ES2592219T3 - Derivados de {(4-(4-morfolino-dihidrotieno[3,4-d]pirimidin-2-il)aril}urea o carbamato como inhibidores de mTOR - Google Patents
Derivados de {(4-(4-morfolino-dihidrotieno[3,4-d]pirimidin-2-il)aril}urea o carbamato como inhibidores de mTOR Download PDFInfo
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- ES2592219T3 ES2592219T3 ES12769098.0T ES12769098T ES2592219T3 ES 2592219 T3 ES2592219 T3 ES 2592219T3 ES 12769098 T ES12769098 T ES 12769098T ES 2592219 T3 ES2592219 T3 ES 2592219T3
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- pyrimidin
- dioxide
- dihydrothiene
- phenyl
- alkyl
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
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Landscapes
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| KR20140070616A (ko) | 2011-09-21 | 2014-06-10 | 셀좀 리미티드 | Mtor 저해제로서의 모르폴리노 치환된 우레아 또는 카바메이트 유도체 |
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| CN106117242B (zh) * | 2016-06-27 | 2018-08-03 | 山东大学 | 四氢噻喃并嘧啶类衍生物及其制备方法与应用 |
| FR3075795A1 (fr) * | 2017-12-21 | 2019-06-28 | Galderma Research & Development | Nouveaux composes inhibiteurs de mtor |
| CA3111980A1 (en) | 2018-09-10 | 2020-03-19 | Mirati Therapeutics, Inc. | Combination therapies |
| WO2020103897A1 (zh) * | 2018-11-22 | 2020-05-28 | 上海迪诺医药科技有限公司 | 杂环稠合嘧啶衍生物、其药物组合物及应用 |
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| US7135298B2 (en) | 2003-03-26 | 2006-11-14 | The Burnham Institute For Medical Research | Screening assay for agents that alter target of Rapamycin activity |
| KR20060123367A (ko) * | 2003-12-22 | 2006-12-01 | 노파르티스 아게 | ｍＴＯＲ 억제제에 대한 증식성 질환의 감수성을 위한바이오마커 |
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| JP2008540391A (ja) | 2005-05-05 | 2008-11-20 | アストラゼネカ アクチボラグ | ピラゾリルアミノ置換ピリミジン、および癌の処置におけるそれらの使用 |
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| AU2007287428B2 (en) | 2006-08-24 | 2011-08-11 | Astrazeneca Ab | Morpholino pyrimidine derivatives useful in the treatment of proliferative disorders |
| AU2007329352B2 (en) * | 2006-12-07 | 2013-01-17 | F. Hoffmann-La Roche Ag | Phosphoinositide 3-kinase inhibitor compounds and methods of use |
| US20080233127A1 (en) | 2007-03-21 | 2008-09-25 | Wyeth | Imidazolopyrimidine analogs and their use as pi3 kinase and mtor inhibitors |
| US20080234262A1 (en) | 2007-03-21 | 2008-09-25 | Wyeth | Pyrazolopyrimidine analogs and their use as mtor kinase and pi3 kinase inhibitors |
| DK2146779T3 (en) | 2007-04-18 | 2016-11-28 | Pfizer Prod Inc | Sulfonylamid derivatives to treat abnormal cell growth. |
| US20090274698A1 (en) | 2007-07-06 | 2009-11-05 | Shripad Bhagwat | Combination anti-cancer therapy |
| CA2692720A1 (en) | 2007-07-09 | 2009-01-15 | Astrazeneca Ab | Morpholino pyrimidine derivatives used in diseases linked to mtor kinase and/or pi3k |
| EP2178866A2 (en) | 2007-07-09 | 2010-04-28 | AstraZeneca AB | Trisubstituted pyrimidine derivatives for the treatment of proliferative diseases |
| AU2008273892A1 (en) | 2007-07-09 | 2009-01-15 | Astrazeneca Ab | Trisubstituted pyrimidine derivatives for the treatment of proliferative diseases |
| EA201000092A1 (ru) | 2007-07-09 | 2010-06-30 | Астразенека Аб | Тризамещенные пиримидиновые производные для лечения пролиферативных заболеваний |
| CN101224207A (zh) | 2007-10-12 | 2008-07-23 | 中国科学院上海有机化学研究所 | 具有诱导自吞噬治疗错误折叠蛋白聚集所致疾病的药物及其筛选方法 |
| EP2410062A1 (en) | 2008-02-04 | 2012-01-25 | Cellzome Ag | Selectivity profiling of PI3K interacting molecules against multiple targets |
| KR101331341B1 (ko) | 2008-05-23 | 2013-11-19 | 와이어쓰 엘엘씨 | Ｐｉ３ 키나제 및 ｍｔｏｒ 억제제로서의 트리아진 화합물 |
| CA2729045A1 (en) | 2008-07-31 | 2010-02-04 | Philippe Bergeron | Pyrimidine compounds, compositions and methods of use |
| GB2465405A (en) * | 2008-11-10 | 2010-05-19 | Univ Basel | Triazine, pyrimidine and pyridine analogues and their use in therapy |
| WO2010096619A1 (en) | 2009-02-23 | 2010-08-26 | Wyeth Llc | Process, purification and crystallization of 1-(4-{[4-(dimethylamino)piperidin-1-yl]carbonyl}phenyl)-3-[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]urea |
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| US8835429B2 (en) | 2009-04-17 | 2014-09-16 | Wyeth Llc | Pyrimidine compounds, their use as mTOR kinase and Pl3 kinase inhibitors, and their syntheses |
| WO2010120987A1 (en) * | 2009-04-17 | 2010-10-21 | Wyeth Llc | Ring fused, ureidoaryl- and carbamoylaryl-bridged morpholino-pyrimidine compounds, their use as mtor kinase and pi3 kinase inhibitors, and their syntheses |
| WO2010120994A2 (en) | 2009-04-17 | 2010-10-21 | Wyeth Llc | Ureidoaryl-and carbamoylaryl-morpholino- pyrimidine compounds, their use as mtor kinase and pi3 kinase inhibitors, and their synthesis |
| US20100331305A1 (en) * | 2009-06-24 | 2010-12-30 | Genentech, Inc. | Oxo-heterocycle fused pyrimidine compounds, compositions and methods of use |
| JP2013500265A (ja) | 2009-07-23 | 2013-01-07 | ザ トラスティーズ オブ プリンストン ユニバーシティ | 抗ウイルス剤として用いられるｍＴＯＲキナーゼ阻害剤 |
| US9249129B2 (en) | 2010-03-04 | 2016-02-02 | Cellzome Limited | Morpholino substituted urea derivatives as mTOR inhibitors |
| US20140163023A1 (en) | 2011-04-04 | 2014-06-12 | Cellzome Limited | Dihydropyrrolo pyrimidine derivatives as mtor inhibitors |
| KR20140070616A (ko) | 2011-09-21 | 2014-06-10 | 셀좀 리미티드 | Mtor 저해제로서의 모르폴리노 치환된 우레아 또는 카바메이트 유도체 |
-
2012
- 2012-10-05 US US14/350,167 patent/US9242993B2/en not_active Expired - Fee Related
- 2012-10-05 ES ES12769098.0T patent/ES2592219T3/es active Active
- 2012-10-05 KR KR1020147012152A patent/KR20140084130A/ko not_active Ceased
- 2012-10-05 JP JP2014533911A patent/JP5995977B2/ja not_active Expired - Fee Related
- 2012-10-05 BR BR112014008241A patent/BR112014008241A2/pt not_active Application Discontinuation
- 2012-10-05 CA CA2850852A patent/CA2850852A1/en not_active Abandoned
- 2012-10-05 CN CN201280057967.2A patent/CN103946222B/zh not_active Expired - Fee Related
- 2012-10-05 RU RU2014109748A patent/RU2609208C2/ru not_active IP Right Cessation
- 2012-10-05 AU AU2012320465A patent/AU2012320465B2/en not_active Ceased
- 2012-10-05 MX MX2014004161A patent/MX341577B/es active IP Right Grant
- 2012-10-05 EP EP12769098.0A patent/EP2763985B1/en active Active
- 2012-10-05 WO PCT/EP2012/069676 patent/WO2013050508A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| US9242993B2 (en) | 2016-01-26 |
| MX2014004161A (es) | 2014-11-26 |
| EP2763985B1 (en) | 2016-06-22 |
| RU2609208C2 (ru) | 2017-01-31 |
| CA2850852A1 (en) | 2013-04-11 |
| CN103946222B (zh) | 2016-12-28 |
| EP2763985A1 (en) | 2014-08-13 |
| CN103946222A (zh) | 2014-07-23 |
| MX341577B (es) | 2016-08-25 |
| KR20140084130A (ko) | 2014-07-04 |
| JP5995977B2 (ja) | 2016-09-21 |
| JP2014528436A (ja) | 2014-10-27 |
| BR112014008241A2 (pt) | 2017-04-18 |
| AU2012320465A1 (en) | 2014-05-08 |
| AU2012320465B2 (en) | 2016-03-03 |
| WO2013050508A1 (en) | 2013-04-11 |
| RU2014109748A (ru) | 2015-11-20 |
| US20140288066A1 (en) | 2014-09-25 |
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