ES2541723T3 - Forma de dosificación efervescente - Google Patents
Forma de dosificación efervescente Download PDFInfo
- Publication number
- ES2541723T3 ES2541723T3 ES13731013.2T ES13731013T ES2541723T3 ES 2541723 T3 ES2541723 T3 ES 2541723T3 ES 13731013 T ES13731013 T ES 13731013T ES 2541723 T3 ES2541723 T3 ES 2541723T3
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- dosage form
- effervescent
- acid
- article
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Landscapes
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261658430P | 2012-06-12 | 2012-06-12 | |
| US201261658430P | 2012-06-12 | ||
| PCT/US2013/045303 WO2013188483A1 (en) | 2012-06-12 | 2013-06-12 | Effervescent dosage form |
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| Publication Number | Publication Date |
|---|---|
| ES2541723T3 true ES2541723T3 (es) | 2015-07-24 |
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| ES13731013.2T Active ES2541723T3 (es) | 2012-06-12 | 2013-06-12 | Forma de dosificación efervescente |
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| EP2604124A1 (en) * | 2011-12-16 | 2013-06-19 | Nestec S.A. | Soluble non-dairy creamer tablet surface-treated with carbohydrate |
| AU2016285446A1 (en) * | 2015-06-29 | 2018-01-18 | Elc Management Llc | Particles with cross-linked coatings for cosmetic applications |
| CN107114795A (zh) * | 2017-07-06 | 2017-09-01 | 胥永贵 | 一种弱碱补钙、苏打碱化姜制剂及其制备方法和应用 |
| US11793876B2 (en) | 2019-10-18 | 2023-10-24 | L. Perrigo Company | Bulk polyethylene glycol compositions |
| WO2022060310A1 (en) * | 2020-09-18 | 2022-03-24 | Pharmacti̇ve İlaç Sanayi̇ Ve Ti̇caret A.Ş. | Pharmaceutical compositions comprising calcium carbonate, magnesium carbonat and simethicone |
| BR112023026531A2 (pt) * | 2021-06-17 | 2024-03-05 | Ocean Spray Cranberries Inc | Açúcares raros em alimentos e bebidas |
| US12053484B2 (en) | 2021-10-29 | 2024-08-06 | Medicated Chews, Llc | Simethicone chewable composition |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1518364A (en) | 1976-05-05 | 1978-07-19 | Beecham Group Ltd | Pharmaceutical composition |
| US4198390A (en) | 1979-01-31 | 1980-04-15 | Rider Joseph A | Simethicone antacid tablet |
| US4396604A (en) | 1982-05-17 | 1983-08-02 | Norcliff Thayer, Inc. | Simethicone antacid lozenge |
| SE462014B (sv) | 1983-09-28 | 1990-04-30 | Gerhard Gergely | Brusgranulat och foerfarande foer dess framstaellning |
| US4678661A (en) * | 1983-09-28 | 1987-07-07 | Gerhard Gergely | Effervescent composition and method of making same |
| US4650669A (en) | 1985-07-30 | 1987-03-17 | Miles Laboratories, Inc. | Method to make effervescent calcium tablets and calcium tablets produced thereby |
| GB8909793D0 (en) | 1989-04-28 | 1989-06-14 | Beecham Group Plc | Pharmaceutical formulation |
| US5073384A (en) | 1989-10-19 | 1991-12-17 | Valentine Enterprises, Inc. | Maltodextrin/defoaming composition combinate |
| DE59203732D1 (de) | 1991-07-01 | 1995-10-26 | Gergely Gerhard | Lutsch- oder Kautablette. |
| WO1994000107A1 (en) | 1992-06-30 | 1994-01-06 | The Procter & Gamble Company | Effervescent calcium supplements |
| US5330760A (en) * | 1992-08-27 | 1994-07-19 | Sterling Winthrop Inc. | Effervescent antacid |
| FR2705966B1 (fr) | 1993-06-04 | 1995-08-25 | Dow Corning Sa | Compositions antimousse utiles notamment pour le traitement de troubles gastriques. |
| EP0804171B1 (de) | 1995-07-31 | 2000-01-05 | Gergely, Gerhard, Dr. | Kautablette mit brausewirkung |
| CA2204599A1 (en) | 1995-09-07 | 1997-03-13 | Otsuka Pharmaceutical Co., Ltd. | Low-pressure tableted effervescent preparation |
| US5807577A (en) | 1995-11-22 | 1998-09-15 | Lab Pharmaceutical Research International Inc. | Fast-melt tablet and method of making same |
| US6489346B1 (en) | 1996-01-04 | 2002-12-03 | The Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and method of using same |
| US5888544A (en) | 1996-06-20 | 1999-03-30 | Gerhard Gergely | Effervescent system for effervescent tablets and effervescent granules |
| DE19814256A1 (de) | 1998-03-31 | 1999-10-07 | Asta Medica Ag | Feste, schnellzerfallende Cetirizin-Formulierungen |
| GB9825033D0 (en) | 1998-11-13 | 1999-01-13 | Nycomed Pharma As | Process |
| US6296868B1 (en) | 1998-11-19 | 2001-10-02 | Advanced Technology Pharmaceuticals Corporation | Chewable tablets containing mannitol and aspartame |
| DE19859231A1 (de) | 1998-12-21 | 2000-06-29 | Kurt Heinz Bauer | Schäumende Antacida-Suspensionstabletten |
| US6589555B2 (en) | 1999-12-29 | 2003-07-08 | Mahendra Pandya | Effervescent vitaceutical compositions and related methods |
| US6544557B2 (en) | 2001-01-09 | 2003-04-08 | Pan Pharmaceutical Limited | Effervescent tablet compositions |
| US20030235613A1 (en) | 2002-06-19 | 2003-12-25 | Cts Chemical Industries Ltd. | Popping oral administration form |
| US20040223921A1 (en) | 2003-05-07 | 2004-11-11 | Rau Allen H. | Oral care tablet |
| US20050074489A1 (en) | 2003-10-01 | 2005-04-07 | Pediamed Pharmaceuticals, Inc. | Effervescent and effervescent-dispersion compositions for medicaments and methods of use thereof |
| ITMI20040242U1 (it) | 2004-05-24 | 2004-08-24 | Istituto Pirri S R L | Contenitore per compresse effervescenti |
| WO2006044595A2 (en) | 2004-10-13 | 2006-04-27 | Cadbury Adams Usa Llc | Effervescent pressed gum tablet compositions |
| US20090004248A1 (en) | 2007-06-29 | 2009-01-01 | Frank Bunick | Dual portion dosage lozenge form |
| EP2189154A1 (en) | 2008-11-25 | 2010-05-26 | Gnosis S.p.A. | Effervescent tablets and mouth-soluble granulates of S-adenosyl methionine and process for the preparation thereof |
| CN101966165B (zh) | 2009-07-14 | 2012-06-13 | 无锡健而乐医药科技有限公司 | 口腔吸收固体泡腾制剂 |
| WO2011113965A1 (es) | 2010-03-18 | 2011-09-22 | Farmalider, S.A. | Composición farmacéutica en forma sólida que contiene isoflavonas, una sal de calcio y vitamina d3 |
| CN102232967A (zh) * | 2010-04-21 | 2011-11-09 | 武汉同济现代医药有限公司 | 一种新型口服补钙泡腾剂及其制备方法 |
| US20140371174A1 (en) | 2013-06-12 | 2014-12-18 | The Procter & Gamble Company | Effervescent Dosage Form |
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2013
- 2013-06-12 IN IN10385DEN2014 patent/IN2014DN10385A/en unknown
- 2013-06-12 CN CN201380031083.4A patent/CN104363897A/zh active Pending
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- 2013-06-12 MX MX2014015253A patent/MX368363B/es active IP Right Grant
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| EP2734192A1 (en) | 2014-05-28 |
| RU2014149581A (ru) | 2016-07-10 |
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| BR112014030680B1 (pt) | 2022-08-30 |
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| US10617714B2 (en) | 2020-04-14 |
| BR112014030680A2 (pt) | 2017-06-27 |
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| CN104363897A (zh) | 2015-02-18 |
| PL2734192T3 (pl) | 2015-09-30 |
| EP2734192B1 (en) | 2015-04-15 |
| AU2013274378B2 (en) | 2016-06-02 |
| CA2876062A1 (en) | 2013-12-19 |
| MX368363B (es) | 2019-09-30 |
| AU2013274378A1 (en) | 2015-01-15 |
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