DK2117502T3 - COMPOSITION TO FIGHT EPISTAXIS - Google Patents
COMPOSITION TO FIGHT EPISTAXIS Download PDFInfo
- Publication number
- DK2117502T3 DK2117502T3 DK08709491.8T DK08709491T DK2117502T3 DK 2117502 T3 DK2117502 T3 DK 2117502T3 DK 08709491 T DK08709491 T DK 08709491T DK 2117502 T3 DK2117502 T3 DK 2117502T3
- Authority
- DK
- Denmark
- Prior art keywords
- gel
- composition
- glycine
- concentration
- per liter
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims description 41
- 208000001780 epistaxis Diseases 0.000 title claims description 17
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims description 33
- 229920000642 polymer Polymers 0.000 claims description 21
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical group OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 20
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 claims description 19
- 229910001424 calcium ion Inorganic materials 0.000 claims description 19
- 229940096529 carboxypolymethylene Drugs 0.000 claims description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 15
- 239000004471 Glycine Substances 0.000 claims description 14
- 238000011282 treatment Methods 0.000 claims description 10
- 238000002560 therapeutic procedure Methods 0.000 claims description 7
- 238000011321 prophylaxis Methods 0.000 claims description 5
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 3
- 239000003814 drug Substances 0.000 claims 1
- 239000000499 gel Substances 0.000 description 41
- 229920002125 Sokalan® Polymers 0.000 description 10
- 229960002449 glycine Drugs 0.000 description 9
- 208000032843 Hemorrhage Diseases 0.000 description 7
- 230000000740 bleeding effect Effects 0.000 description 7
- 239000004615 ingredient Substances 0.000 description 7
- 238000000034 method Methods 0.000 description 7
- 238000003756 stirring Methods 0.000 description 7
- 210000003928 nasal cavity Anatomy 0.000 description 6
- 210000002850 nasal mucosa Anatomy 0.000 description 6
- 239000000463 material Substances 0.000 description 5
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 4
- 102000009123 Fibrin Human genes 0.000 description 4
- 108010073385 Fibrin Proteins 0.000 description 4
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 4
- 239000001110 calcium chloride Substances 0.000 description 4
- 229910001628 calcium chloride Inorganic materials 0.000 description 4
- 229950003499 fibrin Drugs 0.000 description 4
- 210000001331 nose Anatomy 0.000 description 4
- -1 Ca2+ ions Chemical class 0.000 description 3
- 229920000742 Cotton Polymers 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 239000000872 buffer Substances 0.000 description 3
- 229960001631 carbomer Drugs 0.000 description 3
- 210000004877 mucosa Anatomy 0.000 description 3
- 229940068196 placebo Drugs 0.000 description 3
- 239000000902 placebo Substances 0.000 description 3
- 235000002639 sodium chloride Nutrition 0.000 description 3
- 239000002253 acid Substances 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 229940100652 nasal gel Drugs 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 238000003825 pressing Methods 0.000 description 2
- 230000000306 recurrent effect Effects 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- GYDJEQRTZSCIOI-LJGSYFOKSA-N tranexamic acid Chemical compound NC[C@H]1CC[C@H](C(O)=O)CC1 GYDJEQRTZSCIOI-LJGSYFOKSA-N 0.000 description 2
- 229960000401 tranexamic acid Drugs 0.000 description 2
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 1
- JVTIXNMXDLQEJE-UHFFFAOYSA-N 2-decanoyloxypropyl decanoate 2-octanoyloxypropyl octanoate Chemical compound C(CCCCCCC)(=O)OCC(C)OC(CCCCCCC)=O.C(=O)(CCCCCCCCC)OCC(C)OC(=O)CCCCCCCCC JVTIXNMXDLQEJE-UHFFFAOYSA-N 0.000 description 1
- WLAMNBDJUVNPJU-UHFFFAOYSA-N 2-methylbutyric acid Chemical compound CCC(C)C(O)=O WLAMNBDJUVNPJU-UHFFFAOYSA-N 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- RGHNJXZEOKUKBD-SQOUGZDYSA-M D-gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O RGHNJXZEOKUKBD-SQOUGZDYSA-M 0.000 description 1
- 108010049003 Fibrinogen Proteins 0.000 description 1
- 102000008946 Fibrinogen Human genes 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 108090000190 Thrombin Proteins 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 230000001464 adherent effect Effects 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 230000023555 blood coagulation Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 238000007664 blowing Methods 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- GICLSALZHXCILJ-UHFFFAOYSA-N ctk5a5089 Chemical compound NCC(O)=O.NCC(O)=O GICLSALZHXCILJ-UHFFFAOYSA-N 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- BROSRFATIJCNNM-UHFFFAOYSA-L disilver;3-[(3-sulfonatonaphthalen-2-yl)methyl]naphthalene-2-sulfonate Chemical compound [Ag+].[Ag+].C1=CC=C2C=C(S([O-])(=O)=O)C(CC3=CC4=CC=CC=C4C=C3S(=O)(=O)[O-])=CC2=C1 BROSRFATIJCNNM-UHFFFAOYSA-L 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 239000003797 essential amino acid Substances 0.000 description 1
- 235000020776 essential amino acid Nutrition 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- 230000020764 fibrinolysis Effects 0.000 description 1
- 239000003527 fibrinolytic agent Substances 0.000 description 1
- 230000003480 fibrinolytic effect Effects 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 229940050410 gluconate Drugs 0.000 description 1
- 230000000025 haemostatic effect Effects 0.000 description 1
- KUQWZSZYIQGTHT-UHFFFAOYSA-N hexa-1,5-diene-3,4-diol Chemical compound C=CC(O)C(O)C=C KUQWZSZYIQGTHT-UHFFFAOYSA-N 0.000 description 1
- 210000005260 human cell Anatomy 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000006241 metabolic reaction Methods 0.000 description 1
- 230000000420 mucociliary effect Effects 0.000 description 1
- 229940097496 nasal spray Drugs 0.000 description 1
- 239000007922 nasal spray Substances 0.000 description 1
- 230000001473 noxious effect Effects 0.000 description 1
- 239000003002 pH adjusting agent Substances 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 229940071643 prefilled syringe Drugs 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 206010039083 rhinitis Diseases 0.000 description 1
- 201000009890 sinusitis Diseases 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 229960004072 thrombin Drugs 0.000 description 1
- 239000012049 topical pharmaceutical composition Substances 0.000 description 1
- 239000005526 vasoconstrictor agent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/765—Polymers containing oxygen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Otolaryngology (AREA)
- Inorganic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0703377A GB2447012B (en) | 2007-02-21 | 2007-02-21 | Composition for combating epistaxis |
| PCT/GB2008/000608 WO2008102150A2 (en) | 2007-02-21 | 2008-02-21 | Composition for combating epistaxis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2117502T3 true DK2117502T3 (en) | 2017-01-23 |
Family
ID=37909023
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK08709491.8T DK2117502T3 (en) | 2007-02-21 | 2008-02-21 | COMPOSITION TO FIGHT EPISTAXIS |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US9138406B2 (enExample) |
| EP (1) | EP2117502B1 (enExample) |
| JP (1) | JP2010519285A (enExample) |
| KR (1) | KR20090130001A (enExample) |
| CN (1) | CN101677940B (enExample) |
| AU (1) | AU2008217608B2 (enExample) |
| BR (1) | BRPI0807732B8 (enExample) |
| CA (1) | CA2678706C (enExample) |
| DK (1) | DK2117502T3 (enExample) |
| ES (1) | ES2606947T3 (enExample) |
| GB (1) | GB2447012B (enExample) |
| HR (1) | HRP20161626T1 (enExample) |
| HU (1) | HUE031199T2 (enExample) |
| IL (1) | IL200277A0 (enExample) |
| PL (1) | PL2117502T3 (enExample) |
| PT (1) | PT2117502T (enExample) |
| RU (1) | RU2473327C2 (enExample) |
| WO (1) | WO2008102150A2 (enExample) |
| ZA (1) | ZA200905519B (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2447012B (en) | 2007-02-21 | 2011-03-16 | Pharmacure Health Care Ab | Composition for combating epistaxis |
| USD993736S1 (en) | 2023-05-17 | 2023-08-01 | Line Work Bucket Products, LLC | Auger and socket holder |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4363319A (en) * | 1980-06-30 | 1982-12-14 | Applied Medical Devices, Inc. | Ready-to-use bandage incorporating a coagulant composition and method of preparing same |
| JPS63174924A (ja) * | 1987-01-14 | 1988-07-19 | Toko Yakuhin Kogyo Kk | 軟膏基剤および軟膏剤 |
| CA2121028A1 (en) * | 1991-10-11 | 1993-04-15 | Ulla K. E. Hedner | Hemostatic composition for local hemostasis |
| CN1091315A (zh) * | 1992-10-08 | 1994-08-31 | E·R·斯奎布父子公司 | 血纤维蛋白封闭剂组合物及其使用方法 |
| US5928611A (en) * | 1995-06-07 | 1999-07-27 | Closure Medical Corporation | Impregnated applicator tip |
| US6365131B1 (en) * | 1997-10-31 | 2002-04-02 | J. B. Chemicals & Pharmaceuticals Ltd. | Pharmaceutical dental formulation for topical application of metronidazole benzoate, chlorhexidine gluconate and local anesthetic |
| US6818018B1 (en) * | 1998-08-14 | 2004-11-16 | Incept Llc | In situ polymerizable hydrogels |
| CA2377088A1 (en) * | 1999-06-30 | 2001-01-04 | Scott Cordray | Nasal spray having dead sea salts |
| US20050232868A1 (en) * | 1999-10-19 | 2005-10-20 | The Procter & Gamble Company | Methods of entrapping, inactivating, and removing viral infections by the administration of respiratory tract compositions |
| US20030077301A1 (en) * | 1999-12-16 | 2003-04-24 | Maibach Howard I. | Topical pharmaceutical composition for the treatment of inflammatory dermatoses |
| RU2156612C1 (ru) * | 2000-03-13 | 2000-09-27 | Волков Александр Григорьевич | Способ остановки носового кровотечения |
| US7544348B2 (en) * | 2001-02-15 | 2009-06-09 | Access Pharmaceuticals, Inc. | Liquid formulations for the prevention and treatment of mucosal diseases and disorders |
| IL159156A0 (en) * | 2001-06-22 | 2004-06-01 | Millard Marsden Mershon | A gel forming composition containing a polyacrylic acid |
| DE10361306A1 (de) * | 2003-12-24 | 2005-07-28 | Lts Lohmann Therapie-Systeme Ag | Wundauflage und Wundschnellverband mit einem vasokonstriktorischen Inhaltsstoff, sowie Herstellungsverfahren hierfür |
| RU2369408C2 (ru) * | 2004-07-09 | 2009-10-10 | Ферросан А/С | Гемостатическая композиция, включающая гиалуроновую кислоту |
| GB2409162B (en) * | 2004-10-06 | 2005-12-14 | Bhk Holding Ltd | Materials,methods,and apparatus for treating a body cavity |
| RU2290937C1 (ru) * | 2005-10-03 | 2007-01-10 | Владислав Владимирович Петров | Способ остановки носового кровотечения |
| GB2447012B (en) | 2007-02-21 | 2011-03-16 | Pharmacure Health Care Ab | Composition for combating epistaxis |
-
2007
- 2007-02-21 GB GB0703377A patent/GB2447012B/en not_active Expired - Fee Related
-
2008
- 2008-02-21 DK DK08709491.8T patent/DK2117502T3/en active
- 2008-02-21 KR KR1020097019543A patent/KR20090130001A/ko not_active Ceased
- 2008-02-21 PL PL08709491T patent/PL2117502T3/pl unknown
- 2008-02-21 CA CA2678706A patent/CA2678706C/en active Active
- 2008-02-21 BR BRPI0807732A patent/BRPI0807732B8/pt not_active IP Right Cessation
- 2008-02-21 WO PCT/GB2008/000608 patent/WO2008102150A2/en not_active Ceased
- 2008-02-21 HR HRP20161626TT patent/HRP20161626T1/hr unknown
- 2008-02-21 PT PT87094918T patent/PT2117502T/pt unknown
- 2008-02-21 RU RU2009134086/15A patent/RU2473327C2/ru not_active IP Right Cessation
- 2008-02-21 EP EP08709491.8A patent/EP2117502B1/en active Active
- 2008-02-21 CN CN200880005428.8A patent/CN101677940B/zh not_active Expired - Fee Related
- 2008-02-21 ZA ZA200905519A patent/ZA200905519B/xx unknown
- 2008-02-21 ES ES08709491.8T patent/ES2606947T3/es active Active
- 2008-02-21 US US12/525,975 patent/US9138406B2/en active Active
- 2008-02-21 HU HUE08709491A patent/HUE031199T2/en unknown
- 2008-02-21 AU AU2008217608A patent/AU2008217608B2/en not_active Ceased
- 2008-02-21 JP JP2009550758A patent/JP2010519285A/ja active Pending
-
2009
- 2009-08-06 IL IL200277A patent/IL200277A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2678706A1 (en) | 2008-08-28 |
| HUE031199T2 (en) | 2017-07-28 |
| CA2678706C (en) | 2014-11-18 |
| GB0703377D0 (en) | 2007-03-28 |
| IL200277A0 (en) | 2010-04-29 |
| KR20090130001A (ko) | 2009-12-17 |
| CN101677940A (zh) | 2010-03-24 |
| BRPI0807732B8 (pt) | 2021-05-25 |
| HRP20161626T1 (hr) | 2017-03-10 |
| ZA200905519B (en) | 2010-10-27 |
| GB2447012B (en) | 2011-03-16 |
| US9138406B2 (en) | 2015-09-22 |
| PL2117502T3 (pl) | 2017-08-31 |
| RU2009134086A (ru) | 2011-03-27 |
| US20100119472A1 (en) | 2010-05-13 |
| JP2010519285A (ja) | 2010-06-03 |
| AU2008217608A1 (en) | 2008-08-28 |
| BRPI0807732A2 (pt) | 2014-06-03 |
| EP2117502B1 (en) | 2016-11-09 |
| PT2117502T (pt) | 2016-12-13 |
| AU2008217608B2 (en) | 2013-01-10 |
| RU2473327C2 (ru) | 2013-01-27 |
| CN101677940B (zh) | 2014-02-19 |
| BRPI0807732B1 (pt) | 2020-08-04 |
| GB2447012A (en) | 2008-09-03 |
| WO2008102150A3 (en) | 2009-04-30 |
| ES2606947T3 (es) | 2017-03-28 |
| WO2008102150A2 (en) | 2008-08-28 |
| EP2117502A2 (en) | 2009-11-18 |
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