | ES2606947T3 (enExample) |
| GB (1) | GB2447012B (enExample) |
| HR (1) | HRP20161626T1 (enExample) |
| HU (1) | HUE031199T2 (enExample) |
| IL (1) | IL200277A0 (enExample) |
| PL (1) | PL2117502T3 (enExample) |
| PT (1) | PT2117502T (enExample) |
| RU (1) | RU2473327C2 (enExample) |
| WO (1) | WO2008102150A2 (enExample) |
| ZA (1) | ZA200905519B (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2447012B (en) | 2007-02-21 | 2011-03-16 | Pharmacure Health Care Ab | Composition for combating epistaxis |
| USD993736S1 (en) | 2023-05-17 | 2023-08-01 | Line Work Bucket Products, LLC | Auger and socket holder |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4363319A (en) * | 1980-06-30 | 1982-12-14 | Applied Medical Devices, Inc. | Ready-to-use bandage incorporating a coagulant composition and method of preparing same |
| JPS63174924A (ja) * | 1987-01-14 | 1988-07-19 | Toko Yakuhin Kogyo Kk | 軟膏基剤および軟膏剤 |
| CA2121028A1 (en) * | 1991-10-11 | 1993-04-15 | Ulla K. E. Hedner | Hemostatic composition for local hemostasis |
| CN1091315A (zh) * | 1992-10-08 | 1994-08-31 | E·R·斯奎布父子公司 | 血纤维蛋白封闭剂组合物及其使用方法 |
| US5928611A (en) * | 1995-06-07 | 1999-07-27 | Closure Medical Corporation | Impregnated applicator tip |
| US6365131B1 (en) * | 1997-10-31 | 2002-04-02 | J. B. Chemicals & Pharmaceuticals Ltd. | Pharmaceutical dental formulation for topical application of metronidazole benzoate, chlorhexidine gluconate and local anesthetic |
| US6818018B1 (en) * | 1998-08-14 | 2004-11-16 | Incept Llc | In situ polymerizable hydrogels |
| CA2377088A1 (en) * | 1999-06-30 | 2001-01-04 | Scott Cordray | Nasal spray having dead sea salts |
| US20050232868A1 (en) * | 1999-10-19 | 2005-10-20 | The Procter & Gamble Company | Methods of entrapping, inactivating, and removing viral infections by the administration of respiratory tract compositions |
| US20030077301A1 (en) * | 1999-12-16 | 2003-04-24 | Maibach Howard I. | Topical pharmaceutical composition for the treatment of inflammatory dermatoses |
| RU2156612C1 (ru) * | 2000-03-13 | 2000-09-27 | Волков Александр Григорьевич | Способ остановки носового кровотечения |
| US7544348B2 (en) * | 2001-02-15 | 2009-06-09 | Access Pharmaceuticals, Inc. | Liquid formulations for the prevention and treatment of mucosal diseases and disorders |
| IL159156A0 (en) * | 2001-06-22 | 2004-06-01 | Millard Marsden Mershon | A gel forming composition containing a polyacrylic acid |
| DE10361306A1 (de) * | 2003-12-24 | 2005-07-28 | Lts Lohmann Therapie-Systeme Ag | Wundauflage und Wundschnellverband mit einem vasokonstriktorischen Inhaltsstoff, sowie Herstellungsverfahren hierfür |
| RU2369408C2 (ru) * | 2004-07-09 | 2009-10-10 | Ферросан А/С | Гемостатическая композиция, включающая гиалуроновую кислоту |
| GB2409162B (en) * | 2004-10-06 | 2005-12-14 | Bhk Holding Ltd | Materials,methods,and apparatus for treating a body cavity |
| RU2290937C1 (ru) * | 2005-10-03 | 2007-01-10 | Владислав Владимирович Петров | Способ остановки носового кровотечения |
| GB2447012B (en) | 2007-02-21 | 2011-03-16 | Pharmacure Health Care Ab | Composition for combating epistaxis |
-
2007
- 2007-02-21 GB GB0703377A patent/GB2447012B/en not_active Expired - Fee Related
-
2008
- 2008-02-21 DK DK08709491.8T patent/DK2117502T3/en active
- 2008-02-21 KR KR1020097019543A patent/KR20090130001A/ko not_active Ceased
- 2008-02-21 PL PL08709491T patent/PL2117502T3/pl unknown
- 2008-02-21 CA CA2678706A patent/CA2678706C/en active Active
- 2008-02-21 BR BRPI0807732A patent/BRPI0807732B8/pt not_active IP Right Cessation
- 2008-02-21 WO PCT/GB2008/000608 patent/WO2008102150A2/en not_active Ceased
- 2008-02-21 HR HRP20161626TT patent/HRP20161626T1/hr unknown
- 2008-02-21 PT PT87094918T patent/PT2117502T/pt unknown
- 2008-02-21 RU RU2009134086/15A patent/RU2473327C2/ru not_active IP Right Cessation
- 2008-02-21 EP EP08709491.8A patent/EP2117502B1/en active Active
- 2008-02-21 CN CN200880005428.8A patent/CN101677940B/zh not_active Expired - Fee Related
- 2008-02-21 ZA ZA200905519A patent/ZA200905519B/xx unknown
- 2008-02-21 ES ES08709491.8T patent/ES2606947T3/es active Active
- 2008-02-21 US US12/525,975 patent/US9138406B2/en active Active
- 2008-02-21 HU HUE08709491A patent/HUE031199T2/en unknown
- 2008-02-21 AU AU2008217608A patent/AU2008217608B2/en not_active Ceased
- 2008-02-21 JP JP2009550758A patent/JP2010519285A/ja active Pending
-
2009
- 2009-08-06 IL IL200277A patent/IL200277A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2678706A1 (en) | 2008-08-28 |
| HUE031199T2 (en) | 2017-07-28 |
| CA2678706C (en) | 2014-11-18 |
| GB0703377D0 (en) | 2007-03-28 |
| IL200277A0 (en) | 2010-04-29 |
| KR20090130001A (ko) | 2009-12-17 |
| CN101677940A (zh) | 2010-03-24 |
| BRPI0807732B8 (pt) | 2021-05-25 |
| HRP20161626T1 (hr) | 2017-03-10 |
| ZA200905519B (en) | 2010-10-27 |
| GB2447012B (en) | 2011-03-16 |
| US9138406B2 (en) | 2015-09-22 |
| PL2117502T3 (pl) | 2017-08-31 |
| RU2009134086A (ru) | 2011-03-27 |
| US20100119472A1 (en) | 2010-05-13 |
| JP2010519285A (ja) | 2010-06-03 |
| AU2008217608A1 (en) | 2008-08-28 |
| BRPI0807732A2 (pt) | 2014-06-03 |
| EP2117502B1 (en) | 2016-11-09 |
| PT2117502T (pt) | 2016-12-13 |
| AU2008217608B2 (en) | 2013-01-10 |
| RU2473327C2 (ru) | 2013-01-27 |
| CN101677940B (zh) | 2014-02-19 |
| BRPI0807732B1 (pt) | 2020-08-04 |
| GB2447012A (en) | 2008-09-03 |
| WO2008102150A3 (en) | 2009-04-30 |
| WO2008102150A2 (en) | 2008-08-28 |
| DK2117502T3 (en) | 2017-01-23 |
| EP2117502A2 (en) | 2009-11-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101180036B (zh) | 用于医药装置和药物制剂中的含有木葡聚糖的粘膜粘附性制剂 | |
| ES2251997T3 (es) | Composiciones adhesivs a la mucosa para el tratamiento de transtornos del esofago y su uso. | |
| ES2880813T3 (es) | Formulaciones farmacéuticas de naproxeno para encapsulación en gel blando y combinaciones de las mismas | |
| ES2946767T3 (es) | Composiciones terapéuticas antimicrobianas hipertónicas | |
| PT1386613E (pt) | Composição tópica efervescente | |
| EP2520279A1 (en) | Thermoreversible gel pharamaceutical compositions for odontoiatric use | |
| ES2535521T3 (es) | Composición farmacéutica | |
| BRPI0620403B1 (pt) | filme bioadesivo, unidade de dosagem, método de fabricação de um filme bioadesivo, e, uso de uma composição | |
| ES2657598T3 (es) | Preparación para el tratamiento de heridas y llagas que comprende hipoclorito y aminoácidos | |
| ES2385483T3 (es) | Composiciones para la preparación de un gel de dióxido de carbono para uso externo y geles de dióxido de carbono para uso externo | |
| ES2877656T3 (es) | Composiciones acuosas de tratamiento con fluoruro para el cuidado bucal | |
| ES2269393T3 (es) | Inhibicion de pepsina mediante alginatos. | |
| EP0626168B1 (en) | Novel rafting antacid composition | |
| ES2774128T3 (es) | Composición farmacéutica para administración a la mucosa nasal | |
| US9138406B2 (en) | Composition for combating epistaxis | |
| ES2875624T3 (es) | Formulación gelificante a base de gluconato de calcio | |
| JP6595717B2 (ja) | 骨関節炎治療のための親水化されたスルファサラジンおよびヒアルロン酸を含む組成物およびその製造方法 | |
| JP2002255852A (ja) | 口内炎用スプレー製剤 | |
| EP1143914B1 (en) | Preparation for dental treatment | |
| ES2615236T3 (es) | Tratamiento de infecciones víricas | |
| US20230158051A1 (en) | Pharmaceutical paste formulations for site specific application | |
| ES2271483T3 (es) | Preparaciones antiacido liquidas. | |
| US5409691A (en) | Solution comprising aluminum acetate and glycerin | |
| RU2306135C2 (ru) | Способ профилактики и лечения задержания последа и эндометрита у животных пенообразующим препаратом | |
| RU2173139C2 (ru) | Усовершенствования органических композиций или усовершенствования, относящиеся к этим композициям |