ES2592219T3 - Derivados de {(4-(4-morfolino-dihidrotieno[3,4-d]pirimidin-2-il)aril}urea o carbamato como inhibidores de mTOR - Google Patents
Derivados de {(4-(4-morfolino-dihidrotieno[3,4-d]pirimidin-2-il)aril}urea o carbamato como inhibidores de mTOR Download PDFInfo
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- ES2592219T3 ES2592219T3 ES12769098.0T ES12769098T ES2592219T3 ES 2592219 T3 ES2592219 T3 ES 2592219T3 ES 12769098 T ES12769098 T ES 12769098T ES 2592219 T3 ES2592219 T3 ES 2592219T3
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- pyrimidin
- dioxide
- dihydrothiene
- phenyl
- alkyl
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| CA2849189A1 (en) | 2011-09-21 | 2013-03-28 | Cellzome Limited | Morpholino substituted urea or carbamate derivatives as mtor inhibitors |
| US10722484B2 (en) | 2016-03-09 | 2020-07-28 | K-Gen, Inc. | Methods of cancer treatment |
| CN106117242B (zh) * | 2016-06-27 | 2018-08-03 | 山东大学 | 四氢噻喃并嘧啶类衍生物及其制备方法与应用 |
| FR3075795A1 (fr) * | 2017-12-21 | 2019-06-28 | Galderma Research & Development | Nouveaux composes inhibiteurs de mtor |
| WO2020055761A1 (en) | 2018-09-10 | 2020-03-19 | Mirati Therapeutics, Inc. | Combination therapies |
| WO2020103897A1 (zh) * | 2018-11-22 | 2020-05-28 | 上海迪诺医药科技有限公司 | 杂环稠合嘧啶衍生物、其药物组合物及应用 |
| TW202140474A (zh) * | 2020-01-17 | 2021-11-01 | 大陸商江蘇恆瑞醫藥股份有限公司 | 稠合雜芳基類衍生物、其製備方法及其在醫藥上的應用 |
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| GB2465405A (en) * | 2008-11-10 | 2010-05-19 | Univ Basel | Triazine, pyrimidine and pyridine analogues and their use in therapy |
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| WO2010120987A1 (en) * | 2009-04-17 | 2010-10-21 | Wyeth Llc | Ring fused, ureidoaryl- and carbamoylaryl-bridged morpholino-pyrimidine compounds, their use as mtor kinase and pi3 kinase inhibitors, and their syntheses |
| ES2439793T3 (es) | 2009-04-17 | 2014-01-24 | Wyeth Llc | Compuestos de pirimidina, su uso como inhibidores de la mTOR quinasa y de la PI3 quinasa, y su síntesis |
| US20100331305A1 (en) * | 2009-06-24 | 2010-12-30 | Genentech, Inc. | Oxo-heterocycle fused pyrimidine compounds, compositions and methods of use |
| CA2768851A1 (en) | 2009-07-23 | 2011-01-27 | The Trustees Of Princeton University | Inhibitors of mtor kinase as anti-viral agents |
| EP2542536B1 (en) | 2010-03-04 | 2015-01-21 | Cellzome Limited | Morpholino substituted urea derivatives as mtor inhibitors |
| WO2012136622A1 (en) | 2011-04-04 | 2012-10-11 | Cellzome Limited | Dihydropyrrolo pyrimidine derivatives as mtor inhibitors |
| CA2849189A1 (en) | 2011-09-21 | 2013-03-28 | Cellzome Limited | Morpholino substituted urea or carbamate derivatives as mtor inhibitors |
-
2012
- 2012-10-05 JP JP2014533911A patent/JP5995977B2/ja not_active Expired - Fee Related
- 2012-10-05 WO PCT/EP2012/069676 patent/WO2013050508A1/en not_active Ceased
- 2012-10-05 KR KR1020147012152A patent/KR20140084130A/ko not_active Ceased
- 2012-10-05 AU AU2012320465A patent/AU2012320465B2/en not_active Ceased
- 2012-10-05 EP EP12769098.0A patent/EP2763985B1/en active Active
- 2012-10-05 CN CN201280057967.2A patent/CN103946222B/zh not_active Expired - Fee Related
- 2012-10-05 US US14/350,167 patent/US9242993B2/en not_active Expired - Fee Related
- 2012-10-05 CA CA2850852A patent/CA2850852A1/en not_active Abandoned
- 2012-10-05 ES ES12769098.0T patent/ES2592219T3/es active Active
- 2012-10-05 RU RU2014109748A patent/RU2609208C2/ru not_active IP Right Cessation
- 2012-10-05 BR BR112014008241A patent/BR112014008241A2/pt not_active Application Discontinuation
- 2012-10-05 MX MX2014004161A patent/MX341577B/es active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| RU2609208C2 (ru) | 2017-01-31 |
| RU2014109748A (ru) | 2015-11-20 |
| MX2014004161A (es) | 2014-11-26 |
| AU2012320465B2 (en) | 2016-03-03 |
| CN103946222B (zh) | 2016-12-28 |
| KR20140084130A (ko) | 2014-07-04 |
| CN103946222A (zh) | 2014-07-23 |
| CA2850852A1 (en) | 2013-04-11 |
| EP2763985B1 (en) | 2016-06-22 |
| WO2013050508A1 (en) | 2013-04-11 |
| EP2763985A1 (en) | 2014-08-13 |
| JP5995977B2 (ja) | 2016-09-21 |
| MX341577B (es) | 2016-08-25 |
| US9242993B2 (en) | 2016-01-26 |
| JP2014528436A (ja) | 2014-10-27 |
| BR112014008241A2 (pt) | 2017-04-18 |
| AU2012320465A1 (en) | 2014-05-08 |
| US20140288066A1 (en) | 2014-09-25 |
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