ES2569352T3 - Compuestos de bicicloheteroarilo como moduladores de P2X7 y usos de los mismos - Google Patents

Compuestos de bicicloheteroarilo como moduladores de P2X7 y usos de los mismos Download PDF

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Publication number
ES2569352T3
ES2569352T3 ES07753368.5T ES07753368T ES2569352T3 ES 2569352 T3 ES2569352 T3 ES 2569352T3 ES 07753368 T ES07753368 T ES 07753368T ES 2569352 T3 ES2569352 T3 ES 2569352T3
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unsubstituted
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compound
compound according
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Spanish (es)
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Michael G. Kelly
John Kincaid
Yunfeng Fang
Yeyu Cao
Carl Kaub
Sumithra Gowlugari
Zhan Wang
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Second Genome Inc
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Second Genome Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
ES07753368.5T 2006-03-16 2007-03-16 Compuestos de bicicloheteroarilo como moduladores de P2X7 y usos de los mismos Active ES2569352T3 (es)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US78292306P 2006-03-16 2006-03-16
US78312106P 2006-03-16 2006-03-16
US78359006P 2006-03-16 2006-03-16
US782923P 2006-03-16
US783121P 2006-03-16
US783590P 2006-03-16
US83141606P 2006-07-17 2006-07-17
US831416P 2006-07-17
US90604907P 2007-03-09 2007-03-09
US906049P 2007-03-09
PCT/US2007/006735 WO2007109192A2 (en) 2006-03-16 2007-03-16 Bicycloheteroaryl compounds as p2x7 modulators and uses thereof

Publications (1)

Publication Number Publication Date
ES2569352T3 true ES2569352T3 (es) 2016-05-10

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ES07753368.5T Active ES2569352T3 (es) 2006-03-16 2007-03-16 Compuestos de bicicloheteroarilo como moduladores de P2X7 y usos de los mismos

Country Status (12)

Country Link
US (2) US7816371B2 (https=)
EP (1) EP1933622B1 (https=)
JP (1) JP5240941B2 (https=)
CN (1) CN101442909B (https=)
AR (1) AR059920A1 (https=)
BR (1) BRPI0709581A8 (https=)
CA (1) CA2645568C (https=)
DK (1) DK1933622T3 (https=)
ES (1) ES2569352T3 (https=)
MX (1) MX2008011922A (https=)
TW (1) TWI464148B (https=)
WO (1) WO2007109192A2 (https=)

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AR093921A1 (es) 2012-12-12 2015-06-24 Actelion Pharmaceuticals Ltd Derivados de indol carboxamida como antagonistas del receptor p2x7
KR102232744B1 (ko) 2012-12-18 2021-03-26 이도르시아 파마슈티컬스 리미티드 Ｐ２ｘ７ 수용체 길항제로서의 인돌 카르복사미드 유도체
KR102222220B1 (ko) 2013-01-22 2021-03-03 이도르시아 파마슈티컬스 리미티드 Ｐ2ｘ7 수용체 길항제로서의 헤테로시클릭 아미드 유도체
ES2616883T3 (es) 2013-01-22 2017-06-14 Actelion Pharmaceuticals Ltd. Derivados amida heterocíclicos como antagonistas del receptor P2X7
US9938292B2 (en) * 2014-03-24 2018-04-10 Guangdong Zhongsheng Pharmaceutical Co., Ltd Quinoline derivatives as SMO inhibitors
TW201602089A (zh) * 2014-04-17 2016-01-16 諾華公司 多環性ｈｅｒｇ活化劑
CN105596301A (zh) * 2016-01-29 2016-05-25 中国药科大学 一种以异喹啉为基本骨架的p2x7受体拮抗剂的纳米混悬剂及其制备方法
WO2019099509A1 (en) * 2017-11-14 2019-05-23 Second Genome, Inc. Use of a p2x7 receptor antagonist to treat an inflammatory disease or disorder
WO2019237125A1 (en) 2018-06-08 2019-12-12 The General Hospital Corporation Inhibitors of prolyl-trna-synthetase
HUE073311T2 (hu) 2020-03-31 2026-01-28 Remicine Ip B V Hiperinflammatorikus szindróma kezelése
IL302906A (en) * 2020-11-20 2023-07-01 Denali Therapeutics Inc Compounds, compositions, and methods
TWI825637B (zh) 2021-03-31 2023-12-11 美商輝瑞股份有限公司 啶－１，６（２ｈ，７ｈ）－二酮
EP4330236A4 (en) * 2021-04-30 2025-09-24 Denali Therapeutics Inc COMPOUNDS, COMPOSITIONS AND METHODS
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US20070225324A1 (en) 2007-09-27
WO2007109192A2 (en) 2007-09-27
AR059920A1 (es) 2008-05-07
CN101442909A (zh) 2009-05-27
US7816371B2 (en) 2010-10-19
CA2645568C (en) 2014-11-18
WO2007109192A3 (en) 2007-11-22
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MX2008011922A (es) 2008-11-28
JP5240941B2 (ja) 2013-07-17
TWI464148B (zh) 2014-12-11
EP1933622A4 (en) 2010-03-10
TW200800904A (en) 2008-01-01
CN101442909B (zh) 2013-03-27
BRPI0709581A8 (pt) 2018-12-11
EP1933622B1 (en) 2016-03-09
DK1933622T3 (en) 2016-05-02
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BRPI0709581A2 (pt) 2011-07-19

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