ES2586412T3 - Formulaciones de rasagilina con uniformidad de contenido mejorada - Google Patents

Formulaciones de rasagilina con uniformidad de contenido mejorada Download PDF

Info

Publication number
ES2586412T3
ES2586412T3 ES06720975.9T ES06720975T ES2586412T3 ES 2586412 T3 ES2586412 T3 ES 2586412T3 ES 06720975 T ES06720975 T ES 06720975T ES 2586412 T3 ES2586412 T3 ES 2586412T3
Authority
ES
Spain
Prior art keywords
aminoindane
particles
content uniformity
improved content
uniformity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES06720975.9T
Other languages
English (en)
Other versions
ES2586412T5 (es
Inventor
Tirtza Berger Peskin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teva Pharmaceutical Industries Ltd
Original Assignee
Teva Pharmaceutical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36927751&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2586412(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Teva Pharmaceutical Industries Ltd filed Critical Teva Pharmaceutical Industries Ltd
Publication of ES2586412T3 publication Critical patent/ES2586412T3/es
Application granted granted Critical
Publication of ES2586412T5 publication Critical patent/ES2586412T5/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Una composición sólida que comprende una cantidad terapéuticamente eficaz de una mezcla de partículas de una sal farmacéuticamente aceptable de R(+)-N-propargil-1-aminoindano que tiene una distribución de tamaños de partícula en la cual más de 90%, en volumen, de la cantidad total de partículas de sal de mesilato de R(+)-Npropargil- 1-aminoindano tienen un tamaño inferior a 200 micrómetros y al menos 90%, en volumen, de la cantidad total de las partículas de sal de R(+)-N-propargil-1-aminoindano tienen un tamaño superior a 6 micrómetros, siendo la distribución de tamaños de partícula resultado de la molienda de partículas de mayor tamaño, como lo determinan los valores de d(0,9) y d(0,1), en donde el tamaño de partícula se mide mediante difracción láser; y un vehículo farmacéuticamente aceptable .

Description

imagen1
imagen2
imagen3
imagen4
imagen5
imagen6
La uniformidad de mezcla promedio de cada lote de granulado se determinó tomando 10 muestras que representaban la capa superior, la capa media y la capa inferior de cada lote de mezcla final (antes de la compresión), realizando un análisis por HPLC para medir la cantidad de ingrediente activo en las muestras y comparando la cantidad de ingrediente activo en cada muestra con la cantidad declarada de ingrediente activo. Después se determinaron la desviación típica y la desviación típica relativa según las siguientes fórmulas:
imagen7
En las fórmulas anteriores, s es la desviación típica; DTR es la desviación típica relativa; x1, x2, x3 ... xn son cantidades individuales de las muestras ensayadas, expresadas como porcentajes de la cantidad declarada de
10 sustancia medicamentosa en cada muestra; X(con barra) es la media de los valores obtenidos de las muestras analizadas, expresada como porcentaje de la cantidad declarada de sustancia medicamentosa en cada muestra; y n es el número de unidades analizadas.
La uniformidad de contenido de los comprimidos se determinó utilizando 10 comprimidos al azar, realizando un análisis HPLC para medir la cantidad de ingrediente activo en cada comprimido y comparando la cantidad de
15 ingrediente activo en cada comprimido con la cantidad declarada de ingrediente activo. La desviación típica y la desviación típica relativa se determinaron como antes.
Se determinaron d(0,1) y d(0,9) como en el Ejemplo 1. En la Tabla 2 se exponen los resultados.
Tabla 2
Número de lote de sustancia medicamentosa
100 200 300 300
Número de lote de producto medicamentoso
021 022 023 063
d(0,1) (micrómetros)
12,5 12,9 12,1 12,1
d(0,9) (micrómetros)
190,3 111,9 121,0 121,0
Uniformidad de mezcla/DTR (tanto por ciento)
98,2/1,7 99,8/0,8 98,7/1,1 98,1/0,7
Uniformidad de contenido/DTR (tanto por ciento)
99,3/1,6 99,0/1,4 98,6/1,3 100,6/1,2
20 Resultados:
La uniformidad del contenido de los lotes ensayados varió de 98,6% a 100,6%. La DTR (desviación típica relativa, expresada como porcentaje de la media) fue inferior a 2,0% para todos los lotes de comprimidos, lo que indica que la uniformidad de los comprimidos era elevada a pesar de la pequeña cantidad de ingrediente activo en cada comprimido. Así, estos resultados cumplirían los criterios de aceptación establecidos por la primera fase del ensayo
25 USP de uniformidad de contenido.
8

Claims (1)

  1. imagen1
    imagen2
ES06720975T 2005-02-23 2006-02-22 Formulaciones de rasagilina con uniformidad de contenido mejorada Active ES2586412T5 (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US65562205P 2005-02-23 2005-02-23
US655622P 2005-02-23
US72090805P 2005-09-27 2005-09-27
US720908P 2005-09-27
PCT/US2006/006252 WO2006091657A1 (en) 2005-02-23 2006-02-22 Rasagiline formulations of improved content uniformity

Publications (2)

Publication Number Publication Date
ES2586412T3 true ES2586412T3 (es) 2016-10-14
ES2586412T5 ES2586412T5 (es) 2019-05-16

Family

ID=36927751

Family Applications (1)

Application Number Title Priority Date Filing Date
ES06720975T Active ES2586412T5 (es) 2005-02-23 2006-02-22 Formulaciones de rasagilina con uniformidad de contenido mejorada

Country Status (16)

Country Link
US (1) US7815942B2 (es)
EP (1) EP1848402B2 (es)
JP (2) JP5738509B2 (es)
KR (5) KR20170023211A (es)
AU (1) AU2006216696B2 (es)
BR (1) BRPI0608209A2 (es)
CA (2) CA2901244A1 (es)
ES (1) ES2586412T5 (es)
HK (1) HK1103366A1 (es)
IL (2) IL184033A0 (es)
IS (1) IS8669A (es)
MX (1) MX2007010233A (es)
NO (1) NO20074823L (es)
NZ (1) NZ560660A (es)
RU (1) RU2404746C2 (es)
WO (1) WO2006091657A1 (es)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5744500A (en) * 1990-01-03 1998-04-28 Teva Pharmaceutical Industries, Ltd. Use of R-enantiomer of N-propargyl-1-aminoindan, salts, and compositions thereof
AU2003290838A1 (en) 2002-11-15 2004-06-15 Teva Pharmaceutical Industries, Ltd. Use of rasagiline with or without riluzole to treat amyotrophic lateral sclerosis
US20060018957A1 (en) * 2004-07-26 2006-01-26 Lerner E I Pharmaceutical dosage forms including rasagiline
ZA200704917B (en) * 2004-11-24 2008-11-26 Teva Pharma Rasagiline orally disintegrating compositions
AU2006211510B8 (en) * 2005-02-02 2011-04-21 Teva Pharmaceutical Industries, Ltd. Process for producing polypeptide mixtures using hydrogenolysis
PL1848415T3 (pl) * 2005-02-17 2013-10-31 Teva Pharma Terapia kombinowana obejmująca octan glatirameru oraz rasagilinę do leczenia stwardnienia rozsianego
CA2901244A1 (en) 2005-02-23 2006-08-31 Teva Pharmaceutical Industries, Ltd. Rasagiline formulations of improved content uniformity
AU2006316585B2 (en) * 2005-11-17 2012-09-20 Teva Pharmaceutical Industries, Ltd. Methods for isolating propargylated aminoindans
US7572834B1 (en) 2005-12-06 2009-08-11 Teva Pharmaceutical Industries, Ltd. Rasagiline formulations and processes for their preparation
ES2551481T3 (es) 2006-02-21 2015-11-19 Teva Pharmaceutical Industries, Ltd. Uso de rasagilina para el tratamiento de atrofia multisistémica
NZ571591A (en) * 2006-04-03 2011-09-30 Teva Pharma Use of rasagiline for the treatment of restless legs syndrome
EP1892233A1 (de) 2006-08-18 2008-02-27 Ratiopharm GmbH Neue Salze des Wirkstoffs Rasagilin
BRPI0718339A2 (pt) * 2006-12-14 2014-02-18 Teva Pharma Composto, composição, composição farmacêutica e processo de fabricação de tanato de rasagilina
AU2007334428B2 (en) * 2006-12-14 2014-05-29 Teva Pharmaceutical Industries, Ltd. Crystalline solid rasagiline base
EP1987816A1 (de) * 2007-04-30 2008-11-05 Ratiopharm GmbH Adsorbate eines Rasagilinsalzes mit einem wasserlöslichen Hilfsstoff
US20090062400A1 (en) * 2007-09-05 2009-03-05 Laurence Oron Method of treating glaucoma using rasagiline
US8188149B2 (en) * 2007-09-17 2012-05-29 Teva Pharmaceutical Industries, Ltd. Use of R(+)-N-propargy1-1-aminoindan to treat or prevent hearing loss
CN101909438A (zh) * 2008-01-11 2010-12-08 泰华制药工业有限公司 雷沙吉兰制剂、其制备及用途
EP2271612B1 (en) * 2008-03-31 2016-08-10 Actavis Group PTC EHF Rasagiline mesylate particles and process for the preparation thereof
ES2389353T3 (es) * 2008-06-10 2012-10-25 Teva Pharmaceutical Industries Ltd. Cápsulas de gelatina blanda de rasagilina
BRPI0909894A2 (pt) * 2008-06-13 2015-07-28 Teva Pharma "método de redução da velocidade de progressão de mal de parkinson em um paciente com mal de parkinson em estágio inicial, método de redução da velocidade de progressão de mal de parkinson, método de atraso da necessidade de terapia antiparkinsoniana sintomática em um paciente de mal de parkinson em estágio inicial, método de redução do risco de um paciente com mal de parkinson que necessita de terapia antiparkinsoniana, método de redução do declínio funcional de um paciente com mal de parkinson em estágio inicial, método de redução do declínio funcional em um paciente com mal de parkinson, método de tratamento de um paciente que exibe sinais iniciais de mal de parkinson, método de redução da fadiga em um paciente com mal de parkinson em estágio inicial, método de redução da velocidade de progressão clínica e tratamento de sintomas de mal de parkinson em um paciente com mal de parkinson, rasagilina ou um sal farmaceuticamente aceitável de rasagilina, composição farmacêutica.
NZ589547A (en) * 2008-06-19 2013-03-28 Teva Pharma Dried rasagiline base having a water content less than 0.5 % by weight
CA2727021A1 (en) 2008-06-19 2009-12-23 Teva Pharmaceutical Industries Ltd. Process for purifying rasagiline base
EP2657221A1 (en) 2008-11-20 2013-10-30 Dr. Reddy's Laboratories Ltd. Preparation of rasagiline and salts thereof
DE102008064061A1 (de) 2008-12-19 2010-06-24 Ratiopharm Gmbh Feste Zusammensetzung mit dem Wirkstoff Rasagilin
US20100189791A1 (en) * 2009-01-23 2010-07-29 Teva Pharmaceutical Industries, Ltd. Delayed release rasagiline malate formulation
US20120122993A1 (en) 2009-03-05 2012-05-17 Sandoz Ag Pharmaceutical composition containing 1h-inden-1-amine, 2,3-dihydro-n-2-propynyl-(1r)-, methanesulfonate
WO2010111264A2 (en) * 2009-03-24 2010-09-30 Dr. Reddy's Laboratories Ltd. Rasagiline formulations
PL2451771T3 (pl) 2009-07-09 2014-12-31 Ratiopharm Gmbh Sole rasagiliny i ich preparaty farmaceutyczne
US8741962B2 (en) 2009-11-26 2014-06-03 Usv Limited Process for preparation of Rasagiline and salts thereof
US20120321896A1 (en) * 2010-02-01 2012-12-20 Kuppuswamy Nagarajan Rasagiline mesylate having large particle size and a process for preparation thereof
RS55487B1 (sr) * 2010-02-12 2017-04-28 Pfizer Soli i polimorfi 8-fluoro-2-{4-[(metilamino}metil]fenil}-1,3,4,5-tetrahidro-6h-azepino[5,4,3-cd]indol-6-ona
EA023786B1 (ru) 2010-04-30 2016-07-29 ТЕЙКОКУ ФАРМА ЮЭсЭй, ИНК. Трансдермальные композиции на основе пропиниламиноиндана
EP2389927A1 (en) 2010-05-30 2011-11-30 Abdi Ibrahim Ilac Sanayi ve Ticaret Anonim Sirketi Pharmaceutical formulations of rasagiline
CA2806740A1 (en) 2010-07-27 2012-02-02 Teva Pharmaceutical Industries Ltd. Use of rasagiline for the treatment of olfactory dysfunction
AU2011282716A1 (en) 2010-07-27 2013-03-14 Teva Pharmaceutical Industries Ltd. Dispersions of rasagiline citrate
EP2688561B1 (en) 2011-03-24 2018-08-22 Teikoku Pharma USA, Inc. Transdermal compositions comprising an active agent layer and an active agent conversion layer
EP2705021A2 (en) 2011-05-04 2014-03-12 Cadila Healthcare Limited Rasagiline and its pharmaceutically acceptable salts
BR112014008552A2 (pt) 2011-10-10 2017-04-18 Teva Pharma r(+)-n-metil-propargilaminoindano
KR20140090996A (ko) 2011-10-10 2014-07-18 테바 파마슈티컬 인더스트리즈 리미티드 R(+)-n-폼일-프로파길-아미노인단
US9913812B2 (en) 2011-11-09 2018-03-13 Teikoku Pharma Usa, Inc. Methods for the treatment of skin neoplasms
EP2610239A1 (en) 2012-01-02 2013-07-03 Dr. Reddy's Laboratories Ltd. Preparation Of Rasagiline Hemitartrate
MX343986B (es) 2012-03-21 2016-12-01 Synthon Bv Composiciones farmaceuticas estabilizadas que comprenden sales de rasagilina.
BR112015003451A2 (pt) 2012-08-17 2017-07-04 Teva Pharma formulação parentérica de rasagilina
JP6050896B2 (ja) 2012-11-02 2016-12-21 テイコク ファーマ ユーエスエー インコーポレーテッド プロピニルアミノインダン経皮組成物
US20160046582A1 (en) 2013-03-14 2016-02-18 Teva Pharmaceutical Industries Ltd. Crystals of laquinimod sodium and improved process for the manufacture thereof
BR112019009594A2 (pt) * 2016-11-10 2019-10-22 Medisca Pharmaceutique Inc processos e sistemas de composição farmacêutica

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3513249A (en) * 1968-12-24 1970-05-19 Ideal Ind Explosion connector with improved insulating means
GB8914804D0 (en) * 1989-06-28 1989-08-16 Glaxo Group Ltd Process
IL92952A (en) 1990-01-03 1994-06-24 Teva Pharma R-enantiomers of n-propargyl-1-aminoindan compounds, their preparation and pharmaceutical compositions containing them
US5744500A (en) 1990-01-03 1998-04-28 Teva Pharmaceutical Industries, Ltd. Use of R-enantiomer of N-propargyl-1-aminoindan, salts, and compositions thereof
US5444095A (en) * 1991-04-04 1995-08-22 University Of Toronto, Innovations Foundation Use of deprenyl to rescue damaged nerve cells
US5844003A (en) * 1991-04-04 1998-12-01 Innovations Foundation Use of deprenyl compounds to maintain, prevent loss, or recover nerve cell function
US5767164A (en) * 1991-04-04 1998-06-16 Innovations Foundation Use of deprenyl to rescue damaged nerve cells
IL99759A (en) 1991-10-16 1997-06-10 Teva Pharma Mono-fluorinated derivatives of n-propargyl-1-aminoindan, their preparation and pharmaceutical compositions containing them
IL111240A (en) * 1993-10-18 2001-10-31 Teva Pharma Salts of r(+) - enantiomers of n- propargyl-1-aminoindan and pharmaceutical compositions comprising them
DE69535315T2 (de) 1994-01-10 2007-06-28 Teva Pharmaceutical Industries Ltd. 1-aminoindanderivate und zusammensetzungen hiervon
IL115357A (en) 1995-09-20 2000-01-31 Teva Pharma Stable compositions containing N-propargyl-1-aminoindan and polyhydric alcohols
IL118836A (en) 1996-07-11 2001-01-11 Teva Pharma Pharmaceutical compositions comprising s-(-)-n-propargyl-1-aminoindan
CA2275425C (en) 1996-12-18 2009-08-04 Michael Chorev Aminoindan derivatives
EP1052983A2 (en) * 1998-01-27 2000-11-22 Thomas N. Thomas Use of an mao-a or mao-b inhibitor for the treatment of vascular disorders
US7766013B2 (en) * 2001-06-05 2010-08-03 Alexza Pharmaceuticals, Inc. Aerosol generating method and device
MXPA03012041A (es) 2001-07-04 2004-03-26 Sun Pharmaceutical Ind Ltd Sistema de administracion controlada de farmacos de retencion gastrica.
US20040052843A1 (en) * 2001-12-24 2004-03-18 Lerner E. Itzhak Controlled release dosage forms
AU2003219913A1 (en) 2002-02-27 2003-09-09 Teva Pharmaceutical Industries, Ltd. Propargylamino indan derivatives and propargylamino tetralin derivatives as brain-selective mao inhibitors
US20040010038A1 (en) * 2002-02-27 2004-01-15 Eran Blaugrund Propargylamino indan derivatives and propargylamino tetralin derivatives as brain-selective MAO inhibitors
AU2003290838A1 (en) * 2002-11-15 2004-06-15 Teva Pharmaceutical Industries, Ltd. Use of rasagiline with or without riluzole to treat amyotrophic lateral sclerosis
WO2004112799A1 (en) * 2003-06-13 2004-12-29 Chrysalis Technologies Incorporated Methods and apparatus for producing nanoscale particles
US20050026979A1 (en) * 2003-07-31 2005-02-03 Maha Ghazzi Methods for treating inflammation and inflammation-associated diseases with a statin and ether
US7735024B2 (en) * 2003-10-29 2010-06-08 Intel Corporation Methods and apparatus to provide a handheld pointer-based user interface
US20060018957A1 (en) * 2004-07-26 2006-01-26 Lerner E I Pharmaceutical dosage forms including rasagiline
ZA200704917B (en) * 2004-11-24 2008-11-26 Teva Pharma Rasagiline orally disintegrating compositions
NZ555470A (en) 2004-11-24 2011-02-25 Teva Pharma Rasagiline orally disintegrating compositions
CA2901244A1 (en) 2005-02-23 2006-08-31 Teva Pharmaceutical Industries, Ltd. Rasagiline formulations of improved content uniformity
AU2006316585B2 (en) * 2005-11-17 2012-09-20 Teva Pharmaceutical Industries, Ltd. Methods for isolating propargylated aminoindans
US7572834B1 (en) * 2005-12-06 2009-08-11 Teva Pharmaceutical Industries, Ltd. Rasagiline formulations and processes for their preparation
ES2551481T3 (es) 2006-02-21 2015-11-19 Teva Pharmaceutical Industries, Ltd. Uso de rasagilina para el tratamiento de atrofia multisistémica
NZ571591A (en) 2006-04-03 2011-09-30 Teva Pharma Use of rasagiline for the treatment of restless legs syndrome
EP1892233A1 (de) 2006-08-18 2008-02-27 Ratiopharm GmbH Neue Salze des Wirkstoffs Rasagilin
BRPI0718339A2 (pt) * 2006-12-14 2014-02-18 Teva Pharma Composto, composição, composição farmacêutica e processo de fabricação de tanato de rasagilina
AU2007334428B2 (en) 2006-12-14 2014-05-29 Teva Pharmaceutical Industries, Ltd. Crystalline solid rasagiline base
EP1987816A1 (de) 2007-04-30 2008-11-05 Ratiopharm GmbH Adsorbate eines Rasagilinsalzes mit einem wasserlöslichen Hilfsstoff
CN101909438A (zh) * 2008-01-11 2010-12-08 泰华制药工业有限公司 雷沙吉兰制剂、其制备及用途

Also Published As

Publication number Publication date
RU2007135169A (ru) 2009-03-27
IS8669A (is) 2007-08-15
IL184033A0 (en) 2007-10-31
US7815942B2 (en) 2010-10-19
AU2006216696B2 (en) 2011-08-18
JP5738509B2 (ja) 2015-06-24
KR20130129300A (ko) 2013-11-27
JP2013139452A (ja) 2013-07-18
KR20070111534A (ko) 2007-11-21
AU2006216696A1 (en) 2006-08-31
ES2586412T5 (es) 2019-05-16
RU2404746C2 (ru) 2010-11-27
MX2007010233A (es) 2007-11-07
HK1103366A1 (zh) 2007-12-21
EP1848402A4 (en) 2012-01-18
KR20170023211A (ko) 2017-03-02
BRPI0608209A2 (pt) 2010-11-09
CA2901244A1 (en) 2006-08-31
US20060188581A1 (en) 2006-08-24
KR20140103356A (ko) 2014-08-26
EP1848402B1 (en) 2016-05-11
NO20074823L (no) 2007-11-16
EP1848402A1 (en) 2007-10-31
EP1848402B2 (en) 2019-02-20
CA2600011A1 (en) 2006-08-31
CA2600011C (en) 2015-11-10
WO2006091657A1 (en) 2006-08-31
IL244802A (en) 2016-08-31
IL244802A0 (en) 2016-04-21
JP2008531572A (ja) 2008-08-14
NZ560660A (en) 2010-11-26
KR20180026580A (ko) 2018-03-12

Similar Documents

Publication Publication Date Title
ES2586412T3 (es) Formulaciones de rasagilina con uniformidad de contenido mejorada
Elkordy et al. Liquisolid technique to enhance and to sustain griseofulvin dissolution: Effect of choice of non-volatile liquid vehicles
Sayyad et al. Design and development of liquisolid compact of candesartan cilexetil to enhance dissolution
Gaur et al. Formulation and characterization of fast disintegrating tablet of aceclofenac by using sublimation method
Pathan et al. Formulation design and optimization of novel mouth dissolving tablets for venlafaxine hydrochloride using sublimation technique
Moravkar et al. Application of moisture activated dry granulation (MADG) process to develop high dose immediate release (IR) formulations
CN103142525B (zh) 奥氮平胃溶型片剂及其制备方法
ES2588011T3 (es) Composiciones de S-adenosilmetionina orales
Chaitanya et al. Ezetimibe solid dispersions: formulation, development and in vitro evaluation
Vemula et al. Development and characterization of fast disintegrating tablets of terbinafine hydrochloride
Soni et al. DESIGN AND DEVELOPMENT OF QUICK DISSOLVING TABLET CONTAINING LORATADINE BY DIRECT COMPRESSION METHOD.
Daravath et al. Formulation and in vitro evaluation of flurbiprofen-polyethylene glycol 20000 solid dispersions
Shanmugam et al. Formulation and evaluation of sustained release matrix tablet of Zidovudine using different polymers
Zaid et al. Influence of physical factors on tablet splitting, weight and content uniformity of atenolol tablets
Das et al. Agglomerate properties and dispersibility changes of salmeterol xinafoate from powders for inhalation after storage at high relative humidity
ES2549106T1 (es) Composiciones farmacéuticas que comprenden anagrelida
Sravanthi et al. Formulation and evaluation of bi-layer floating tablets of amlodipine besylate and metoprolol succinate
Masareddy et al. Effect of polymers as matrix system in formulation of sustained release theophylline matrix tablet
Sharma et al. Formulation, evaluation and optimization of mouth dissolving tablets of losartan potassium: effect of coprocessed superdisintegrants
Devi et al. Design and characterization of melt-in-mouth tablets of metoprolol tartarate.
Srivastava et al. Liquisolid technique for enhancement of dissolution properties of lornoxicam
AR077189A1 (es) Comprimidos de ibuprofeno de sodio y procedimiento de fabricacion de composiciones farmaceuticas que incluyen ibuprofeno de sodio
Bala et al. Formulation design and optimization of sustained released matrix tablets of propranolol HCl using natural and synthetic polymers
Kopparam et al. Neem Gum as an Alternative to Synthetic Pharmaceutical Excipients
Singh et al. Formulation and Evaluation of Solid Lipid Nanoparticles Containing Levosulpiride