ES2550757T3 - Anticuerpos que reconocen un epítopo que contiene carbohidratos en CD43 y ACE expresados en células cancerosas y métodos de uso de los mismos - Google Patents
Anticuerpos que reconocen un epítopo que contiene carbohidratos en CD43 y ACE expresados en células cancerosas y métodos de uso de los mismos Download PDFInfo
- Publication number
- ES2550757T3 ES2550757T3 ES08863057.9T ES08863057T ES2550757T3 ES 2550757 T3 ES2550757 T3 ES 2550757T3 ES 08863057 T ES08863057 T ES 08863057T ES 2550757 T3 ES2550757 T3 ES 2550757T3
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3007—Carcino-embryonic Antigens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3076—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1471607P | 2007-12-18 | 2007-12-18 | |
US14716P | 2007-12-18 | ||
PCT/US2008/087515 WO2009079649A1 (en) | 2007-12-18 | 2008-12-18 | Antibodies recognizing a carbohydrate containing epitope on cd-43 and cea expressed on cancer cells and methods using same |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2550757T3 true ES2550757T3 (es) | 2015-11-12 |
Family
ID=40578003
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES08863057.9T Active ES2550757T3 (es) | 2007-12-18 | 2008-12-18 | Anticuerpos que reconocen un epítopo que contiene carbohidratos en CD43 y ACE expresados en células cancerosas y métodos de uso de los mismos |
Country Status (18)
Country | Link |
---|---|
US (3) | US7982017B2 (ja) |
EP (1) | EP2245063B1 (ja) |
JP (2) | JP5568478B2 (ja) |
KR (1) | KR101672271B1 (ja) |
CN (2) | CN101918448A (ja) |
AU (1) | AU2008338313B2 (ja) |
BR (1) | BRPI0820452A2 (ja) |
CA (1) | CA2706502C (ja) |
DK (1) | DK2245063T3 (ja) |
ES (1) | ES2550757T3 (ja) |
HK (1) | HK1150167A1 (ja) |
HU (1) | HUE026846T2 (ja) |
IL (1) | IL205487A (ja) |
NZ (1) | NZ585959A (ja) |
RU (1) | RU2528738C2 (ja) |
SG (1) | SG186669A1 (ja) |
TW (1) | TWI439545B (ja) |
WO (1) | WO2009079649A1 (ja) |
Families Citing this family (36)
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JP5620626B2 (ja) | 2005-03-31 | 2014-11-05 | 中外製薬株式会社 | 会合制御によるポリペプチド製造方法 |
US9670269B2 (en) | 2006-03-31 | 2017-06-06 | Chugai Seiyaku Kabushiki Kaisha | Methods of modifying antibodies for purification of bispecific antibodies |
EP4001409A1 (en) | 2006-03-31 | 2022-05-25 | Chugai Seiyaku Kabushiki Kaisha | Methods for controlling blood pharmacokinetics of antibodies |
TWI429658B (zh) | 2006-06-07 | 2014-03-11 | Bioalliance Cv | 辨認癌症細胞上表現的cd43與cea之含碳水化合物抗原決定區的抗體及其使用方法 |
AU2008296361B2 (en) | 2007-09-04 | 2013-04-11 | Compugen, Ltd. | Polypeptides and polynucleotides, and uses thereof as a drug target for producing drugs and biologics |
KR102467302B1 (ko) | 2007-09-26 | 2022-11-14 | 추가이 세이야쿠 가부시키가이샤 | 항체 정상영역 개변체 |
DK2202245T3 (en) | 2007-09-26 | 2016-11-21 | Chugai Pharmaceutical Co Ltd | A method of modifying an antibody isoelectric point VIA amino acid substitution in CDR |
AU2008338313B2 (en) | 2007-12-18 | 2014-01-16 | Bioalliance C.V. | Antibodies recognizing a carbohydrate containing epitope on CD-43 and CEA expressed on cancer cells and methods using same |
US20120071634A1 (en) | 2009-03-19 | 2012-03-22 | Chugai Seiyaku Kabushiki Kaisha | Antibody Constant Region Variant |
US9228017B2 (en) | 2009-03-19 | 2016-01-05 | Chugai Seiyaku Kabushiki Kaisha | Antibody constant region variant |
US10150808B2 (en) | 2009-09-24 | 2018-12-11 | Chugai Seiyaku Kabushiki Kaisha | Modified antibody constant regions |
EP2543730B1 (en) | 2010-03-04 | 2018-10-31 | Chugai Seiyaku Kabushiki Kaisha | Antibody constant region variant |
KR101244708B1 (ko) | 2010-10-07 | 2013-03-18 | 기아자동차주식회사 | 측면 조립형 트랜스미션 마운트 |
EP2726503B1 (en) | 2011-06-30 | 2019-09-04 | Compugen Ltd. | Polypeptides and uses thereof for treatment of autoimmune disorders and infection |
CA2848985A1 (en) | 2012-02-01 | 2013-08-08 | Compugen Ltd. | C10rf32 antibodies, and uses thereof for treatment of cancer |
ME03486B (me) | 2012-10-12 | 2020-01-20 | Medimmune Ltd | Pirolobenzodiazepini i njihovi konjugati |
SG11201504887TA (en) | 2012-12-21 | 2015-07-30 | Bioalliance Cv | Hydrophilic self-immolative linkers and conjugates thereof |
CN105209077B (zh) | 2013-03-13 | 2019-06-11 | 麦迪穆有限责任公司 | 吡咯并苯并二氮杂卓以及其结合物 |
RU2758952C1 (ru) | 2013-09-27 | 2021-11-03 | Чугаи Сейяку Кабусики Кайся | Способ получения полипептидного гетеромультимера |
EP2871190A1 (en) * | 2013-11-11 | 2015-05-13 | ATLAB Pharma | Antibody against GD2-O-acetylated ganglioside with pro-apoptotic activity |
JP2017528418A (ja) | 2014-06-20 | 2017-09-28 | バイオアライアンス コマンディテール フェンノートシャップ | 抗葉酸受容体アルファ(fra)抗体−薬物コンジュゲート及びその使用方法 |
US10188746B2 (en) | 2014-09-10 | 2019-01-29 | Medimmune Limited | Pyrrolobenzodiazepines and conjugates thereof |
JP7082484B2 (ja) | 2015-04-01 | 2022-06-08 | 中外製薬株式会社 | ポリペプチド異種多量体の製造方法 |
US11524989B2 (en) * | 2015-06-24 | 2022-12-13 | Kling Biotherapeutics B.V. | AML antigens and uses thereof |
SG11201803008RA (en) | 2015-10-12 | 2018-05-30 | Aprogen Kic Inc | Anti-cd43 antibody and use thereof for cancer treatment |
WO2017106326A1 (en) * | 2015-12-14 | 2017-06-22 | The Trustees Of The University Of Pennsylvania | Aav-anti pcsk9 antibody constructs and uses thereof |
KR20180091918A (ko) | 2015-12-28 | 2018-08-16 | 추가이 세이야쿠 가부시키가이샤 | Fc 영역 함유 폴리펩타이드의 정제를 효율화하기 위한 방법 |
CN108713026B (zh) | 2016-01-08 | 2023-01-06 | 美国全心医药生技股份有限公司 | 四价抗psgl-1抗体及其用途 |
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CA3077247A1 (en) | 2017-10-16 | 2019-04-25 | Eisai R & D Management Co., Ltd. | Anti-tau antibodies and uses thereof |
MX2020012418A (es) | 2018-05-23 | 2021-04-28 | Adc Therapeutics Sa | Adyuvante molecular. |
CN112153983A (zh) * | 2018-05-23 | 2020-12-29 | 杰克逊实验室 | 抗ngly-1抗体及使用方法 |
JP2022514786A (ja) * | 2018-12-21 | 2022-02-15 | マルチチュード インコーポレーテッド | Muc18に特異的な抗体 |
WO2021081515A2 (en) * | 2019-10-25 | 2021-04-29 | Cidara Therapeutics, Inc. | Compositions and methods for the treatment of human immunodeficiency virus |
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2008
- 2008-12-18 AU AU2008338313A patent/AU2008338313B2/en not_active Ceased
- 2008-12-18 CN CN2008801215817A patent/CN101918448A/zh active Pending
- 2008-12-18 SG SG2012093167A patent/SG186669A1/en unknown
- 2008-12-18 ES ES08863057.9T patent/ES2550757T3/es active Active
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- 2008-12-18 JP JP2010539824A patent/JP5568478B2/ja not_active Expired - Fee Related
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- 2008-12-18 BR BRPI0820452-7A patent/BRPI0820452A2/pt not_active Application Discontinuation
- 2008-12-18 KR KR1020107011796A patent/KR101672271B1/ko active IP Right Grant
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KR20100097661A (ko) | 2010-09-03 |
EP2245063A1 (en) | 2010-11-03 |
WO2009079649A1 (en) | 2009-06-25 |
US9334329B2 (en) | 2016-05-10 |
KR101672271B1 (ko) | 2016-11-03 |
JP2013247963A (ja) | 2013-12-12 |
IL205487A0 (en) | 2010-12-30 |
AU2008338313B2 (en) | 2014-01-16 |
TWI439545B (zh) | 2014-06-01 |
JP5568478B2 (ja) | 2014-08-06 |
CA2706502A1 (en) | 2009-06-25 |
BRPI0820452A2 (pt) | 2015-06-16 |
AU2008338313A1 (en) | 2009-06-25 |
HUE026846T2 (en) | 2016-08-29 |
HK1150167A1 (en) | 2011-11-04 |
CN105732813A (zh) | 2016-07-06 |
RU2010129423A (ru) | 2012-01-27 |
US20140105899A1 (en) | 2014-04-17 |
US7982017B2 (en) | 2011-07-19 |
NZ585959A (en) | 2012-09-28 |
RU2528738C2 (ru) | 2014-09-20 |
JP2011505875A (ja) | 2011-03-03 |
CA2706502C (en) | 2018-08-07 |
IL205487A (en) | 2017-02-28 |
TW200938629A (en) | 2009-09-16 |
US20090191221A1 (en) | 2009-07-30 |
EP2245063B1 (en) | 2015-08-26 |
US20110280888A1 (en) | 2011-11-17 |
DK2245063T3 (en) | 2015-12-07 |
CN101918448A (zh) | 2010-12-15 |
US8568718B2 (en) | 2013-10-29 |
SG186669A1 (en) | 2013-01-30 |
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