ES2533074T3 - Medio de cultivo celular mejorado - Google Patents
Medio de cultivo celular mejorado Download PDFInfo
- Publication number
- ES2533074T3 ES2533074T3 ES11717240.3T ES11717240T ES2533074T3 ES 2533074 T3 ES2533074 T3 ES 2533074T3 ES 11717240 T ES11717240 T ES 11717240T ES 2533074 T3 ES2533074 T3 ES 2533074T3
- Authority
- ES
- Spain
- Prior art keywords
- cell culture
- cells
- culture medium
- medium
- concentration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
- C12N5/0031—Serum-free culture media
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
- C12N5/005—Protein-free medium
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/05—Inorganic components
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/05—Inorganic components
- C12N2500/10—Metals; Metal chelators
- C12N2500/12—Light metals, i.e. alkali, alkaline earth, Be, Al, Mg
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32783610P | 2010-04-26 | 2010-04-26 | |
| US327836P | 2010-04-26 | ||
| PCT/EP2011/056508 WO2011134920A1 (en) | 2010-04-26 | 2011-04-25 | Improved cell culture medium |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2533074T3 true ES2533074T3 (es) | 2015-04-07 |
Family
ID=44074260
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES11717240.3T Active ES2533074T3 (es) | 2010-04-26 | 2011-04-25 | Medio de cultivo celular mejorado |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | USRE48864E1 (e) |
| EP (1) | EP2563904B1 (e) |
| JP (3) | JP6347949B2 (e) |
| KR (1) | KR101828623B1 (e) |
| CN (1) | CN102858952B (e) |
| AU (1) | AU2011246503B2 (e) |
| BR (1) | BR112012027282B1 (e) |
| CA (1) | CA2797356C (e) |
| DK (1) | DK2563904T3 (e) |
| ES (1) | ES2533074T3 (e) |
| IL (1) | IL222452B (e) |
| MX (1) | MX2012012526A (e) |
| PL (1) | PL2563904T3 (e) |
| PT (1) | PT2563904E (e) |
| RU (1) | RU2644651C2 (e) |
| SG (1) | SG185038A1 (e) |
| WO (1) | WO2011134920A1 (e) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8911964B2 (en) | 2006-09-13 | 2014-12-16 | Abbvie Inc. | Fed-batch method of making human anti-TNF-alpha antibody |
| AU2007294731B2 (en) | 2006-09-13 | 2014-04-17 | Abbvie Inc. | Cell culture improvements |
| CA2911256A1 (en) | 2008-10-20 | 2010-12-09 | Robert K. Hickman | Isolation and purification of antibodies using protein a affinity chromatography |
| NZ592097A (en) | 2008-10-20 | 2013-01-25 | Abbott Lab | Viral inactivation during purification of il-12 and il-18 antibodies |
| AU2011246504B2 (en) | 2010-04-26 | 2013-09-26 | Novartis Ag | Improved cell culture medium |
| SG185038A1 (en) * | 2010-04-26 | 2012-11-29 | Novartis Ag | Improved cell culture medium |
| KR101507254B1 (ko) | 2010-12-07 | 2015-03-30 | 에프. 호프만-라 로슈 아게 | 공급물 혼합 장치 및 그 용도 |
| WO2012149197A2 (en) | 2011-04-27 | 2012-11-01 | Abbott Laboratories | Methods for controlling the galactosylation profile of recombinantly-expressed proteins |
| US10493151B2 (en) | 2011-10-18 | 2019-12-03 | Coherus Biosciences, Inc. | Etanercept formulations stabilized with sodium chloride |
| WO2013059406A1 (en) | 2011-10-18 | 2013-04-25 | Coherus Biosciences, Inc. | Etanercept formulations stabilized with metal ions |
| WO2013158273A1 (en) | 2012-04-20 | 2013-10-24 | Abbvie Inc. | Methods to modulate c-terminal lysine variant distribution |
| US9067990B2 (en) | 2013-03-14 | 2015-06-30 | Abbvie, Inc. | Protein purification using displacement chromatography |
| US9334319B2 (en) | 2012-04-20 | 2016-05-10 | Abbvie Inc. | Low acidic species compositions |
| US20130281355A1 (en) | 2012-04-24 | 2013-10-24 | Genentech, Inc. | Cell culture compositions and methods for polypeptide production |
| WO2013176754A1 (en) | 2012-05-24 | 2013-11-28 | Abbvie Inc. | Novel purification of antibodies using hydrophobic interaction chromatography |
| EP2869817A4 (en) | 2012-07-09 | 2016-04-06 | Coherus Biosciences Inc | STABLE AQUEOUS FORMULATIONS OF ETANERCEPT |
| KR20150043523A (ko) | 2012-09-02 | 2015-04-22 | 애브비 인코포레이티드 | 단백질 불균일성의 제어 방법 |
| US9512214B2 (en) | 2012-09-02 | 2016-12-06 | Abbvie, Inc. | Methods to control protein heterogeneity |
| BR112015005161A2 (pt) | 2012-09-11 | 2017-07-04 | Coherus Biosciences Inc | etanercepte corretamente dobrado em alta pureza e excelente rendimento |
| SG11201507230PA (en) | 2013-03-12 | 2015-10-29 | Abbvie Inc | Human antibodies that bind human tnf-alpha and methods of preparing the same |
| US9017687B1 (en) | 2013-10-18 | 2015-04-28 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same using displacement chromatography |
| WO2014158231A1 (en) | 2013-03-14 | 2014-10-02 | Abbvie Inc. | Low acidic species compositions and methods for producing and using the same |
| WO2014159579A1 (en) | 2013-03-14 | 2014-10-02 | Abbvie Inc. | MUTATED ANTI-TNFα ANTIBODIES AND METHODS OF THEIR USE |
| BR112016002622B1 (pt) | 2013-08-20 | 2023-04-11 | Lek Pharmaceuticals D.D | Meio de cultura celular e uso de selênio |
| US9598667B2 (en) | 2013-10-04 | 2017-03-21 | Abbvie Inc. | Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins |
| KR102510238B1 (ko) * | 2013-10-11 | 2023-03-16 | 리제너론 파마슈티칼스 인코포레이티드 | 대사적으로 최적화된 세포 배양 |
| US11390663B2 (en) | 2013-10-11 | 2022-07-19 | Regeneron Pharmaceuticals, Inc. | Metabolically optimized cell culture |
| US8946395B1 (en) | 2013-10-18 | 2015-02-03 | Abbvie Inc. | Purification of proteins using hydrophobic interaction chromatography |
| US9181337B2 (en) | 2013-10-18 | 2015-11-10 | Abbvie, Inc. | Modulated lysine variant species compositions and methods for producing and using the same |
| US9085618B2 (en) | 2013-10-18 | 2015-07-21 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same |
| WO2015073884A2 (en) | 2013-11-15 | 2015-05-21 | Abbvie, Inc. | Glycoengineered binding protein compositions |
| JP6749838B2 (ja) * | 2014-01-30 | 2020-09-02 | コヒラス・バイオサイエンシズ・インコーポレイテッド | かん流培地 |
| LT3137595T (lt) | 2014-04-29 | 2019-06-25 | Novartis Ag | Naujos stuburinių ląstelės ir dominančio polipeptido rekombinantinės raiškos būdai |
| EP2975050B1 (en) | 2014-07-18 | 2019-05-29 | Sandoz Ag | Quantification of misfolded TNFR2:Fc |
| WO2017106783A1 (en) * | 2015-12-17 | 2017-06-22 | Life Technologies Corporation | Pellets used in cell culture and methods of making thereof |
| IL261999B2 (en) * | 2016-04-05 | 2023-04-01 | Pfizer | Cell culture process |
| US11702628B2 (en) | 2017-03-31 | 2023-07-18 | Boehringer Ingelheim International Gmbh | Perfusion medium for culturing mammalian cells and reducing cell bleed in a perfusion cell culture |
| WO2018178063A1 (en) * | 2017-03-31 | 2018-10-04 | Boehringer Ingelheim International Gmbh | Perfusion medium |
| JPWO2021090888A1 (e) * | 2019-11-05 | 2021-05-14 | ||
| EP4196597A2 (en) * | 2020-08-14 | 2023-06-21 | Bristol-Myers Squibb Company | Manufacturing process for protein |
| UY39484A (es) | 2020-11-02 | 2022-06-30 | Novartis Ag | Inhibidores de interleucina-17 |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5672502A (en) | 1985-06-28 | 1997-09-30 | Celltech Therapeutics Limited | Animal cell culture |
| EP0283942B1 (en) | 1987-03-24 | 1992-05-20 | W.R. Grace & Co.-Conn. | Basal nutrient medium for cell culture |
| US6048728A (en) * | 1988-09-23 | 2000-04-11 | Chiron Corporation | Cell culture medium for enhanced cell growth, culture longevity, and product expression |
| CA2001550A1 (en) | 1989-03-03 | 1990-09-03 | Aaron H. Heifetz | Very low protein nutrient medium for cell culture |
| US5135866A (en) | 1989-03-03 | 1992-08-04 | W. R. Grace & Co.-Conn. | Very low protein nutrient medium for cell culture |
| US5122469A (en) | 1990-10-03 | 1992-06-16 | Genentech, Inc. | Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins |
| GB9022545D0 (en) | 1990-10-17 | 1990-11-28 | Wellcome Found | Culture medium |
| JPH0789908B2 (ja) | 1991-02-28 | 1995-10-04 | 倉敷紡績株式会社 | 動物細胞培養用無血清培地 |
| GB9118664D0 (en) * | 1991-08-30 | 1991-10-16 | Celltech Ltd | Cell culture |
| US5856179A (en) | 1994-03-10 | 1999-01-05 | Genentech, Inc. | Polypeptide production in animal cell culture |
| US5830761A (en) | 1995-06-07 | 1998-11-03 | Genetics Institute, Inc. | Medium and methods for culturing mammalian cho cells |
| EP2221361A3 (en) | 1996-08-30 | 2011-02-09 | Life Technologies Corporation | Method for producing a polypeptide in vitro in mammalian cells in a protein-free and serum-free culture medium |
| US5804420A (en) | 1997-04-18 | 1998-09-08 | Bayer Corporation | Preparation of recombinant Factor VIII in a protein free medium |
| US6406909B1 (en) | 1998-07-10 | 2002-06-18 | Chugai Seiyaku Kabushiki Kaisha | Serum-free medium for culturing animal cells |
| US7294481B1 (en) | 1999-01-05 | 2007-11-13 | Immunex Corporation | Method for producing recombinant proteins |
| EP1757700A3 (en) | 1999-04-26 | 2009-03-11 | Genentech, Inc. | Cell culture process for glycoproteins |
| AU4980200A (en) | 1999-05-27 | 2000-12-18 | Pharmacia & Upjohn Company | Methods and compositions for measuring ion channel conductance |
| AT409379B (de) * | 1999-06-02 | 2002-07-25 | Baxter Ag | Medium zur protein- und serumfreien kultivierung von zellen |
| CA2395271A1 (en) | 1999-12-28 | 2001-07-05 | Isotis N.V. | Cell culture medium containing growth factors and l-glutamine |
| EP1360314B1 (en) | 2001-02-15 | 2009-01-14 | Centocor, Inc. | Chemically defined medium for cultured mammalian cells |
| US20030087372A1 (en) | 2001-06-13 | 2003-05-08 | Genentech, Inc. | Methods of culturing animal cells and polypeptide production in animal cells |
| AU2003249055B2 (en) | 2002-07-15 | 2008-06-26 | Immunex Corporation | Methods and media for controlling sialylation of proteins produced by mammalian cells |
| WO2004058800A2 (en) | 2002-12-23 | 2004-07-15 | Bristol-Myers Squibb Company | Mammalian cell culture processes for protein production |
| GB0304799D0 (en) * | 2003-03-03 | 2003-04-09 | Glaxosmithkline Biolog Sa | Novel method |
| DE10338536A1 (de) | 2003-08-19 | 2005-04-07 | Bircher Reglomat Ag | Verfahren zum Betreiben eines Radarsensors |
| TWI384069B (zh) * | 2004-08-27 | 2013-02-01 | Pfizer Ireland Pharmaceuticals | 多胜肽之製法 |
| US7335491B2 (en) | 2004-08-27 | 2008-02-26 | Wyeth Research Ireland Limited | Production of anti-abeta |
| EP1707634A1 (en) | 2005-03-29 | 2006-10-04 | Octapharma AG | Method for isolation of recombinantly produced proteins |
| EP1937798A4 (en) * | 2005-04-15 | 2009-05-13 | Univ Columbia | CHEMICALLY DEFINED CULTURAL MEDIA FOR THE EXPANSION AND DIFFERENTIATION OF EPIDERMIC CELLS AND USES THEREOF FOR THE IN VITRO FARMING OF HAIRFOLLICLES |
| US20070231895A1 (en) | 2005-11-02 | 2007-10-04 | Lee Gene W | Methods for adapting mammalian cells |
| US20070190057A1 (en) | 2006-01-23 | 2007-08-16 | Jian Wu | Methods for modulating mannose content of recombinant proteins |
| KR101523782B1 (ko) * | 2006-11-08 | 2015-05-28 | 와이어쓰 엘엘씨 | 세포 배양을 위한 합리적으로 설계된 배지 |
| SG185038A1 (en) * | 2010-04-26 | 2012-11-29 | Novartis Ag | Improved cell culture medium |
-
2011
- 2011-04-25 SG SG2012079174A patent/SG185038A1/en unknown
- 2011-04-25 AU AU2011246503A patent/AU2011246503B2/en active Active
- 2011-04-25 BR BR112012027282-9A patent/BR112012027282B1/pt active IP Right Grant
- 2011-04-25 EP EP11717240.3A patent/EP2563904B1/en not_active Revoked
- 2011-04-25 MX MX2012012526A patent/MX2012012526A/es active IP Right Grant
- 2011-04-25 DK DK11717240T patent/DK2563904T3/en active
- 2011-04-25 RU RU2012150346A patent/RU2644651C2/ru active
- 2011-04-25 PT PT117172403T patent/PT2563904E/pt unknown
- 2011-04-25 US US16/114,731 patent/USRE48864E1/en active Active
- 2011-04-25 CN CN201180021024.XA patent/CN102858952B/zh active Active
- 2011-04-25 US US13/643,998 patent/US9428727B2/en not_active Ceased
- 2011-04-25 JP JP2013506612A patent/JP6347949B2/ja active Active
- 2011-04-25 ES ES11717240.3T patent/ES2533074T3/es active Active
- 2011-04-25 PL PL11717240T patent/PL2563904T3/pl unknown
- 2011-04-25 KR KR1020127030709A patent/KR101828623B1/ko active IP Right Grant
- 2011-04-25 CA CA2797356A patent/CA2797356C/en active Active
- 2011-04-25 WO PCT/EP2011/056508 patent/WO2011134920A1/en active Application Filing
-
2012
- 2012-10-15 IL IL222452A patent/IL222452B/en active IP Right Grant
-
2016
- 2016-08-03 JP JP2016152747A patent/JP6603628B2/ja active Active
-
2019
- 2019-08-01 JP JP2019142124A patent/JP7034991B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US9428727B2 (en) | 2016-08-30 |
| AU2011246503B2 (en) | 2013-09-26 |
| JP7034991B2 (ja) | 2022-03-14 |
| RU2018101201A3 (e) | 2021-05-27 |
| USRE48864E1 (en) | 2021-12-28 |
| RU2012150346A (ru) | 2014-06-10 |
| EP2563904B1 (en) | 2015-01-21 |
| IL222452B (en) | 2019-03-31 |
| PT2563904E (pt) | 2015-05-12 |
| WO2011134920A1 (en) | 2011-11-03 |
| IL222452A0 (en) | 2012-12-31 |
| CA2797356C (en) | 2020-12-29 |
| US20130122543A1 (en) | 2013-05-16 |
| CN102858952B (zh) | 2015-10-14 |
| RU2644651C2 (ru) | 2018-02-13 |
| CN102858952A (zh) | 2013-01-02 |
| AU2011246503A1 (en) | 2012-11-22 |
| JP2019216728A (ja) | 2019-12-26 |
| CA2797356A1 (en) | 2011-11-03 |
| BR112012027282B1 (pt) | 2020-09-29 |
| JP2013524825A (ja) | 2013-06-20 |
| EP2563904A1 (en) | 2013-03-06 |
| KR20130058699A (ko) | 2013-06-04 |
| MX2012012526A (es) | 2012-11-23 |
| SG185038A1 (en) | 2012-11-29 |
| JP6603628B2 (ja) | 2019-11-06 |
| JP6347949B2 (ja) | 2018-06-27 |
| BR112012027282A2 (pt) | 2015-09-22 |
| DK2563904T3 (en) | 2015-04-07 |
| KR101828623B1 (ko) | 2018-02-12 |
| RU2018101201A (ru) | 2019-02-21 |
| JP2017012180A (ja) | 2017-01-19 |
| PL2563904T3 (pl) | 2015-06-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2533074T3 (es) | Medio de cultivo celular mejorado | |
| ES2659117T3 (es) | Proceso de cultivo celular de CHO | |
| ES2755907T3 (es) | Medio de cultivo celular mejorado | |
| US5122469A (en) | Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins | |
| KR101832795B1 (ko) | 소형 펩티드를 포함하는 세포 배양 배지 | |
| RU2798069C2 (ru) | Улучшенная среда для культивирования клеток | |
| WO2012008920A1 (en) | Materials and methods for enhanced iron uptake in cell culture |