CN101677940B - 一种治疗鼻出血的组合物 - Google Patents

一种治疗鼻出血的组合物 Download PDF

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Publication number
CN101677940B
CN101677940B CN200880005428.8A CN200880005428A CN101677940B CN 101677940 B CN101677940 B CN 101677940B CN 200880005428 A CN200880005428 A CN 200880005428A CN 101677940 B CN101677940 B CN 101677940B
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CN
China
Prior art keywords
gel
composition according
glycine
concentration
calcium ions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN200880005428.8A
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English (en)
Chinese (zh)
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CN101677940A (zh
Inventor
比约恩·彼特森
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Pharmacure Health Care AB
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Pharmacure Health Care AB
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Publication of CN101677940A publication Critical patent/CN101677940A/zh
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Publication of CN101677940B publication Critical patent/CN101677940B/zh
Expired - Fee Related legal-status Critical Current
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/765—Polymers containing oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Otolaryngology (AREA)
  • Inorganic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN200880005428.8A 2007-02-21 2008-02-21 一种治疗鼻出血的组合物 Expired - Fee Related CN101677940B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0703377.2 2007-02-21
GB0703377A GB2447012B (en) 2007-02-21 2007-02-21 Composition for combating epistaxis
PCT/GB2008/000608 WO2008102150A2 (en) 2007-02-21 2008-02-21 Composition for combating epistaxis

Publications (2)

Publication Number Publication Date
CN101677940A CN101677940A (zh) 2010-03-24
CN101677940B true CN101677940B (zh) 2014-02-19

Family

ID=37909023

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200880005428.8A Expired - Fee Related CN101677940B (zh) 2007-02-21 2008-02-21 一种治疗鼻出血的组合物

Country Status (19)

Country Link
US (1) US9138406B2 (enExample)
EP (1) EP2117502B1 (enExample)
JP (1) JP2010519285A (enExample)
KR (1) KR20090130001A (enExample)
CN (1) CN101677940B (enExample)
AU (1) AU2008217608B2 (enExample)
BR (1) BRPI0807732B8 (enExample)
CA (1) CA2678706C (enExample)
DK (1) DK2117502T3 (enExample)
ES (1) ES2606947T3 (enExample)
GB (1) GB2447012B (enExample)
HR (1) HRP20161626T1 (enExample)
HU (1) HUE031199T2 (enExample)
IL (1) IL200277A0 (enExample)
PL (1) PL2117502T3 (enExample)
PT (1) PT2117502T (enExample)
RU (1) RU2473327C2 (enExample)
WO (1) WO2008102150A2 (enExample)
ZA (1) ZA200905519B (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2447012B (en) 2007-02-21 2011-03-16 Pharmacure Health Care Ab Composition for combating epistaxis
USD993736S1 (en) 2023-05-17 2023-08-01 Line Work Bucket Products, LLC Auger and socket holder

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993006855A1 (en) * 1991-10-11 1993-04-15 Novo Nordisk A/S Hemostatic composition for local hemostasis
WO2003000155A2 (en) * 2001-06-22 2003-01-03 Millard Marsden Mershon Compositions and methods for reducing blood and fluid loss from open wounds
US20070009578A1 (en) * 2004-07-09 2007-01-11 Lene Moller Haemostatic composition comprising hyaluronic acid

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4363319A (en) * 1980-06-30 1982-12-14 Applied Medical Devices, Inc. Ready-to-use bandage incorporating a coagulant composition and method of preparing same
JPS63174924A (ja) * 1987-01-14 1988-07-19 Toko Yakuhin Kogyo Kk 軟膏基剤および軟膏剤
CN1091315A (zh) * 1992-10-08 1994-08-31 E·R·斯奎布父子公司 血纤维蛋白封闭剂组合物及其使用方法
US5928611A (en) * 1995-06-07 1999-07-27 Closure Medical Corporation Impregnated applicator tip
US6365131B1 (en) * 1997-10-31 2002-04-02 J. B. Chemicals & Pharmaceuticals Ltd. Pharmaceutical dental formulation for topical application of metronidazole benzoate, chlorhexidine gluconate and local anesthetic
US6818018B1 (en) * 1998-08-14 2004-11-16 Incept Llc In situ polymerizable hydrogels
CA2377088A1 (en) * 1999-06-30 2001-01-04 Scott Cordray Nasal spray having dead sea salts
US20050232868A1 (en) * 1999-10-19 2005-10-20 The Procter & Gamble Company Methods of entrapping, inactivating, and removing viral infections by the administration of respiratory tract compositions
US20030077301A1 (en) * 1999-12-16 2003-04-24 Maibach Howard I. Topical pharmaceutical composition for the treatment of inflammatory dermatoses
RU2156612C1 (ru) * 2000-03-13 2000-09-27 Волков Александр Григорьевич Способ остановки носового кровотечения
US7544348B2 (en) * 2001-02-15 2009-06-09 Access Pharmaceuticals, Inc. Liquid formulations for the prevention and treatment of mucosal diseases and disorders
DE10361306A1 (de) * 2003-12-24 2005-07-28 Lts Lohmann Therapie-Systeme Ag Wundauflage und Wundschnellverband mit einem vasokonstriktorischen Inhaltsstoff, sowie Herstellungsverfahren hierfür
GB2409162B (en) * 2004-10-06 2005-12-14 Bhk Holding Ltd Materials,methods,and apparatus for treating a body cavity
RU2290937C1 (ru) * 2005-10-03 2007-01-10 Владислав Владимирович Петров Способ остановки носового кровотечения
GB2447012B (en) 2007-02-21 2011-03-16 Pharmacure Health Care Ab Composition for combating epistaxis

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993006855A1 (en) * 1991-10-11 1993-04-15 Novo Nordisk A/S Hemostatic composition for local hemostasis
WO2003000155A2 (en) * 2001-06-22 2003-01-03 Millard Marsden Mershon Compositions and methods for reducing blood and fluid loss from open wounds
US20070009578A1 (en) * 2004-07-09 2007-01-11 Lene Moller Haemostatic composition comprising hyaluronic acid

Also Published As

Publication number Publication date
CA2678706A1 (en) 2008-08-28
HUE031199T2 (en) 2017-07-28
CA2678706C (en) 2014-11-18
GB0703377D0 (en) 2007-03-28
IL200277A0 (en) 2010-04-29
KR20090130001A (ko) 2009-12-17
CN101677940A (zh) 2010-03-24
BRPI0807732B8 (pt) 2021-05-25
HRP20161626T1 (hr) 2017-03-10
ZA200905519B (en) 2010-10-27
GB2447012B (en) 2011-03-16
US9138406B2 (en) 2015-09-22
PL2117502T3 (pl) 2017-08-31
RU2009134086A (ru) 2011-03-27
US20100119472A1 (en) 2010-05-13
JP2010519285A (ja) 2010-06-03
AU2008217608A1 (en) 2008-08-28
BRPI0807732A2 (pt) 2014-06-03
EP2117502B1 (en) 2016-11-09
PT2117502T (pt) 2016-12-13
AU2008217608B2 (en) 2013-01-10
RU2473327C2 (ru) 2013-01-27
BRPI0807732B1 (pt) 2020-08-04
GB2447012A (en) 2008-09-03
WO2008102150A3 (en) 2009-04-30
ES2606947T3 (es) 2017-03-28
WO2008102150A2 (en) 2008-08-28
DK2117502T3 (en) 2017-01-23
EP2117502A2 (en) 2009-11-18

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