ES2558168T3 - Eliminación de virus contaminantes en preparaciones AVV - Google Patents
Eliminación de virus contaminantes en preparaciones AVV Download PDFInfo
- Publication number
- ES2558168T3 ES2558168T3 ES12758663.4T ES12758663T ES2558168T3 ES 2558168 T3 ES2558168 T3 ES 2558168T3 ES 12758663 T ES12758663 T ES 12758663T ES 2558168 T3 ES2558168 T3 ES 2558168T3
- Authority
- ES
- Spain
- Prior art keywords
- filter
- virus
- sample
- virions
- baculovirus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/14—Ultrafiltration; Microfiltration
- B01D61/145—Ultrafiltration
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/14—Ultrafiltration; Microfiltration
- B01D61/16—Feed pretreatment
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
- B01D71/06—Organic material
- B01D71/08—Polysaccharides
- B01D71/10—Cellulose; Modified cellulose
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- C12N7/02—Recovery or purification
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2311/00—Details relating to membrane separation process operations and control
- B01D2311/04—Specific process operations in the feed stream; Feed pretreatment
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2311/00—Details relating to membrane separation process operations and control
- B01D2311/26—Further operations combined with membrane separation processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2311/00—Details relating to membrane separation process operations and control
- B01D2311/26—Further operations combined with membrane separation processes
- B01D2311/2623—Ion-Exchange
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2311/00—Details relating to membrane separation process operations and control
- B01D2311/26—Further operations combined with membrane separation processes
- B01D2311/2649—Filtration
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/14011—Baculoviridae
- C12N2710/14041—Use of virus, viral particle or viral elements as a vector
- C12N2710/14043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vectore
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/14011—Baculoviridae
- C12N2710/14051—Methods of production or purification of viral material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14051—Methods of production or purification of viral material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14311—Parvovirus, e.g. minute virus of mice
- C12N2750/14332—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14311—Parvovirus, e.g. minute virus of mice
- C12N2750/14351—Methods of production or purification of viral material
Landscapes
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Water Supply & Treatment (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Plant Pathology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161532176P | 2011-09-08 | 2011-09-08 | |
| EP11180594 | 2011-09-08 | ||
| US201161532176P | 2011-09-08 | ||
| EP11180594 | 2011-09-08 | ||
| PCT/NL2012/050619 WO2013036118A1 (fr) | 2011-09-08 | 2012-09-07 | Élimination de virus contaminants à partir de préparations de virus adéno-associés (vaa) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2558168T3 true ES2558168T3 (es) | 2016-02-02 |
Family
ID=47832422
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES12758663.4T Active ES2558168T3 (es) | 2011-09-08 | 2012-09-07 | Eliminación de virus contaminantes en preparaciones AVV |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US9840694B2 (fr) |
| EP (3) | EP3425044A1 (fr) |
| JP (2) | JP6198278B2 (fr) |
| KR (1) | KR101961347B1 (fr) |
| CN (2) | CN103857790B (fr) |
| AU (1) | AU2012304993B2 (fr) |
| BR (1) | BR112014005255A2 (fr) |
| CA (1) | CA2847604A1 (fr) |
| DK (1) | DK2744895T3 (fr) |
| EA (1) | EA027511B1 (fr) |
| ES (1) | ES2558168T3 (fr) |
| HK (1) | HK1220229A1 (fr) |
| HU (1) | HUE026579T2 (fr) |
| IL (1) | IL231398A (fr) |
| MX (1) | MX349601B (fr) |
| PL (1) | PL2744895T3 (fr) |
| PT (1) | PT2744895E (fr) |
| SI (1) | SI2744895T1 (fr) |
| WO (1) | WO2013036118A1 (fr) |
| ZA (1) | ZA201401714B (fr) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2744895T3 (en) | 2011-09-08 | 2016-01-04 | Uniqure Ip Bv | REMOVAL OF INFECTED VIRA FROM AAV PREPARATIONS |
| US20160243260A1 (en) | 2013-10-24 | 2016-08-25 | Uniqure Ip B.V. | Treatment of neurological diseases using adeno-associated virus (AAV) comprising AAV-5 capsid proteins |
| WO2015191508A1 (fr) | 2014-06-09 | 2015-12-17 | Voyager Therapeutics, Inc. | Capsides chimériques |
| RU2716991C2 (ru) | 2014-11-05 | 2020-03-17 | Вояджер Терапьютикс, Инк. | Полинуклеотиды aadc для лечения болезни паркинсона |
| IL292999A (en) | 2014-11-14 | 2022-07-01 | Voyager Therapeutics Inc | Preparations and methods for the treatment of amyotrophic lateral sclerosis |
| JP6863891B2 (ja) | 2014-11-14 | 2021-04-21 | ボイジャー セラピューティクス インコーポレイテッドＶｏｙａｇｅｒ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． | 調節性ポリヌクレオチド |
| WO2016094783A1 (fr) | 2014-12-12 | 2016-06-16 | Voyager Therapeutics, Inc. | Compositions et méthodes pour la production de scaav |
| HUE043842T2 (hu) | 2014-12-24 | 2019-09-30 | Uniqure Ip Bv | RNAi-indukált huntingtin gén szuppresszió |
| EP3054007A1 (fr) | 2015-02-09 | 2016-08-10 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Purification de particules de virus adéno-associés de recombinaison comprenant une étape de purification par affinité immunologique |
| US11326182B2 (en) | 2016-04-29 | 2022-05-10 | Voyager Therapeutics, Inc. | Compositions for the treatment of disease |
| US11299751B2 (en) | 2016-04-29 | 2022-04-12 | Voyager Therapeutics, Inc. | Compositions for the treatment of disease |
| BR112018073472A2 (pt) | 2016-05-18 | 2019-08-27 | Voyager Therapeutics Inc | composições e métodos de tratamento da doença de huntington |
| IL302748A (en) | 2016-05-18 | 2023-07-01 | Voyager Therapeutics Inc | modulatory polynucleotides |
| CA3035522A1 (fr) | 2016-08-30 | 2018-03-08 | The Regents Of The University Of California | Procedes de ciblage et d'administration biomedicaux, et dispositifs et systemes pour la mise en uvre de ceux-ci |
| CN111108198A (zh) | 2017-05-05 | 2020-05-05 | 沃雅戈治疗公司 | 治疗亨廷顿病的组合物和方法 |
| AU2018261790A1 (en) | 2017-05-05 | 2019-11-28 | Voyager Therapeutics, Inc. | Compositions and methods of treating amyotrophic lateral sclerosis (ALS) |
| JOP20190269A1 (ar) | 2017-06-15 | 2019-11-20 | Voyager Therapeutics Inc | بولي نوكليوتيدات aadc لعلاج مرض باركنسون |
| US11497576B2 (en) | 2017-07-17 | 2022-11-15 | Voyager Therapeutics, Inc. | Trajectory array guide system |
| WO2019079240A1 (fr) | 2017-10-16 | 2019-04-25 | Voyager Therapeutics, Inc. | Traitement de la sclérose latérale amyotrophique (sla) |
| US20200237799A1 (en) | 2017-10-16 | 2020-07-30 | Voyager Therapeutics, Inc. | Treatment of amyotrophic lateral sclerosis (als) |
| MX2020006764A (es) | 2018-01-17 | 2021-01-08 | Meiragtx Uk Ii Ltd | Una proteína de la cápside de raav modificada para terapia génica. |
| WO2020053258A1 (fr) | 2018-09-12 | 2020-03-19 | Uniqure Ip B.V. | Suppression de c9orf72 induite par arni pour le traitement de la sla/dft |
| WO2020104480A1 (fr) | 2018-11-19 | 2020-05-28 | Uniqure Biopharma B.V. | Vecteurs à base de virus adéno-associé pour l'expression de fviii mimétiques, et utilisations correspondantes |
| EP3884067A1 (fr) | 2018-11-19 | 2021-09-29 | uniQure IP B.V. | Diagnostic d'accompagnement pour mesurer les effets d'une thérapie génique |
| AU2019385598A1 (en) | 2018-11-19 | 2021-06-03 | Uniqure Ip B.V. | RNAi induced reduction of ataxin-3 for the treatment of Spinocerebellar ataxia type 3 |
| EP3883582A1 (fr) | 2018-11-19 | 2021-09-29 | uniQure IP B.V. | Procédé et moyens pour délivrer du miarn à des cellules cibles |
| US11718834B2 (en) | 2019-02-15 | 2023-08-08 | Sangamo Therapeutics, Inc. | Compositions and methods for producing recombinant AAV |
| WO2020219897A1 (fr) * | 2019-04-24 | 2020-10-29 | Biogen Ma Inc. | Procédés de production de virus adéno-associés recombinants |
| EP3999119A1 (fr) | 2019-07-15 | 2022-05-25 | Meiragtx UK II Limited | Protéines capsidiques de virus adéno-associés modifiés pour le traitement de maladies arthritiques |
| EP4031148A1 (fr) | 2019-09-16 | 2022-07-27 | uniQure IP B.V. | Ciblage de transcrits mal épissés dans des troubles génétiques |
| US20230020565A1 (en) | 2019-12-04 | 2023-01-19 | Sangamo Therapeutics, Inc. | Novel compositions and methods for producing recombinant aav |
| WO2021172573A1 (fr) * | 2020-02-28 | 2021-09-02 | 旭化成メディカル株式会社 | Procédé d'évaluation de la performance de clairance virale |
| WO2021204872A1 (fr) | 2020-04-07 | 2021-10-14 | Uniqure Ip B.V. | Constructions géniques pour le silençage de l'angiopoïétine like 3 (angptl3) et leurs utilisations |
| EP4305157A1 (fr) | 2021-03-09 | 2024-01-17 | Huidagene Therapeutics (Singapore) Pte. Ltd. | Système crispr/cas13 ingéniérisé et ses utilisations |
| JP2024515027A (ja) * | 2021-03-30 | 2024-04-04 | スリーエム イノベイティブ プロパティズ カンパニー | 中空糸膜及びその作製方法 |
| WO2022214635A1 (fr) | 2021-04-08 | 2022-10-13 | Stichting Vu | Molécules d'acide nucléique de compensation de l'haplo-insuffisance stxbp1 et leur utilisation dans le traitement de troubles liés à stxbp1 |
| WO2022253974A1 (fr) | 2021-06-02 | 2022-12-08 | Uniqure Biopharma B.V. | Vecteurs de virus adéno-associés modifiés pour se lier à une lipoprotéine de haute densité |
| EP4359525A1 (fr) | 2021-06-21 | 2024-05-01 | uniQure biopharma B.V. | Constructions géniques pour le silençage de l'alpha-synucléine et leurs utilisations |
| WO2022268811A1 (fr) | 2021-06-21 | 2022-12-29 | Uniqure Biopharma B.V. | Procédures de lyse améliorées |
| WO2023283962A1 (fr) | 2021-07-16 | 2023-01-19 | Huigene Therapeutics Co., Ltd. | Capside aav modifiée pour thérapie génique et méthodes associées |
| WO2023198702A1 (fr) | 2022-04-12 | 2023-10-19 | Uniqure Biopharma B.V. | Régulation d'acide nucléique de c9orf72 |
| WO2023198662A1 (fr) | 2022-04-12 | 2023-10-19 | Uniqure Biopharma B.V. | Nouveaux systèmes de régulation d'acide nucléique |
| WO2023198663A1 (fr) | 2022-04-12 | 2023-10-19 | Uniqure Biopharma B.V. | Régulation du snca par acides nucléiques |
| WO2023198745A1 (fr) | 2022-04-12 | 2023-10-19 | Uniqure Biopharma B.V. | Régulation d'apoe par un acide nucléique |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4745051A (en) | 1983-05-27 | 1988-05-17 | The Texas A&M University System | Method for producing a recombinant baculovirus expression vector |
| WO1996011272A2 (fr) | 1994-10-07 | 1996-04-18 | Medigene Gesellschaft Für Molekularbiologische Diagnostik, Theraphie Und Technologie Mbh | Particules semblables au virus du papillome, proteines de fusion et leur procede de production |
| DE19709186C2 (de) | 1997-03-06 | 1999-10-14 | Medigene Ag | Filtrationsverfahren zur Trennung von Viren |
| US6103526A (en) | 1998-10-08 | 2000-08-15 | Protein Sciences Corporation | Spodoptera frugiperda single cell suspension cell line in serum-free media, methods of producing and using |
| JP2002538770A (ja) | 1998-11-10 | 2002-11-19 | ユニバーシティ オブ ノース カロライナ アット チャペル ヒル | ウイルスベクターとその製造及び投与の方法 |
| US6593123B1 (en) * | 2000-08-07 | 2003-07-15 | Avigen, Inc. | Large-scale recombinant adeno-associated virus (rAAV) production and purification |
| US6723551B2 (en) | 2001-11-09 | 2004-04-20 | The United States Of America As Represented By The Department Of Health And Human Services | Production of adeno-associated virus in insect cells |
| WO2003074714A1 (fr) | 2002-03-05 | 2003-09-12 | Stichting Voor De Technische Wetenschappen | Systeme d'expression de baculovirus |
| US20050009168A1 (en) * | 2003-05-12 | 2005-01-13 | Robbins Joan Marie | Methods and apparatus for Adeno associated virus purification |
| KR101589259B1 (ko) * | 2006-06-21 | 2016-02-01 | 유니큐어 아이피 비.브이. | 곤충세포 내 ａａｖ의 생산에 유용한 ａａｖ-ｒｅｐ78의 번역을 위한 변형된 개시 코돈을 갖는 벡터 |
| WO2008109721A1 (fr) * | 2007-03-06 | 2008-09-12 | Introgen Therapeutics, Inc. | Procédés chromatographiques pour évaluer la pureté d'adénovirus |
| US20100323429A1 (en) * | 2008-04-10 | 2010-12-23 | Yu-Chen Hu | Methods for purifying baculovirus |
| MX2011013613A (es) * | 2009-06-16 | 2012-01-19 | Genzyme Corp | Metodos mejorados para purificacion de vecotres de aav recombinantes. |
| CA2787827C (fr) * | 2010-01-28 | 2020-11-10 | The Children's Hospital Of Philadelphia | Plateforme de fabrication evolutive pour purification de vecteurs viraux et vecteurs viraux ainsi purifies utilisables en therapie genique |
| DK2744895T3 (en) * | 2011-09-08 | 2016-01-04 | Uniqure Ip Bv | REMOVAL OF INFECTED VIRA FROM AAV PREPARATIONS |
-
2012
- 2012-09-07 DK DK12758663.4T patent/DK2744895T3/en active
- 2012-09-07 KR KR1020147009146A patent/KR101961347B1/ko active IP Right Grant
- 2012-09-07 HU HUE12758663A patent/HUE026579T2/en unknown
- 2012-09-07 EP EP18191023.3A patent/EP3425044A1/fr not_active Withdrawn
- 2012-09-07 CN CN201280049899.5A patent/CN103857790B/zh not_active Expired - Fee Related
- 2012-09-07 US US14/343,884 patent/US9840694B2/en active Active
- 2012-09-07 EP EP15186937.7A patent/EP2990477B8/fr not_active Revoked
- 2012-09-07 EA EA201490583A patent/EA027511B1/ru not_active IP Right Cessation
- 2012-09-07 ES ES12758663.4T patent/ES2558168T3/es active Active
- 2012-09-07 SI SI201230372T patent/SI2744895T1/sl unknown
- 2012-09-07 PT PT127586634T patent/PT2744895E/pt unknown
- 2012-09-07 EP EP12758663.4A patent/EP2744895B1/fr active Active
- 2012-09-07 PL PL12758663T patent/PL2744895T3/pl unknown
- 2012-09-07 BR BR112014005255A patent/BR112014005255A2/pt active Search and Examination
- 2012-09-07 MX MX2014002733A patent/MX349601B/es active IP Right Grant
- 2012-09-07 CN CN201710697343.1A patent/CN107502597A/zh active Pending
- 2012-09-07 JP JP2014529633A patent/JP6198278B2/ja not_active Expired - Fee Related
- 2012-09-07 WO PCT/NL2012/050619 patent/WO2013036118A1/fr active Application Filing
- 2012-09-07 CA CA2847604A patent/CA2847604A1/fr not_active Abandoned
- 2012-09-07 AU AU2012304993A patent/AU2012304993B2/en not_active Ceased
-
2014
- 2014-03-06 IL IL231398A patent/IL231398A/en active IP Right Grant
- 2014-03-07 ZA ZA2014/01714A patent/ZA201401714B/en unknown
-
2016
- 2016-07-15 HK HK16108340.2A patent/HK1220229A1/zh not_active IP Right Cessation
-
2017
- 2017-06-27 JP JP2017125458A patent/JP6624690B2/ja not_active Expired - Fee Related
- 2017-12-08 US US15/836,220 patent/US10253301B2/en not_active Expired - Fee Related
-
2019
- 2019-03-20 US US16/359,593 patent/US20190218523A1/en not_active Abandoned
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