ES2603061T3 - Interrupción de la percepción de quórum en bacterias mediada por anticuerpos - Google Patents

Interrupción de la percepción de quórum en bacterias mediada por anticuerpos Download PDF

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Publication number
ES2603061T3
ES2603061T3 ES14180831.1T ES14180831T ES2603061T3 ES 2603061 T3 ES2603061 T3 ES 2603061T3 ES 14180831 T ES14180831 T ES 14180831T ES 2603061 T3 ES2603061 T3 ES 2603061T3
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Spain
Prior art keywords
seq
amino acid
kynp
hapten
cyclic peptide
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Active
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ES14180831.1T
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English (en)
Spanish (es)
Inventor
Kim D. Janda
Gunnar F. Kaufmann
Junguk Park
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Scripps Research Institute
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Scripps Research Institute
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/12—Cyclic peptides with only normal peptide bonds in the ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/085—Staphylococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
    • C07K16/1271—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Micrococcaceae (F), e.g. Staphylococcus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Inorganic Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
ES14180831.1T 2007-10-25 2008-10-24 Interrupción de la percepción de quórum en bacterias mediada por anticuerpos Active ES2603061T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US98259307P 2007-10-25 2007-10-25
US982593P 2007-10-25

Publications (1)

Publication Number Publication Date
ES2603061T3 true ES2603061T3 (es) 2017-02-23

Family

ID=40580303

Family Applications (1)

Application Number Title Priority Date Filing Date
ES14180831.1T Active ES2603061T3 (es) 2007-10-25 2008-10-24 Interrupción de la percepción de quórum en bacterias mediada por anticuerpos

Country Status (9)

Country Link
US (2) US9394371B2 (enExample)
EP (2) EP2842565B1 (enExample)
JP (3) JP5581490B2 (enExample)
KR (1) KR101557173B1 (enExample)
CN (2) CN101835484B (enExample)
AU (1) AU2008317331B2 (enExample)
CA (2) CA2703133C (enExample)
ES (1) ES2603061T3 (enExample)
WO (1) WO2009055054A2 (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2911694A4 (en) 2012-10-26 2016-07-13 Sorrento Therapeutics Inc ANTI-INFECTIOUS BINDING PROTEINS THAT BIND TO AIP2
DE102013211850A1 (de) * 2013-06-21 2014-12-24 Gilupi Gmbh Schnelltest zum Nachweisen von Erregermaterial, insbesondere zur Unterstützung der Diagnose einer Sepsis, sowie Kit und Vorrichtung zur Durchführung eines Sepsistests
NZ717476A (en) * 2013-08-01 2022-04-29 Univ Catholique Louvain Anti-garp protein and uses thereof
CN105849087A (zh) 2013-12-27 2016-08-10 诺华丝国际股份有限公司 乙氧基化表面活性剂
KR102538555B1 (ko) 2014-01-29 2023-05-30 케이엠 바이올로직스 가부시키가이샤 항-트랜스티레틴 인간화 항체
EP3981874A1 (en) * 2014-01-29 2022-04-13 KM Biologics Co., Ltd. Anti-transthyretin human antibody
WO2015119170A1 (ja) * 2014-02-07 2015-08-13 ミヤリサン製薬株式会社 クロストリジウム属の菌の毒素産生抑制活性を有するペプチド
WO2017136400A1 (en) * 2016-02-02 2017-08-10 Stc. Unm Vlp-based vaccines for targeting staphylococcus aureus secreted virulence factors
JP7058638B2 (ja) * 2016-08-11 2022-04-22 ザ ユナイテッド ステイツ オブ アメリカ， アズ リプレゼンテッド バイ ザ セクレタリー， デパートメント オブ ヘルス アンド ヒューマン サービシーズ ホスホグリセリン酸ムターゼのペプチド阻害剤および使用方法
WO2018152452A1 (en) 2017-02-17 2018-08-23 Mapp Biopharmaceutical, Inc. Monoclonal antibodies and cocktails for treatment of ebola infections
US10584306B2 (en) 2017-08-11 2020-03-10 Board Of Regents Of The University Of Oklahoma Surfactant microemulsions
JP7373176B2 (ja) * 2017-08-31 2023-11-02 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 皮膚の酵素活性を制御する分子的細菌療法
EP3681903B1 (en) * 2017-09-15 2023-07-19 Lentigen Technology, Inc. Compositions and methods for treating cancer with anti-cd19 immunotherapy
US10774135B2 (en) 2017-12-22 2020-09-15 Sorrento Therapeutics, Inc. Variant antibodies that bind AIP2
US11459445B2 (en) 2018-02-13 2022-10-04 Sumitomo Chemical Company, Limited Composition and molded body
US11638759B2 (en) 2019-08-13 2023-05-02 Darlene E. McCord Non-activated, amorphous, pH neutral, two-part bedside-ready clay delivery system that treats pathogen infections in humans and animals
CN111573853B (zh) * 2020-05-29 2020-11-20 南京大学 一种削减生物法处理废水毒性的方法
WO2023076855A1 (en) 2021-10-25 2023-05-04 Mccord Darlene E Coated medicinal clay compositions, pharmaceutical compositions, and delivery of cation sources and methods of use thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0932613B1 (en) * 1996-05-22 2005-03-09 New York University Blocking expression of virulence factors in s. aureus
US6248329B1 (en) * 1998-06-01 2001-06-19 Ramaswamy Chandrashekar Parasitic helminth cuticlin nucleic acid molecules and uses thereof
WO2001085664A2 (en) * 2000-05-10 2001-11-15 Princeton University Compounds and methods for regulating bacterial growth and pathogenesis
US7786257B2 (en) 2000-12-18 2010-08-31 University Of Kansas Signal-1/signal-2 bifunctional peptide inhibitors
US6463632B2 (en) * 2001-02-07 2002-10-15 Hans Oetiker Ag Maschinen-Und Apparatefabrik Guide arrangement for tightening tool emplacement in hose clamps provided with plastically deformable ears
CN1164612C (zh) * 2001-09-11 2004-09-01 四川新泰克控股有限责任公司 人工组合的抗菌工程多肽及其制备方法
CA2495725C (en) 2002-08-13 2013-06-25 Haptogen Ltd Methods for the treatment of an infectious bacterial disease with an anti-lactone or lactone derived signal molecules antibody

Also Published As

Publication number Publication date
AU2008317331B2 (en) 2013-08-29
EP2211889A4 (en) 2012-01-11
CN101835484B (zh) 2014-07-16
AU2008317331A1 (en) 2009-04-30
JP2014221774A (ja) 2014-11-27
WO2009055054A3 (en) 2009-09-03
JP2011500814A (ja) 2011-01-06
WO2009055054A2 (en) 2009-04-30
CN101835484A (zh) 2010-09-15
CA2703133C (en) 2017-09-19
CN104211775A (zh) 2014-12-17
US9394371B2 (en) 2016-07-19
EP2842565A1 (en) 2015-03-04
CA2975568A1 (en) 2009-04-30
US20170043020A1 (en) 2017-02-16
JP2018021021A (ja) 2018-02-08
CA2703133A1 (en) 2009-04-30
KR101557173B1 (ko) 2015-10-05
KR20100102100A (ko) 2010-09-20
JP5581490B2 (ja) 2014-09-03
EP2211889B1 (en) 2014-08-20
JP6183910B2 (ja) 2017-08-23
EP2842565B1 (en) 2016-08-24
EP2211889A2 (en) 2010-08-04
US20100291093A1 (en) 2010-11-18

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