ES2575873T3 - Inhibidores selectivos de histona desacetilasa - Google Patents
Inhibidores selectivos de histona desacetilasa Download PDFInfo
- Publication number
- ES2575873T3 ES2575873T3 ES09733489.0T ES09733489T ES2575873T3 ES 2575873 T3 ES2575873 T3 ES 2575873T3 ES 09733489 T ES09733489 T ES 09733489T ES 2575873 T3 ES2575873 T3 ES 2575873T3
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- Prior art keywords
- alkylene
- substituted
- unsubstituted
- alkyl
- compound
- Prior art date
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| JP5670877B2 (ja) | 2008-04-15 | 2015-02-18 | ファーマサイクリックス,インク. | ヒストン脱アセチル化酵素の選択的インヒビター |
| US8624040B2 (en) | 2009-06-22 | 2014-01-07 | Millennium Pharmaceuticals, Inc. | Substituted hydroxamic acids and uses thereof |
| EP2445340B1 (en) | 2009-06-22 | 2016-05-18 | Millennium Pharmaceuticals, Inc. | Substituted hydroxamic acids and uses thereof |
| WO2011106627A1 (en) | 2010-02-26 | 2011-09-01 | Millennium Pharmaceuticals, Inc. | Substituted hydroxamic acids and uses thereof |
| TWI429628B (zh) * | 2010-03-29 | 2014-03-11 | Univ Taipei Medical | 吲哚基或吲哚啉基羥肟酸化合物 |
| WO2011130163A1 (en) | 2010-04-12 | 2011-10-20 | Millennium Pharmaceuticals, Inc. | Substituted hydroxamic acids and uses thereof |
| EP2557923A4 (en) * | 2010-04-16 | 2013-10-23 | Curis Inc | TREATMENT OF CANCER DISORDERS WITH K-RAS MUTATIONS |
| WO2012027564A1 (en) | 2010-08-26 | 2012-03-01 | Millennium Pharmaceuticals, Inc. | Substituted hydroxamic acids and uses thereof |
| US8765773B2 (en) | 2010-10-18 | 2014-07-01 | Millennium Pharmaceuticals, Inc. | Substituted hydroxamic acids and uses thereof |
| US8778931B2 (en) | 2010-12-22 | 2014-07-15 | Millennium Pharmaceuticals, Inc. | Substituted hydroxamic acids and uses thereof |
| US8404738B2 (en) * | 2011-01-21 | 2013-03-26 | Hoffmann-La Roche Inc. | 4-amino-N-hydroxy-benzamides for the treatment of cancer |
| CN103328446B (zh) * | 2011-01-21 | 2016-01-20 | 霍夫曼-拉罗奇有限公司 | 用于治疗癌症的新的4-氨基-n-羟基-苯甲酰胺 |
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| WO2012178208A2 (en) * | 2011-06-24 | 2012-12-27 | The Trustees Of The Stevens Institute Of Technology | Selective inhibitors of histone deacetylase isoform 6 and methods thereof |
| EP2771321A4 (en) * | 2011-10-28 | 2015-04-08 | Chong Kun Dang Pharm Corp | HYDROXAMATE DERIVATIVES FOR HDAC INHIBITORS AND PHARMACEUTICAL COMPOSITIONS THEREWITH |
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| TWI692469B (zh) | 2012-11-09 | 2020-05-01 | 南韓商Lg化學股份有限公司 | Gpr40受體促效劑,製造該促效劑的方法以及含有該促效劑作爲活性劑的醫藥組成物 |
| CN103086971B (zh) * | 2013-01-11 | 2015-08-26 | 中国科学院广州生物医药与健康研究院 | 含氮杂环衍生物,其制备方法及其在制备组蛋白去乙酰化酶ⅰ抑制剂中的应用 |
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| WO2015048718A2 (en) | 2013-09-30 | 2015-04-02 | Institute For Cancer Research D/B/A The Research Institute Of Fox Chase Cancer Center | Inhibition of thymine dna glycosylase in the treatment of cancer |
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| US11278602B2 (en) | 2020-03-25 | 2022-03-22 | Therapeutica Borealis Oy | Medicine for Covid-19 and treatment |
| US11007187B1 (en) * | 2020-03-25 | 2021-05-18 | Therapeutica Borealis Oy | Medicine for Covid-19 and treatment |
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| CN111518031B (zh) * | 2020-05-29 | 2023-01-17 | 中国药科大学 | 一种含有异羟肟酸的化合物及其制备方法、应用 |
| AU2022380979A1 (en) | 2021-11-02 | 2024-06-06 | Flare Therapeutics Inc. | Pparg inverse agonists and uses thereof |
| CN114409638B (zh) * | 2022-02-09 | 2023-02-14 | 深圳大学 | 组蛋白去乙酰化酶8选择性降解剂、制备方法及其在抗肿瘤活性中的应用 |
| US20250197369A1 (en) * | 2022-03-17 | 2025-06-19 | Sookmyung Women's University Industry-Academic Cooperation Foundation | Novel heterocyclic inhibitor for histone deacetylase, and pharmaceutical composition comprising same |
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| AU2024207083A1 (en) * | 2023-01-09 | 2025-07-17 | University Of Florida Research Foundation, Incorporated | Pparg modulators |
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| US5747469A (en) | 1991-03-06 | 1998-05-05 | Board Of Regents, The University Of Texas System | Methods and compositions comprising DNA damaging agents and p53 |
| GB9523946D0 (en) | 1995-11-23 | 1996-01-24 | Bayer Ag | Leukotriene antagonistic benzoic acid derivatives |
| EP1151002A4 (en) | 1999-01-29 | 2002-05-02 | Imclone Systems Inc | KDR-SPECIFIC ANTIBODIES AND USES THEREOF |
| GB9904387D0 (en) | 1999-02-25 | 1999-04-21 | Pharmacia & Upjohn Spa | Antitumour synergistic composition |
| AU4972900A (en) | 1999-04-08 | 2000-11-14 | Arch Development Corporation | Use of anti-vegf antibody to enhance radiation in cancer therapy |
| US6875598B1 (en) | 1999-12-08 | 2005-04-05 | Applera Corporation | Histone deacetylase-8 proteins, nuclei acids, and methods for use |
| JP2003083067A (ja) * | 2001-09-13 | 2003-03-19 | Toyota Motor Corp | 内燃機関のピストン温度制御装置 |
| US20040077591A1 (en) * | 2002-03-28 | 2004-04-22 | The Brigham And Women's Hospital, Inc. | Histone deacetylase inhibitors for the treatment of multiple sclerosis, amyotrophic lateral sclerosis and Alzheimer's Disease |
| AR046411A1 (es) * | 2003-09-22 | 2005-12-07 | S Bio Pte Ltd | Derivados de bencimidazol. aplicaciones farmaceuticas |
| US20050137234A1 (en) | 2003-12-19 | 2005-06-23 | Syrrx, Inc. | Histone deacetylase inhibitors |
| WO2007109178A2 (en) | 2006-03-16 | 2007-09-27 | Pharmacyclics, Inc. | Indole derivatives as inhibitors of histone deacetylase |
| US20110150825A1 (en) * | 2006-11-14 | 2011-06-23 | Pharmacyclics, Inc. | Uses of selective inhibitors of hdac8 for treatment of inflammatory conditions |
| US7820711B2 (en) * | 2006-11-14 | 2010-10-26 | Pharmacyclics Inc. | Uses of selective inhibitors of HDAC8 for treatment of T-cell proliferative disorders |
| JP5670877B2 (ja) | 2008-04-15 | 2015-02-18 | ファーマサイクリックス,インク. | ヒストン脱アセチル化酵素の選択的インヒビター |
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2009
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| EP2265590A2 (en) | 2010-12-29 |
| JP5670877B2 (ja) | 2015-02-18 |
| JP2011518173A (ja) | 2011-06-23 |
| WO2009129335A2 (en) | 2009-10-22 |
| US20110081409A1 (en) | 2011-04-07 |
| US20140004174A1 (en) | 2014-01-02 |
| CA2875549A1 (en) | 2009-10-22 |
| MX2010011168A (es) | 2010-12-21 |
| EP2265590B1 (en) | 2016-04-13 |
| WO2009129335A3 (en) | 2010-04-01 |
| US8906954B2 (en) | 2014-12-09 |
| CA2721218C (en) | 2015-03-24 |
| US20150320758A1 (en) | 2015-11-12 |
| US8466193B2 (en) | 2013-06-18 |
| EP2265590B8 (en) | 2016-07-27 |
| JP2015057414A (ja) | 2015-03-26 |
| CA2721218A1 (en) | 2009-10-22 |
| EP2265590A4 (en) | 2012-04-25 |
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