ES2534465T3 - Producción de glucoproteínas con O-glucosilación reducida - Google Patents

Producción de glucoproteínas con O-glucosilación reducida Download PDF

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Publication number
ES2534465T3
ES2534465T3 ES06837184.8T ES06837184T ES2534465T3 ES 2534465 T3 ES2534465 T3 ES 2534465T3 ES 06837184 T ES06837184 T ES 06837184T ES 2534465 T3 ES2534465 T3 ES 2534465T3
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ES
Spain
Prior art keywords
host cell
reduced
linked glycosylation
protein
nucleic acid
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Application number
ES06837184.8T
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English (en)
Spanish (es)
Inventor
Piotr Bobrowicz
James W. Cook
Warren Kett
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Glycofi Inc
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Glycofi Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/005—Glycopeptides, glycoproteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
ES06837184.8T 2005-11-15 2006-11-10 Producción de glucoproteínas con O-glucosilación reducida Active ES2534465T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US73710805P 2005-11-15 2005-11-15
US737108P 2005-11-22
PCT/US2006/043535 WO2007061631A2 (en) 2005-11-15 2006-11-10 Production of glycoproteins with reduced o-glycosylation

Publications (1)

Publication Number Publication Date
ES2534465T3 true ES2534465T3 (es) 2015-04-23

Family

ID=38067716

Family Applications (1)

Application Number Title Priority Date Filing Date
ES06837184.8T Active ES2534465T3 (es) 2005-11-15 2006-11-10 Producción de glucoproteínas con O-glucosilación reducida

Country Status (8)

Country Link
US (3) US8206949B2 (https=)
EP (1) EP1954815B1 (https=)
JP (1) JP5284789B2 (https=)
CN (1) CN101365783B (https=)
AU (1) AU2006316838B2 (https=)
CA (1) CA2628725A1 (https=)
ES (1) ES2534465T3 (https=)
WO (1) WO2007061631A2 (https=)

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CN107375919B (zh) 2009-03-27 2022-07-29 台湾地区“中央研究院” 抗病毒免疫的方法和组合物
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AU2010307098A1 (en) * 2009-10-16 2012-04-26 Merck Sharp & Dohme Corp. Method for producing proteins in Pichia pastoris that lack detectable cross binding activity to antibodies against host cell antigens
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KR101578137B1 (ko) * 2010-02-02 2015-12-28 삼성전자주식회사 이기종 시스템을 지원하는 이동 단말에서 핸드오버 방법 및 장치
MX2012009349A (es) * 2010-02-10 2013-02-11 Biocon Ltd Metodo para reducir glucosilacion de proteinas, procedimientos y proteinas de los mismos.
RU2012140429A (ru) 2010-02-24 2014-03-27 Мерк Шарп Энд Домэ Корп. Способ увеличения занятости участков n-ликозилирования на терапевтических гликопротеинах, продуцируемых в p pastoris
JP5956982B2 (ja) 2010-05-27 2016-07-27 メルク・シャープ・エンド・ドーム・コーポレイション 改善された特性を有する抗体の製造方法
TWI537385B (zh) 2010-11-04 2016-06-11 中央研究院 產生具簡單醣基化之表面蛋白質之病毒顆粒的方法
US9365846B2 (en) 2010-12-01 2016-06-14 Merck Sharp & Dohme Corp. Surface, anchored Fc-bait antibody display system
CN103764837A (zh) 2011-02-25 2014-04-30 默沙东公司 用于生产具有修饰的o-糖基化的蛋白的酵母菌株
EP2678030A4 (en) * 2011-02-25 2015-02-18 Merck Sharp & Dohme PREPARATION OF N- AND O-SIALYLATED TNFRII-FC FUSION PROTEINS IN YEAST
AU2012258907A1 (en) 2011-05-25 2013-11-07 Merck Sharp & Dohme Corp. Method for preparing Fc-containing polypeptides having improved properties
WO2013062886A1 (en) * 2011-10-27 2013-05-02 Merck Sharp & Dohme Corp. Controlling o-glycosylation in lower eukaryotes
EP2847368B1 (en) 2012-05-11 2020-08-19 Merck Sharp & Dohme Corp. Surface anchored light chain bait antibody display system
US10683521B2 (en) * 2012-06-19 2020-06-16 Nanyang Technological University Expression construct for sensing cell density and substrate availability and its use in conversion of hydroxycinnamic acids
US9707276B2 (en) 2012-12-03 2017-07-18 Merck Sharp & Dohme Corp. O-glycosylated carboxy terminal portion (CTP) peptide-based insulin and insulin analogues
US20140273094A1 (en) * 2013-03-15 2014-09-18 Bristol-Myers Squibb Company Methods of enhancing protein quality and quantity by yeast fed-batch fermentation
WO2015001049A1 (en) 2013-07-04 2015-01-08 Novartis Ag O-mannosyltransferase deficient filamentous fungal cells and methods of use thereof
WO2015013116A1 (en) * 2013-07-25 2015-01-29 Merck Sharp & Dohme Corp. Method for reducing the extent of o-mannosylation of glycoproteins
EP2871235A1 (en) * 2013-11-07 2015-05-13 Centre National de la Recherche Scientifique (CNRS) New methods to produce active hTERT
CN106795532A (zh) * 2014-06-16 2017-05-31 英威达技术有限责任公司 用于生物合成化合物的方法、试剂和细胞
SG11201700446XA (en) * 2014-07-21 2017-02-27 Glykos Finland Oy Production of glycoproteins with mammalian-like n-glycans in filamentous fungi
CN104198613B (zh) * 2014-09-17 2016-04-06 山东大学 一种分析蛋白o-糖基化位点的方法
WO2020010284A1 (en) * 2018-07-04 2020-01-09 Cytoimmune Therapeutics, LLC Compositions and methods for immunotherapy targeting flt3, pd-1, and/or pd-l1
JP2021534763A (ja) * 2018-08-21 2021-12-16 クララ フーズ カンパニー 微生物におけるタンパク質のグリコシル化の修飾
JP2026501773A (ja) 2023-01-05 2026-01-16 グリコエラ アーゲー 免疫グロブリンａを標的とする糖鎖改変ポリペプチド及びそれを含む複合体
WO2024147113A1 (en) 2023-01-05 2024-07-11 Glycoera Ag Glycoengineered polypeptides targeting anti-podocyte autoantibodies and uses thereof
US20260055211A1 (en) 2023-01-05 2026-02-26 Glycoera Ag Glycoengineered polypeptides targeting anti-neutrophil autoantibodies and uses thereof
WO2024218743A1 (en) 2023-04-21 2024-10-24 Glycoera Ag Multi-functional molecules comprising glycans and uses thereof
WO2025215516A1 (en) 2024-04-08 2025-10-16 Glycoera Ag Glycoengineered polypeptides targeting igg4 autoantibodies and uses thereof

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Also Published As

Publication number Publication date
US20120237973A1 (en) 2012-09-20
EP1954815A2 (en) 2008-08-13
JP5284789B2 (ja) 2013-09-11
WO2007061631A3 (en) 2008-10-23
CN101365783B (zh) 2013-07-17
US20090170159A1 (en) 2009-07-02
EP1954815A4 (en) 2010-07-07
AU2006316838B2 (en) 2012-04-12
US8501438B2 (en) 2013-08-06
AU2006316838A1 (en) 2007-05-31
US20120322101A1 (en) 2012-12-20
JP2009515963A (ja) 2009-04-16
US8795984B2 (en) 2014-08-05
US8206949B2 (en) 2012-06-26
WO2007061631A2 (en) 2007-05-31
WO2007061631A8 (en) 2008-05-02
EP1954815B1 (en) 2015-02-25
CA2628725A1 (en) 2007-05-31
CN101365783A (zh) 2009-02-11

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