JP2008531572A - 内容物均一性が改善されたラサギリン製剤 - Google Patents
内容物均一性が改善されたラサギリン製剤 Download PDFInfo
- Publication number
- JP2008531572A JP2008531572A JP2007557120A JP2007557120A JP2008531572A JP 2008531572 A JP2008531572 A JP 2008531572A JP 2007557120 A JP2007557120 A JP 2007557120A JP 2007557120 A JP2007557120 A JP 2007557120A JP 2008531572 A JP2008531572 A JP 2008531572A
- Authority
- JP
- Japan
- Prior art keywords
- propargyl
- aminoindan
- mixture
- particles
- less
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 74
- 238000009472 formulation Methods 0.000 title description 8
- RUOKEQAAGRXIBM-GFCCVEGCSA-N rasagiline Chemical compound C1=CC=C2[C@H](NCC#C)CCC2=C1 RUOKEQAAGRXIBM-GFCCVEGCSA-N 0.000 title description 2
- 229960000245 rasagiline Drugs 0.000 title description 2
- 238000000034 method Methods 0.000 claims abstract description 44
- RUOKEQAAGRXIBM-UHFFFAOYSA-N n-prop-2-ynyl-2,3-dihydro-1h-inden-1-amine Chemical class C1=CC=C2C(NCC#C)CCC2=C1 RUOKEQAAGRXIBM-UHFFFAOYSA-N 0.000 claims abstract description 42
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 8
- 239000002245 particle Substances 0.000 claims description 80
- 150000003839 salts Chemical class 0.000 claims description 31
- 239000008187 granular material Substances 0.000 claims description 21
- 239000007909 solid dosage form Substances 0.000 claims description 14
- 238000003801 milling Methods 0.000 claims description 11
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical class CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims description 10
- 238000004519 manufacturing process Methods 0.000 claims description 10
- 239000006186 oral dosage form Substances 0.000 claims description 9
- 208000018737 Parkinson disease Diseases 0.000 claims description 8
- 238000000227 grinding Methods 0.000 claims description 8
- 239000008247 solid mixture Substances 0.000 claims description 6
- 238000002156 mixing Methods 0.000 claims description 5
- 239000003937 drug carrier Substances 0.000 claims description 4
- 239000007787 solid Substances 0.000 claims description 4
- CCIVGXIOQKPBKL-UHFFFAOYSA-M ethanesulfonate Chemical class CCS([O-])(=O)=O CCIVGXIOQKPBKL-UHFFFAOYSA-M 0.000 claims description 3
- 150000003467 sulfuric acid derivatives Chemical class 0.000 claims description 2
- XJEVHMGJSYVQBQ-UHFFFAOYSA-N 2,3-dihydro-1h-inden-1-amine Chemical class C1=CC=C2C(N)CCC2=C1 XJEVHMGJSYVQBQ-UHFFFAOYSA-N 0.000 claims 2
- 150000003892 tartrate salts Chemical group 0.000 claims 1
- 239000003826 tablet Substances 0.000 description 30
- 235000002639 sodium chloride Nutrition 0.000 description 21
- 239000008186 active pharmaceutical agent Substances 0.000 description 12
- 229940088679 drug related substance Drugs 0.000 description 12
- 239000004480 active ingredient Substances 0.000 description 10
- 229940079593 drug Drugs 0.000 description 9
- 239000003814 drug Substances 0.000 description 9
- 238000005259 measurement Methods 0.000 description 7
- 239000002552 dosage form Substances 0.000 description 6
- 102000010909 Monoamine Oxidase Human genes 0.000 description 5
- 108010062431 Monoamine oxidase Proteins 0.000 description 5
- 238000004090 dissolution Methods 0.000 description 5
- 238000009826 distribution Methods 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- 238000010521 absorption reaction Methods 0.000 description 4
- 229940126534 drug product Drugs 0.000 description 4
- 239000000825 pharmaceutical preparation Substances 0.000 description 4
- 239000000725 suspension Substances 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 229920002472 Starch Polymers 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 230000002496 gastric effect Effects 0.000 description 3
- 239000000314 lubricant Substances 0.000 description 3
- 238000010951 particle size reduction Methods 0.000 description 3
- 239000000546 pharmaceutical excipient Substances 0.000 description 3
- 239000008107 starch Substances 0.000 description 3
- 229940032147 starch Drugs 0.000 description 3
- 235000019698 starch Nutrition 0.000 description 3
- 229920001817 Agar Polymers 0.000 description 2
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical group OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 2
- 108010010803 Gelatin Proteins 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- 239000005662 Paraffin oil Substances 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 239000008272 agar Substances 0.000 description 2
- 235000010419 agar Nutrition 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 2
- 239000011230 binding agent Substances 0.000 description 2
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 description 2
- 239000000969 carrier Substances 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 239000000839 emulsion Substances 0.000 description 2
- 229920000159 gelatin Polymers 0.000 description 2
- 239000008273 gelatin Substances 0.000 description 2
- 235000019322 gelatine Nutrition 0.000 description 2
- 235000011852 gelatine desserts Nutrition 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- 238000004128 high performance liquid chromatography Methods 0.000 description 2
- 230000001965 increasing effect Effects 0.000 description 2
- 230000001788 irregular Effects 0.000 description 2
- 238000002844 melting Methods 0.000 description 2
- 230000008018 melting Effects 0.000 description 2
- 229920000609 methyl cellulose Polymers 0.000 description 2
- 239000001923 methylcellulose Substances 0.000 description 2
- 235000010981 methylcellulose Nutrition 0.000 description 2
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 2
- 229960000564 nitrofurantoin Drugs 0.000 description 2
- NXFQHRVNIOXGAQ-YCRREMRBSA-N nitrofurantoin Chemical compound O1C([N+](=O)[O-])=CC=C1\C=N\N1C(=O)NC(=O)C1 NXFQHRVNIOXGAQ-YCRREMRBSA-N 0.000 description 2
- 229940095064 tartrate Drugs 0.000 description 2
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 description 1
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
- 244000215068 Acacia senegal Species 0.000 description 1
- 241000416162 Astragalus gummifer Species 0.000 description 1
- GUBGYTABKSRVRQ-DCSYEGIMSA-N Beta-Lactose Chemical compound OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-DCSYEGIMSA-N 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- 229920002261 Corn starch Polymers 0.000 description 1
- 229920002785 Croscarmellose sodium Polymers 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- 235000019739 Dicalciumphosphate Nutrition 0.000 description 1
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 1
- 229920000084 Gum arabic Polymers 0.000 description 1
- CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 description 1
- WTDRDQBEARUVNC-LURJTMIESA-N L-DOPA Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-LURJTMIESA-N 0.000 description 1
- WTDRDQBEARUVNC-UHFFFAOYSA-N L-Dopa Natural products OC(=O)C(N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-UHFFFAOYSA-N 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 1
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 1
- 206010028813 Nausea Diseases 0.000 description 1
- 102000004316 Oxidoreductases Human genes 0.000 description 1
- 108090000854 Oxidoreductases Proteins 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- BKRGVLQUQGGVSM-KBXCAEBGSA-N Revanil Chemical compound C1=CC(C=2[C@H](N(C)C[C@H](C=2)NC(=O)N(CC)CC)C2)=C3C2=CNC3=C1 BKRGVLQUQGGVSM-KBXCAEBGSA-N 0.000 description 1
- 241000220010 Rhode Species 0.000 description 1
- 229940124639 Selective inhibitor Drugs 0.000 description 1
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 1
- BCKXLBQYZLBQEK-KVVVOXFISA-M Sodium oleate Chemical compound [Na+].CCCCCCCC\C=C/CCCCCCCC([O-])=O BCKXLBQYZLBQEK-KVVVOXFISA-M 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 229920001615 Tragacanth Polymers 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- 239000000205 acacia gum Substances 0.000 description 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 229940023476 agar Drugs 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000000440 bentonite Substances 0.000 description 1
- 229910000278 bentonite Inorganic materials 0.000 description 1
- 229940092782 bentonite Drugs 0.000 description 1
- 235000012216 bentonite Nutrition 0.000 description 1
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 1
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 1
- 229960002802 bromocriptine Drugs 0.000 description 1
- OZVBMTJYIDMWIL-AYFBDAFISA-N bromocriptine Chemical compound C1=CC(C=2[C@H](N(C)C[C@@H](C=2)C(=O)N[C@]2(C(=O)N3[C@H](C(N4CCC[C@H]4[C@]3(O)O2)=O)CC(C)C)C(C)C)C2)=C3C2=C(Br)NC3=C1 OZVBMTJYIDMWIL-AYFBDAFISA-N 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 235000011132 calcium sulphate Nutrition 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 229940105329 carboxymethylcellulose Drugs 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 239000008120 corn starch Substances 0.000 description 1
- 229960001681 croscarmellose sodium Drugs 0.000 description 1
- 235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- NEFBYIFKOOEVPA-UHFFFAOYSA-K dicalcium phosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])([O-])=O NEFBYIFKOOEVPA-UHFFFAOYSA-K 0.000 description 1
- 229940038472 dicalcium phosphate Drugs 0.000 description 1
- 229910000390 dicalcium phosphate Inorganic materials 0.000 description 1
- 235000019329 dioctyl sodium sulphosuccinate Nutrition 0.000 description 1
- 239000007884 disintegrant Substances 0.000 description 1
- 229940052760 dopamine agonists Drugs 0.000 description 1
- 239000003136 dopamine receptor stimulating agent Substances 0.000 description 1
- 239000008298 dragée Substances 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- MVPICKVDHDWCJQ-UHFFFAOYSA-N ethyl 3-pyrrolidin-1-ylpropanoate Chemical compound CCOC(=O)CCN1CCCC1 MVPICKVDHDWCJQ-UHFFFAOYSA-N 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 239000007903 gelatin capsule Substances 0.000 description 1
- 235000001727 glucose Nutrition 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000013038 irreversible inhibitor Substances 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 229960003587 lisuride Drugs 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000010297 mechanical methods and process Methods 0.000 description 1
- 230000005226 mechanical processes and functions Effects 0.000 description 1
- FJQXCDYVZAHXNS-UHFFFAOYSA-N methadone hydrochloride Chemical compound Cl.C=1C=CC=CC=1C(CC(C)N(C)C)(C(=O)CC)C1=CC=CC=C1 FJQXCDYVZAHXNS-UHFFFAOYSA-N 0.000 description 1
- 229960002900 methylcellulose Drugs 0.000 description 1
- 239000003697 methyltransferase inhibitor Substances 0.000 description 1
- 239000008108 microcrystalline cellulose Substances 0.000 description 1
- 229940016286 microcrystalline cellulose Drugs 0.000 description 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
- 238000001000 micrograph Methods 0.000 description 1
- 238000007431 microscopic evaluation Methods 0.000 description 1
- 238000000386 microscopy Methods 0.000 description 1
- 230000008450 motivation Effects 0.000 description 1
- 230000008693 nausea Effects 0.000 description 1
- 239000012457 nonaqueous media Substances 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 239000008184 oral solid dosage form Substances 0.000 description 1
- 229960004851 pergolide Drugs 0.000 description 1
- YEHCICAEULNIGD-MZMPZRCHSA-N pergolide Chemical compound C1=CC([C@H]2C[C@@H](CSC)CN([C@@H]2C2)CCC)=C3C2=CNC3=C1 YEHCICAEULNIGD-MZMPZRCHSA-N 0.000 description 1
- 235000021317 phosphate Nutrition 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 230000036470 plasma concentration Effects 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 229940069328 povidone Drugs 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000005029 sieve analysis Methods 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- APSBXTVYXVQYAB-UHFFFAOYSA-M sodium docusate Chemical compound [Na+].CCCCC(CC)COC(=O)CC(S([O-])(=O)=O)C(=O)OCC(CC)CCCC APSBXTVYXVQYAB-UHFFFAOYSA-M 0.000 description 1
- RYYKJJJTJZKILX-UHFFFAOYSA-M sodium octadecanoate Chemical compound [Na+].CCCCCCCCCCCCCCCCCC([O-])=O RYYKJJJTJZKILX-UHFFFAOYSA-M 0.000 description 1
- 229920003109 sodium starch glycolate Polymers 0.000 description 1
- 239000008109 sodium starch glycolate Substances 0.000 description 1
- 229940079832 sodium starch glycolate Drugs 0.000 description 1
- 229940045902 sodium stearyl fumarate Drugs 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 235000010356 sorbitol Nutrition 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 239000006190 sub-lingual tablet Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000007916 tablet composition Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- 230000037317 transdermal delivery Effects 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 238000000844 transformation Methods 0.000 description 1
- 238000001665 trituration Methods 0.000 description 1
- 238000009827 uniform distribution Methods 0.000 description 1
- 208000019206 urinary tract infection Diseases 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 229930195724 β-lactose Natural products 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
【選択図】なし
Description
a) R(+)-N-プロパルギル-1-アミノインダンの医薬的に許容可能な塩の粒子の1バッチを粉砕に供する;
b) 工程a)の生成物と担体を混合し顆粒を形成する;
c) 顆粒の混合物均一性(blend uniformity)を決定する;および
d) 組成物を製造するため、顆粒の混合物均一性が予め決めた基準を満たす場合にのみ、顆粒を、顆粒由来の組成物へとする。
製粉前のR(+) PAIメシレートサンプルは、様々なサイズの、大きく、不規則な、平板状の粒子を含んでいる(図1参照)。4つの異なるバッチのPSDを、製粉の前後で測定した。PSDは、マスターサイザーSモデル(Mastersizer S model)を用いたマルバーンレーザー回折(Malvern Laser Diffraction)によって測定した。レーザー回折は、光の回折の角度は粒子のサイズに反比例するという事実に基づいている。粒子の特性が測定され、球体(1つの特有の数字によって記載することが可能な、唯一の形状である球体)の測定値として理解される。加えて、レーザー回折は、体積の項(volume terms)に基づいて粒子サイズ分布を算出し、従って粒子サイズの測定から粒子数は除外される。マスターサイザーSモデルは、単一の技術および単一の範囲の設定を用いて粒子を測定する。
実施例1より、原体の製粉はPSDを変化させ、それゆえより小さな粒子が得られることが明らかである。
製剤は、実施例1で使用された方法によって決定される調節されたPSDを有する幾つかのバッチのR(+) PAIを用いて、以下の方法に従って作製される。
試験したバッチの内容物均一性は、98.6%から100.6%にわたった。RSD(相対標準偏差、平均のパーセンテージで表される)は、錠剤の全バッチで2.0%未満であった。このことは、それぞれの錠剤における活性成分の量が少ないにも関わらず、錠剤の均一性は高いことを意味している。それゆえ、これらの結果は、USP内容物均一性試験の第1段階に設定される許容性基準を満たしている。
Claims (41)
- R(+)-N-プロパルギル-1-アミノインダンの医薬的に許容可能な塩の粒子の混合物であって、体積で表して全量の90%超のR(+)-N-プロパルギル-1-アミノインダン塩の粒子が、250ミクロン未満のサイズを有する混合物。
- 請求項1に記載の混合物であって、体積で表して全量の90%超のR(+)-N-プロパルギル-1-アミノインダン塩の粒子が、220ミクロン未満のサイズを有する混合物。
- 請求項2に記載の混合物であって、体積で表して全量の90%超のR(+)-N-プロパルギル-1-アミノインダン塩の粒子が、200ミクロン未満のサイズを有する混合物。
- 請求項1から請求項3の何れか1項に記載の混合物であって、体積で表して全量の少なくとも90%のR(+)-N-プロパルギル-1-アミノインダン塩の粒子が、6ミクロンより大きいサイズを有する混合物。
- 請求項1から請求項4の何れか1項に記載の混合物であって、前記医薬的に許容可能な塩が、酒石酸塩、エシレート塩、メシレート塩、または硫酸塩である混合物。
- 請求項5に記載の混合物であって、前記医薬的に許容可能な塩がメシレート塩である混合物。
- 請求項1から請求項6の何れか1項に記載の粒子および担体の、ある量の(an amount of)混合物を含む固体組成物。
- 請求項7に記載の固体組成物であって、粒子および医薬的に許容可能な担体の、治療的に有効量の混合物を含む固体組成物。
- 請求項7または請求項8に記載の固体組成物であって、前記粒子および担体の混合物が顆粒を構成する固体組成物。
- 固体剤形である、請求項9に記載の組成物。
- 経口剤形である、請求項10に記載の組成物。
- 前記経口剤形が錠剤である、請求項11に記載の組成物
- 請求項10から請求項12の何れか1項に記載の組成物であって、前記固体剤形におけるR(+)-N-プロパルギル-1-アミノインダン塩の内容物の相対標準偏差(RSD)が、4%未満である組成物。
- 請求項13に記載の組成物であって、前記R(+)-N-プロパルギル-1-アミノインダン塩の内容物の相対標準偏差(RSD)が3%未満である組成物。
- 請求項14に記載の組成物であって、前記R(+)-N-プロパルギル-1-アミノインダン塩の内容物の相対標準偏差(RSD)が2%未満である組成物。
- 請求項10から請求項15の何れか1項に記載の組成物であって、内容物均一性が、95%から105%の間である組成物。
- パーキンソン病を患う患者を治療する方法であって、請求項7から請求項16の何れか1項に記載の組成物を該患者に投与することを含む方法。
- R(+)-N-プロパルギル-1-アミノインダンの医薬的に許容可能な塩の粒子サイズを、250ミクロン未満の粒子サイズに縮小することを含む、組成物の製造方法。
- 請求項18に記載の方法であって、前記粒子サイズが200ミクロン未満である方法。
- 請求項18または請求項19に記載の方法であって、縮小する工程が、R(+)-N-プロパルギル-1-アミノインダンの医薬的に許容可能な塩の粒子の粉砕を含む方法。
- 請求項18から請求項20の何れか1項に記載の方法であって、さらに、R(+)-N-プロパルギル-1-アミノインダンの粒子と担体とを混合し顆粒を形成することを含む方法。
- 請求項21に記載の方法であって、前記顆粒の混合物均一性が90%から110%の間であり、および混合物均一性の相対標準偏差(RSD)が2%未満である方法。
- 請求項22に記載の方法であって、前記混合物均一性が95%から105%の間であり、および前記混合物均一性の相対標準偏差(RSD)が2%未満である方法。
- 請求項21から請求項23の何れか1項に記載の方法であって、さらに、250ミクロン未満の粒子サイズを有するR(+)-N-プロパルギル-1-アミノインダンの医薬的に許容可能な塩の粒子を含む顆粒を、固体剤形に圧縮することを含む方法。
- 前記固体剤形が錠剤である請求項24に記載の方法。
- 以下を含む、固体組成物を製造する方法:
a) R(+)-N-プロパルギル-1-アミノインダンの医薬的に許容可能な塩の粒子の1バッチを粉砕に供する;
b) 工程a)の生成物と担体を混合し顆粒を形成する;
c) 顆粒の混合物均一性を決定する;および
d) 組成物を製造するため、顆粒の混合物均一性が予め決めた基準を満たす場合にのみ、顆粒から組成物を形成する。 - 請求項26に記載の方法であって、前記予め決めた基準が、90%から110%の間の混合物均一性および2%の未満の相対標準偏差である方法。
- 請求項26に記載の方法であって、前記予め決めた基準が、95%から105%の間の混合物均一性および2%の未満の相対標準偏差である方法。
- 請求項26から請求項28の何れか1項に記載の方法であって、形成工程c)が固体剤形の製造を含む方法。
- 請求項29に記載の方法であって、前記形成工程c)が経口剤形の製造を含む方法。
- 請求項30に記載の方法であって、前記経口剤形が錠剤である方法。
- 請求項29から請求項31の何れか1項に記載の方法であって、さらに、固体剤形の内容物均一性の決定を含む方法。
- 請求項32に記載の方法であって、さらに、内容物均一性が予め決めた基準を満たす場合にのみ、許容可能な組成物として固体剤形を定量する工程を含む方法。
- 請求項33に記載の方法であって、前記予め決めた基準が、95%から105%の間の内容物均一性である方法。
- 請求項33に記載の方法であって、前記予め決めた基準が、4%未満の内容物均一性の相対標準偏差である方法。
- 請求項33に記載の方法であって、前記予め決めた基準が、3%未満の内容物均一性の相対標準偏差である方法。
- 請求項33に記載の方法であって、前記予め決めた基準が、2%未満の内容物均一性の相対標準偏差である方法。
- 請求項26から請求項37の何れか1項に記載の方法であって、さらに、工程c)の後に、予め決めた基準を満たさない何れかのバッチのR(+)-N-プロパルギル-1-アミノインダンの医薬的に許容可能な塩の粒子のサイズを縮小する工程を含む方法。
- 請求項26から請求項37の何れか1項に記載の方法であって、工程b)が、R(+)-N-プロパルギル-1-アミノインダンの医薬的に許容可能な塩の粒子のサイズの縮小を含む方法。
- 請求項38または請求項39の何れか1項に記載の方法であって、縮小する工程が、R(+)-N-プロパルギル-1-アミノインダンの医薬的に許容可能な塩の粒子を製粉する方法。
- 請求項18から請求項40の何れか1項に記載の方法によって製造される、治療的な有効量のR(+)-N-プロパルギル-1-アミノインダンの医薬的に許容可能な塩を含む、固体医薬組成物。
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US65562205P | 2005-02-23 | 2005-02-23 | |
US60/655,622 | 2005-02-23 | ||
US72090805P | 2005-09-27 | 2005-09-27 | |
US60/720,908 | 2005-09-27 | ||
PCT/US2006/006252 WO2006091657A1 (en) | 2005-02-23 | 2006-02-22 | Rasagiline formulations of improved content uniformity |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2013024784A Division JP2013139452A (ja) | 2005-02-23 | 2013-02-12 | 内容物均一性が改善されたラサギリン製剤 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2008531572A true JP2008531572A (ja) | 2008-08-14 |
JP5738509B2 JP5738509B2 (ja) | 2015-06-24 |
Family
ID=36927751
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2007557120A Active JP5738509B2 (ja) | 2005-02-23 | 2006-02-22 | 内容物均一性が改善されたラサギリン製剤 |
JP2013024784A Pending JP2013139452A (ja) | 2005-02-23 | 2013-02-12 | 内容物均一性が改善されたラサギリン製剤 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2013024784A Pending JP2013139452A (ja) | 2005-02-23 | 2013-02-12 | 内容物均一性が改善されたラサギリン製剤 |
Country Status (16)
Country | Link |
---|---|
US (1) | US7815942B2 (ja) |
EP (1) | EP1848402B2 (ja) |
JP (2) | JP5738509B2 (ja) |
KR (5) | KR20170023211A (ja) |
AU (1) | AU2006216696B2 (ja) |
BR (1) | BRPI0608209A2 (ja) |
CA (2) | CA2901244A1 (ja) |
ES (1) | ES2586412T5 (ja) |
HK (1) | HK1103366A1 (ja) |
IL (2) | IL184033A0 (ja) |
IS (1) | IS8669A (ja) |
MX (1) | MX2007010233A (ja) |
NO (1) | NO20074823L (ja) |
NZ (1) | NZ560660A (ja) |
RU (1) | RU2404746C2 (ja) |
WO (1) | WO2006091657A1 (ja) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2019535708A (ja) * | 2016-11-10 | 2019-12-12 | メディスカ ファーマシューティック インコーポレイテッド | 薬剤の配合方法およびシステム |
JP2020050671A (ja) * | 2010-02-12 | 2020-04-02 | ファイザー・インク | 8−フルオロ−2−{4−[(メチルアミノ)メチル]フェニル}−1,3,4,5−テトラヒドロ−6H−アゼピノ[5,4,3−cd]インドール−6−オンの塩および多形体 |
Families Citing this family (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5744500A (en) * | 1990-01-03 | 1998-04-28 | Teva Pharmaceutical Industries, Ltd. | Use of R-enantiomer of N-propargyl-1-aminoindan, salts, and compositions thereof |
AU2003290838A1 (en) | 2002-11-15 | 2004-06-15 | Teva Pharmaceutical Industries, Ltd. | Use of rasagiline with or without riluzole to treat amyotrophic lateral sclerosis |
US20060018957A1 (en) * | 2004-07-26 | 2006-01-26 | Lerner E I | Pharmaceutical dosage forms including rasagiline |
ZA200704917B (en) * | 2004-11-24 | 2008-11-26 | Teva Pharma | Rasagiline orally disintegrating compositions |
AU2006211510B8 (en) * | 2005-02-02 | 2011-04-21 | Teva Pharmaceutical Industries, Ltd. | Process for producing polypeptide mixtures using hydrogenolysis |
PL1848415T3 (pl) * | 2005-02-17 | 2013-10-31 | Teva Pharma | Terapia kombinowana obejmująca octan glatirameru oraz rasagilinę do leczenia stwardnienia rozsianego |
CA2901244A1 (en) | 2005-02-23 | 2006-08-31 | Teva Pharmaceutical Industries, Ltd. | Rasagiline formulations of improved content uniformity |
AU2006316585B2 (en) * | 2005-11-17 | 2012-09-20 | Teva Pharmaceutical Industries, Ltd. | Methods for isolating propargylated aminoindans |
US7572834B1 (en) | 2005-12-06 | 2009-08-11 | Teva Pharmaceutical Industries, Ltd. | Rasagiline formulations and processes for their preparation |
ES2551481T3 (es) | 2006-02-21 | 2015-11-19 | Teva Pharmaceutical Industries, Ltd. | Uso de rasagilina para el tratamiento de atrofia multisistémica |
NZ571591A (en) * | 2006-04-03 | 2011-09-30 | Teva Pharma | Use of rasagiline for the treatment of restless legs syndrome |
EP1892233A1 (de) | 2006-08-18 | 2008-02-27 | Ratiopharm GmbH | Neue Salze des Wirkstoffs Rasagilin |
BRPI0718339A2 (pt) * | 2006-12-14 | 2014-02-18 | Teva Pharma | Composto, composição, composição farmacêutica e processo de fabricação de tanato de rasagilina |
AU2007334428B2 (en) * | 2006-12-14 | 2014-05-29 | Teva Pharmaceutical Industries, Ltd. | Crystalline solid rasagiline base |
EP1987816A1 (de) * | 2007-04-30 | 2008-11-05 | Ratiopharm GmbH | Adsorbate eines Rasagilinsalzes mit einem wasserlöslichen Hilfsstoff |
US20090062400A1 (en) * | 2007-09-05 | 2009-03-05 | Laurence Oron | Method of treating glaucoma using rasagiline |
US8188149B2 (en) * | 2007-09-17 | 2012-05-29 | Teva Pharmaceutical Industries, Ltd. | Use of R(+)-N-propargy1-1-aminoindan to treat or prevent hearing loss |
CN101909438A (zh) * | 2008-01-11 | 2010-12-08 | 泰华制药工业有限公司 | 雷沙吉兰制剂、其制备及用途 |
EP2271612B1 (en) * | 2008-03-31 | 2016-08-10 | Actavis Group PTC EHF | Rasagiline mesylate particles and process for the preparation thereof |
ES2389353T3 (es) * | 2008-06-10 | 2012-10-25 | Teva Pharmaceutical Industries Ltd. | Cápsulas de gelatina blanda de rasagilina |
BRPI0909894A2 (pt) * | 2008-06-13 | 2015-07-28 | Teva Pharma | "método de redução da velocidade de progressão de mal de parkinson em um paciente com mal de parkinson em estágio inicial, método de redução da velocidade de progressão de mal de parkinson, método de atraso da necessidade de terapia antiparkinsoniana sintomática em um paciente de mal de parkinson em estágio inicial, método de redução do risco de um paciente com mal de parkinson que necessita de terapia antiparkinsoniana, método de redução do declínio funcional de um paciente com mal de parkinson em estágio inicial, método de redução do declínio funcional em um paciente com mal de parkinson, método de tratamento de um paciente que exibe sinais iniciais de mal de parkinson, método de redução da fadiga em um paciente com mal de parkinson em estágio inicial, método de redução da velocidade de progressão clínica e tratamento de sintomas de mal de parkinson em um paciente com mal de parkinson, rasagilina ou um sal farmaceuticamente aceitável de rasagilina, composição farmacêutica. |
NZ589547A (en) * | 2008-06-19 | 2013-03-28 | Teva Pharma | Dried rasagiline base having a water content less than 0.5 % by weight |
CA2727021A1 (en) | 2008-06-19 | 2009-12-23 | Teva Pharmaceutical Industries Ltd. | Process for purifying rasagiline base |
EP2657221A1 (en) | 2008-11-20 | 2013-10-30 | Dr. Reddy's Laboratories Ltd. | Preparation of rasagiline and salts thereof |
DE102008064061A1 (de) | 2008-12-19 | 2010-06-24 | Ratiopharm Gmbh | Feste Zusammensetzung mit dem Wirkstoff Rasagilin |
US20100189791A1 (en) * | 2009-01-23 | 2010-07-29 | Teva Pharmaceutical Industries, Ltd. | Delayed release rasagiline malate formulation |
US20120122993A1 (en) | 2009-03-05 | 2012-05-17 | Sandoz Ag | Pharmaceutical composition containing 1h-inden-1-amine, 2,3-dihydro-n-2-propynyl-(1r)-, methanesulfonate |
WO2010111264A2 (en) * | 2009-03-24 | 2010-09-30 | Dr. Reddy's Laboratories Ltd. | Rasagiline formulations |
PL2451771T3 (pl) | 2009-07-09 | 2014-12-31 | Ratiopharm Gmbh | Sole rasagiliny i ich preparaty farmaceutyczne |
US8741962B2 (en) | 2009-11-26 | 2014-06-03 | Usv Limited | Process for preparation of Rasagiline and salts thereof |
US20120321896A1 (en) * | 2010-02-01 | 2012-12-20 | Kuppuswamy Nagarajan | Rasagiline mesylate having large particle size and a process for preparation thereof |
EA023786B1 (ru) | 2010-04-30 | 2016-07-29 | ТЕЙКОКУ ФАРМА ЮЭсЭй, ИНК. | Трансдермальные композиции на основе пропиниламиноиндана |
EP2389927A1 (en) | 2010-05-30 | 2011-11-30 | Abdi Ibrahim Ilac Sanayi ve Ticaret Anonim Sirketi | Pharmaceutical formulations of rasagiline |
CA2806740A1 (en) | 2010-07-27 | 2012-02-02 | Teva Pharmaceutical Industries Ltd. | Use of rasagiline for the treatment of olfactory dysfunction |
AU2011282716A1 (en) | 2010-07-27 | 2013-03-14 | Teva Pharmaceutical Industries Ltd. | Dispersions of rasagiline citrate |
EP2688561B1 (en) | 2011-03-24 | 2018-08-22 | Teikoku Pharma USA, Inc. | Transdermal compositions comprising an active agent layer and an active agent conversion layer |
EP2705021A2 (en) | 2011-05-04 | 2014-03-12 | Cadila Healthcare Limited | Rasagiline and its pharmaceutically acceptable salts |
BR112014008552A2 (pt) | 2011-10-10 | 2017-04-18 | Teva Pharma | r(+)-n-metil-propargilaminoindano |
KR20140090996A (ko) | 2011-10-10 | 2014-07-18 | 테바 파마슈티컬 인더스트리즈 리미티드 | R(+)-n-폼일-프로파길-아미노인단 |
US9913812B2 (en) | 2011-11-09 | 2018-03-13 | Teikoku Pharma Usa, Inc. | Methods for the treatment of skin neoplasms |
EP2610239A1 (en) | 2012-01-02 | 2013-07-03 | Dr. Reddy's Laboratories Ltd. | Preparation Of Rasagiline Hemitartrate |
MX343986B (es) | 2012-03-21 | 2016-12-01 | Synthon Bv | Composiciones farmaceuticas estabilizadas que comprenden sales de rasagilina. |
BR112015003451A2 (pt) | 2012-08-17 | 2017-07-04 | Teva Pharma | formulação parentérica de rasagilina |
JP6050896B2 (ja) | 2012-11-02 | 2016-12-21 | テイコク ファーマ ユーエスエー インコーポレーテッド | プロピニルアミノインダン経皮組成物 |
US20160046582A1 (en) | 2013-03-14 | 2016-02-18 | Teva Pharmaceutical Industries Ltd. | Crystals of laquinimod sodium and improved process for the manufacture thereof |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995011016A1 (en) * | 1993-10-18 | 1995-04-27 | Teva Pharmaceutical Industries Ltd. | R-enantiomer of n-propargyl-1-aminoindan, salts, compositions and uses thereof |
Family Cites Families (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3513249A (en) * | 1968-12-24 | 1970-05-19 | Ideal Ind | Explosion connector with improved insulating means |
GB8914804D0 (en) * | 1989-06-28 | 1989-08-16 | Glaxo Group Ltd | Process |
IL92952A (en) | 1990-01-03 | 1994-06-24 | Teva Pharma | R-enantiomers of n-propargyl-1-aminoindan compounds, their preparation and pharmaceutical compositions containing them |
US5744500A (en) | 1990-01-03 | 1998-04-28 | Teva Pharmaceutical Industries, Ltd. | Use of R-enantiomer of N-propargyl-1-aminoindan, salts, and compositions thereof |
US5444095A (en) * | 1991-04-04 | 1995-08-22 | University Of Toronto, Innovations Foundation | Use of deprenyl to rescue damaged nerve cells |
US5844003A (en) * | 1991-04-04 | 1998-12-01 | Innovations Foundation | Use of deprenyl compounds to maintain, prevent loss, or recover nerve cell function |
US5767164A (en) * | 1991-04-04 | 1998-06-16 | Innovations Foundation | Use of deprenyl to rescue damaged nerve cells |
IL99759A (en) | 1991-10-16 | 1997-06-10 | Teva Pharma | Mono-fluorinated derivatives of n-propargyl-1-aminoindan, their preparation and pharmaceutical compositions containing them |
DE69535315T2 (de) | 1994-01-10 | 2007-06-28 | Teva Pharmaceutical Industries Ltd. | 1-aminoindanderivate und zusammensetzungen hiervon |
IL115357A (en) | 1995-09-20 | 2000-01-31 | Teva Pharma | Stable compositions containing N-propargyl-1-aminoindan and polyhydric alcohols |
IL118836A (en) | 1996-07-11 | 2001-01-11 | Teva Pharma | Pharmaceutical compositions comprising s-(-)-n-propargyl-1-aminoindan |
CA2275425C (en) | 1996-12-18 | 2009-08-04 | Michael Chorev | Aminoindan derivatives |
EP1052983A2 (en) * | 1998-01-27 | 2000-11-22 | Thomas N. Thomas | Use of an mao-a or mao-b inhibitor for the treatment of vascular disorders |
US7766013B2 (en) * | 2001-06-05 | 2010-08-03 | Alexza Pharmaceuticals, Inc. | Aerosol generating method and device |
MXPA03012041A (es) | 2001-07-04 | 2004-03-26 | Sun Pharmaceutical Ind Ltd | Sistema de administracion controlada de farmacos de retencion gastrica. |
US20040052843A1 (en) * | 2001-12-24 | 2004-03-18 | Lerner E. Itzhak | Controlled release dosage forms |
AU2003219913A1 (en) | 2002-02-27 | 2003-09-09 | Teva Pharmaceutical Industries, Ltd. | Propargylamino indan derivatives and propargylamino tetralin derivatives as brain-selective mao inhibitors |
US20040010038A1 (en) * | 2002-02-27 | 2004-01-15 | Eran Blaugrund | Propargylamino indan derivatives and propargylamino tetralin derivatives as brain-selective MAO inhibitors |
AU2003290838A1 (en) * | 2002-11-15 | 2004-06-15 | Teva Pharmaceutical Industries, Ltd. | Use of rasagiline with or without riluzole to treat amyotrophic lateral sclerosis |
WO2004112799A1 (en) * | 2003-06-13 | 2004-12-29 | Chrysalis Technologies Incorporated | Methods and apparatus for producing nanoscale particles |
US20050026979A1 (en) * | 2003-07-31 | 2005-02-03 | Maha Ghazzi | Methods for treating inflammation and inflammation-associated diseases with a statin and ether |
US7735024B2 (en) * | 2003-10-29 | 2010-06-08 | Intel Corporation | Methods and apparatus to provide a handheld pointer-based user interface |
US20060018957A1 (en) * | 2004-07-26 | 2006-01-26 | Lerner E I | Pharmaceutical dosage forms including rasagiline |
ZA200704917B (en) * | 2004-11-24 | 2008-11-26 | Teva Pharma | Rasagiline orally disintegrating compositions |
NZ555470A (en) | 2004-11-24 | 2011-02-25 | Teva Pharma | Rasagiline orally disintegrating compositions |
CA2901244A1 (en) | 2005-02-23 | 2006-08-31 | Teva Pharmaceutical Industries, Ltd. | Rasagiline formulations of improved content uniformity |
AU2006316585B2 (en) * | 2005-11-17 | 2012-09-20 | Teva Pharmaceutical Industries, Ltd. | Methods for isolating propargylated aminoindans |
US7572834B1 (en) * | 2005-12-06 | 2009-08-11 | Teva Pharmaceutical Industries, Ltd. | Rasagiline formulations and processes for their preparation |
ES2551481T3 (es) | 2006-02-21 | 2015-11-19 | Teva Pharmaceutical Industries, Ltd. | Uso de rasagilina para el tratamiento de atrofia multisistémica |
NZ571591A (en) | 2006-04-03 | 2011-09-30 | Teva Pharma | Use of rasagiline for the treatment of restless legs syndrome |
EP1892233A1 (de) | 2006-08-18 | 2008-02-27 | Ratiopharm GmbH | Neue Salze des Wirkstoffs Rasagilin |
BRPI0718339A2 (pt) * | 2006-12-14 | 2014-02-18 | Teva Pharma | Composto, composição, composição farmacêutica e processo de fabricação de tanato de rasagilina |
AU2007334428B2 (en) | 2006-12-14 | 2014-05-29 | Teva Pharmaceutical Industries, Ltd. | Crystalline solid rasagiline base |
EP1987816A1 (de) | 2007-04-30 | 2008-11-05 | Ratiopharm GmbH | Adsorbate eines Rasagilinsalzes mit einem wasserlöslichen Hilfsstoff |
CN101909438A (zh) * | 2008-01-11 | 2010-12-08 | 泰华制药工业有限公司 | 雷沙吉兰制剂、其制备及用途 |
-
2006
- 2006-02-22 CA CA2901244A patent/CA2901244A1/en not_active Abandoned
- 2006-02-22 CA CA2600011A patent/CA2600011C/en active Active
- 2006-02-22 ES ES06720975T patent/ES2586412T5/es active Active
- 2006-02-22 RU RU2007135169/15A patent/RU2404746C2/ru active
- 2006-02-22 KR KR1020177004882A patent/KR20170023211A/ko active Application Filing
- 2006-02-22 NZ NZ560660A patent/NZ560660A/en unknown
- 2006-02-22 JP JP2007557120A patent/JP5738509B2/ja active Active
- 2006-02-22 KR KR1020137025486A patent/KR20130129300A/ko active Application Filing
- 2006-02-22 EP EP06720975.9A patent/EP1848402B2/en active Active
- 2006-02-22 KR KR1020077021509A patent/KR20070111534A/ko active Application Filing
- 2006-02-22 MX MX2007010233A patent/MX2007010233A/es active IP Right Grant
- 2006-02-22 AU AU2006216696A patent/AU2006216696B2/en active Active
- 2006-02-22 KR KR1020187006228A patent/KR20180026580A/ko not_active Application Discontinuation
- 2006-02-22 KR KR1020147021536A patent/KR20140103356A/ko active Search and Examination
- 2006-02-22 US US11/359,324 patent/US7815942B2/en active Active
- 2006-02-22 BR BRPI0608209-2A patent/BRPI0608209A2/pt not_active Application Discontinuation
- 2006-02-22 WO PCT/US2006/006252 patent/WO2006091657A1/en active Application Filing
-
2007
- 2007-06-19 IL IL184033A patent/IL184033A0/en unknown
- 2007-08-15 IS IS8669A patent/IS8669A/is unknown
- 2007-09-21 NO NO20074823A patent/NO20074823L/no not_active Application Discontinuation
- 2007-11-05 HK HK07112028.4A patent/HK1103366A1/zh not_active IP Right Cessation
-
2013
- 2013-02-12 JP JP2013024784A patent/JP2013139452A/ja active Pending
-
2016
- 2016-03-28 IL IL244802A patent/IL244802A/en active IP Right Grant
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995011016A1 (en) * | 1993-10-18 | 1995-04-27 | Teva Pharmaceutical Industries Ltd. | R-enantiomer of n-propargyl-1-aminoindan, salts, compositions and uses thereof |
Non-Patent Citations (4)
Title |
---|
JPN6012004298; 加藤博信他, 薬剤学, 2003, vol.63, no.4, p.218-27 * |
JPN6012004300; 服部直人, 日本薬学会年会要旨集, 2003, vol.123, no.4, p.94 * |
JPN6012004302; YALKOWSKY, S.H. et al, Pharmaceutical Research, 1990, vol.7, no.9, p.962-6 * |
JPN6012004304; ZHANG, Y et al, International Journal of Pharmaceutics, 1997, vol.154, p.179-83 * |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2020050671A (ja) * | 2010-02-12 | 2020-04-02 | ファイザー・インク | 8−フルオロ−2−{4−[(メチルアミノ)メチル]フェニル}−1,3,4,5−テトラヒドロ−6H−アゼピノ[5,4,3−cd]インドール−6−オンの塩および多形体 |
JP2019535708A (ja) * | 2016-11-10 | 2019-12-12 | メディスカ ファーマシューティック インコーポレイテッド | 薬剤の配合方法およびシステム |
US11883359B2 (en) | 2016-11-10 | 2024-01-30 | Medisca Pharmaceutique Inc. | Adapter for use in a planetary mixer |
Also Published As
Publication number | Publication date |
---|---|
RU2007135169A (ru) | 2009-03-27 |
IS8669A (is) | 2007-08-15 |
IL184033A0 (en) | 2007-10-31 |
US7815942B2 (en) | 2010-10-19 |
AU2006216696B2 (en) | 2011-08-18 |
JP5738509B2 (ja) | 2015-06-24 |
ES2586412T3 (es) | 2016-10-14 |
KR20130129300A (ko) | 2013-11-27 |
JP2013139452A (ja) | 2013-07-18 |
KR20070111534A (ko) | 2007-11-21 |
AU2006216696A1 (en) | 2006-08-31 |
ES2586412T5 (es) | 2019-05-16 |
RU2404746C2 (ru) | 2010-11-27 |
MX2007010233A (es) | 2007-11-07 |
HK1103366A1 (zh) | 2007-12-21 |
EP1848402A4 (en) | 2012-01-18 |
KR20170023211A (ko) | 2017-03-02 |
BRPI0608209A2 (pt) | 2010-11-09 |
CA2901244A1 (en) | 2006-08-31 |
US20060188581A1 (en) | 2006-08-24 |
KR20140103356A (ko) | 2014-08-26 |
EP1848402B1 (en) | 2016-05-11 |
NO20074823L (no) | 2007-11-16 |
EP1848402A1 (en) | 2007-10-31 |
EP1848402B2 (en) | 2019-02-20 |
CA2600011A1 (en) | 2006-08-31 |
CA2600011C (en) | 2015-11-10 |
WO2006091657A1 (en) | 2006-08-31 |
IL244802A (en) | 2016-08-31 |
IL244802A0 (en) | 2016-04-21 |
NZ560660A (en) | 2010-11-26 |
KR20180026580A (ko) | 2018-03-12 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP5738509B2 (ja) | 内容物均一性が改善されたラサギリン製剤 | |
US11666567B2 (en) | Bromocriptine formulations | |
EP2732810A1 (en) | Spherical particles of clopidogrel bisulfate, pharmaceutical composition including same, and method for manufacturing same | |
TW201840320A (zh) | 包含5-氯-n4-[2-(二甲基磷醯基)苯基]-n2-{2-甲氧基-4-[4-(4-甲基哌嗪-1-基)哌啶-1-基]苯基}嘧啶-2,4-二胺之醫藥調配物 | |
CN114767645A (zh) | 叶酸片及其制备方法 | |
CN106994121A (zh) | 一种用于治疗癌症的药物组合物 | |
CN101123946A (zh) | 改良含量均匀度的雷沙吉兰制剂 | |
CN115212177A (zh) | 一种含有布鲁顿氏酪氨酸激酶抑制剂的口服固体刻痕片剂及其制备方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20090218 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20120131 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20120427 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20120509 |
|
RD04 | Notification of resignation of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7424 Effective date: 20120529 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20120530 |
|
A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20121009 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20130212 |
|
A911 | Transfer to examiner for re-examination before appeal (zenchi) |
Free format text: JAPANESE INTERMEDIATE CODE: A911 Effective date: 20130404 |
|
A912 | Re-examination (zenchi) completed and case transferred to appeal board |
Free format text: JAPANESE INTERMEDIATE CODE: A912 Effective date: 20130510 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20150225 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20150422 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 5738509 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R153 | Grant of patent term extension |
Free format text: JAPANESE INTERMEDIATE CODE: R153 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |