ES2592219T3 - Derivados de {(4-(4-morfolino-dihidrotieno[3,4-d]pirimidin-2-il)aril}urea o carbamato como inhibidores de mTOR - Google Patents
Derivados de {(4-(4-morfolino-dihidrotieno[3,4-d]pirimidin-2-il)aril}urea o carbamato como inhibidores de mTOR Download PDFInfo
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- ES2592219T3 ES2592219T3 ES12769098.0T ES12769098T ES2592219T3 ES 2592219 T3 ES2592219 T3 ES 2592219T3 ES 12769098 T ES12769098 T ES 12769098T ES 2592219 T3 ES2592219 T3 ES 2592219T3
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- pyrimidin
- dioxide
- dihydrothiene
- phenyl
- alkyl
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| CN106117242B (zh) * | 2016-06-27 | 2018-08-03 | 山东大学 | 四氢噻喃并嘧啶类衍生物及其制备方法与应用 |
| FR3075795A1 (fr) * | 2017-12-21 | 2019-06-28 | Galderma Research & Development | Nouveaux composes inhibiteurs de mtor |
| EP3849535A4 (en) | 2018-09-10 | 2022-06-29 | Mirati Therapeutics, Inc. | Combination therapies |
| CN111205310B (zh) * | 2018-11-22 | 2023-12-19 | 上海迪诺医药科技有限公司 | 杂环稠合嘧啶衍生物、其药物组合物及应用 |
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| US7888352B2 (en) * | 2006-12-07 | 2011-02-15 | Piramed Limited | Phosphoinositide 3-kinase inhibitor compounds and methods of use |
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| EP2178563A2 (en) | 2007-07-06 | 2010-04-28 | OSI Pharmaceuticals, Inc. | Combination anti-cancer therapy comprising an inhibitor of both mtorc1 and mtorc2 |
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| ATE554075T1 (de) | 2007-07-09 | 2012-05-15 | Astrazeneca Ab | Bei mit mtor-kinase und/oder pi3k in zusammenhang stehenden krankheiten angewendete morpholinopyrimidinderivate |
| CN101224207A (zh) | 2007-10-12 | 2008-07-23 | 中国科学院上海有机化学研究所 | 具有诱导自吞噬治疗错误折叠蛋白聚集所致疾病的药物及其筛选方法 |
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| WO2011011716A1 (en) | 2009-07-23 | 2011-01-27 | The Trustees Of Princeton University | Inhibitors of mtor kinase as anti-viral agents |
| US9249129B2 (en) | 2010-03-04 | 2016-02-02 | Cellzome Limited | Morpholino substituted urea derivatives as mTOR inhibitors |
| EP2694511A1 (en) | 2011-04-04 | 2014-02-12 | Cellzome Limited | Dihydropyrrolo pyrimidine derivatives as mtor inhibitors |
| KR20140070616A (ko) | 2011-09-21 | 2014-06-10 | 셀좀 리미티드 | Mtor 저해제로서의 모르폴리노 치환된 우레아 또는 카바메이트 유도체 |
-
2012
- 2012-10-05 BR BR112014008241A patent/BR112014008241A2/pt not_active Application Discontinuation
- 2012-10-05 CN CN201280057967.2A patent/CN103946222B/zh not_active Expired - Fee Related
- 2012-10-05 RU RU2014109748A patent/RU2609208C2/ru not_active IP Right Cessation
- 2012-10-05 US US14/350,167 patent/US9242993B2/en not_active Expired - Fee Related
- 2012-10-05 KR KR1020147012152A patent/KR20140084130A/ko not_active Ceased
- 2012-10-05 CA CA2850852A patent/CA2850852A1/en not_active Abandoned
- 2012-10-05 ES ES12769098.0T patent/ES2592219T3/es active Active
- 2012-10-05 MX MX2014004161A patent/MX341577B/es active IP Right Grant
- 2012-10-05 EP EP12769098.0A patent/EP2763985B1/en active Active
- 2012-10-05 AU AU2012320465A patent/AU2012320465B2/en not_active Ceased
- 2012-10-05 JP JP2014533911A patent/JP5995977B2/ja not_active Expired - Fee Related
- 2012-10-05 WO PCT/EP2012/069676 patent/WO2013050508A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP2763985A1 (en) | 2014-08-13 |
| WO2013050508A1 (en) | 2013-04-11 |
| RU2014109748A (ru) | 2015-11-20 |
| JP2014528436A (ja) | 2014-10-27 |
| BR112014008241A2 (pt) | 2017-04-18 |
| CN103946222B (zh) | 2016-12-28 |
| EP2763985B1 (en) | 2016-06-22 |
| US9242993B2 (en) | 2016-01-26 |
| RU2609208C2 (ru) | 2017-01-31 |
| KR20140084130A (ko) | 2014-07-04 |
| MX341577B (es) | 2016-08-25 |
| AU2012320465A1 (en) | 2014-05-08 |
| US20140288066A1 (en) | 2014-09-25 |
| JP5995977B2 (ja) | 2016-09-21 |
| CN103946222A (zh) | 2014-07-23 |
| AU2012320465B2 (en) | 2016-03-03 |
| MX2014004161A (es) | 2014-11-26 |
| CA2850852A1 (en) | 2013-04-11 |
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