ES2570962T3 - Producción incrementada de un producto diana vía estabilización del ARNm - Google Patents
Producción incrementada de un producto diana vía estabilización del ARNmInfo
- Publication number
- ES2570962T3 ES2570962T3 ES08801456T ES08801456T ES2570962T3 ES 2570962 T3 ES2570962 T3 ES 2570962T3 ES 08801456 T ES08801456 T ES 08801456T ES 08801456 T ES08801456 T ES 08801456T ES 2570962 T3 ES2570962 T3 ES 2570962T3
- Authority
- ES
- Spain
- Prior art keywords
- polynucleotide
- microorganism
- vitamin
- production
- target product
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
- C12N15/75—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Bacillus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
- C12P1/04—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using bacteria
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/10—Nitrogen as only ring hetero atom
- C12P17/12—Nitrogen as only ring hetero atom containing a six-membered hetero ring
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/16—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing two or more hetero rings
- C12P17/167—Heterorings having sulfur atoms as ring heteroatoms, e.g. vitamin B1, thiamine nucleus and open chain analogs
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/182—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/185—Heterocyclic compounds containing sulfur atoms as ring hetero atoms in the condensed system
- C12P17/186—Heterocyclic compounds containing sulfur atoms as ring hetero atoms in the condensed system containing a 2-oxo-thieno[3,4-d]imidazol nucleus, e.g. Biotin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P25/00—Preparation of compounds containing alloxazine or isoalloxazine nucleus, e.g. riboflavin
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Mycology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Fodder In General (AREA)
Abstract
Un procedimiento para la producción de una vitamina con un microorganismo, en el que dicho microorganismo se incuba en un medio acuoso en condiciones que permiten la producción de dicha vitamina a partir de una fuente de carbono, y en el que opcionalmente se aísla la vitamina, en el que dicho microorganismo se altera genéticamente mediante introducción de un polinucleótido que conduce a un rendimiento y/o eficiencia mejorados de la producción de la vitamina producida por dicho microorganismo, seleccionándose dicho polinucleótido del grupo que consiste en: (a) polinucleótidos que comprenden la secuencia nucleotídica según SEC ID NO:2; (b) y polinucleótidos que son al menos 95% idénticos a un polinucleótido como se define en (a) y que tiene la actividad de un elemento estabilizador del ARNm, o la hebra complementaria de tal polinucleótido.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07011200A EP2000477A1 (en) | 2007-06-07 | 2007-06-07 | Increased production of a target product via stabilization of mRNA |
EP07011415 | 2007-06-11 | ||
EP07011681 | 2007-06-14 | ||
PCT/EP2008/004583 WO2008148575A2 (en) | 2007-06-07 | 2008-06-09 | Increased production of a target product via stabilization of mrna |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2570962T3 true ES2570962T3 (es) | 2016-05-23 |
Family
ID=39731439
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES08801456T Active ES2570962T3 (es) | 2007-06-07 | 2008-06-09 | Producción incrementada de un producto diana vía estabilización del ARNm |
Country Status (6)
Country | Link |
---|---|
US (1) | US8551732B2 (es) |
EP (1) | EP2150559B1 (es) |
KR (1) | KR101558622B1 (es) |
CN (1) | CN101679490B (es) |
ES (1) | ES2570962T3 (es) |
WO (1) | WO2008148575A2 (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2012175574A1 (en) | 2011-06-21 | 2012-12-27 | Dsm Ip Assets B.V. | Increased pantothenate (vitamin b5) production |
WO2012175575A2 (en) | 2011-06-21 | 2012-12-27 | Dsm Ip Assets B.V. | Increased vitamin b5 production |
CN104053780A (zh) * | 2011-12-09 | 2014-09-17 | 丹尼斯科美国公司 | 用于在微生物中生产蛋白质的来自枯草芽孢杆菌的核糖体启动子 |
JP6625521B2 (ja) | 2013-05-15 | 2020-01-08 | リボカイン,エルエルシー | 環状rnaの細胞内翻訳 |
US10287592B2 (en) | 2014-02-07 | 2019-05-14 | Dsm Ip Assets B.V. | Bacillus host |
KR20170116159A (ko) * | 2015-02-19 | 2017-10-18 | 다니스코 유에스 인크. | 향상된 단백질 발현 |
CN107922464B (zh) * | 2015-08-28 | 2022-03-15 | 帝斯曼知识产权资产管理有限公司 | 经改进的维生素生产 |
WO2021224152A1 (en) | 2020-05-05 | 2021-11-11 | Basf Se | Improving expression in fermentation processes |
JP2023534719A (ja) | 2020-07-24 | 2023-08-10 | ビーエーエスエフ ソシエタス・ヨーロピア | アラニンラセマーゼ二重欠失及びトランス相補性 |
WO2022074056A2 (en) | 2020-10-07 | 2022-04-14 | Basf Se | Bacillus cell with reduced lipase and/or esterase side activities |
WO2022161914A1 (en) | 2021-01-26 | 2022-08-04 | Basf Se | High temperature fermentation process and microorganisms |
BR112023027009A2 (pt) | 2021-06-24 | 2024-03-12 | Basf Se | Célula hospedeira modificada de bacillus licheniformis, e, métodos para produzir um composto de interesse e para aumentar a pureza de um composto de interesse |
EP4359424A1 (en) | 2021-06-24 | 2024-05-01 | Basf Se | Improved bacillus production host |
WO2022269084A1 (en) | 2021-06-24 | 2022-12-29 | Basf Se | Improved bacillus host cell with altered rema/remb protein |
WO2023117970A1 (en) | 2021-12-20 | 2023-06-29 | Basf Se | Method for improved production of intracellular proteins in bacillus |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5017477A (en) * | 1985-10-25 | 1991-05-21 | Biotechnica International, Inc. | Enhancing DNA sequencies derived from the sacQ gene |
CN1962872A (zh) * | 2005-11-07 | 2007-05-16 | 上海市肿瘤研究所 | 特异性切割血管内皮生长因子rna的核酶及其应用 |
EP1957651B1 (en) * | 2005-12-05 | 2014-03-05 | DSM IP Assets B.V. | Method for mrna stabilization |
-
2008
- 2008-06-09 ES ES08801456T patent/ES2570962T3/es active Active
- 2008-06-09 US US12/601,614 patent/US8551732B2/en not_active Expired - Fee Related
- 2008-06-09 WO PCT/EP2008/004583 patent/WO2008148575A2/en active Application Filing
- 2008-06-09 KR KR1020107000214A patent/KR101558622B1/ko active IP Right Grant
- 2008-06-09 CN CN200880019197.6A patent/CN101679490B/zh not_active Expired - Fee Related
- 2008-06-09 EP EP08801456.8A patent/EP2150559B1/en not_active Not-in-force
Also Published As
Publication number | Publication date |
---|---|
WO2008148575A2 (en) | 2008-12-11 |
CN101679490B (zh) | 2014-05-07 |
WO2008148575A3 (en) | 2009-04-23 |
EP2150559A2 (en) | 2010-02-10 |
US20100173356A1 (en) | 2010-07-08 |
CN101679490A (zh) | 2010-03-24 |
EP2150559B1 (en) | 2016-02-10 |
US8551732B2 (en) | 2013-10-08 |
KR101558622B1 (ko) | 2015-10-07 |
KR20100018044A (ko) | 2010-02-16 |
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